Funding Opportunity Announcements

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Title FOA # Status Expires Priority Area Purpose
BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01) RFA-NS-18-008 Closed December 16, 2017
  • Integrated Approaches

The purpose of this FOA is to promote the integration of experimental, analytic, and theoretical capabilities for large-scale analysis of neural systems and circuits. This FOA seeks applications for exploratory research studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions. Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions.  Studies should incorporate rich information on cell-types, on circuit functionality and connectivity, and should be performed in conjunction with sophisticated analysis of complex, ethologically relevant behaviors. Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration by bridging fields and linking theory and data analysis to experimental design. Exploratory studies supported by this FOA are intended to develop experimental capabilities and quantitative, theoretical frameworks in preparation for a future competition for larger-scale, multi-component, Team-Research Circuit Programs (U19) awards.

BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24) - Clinical Trial Not Allowed RFA-NS-18-005 Closed February 10, 2018
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice.  Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document "BRAIN 2025: A Scientific Vision." They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users are allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.

BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44) RFA-NS-17-007 Closed October 19, 2017
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain.  The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical study (e.g., Early Feasibility Study).  Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. The small clinical study should provide data to answer key questions about the function or final design of a device.  This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval.  The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System RFA-NS-15-004 Closed
  • Monitor Neural Activity
  • Interventional Tools
Although invention and proof-of-concept testing of new technologies are key components of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. In this FOA we seek applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain.
Integrated Approaches to Understanding Circuit Function in the Nervous System RFA-NS-15-005 Closed
  • Cell Type
  • Circuit Diagrams
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

The purpose of this FOA is to promote the integration of experimental, analytic, and theoretical capabilities for large-scale analysis of neural systems and circuits. This FOA seeks applications for exploratory research studies that use new and emerging methods for large scale recording and manipulation of neural circuits across multiple brain regions. Applications should propose to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.

Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-15-006 Closed
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.

Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-15-008 Closed
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this FOA is to encourage applications to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board, or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR)(Clinical Trial Not Allowed) PAR-18-501 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Innovation Research (SBIR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through the BRAIN initiative or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience research.
Transformative Approaches for Cell-Type Classification in the Brain RFA-MH-14-215 Closed
  • Cell Type
aims to pilot classification strategies to generate a systematic inventory/cell census of cell types in the brain, integrating molecular identity of cell types with connectivity, morphology, and location. These pilot projects and methodologies should be designed to demonstrate their utility and scalability to ultimately complete a comprehensive cell census of the human brain.
Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)(Clinical Trial Not Allowed) PAR-18-515 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research. This FOA specifically supports the development of novel neurotechnologies as well as the translation of technologies developed through the BRAIN initiative or through other funding programs, towards commercialization. Funding can support the iterative refinement of these tools and technologies with the end-user community, with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice.
Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain RFA-MH-14-216 Closed
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
aims to develop and validate novel tools that possess a high degree of cell-type and/or circuit-level specificity to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. A particular emphasis is the development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest; new approaches are also expected to target specific cell types and or circuits in the nervous system with greater precision and sensitivity than currently established methods.
Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) PAR-15-091 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the Small Business Innovation Research (SBIR) program to advance the field of neuroscience research including 1) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function, 2) proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, and 3) iterative refinement of such tools and technologies with the end-user community with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice. Application Receipt Date(s): Standard Dates Apply
Planning for Next Generation Human Brain Imaging RFA-MH-14-217 Closed
  • Monitor Neural Activity
  • Interventional Tools
  • Human Neuroscience
aims to create teams of imaging scientist together with other experts from a range of disciplines such as engineering, material sciences, nanotechnology and computer science, to plan for a new generation of non-invasive imaging techniques that would be used to understand human brain function. Incremental improvements to existing technologies will not be funded under this announcement.
SBIR Phase II - Optimization of Novel Tools and Technologies for Neuroscience Research PAR-15-121 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
In this Funding Opportunity Announcement (FOA) we seek applications through the Small Business Innovation Research (SBIR) program for the optimization of existing and emerging technologies and approaches including 1) technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, 2) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development with an end-goal of broad dissemination and incorporation into regular neuroscience practice. Note, this FOA is distinct from PAR-15-091 only in that it is direct to Phase II. All other goals are the same. Application Receipt Date(s): April 28, 2015 and then Standard Dates Apply
Notice to Extend RFA-MH-17-220 "BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)" NOT-MH-16-026 Closed The purpose of this Notice is to extend RFA-MH-17-220 “BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)" that invites application to develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function.
New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System RFA-NS-14-007 Closed
  • Monitor Neural Activity
  • Interventional Tools
focuses on development and proof-of-concept testing of new technologies and novel approaches for large scale recording and manipulation of neural activity, with cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. The proposed research may be high risk, but if successful could profoundly change the course of neuroscience research.
Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR) PAR-15-090 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this funding opportunity announcement (FOA) is to support the development of novel tools and technologies through the through the Small Business Technology Transfer (STTR) program to advance the field of neuroscience research, including 1) tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function, 2) proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain, and 3) iterative refinement of such tools and technologies with the end-user community with an end-goal of scaling manufacture towards reliable, broad, sustainable dissemination and incorporation into regular neuroscience practice. Application Receipt Date(s): Standard Dates Apply
Notice to extend RFA-MH-17-235 “BRAIN Initiative: Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities (R01)" NOT-MH-16-025 Closed The purpose of this Notice is to extend RFA-MH-17-235 “BRAIN Initiative: Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities (R01)" that invites application to support effort that will revolutionize our understanding of the biological activity underlying, and bioinformatic content of data collected using contemporary non-invasive functional brain imaging techniques.
Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System RFA-NS-14-008 Closed
  • Monitor Neural Activity
  • Interventional Tools
aims to optimize existing and emerging technologies and approaches that have the potential to address major challenges associated with recording and manipulating neural activity. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated engineering development with an end-goal of broad dissemination and incorporation into regular neuroscience research.
Notice of NIH/FDA Informational Webinar - Common Misunderstandings of the Investigational Device Exemption Process for Invasive Neuromodulation Devices NOT-NS-16-006 Closed

This Notice is to inform potential applicants to Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative FOAs for Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (RFA-NS-16-009, RFA-NS-16-010, RFA-NS-16-011 and RFA-NS-16-018) of a webinar with both FDA and NIH staff to provide assistance for the Investigational Device Exemption (IDE) process for neuromodulation devices. The webinar is optional and is not required for submission to RFA-NS-16-009, RFA-NS-16-010, RFA-NS-16-011 or RFA-NS-16-018. To register for the webinar, and to submit questions, please email BRAIN-FOAs@nih.gov by Tuesday, February 23, 2016.

Notice to extend RFA-MH-17-240 “BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01)" NOT-MH-16-024 Closed The purpose of this Notice is to extend RFA-MH-17-240 “BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01)" that invites application to develop and test novel tools and methods of neuromodulation that go beyond the existing variations.
Integrated Approaches to Understanding Circuit Function in the Nervous System RFA-NS-14-009 Closed
  • Cell Type
  • Circuit Diagrams
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

focuses onexploratory studies that use new and emerging methods for large scale recording and manipulation to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system. Applications should propose teams of investigators that seek to cross boundaries of interdisciplinary collaboration, for integrated development of experimental, analytic and theoretical capabilities in preparation for a future competition for large-scale awards.

Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain RFA-NS-17-019 Closed
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity

Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system. The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice as well as supplemental opportunities to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

Notice to Extend RFA-MH-17-245 "BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects (R01)" NOT-MH-16-023 Closed The purpose of this Notice is to extend RFA-MH-17-245 “BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01)" that invites application to encourage the optimization of existing electrical and magnetic stimulation methods.
New Concepts and Early- Stage Research for Large-Scale Recording and Modulation in the Nervous System RFA-EY-15-001 Closed
  • Monitor Neural Activity
  • Interventional Tools
Previous BRAIN FOAs sought technologies ready for in-vivo proof-of-concept testing and collection of preliminary data. This FOA seeks applications for technology at an earlier stage of development. Support might enable simulations or other mathematical approaches, building and testing prototypes, or in vitro or other bench-top models, to validate theoretical assumptions regarding brain signal sources or proposed measurement technologies. Invasive or non-invasive approaches are sought that will enable or reduce barriers to large-scale recording or manipulation of neural activity, compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved in neuroscience research.
Request for Information (RFI): Guidance for Opportunities in Neuroethics NOT-MH-16-014 Closed
Planning for Next Generation Human Brain Imaging RFA-MH-15-200 Closed
  • Monitor Neural Activity
  • Interventional Tools
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support planning activities and the initial stages of development of entirely new or next generation brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain.
Foundations of Non-Invasive Human Brain Imaging and Neuro-Recording Techniques (R01) and Participation by the Australian National Health and Medical Research Council NOT-MH-15-022 Closed The NIMH, with other NIH Institutes and Centers (ICs) that are part of the BRAIN Initiative, intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on the foundations of non-invasive human brain imaging and neuro-recording techniques. The goal of this FOA will be to support integrative, multidisciplinary efforts that will revolutionize our understanding of the meaning of the data collected from non-invasive human brain imaging and functional evaluation techniques. The NIH Institutes and Centers that are part of the NIH BRAIN Initiative announce a new partnership, formalized by a letter of agreement, with the Australian National Health and Medical Research Council (NHMRC) to support the involvement of Australian researchers in specific NIH BRAIN Initiative programs. Both the NIH and the NHMRC believe that the ambitious goals of the BRAIN Initiative can best be attained by collaborating across disciplinary boundaries as well as geographic boundaries. Details about NHMRC application procedures, funding rules, and eligibility requirements will be available on the NHMRC website.
Short Courses in Computational Neuroscience RFA-MH-15-215 Closed
  • Theory & Data Analysis Tools
This funding opportunity announcement (FOA) will support short courses to facilitate the development of a sophisticated cadre of investigators with the requisite knowledge and skills in computational neuroscience perspectives and techniques for analyzing and interpreting complex, high-dimensional neuroscience data to advance the BRAIN Initiative. For the purposes of this FOA, computational neuroscience encompasses theoretical neuroscience, computational and mathematical modeling of neural systems, and/or statistical perspectives and techniques. Each short course is expected to include both didactics and in-person/hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.
BRAIN Initiative Multi-Council Working Group Clearance of Initiative Concepts for FY2017 NOT-NS-16-041 Closed The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is an ambitious multi-agency effort announced by President Obama in April 2013. Specific goals for NIH contributions to the Initiative were formulated over a year-long planning process that culminated in the release of BRAIN 2025: A Scientific Vision, a seminal planning document produced by a working committee of the Advisory Council to the NIH Director. NIH continues to be guided by this document and by input from the BRAIN Multi-Council Working Group (MCWG), a committee that includes Advisory Council members from each of the ten NIH Institutes and Centers (ICs) contributing to the BRAIN Initiative.
Short Courses in Research Tools and Methods RFA-MH-15-220 Closed
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
  • Theory & Data Analysis Tools
This funding opportunity announcement (FOA) will support creative educational activities with a primary focus on Courses for Skills Development that will build participants’ foundational knowledge and skills in the rigorous use of state-of-the art scientific tools and methods that contribute to, and are developed in response to, the major goals of the BRAIN Initiative. Each short course is expected to include both didactics and in-person / hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.
Notice of Change to the Application Due Date and to Allow Foreign Components for Applications to RFA-NS-16-008 “BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01) NOT-NS-15-044 Closed

This Notice is to change the application due date, and to correct the information on eligible organizations for RFA-NS-16-008 “BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01).” The new due date will be January 13, 2016. Also the changed Funding Opportunity Announcement (FOA) will allow applications that include foreign components, such as sub-contracts to foreign organizations and/or activities performed at foreign organizations.

Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain RFA-MH-15-225 Closed
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
This announcement supports development and validation of novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function.
New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System RFA-NS-15-003 Closed
  • Monitor Neural Activity
  • Interventional Tools
Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, to enable transformative understanding of dynamic signaling in the nervous system.
Theories, Models and Methods for Analysis of Complex Data from the Brain RFA-EB-15-006 Closed October 21, 2015
  • Integrated Approaches
  • Theory & Data Analysis Tools

This FOA solicits new theories, computational models, and statistical methods to derive understanding of brain function from complex neuroscience data. Approaches could include the creation of new theories, ideas, and conceptual frameworks to organize/unify data and infer general principles of brain function; new computational models to develop testable hypotheses and design/drive experiments; and new mathematical and statistical methods to support or refute a stated hypothesis about brain function, and/or assist in detecting features in complex brain data.

Short Courses in Computational Neuroscience RFA-MH-16-700 Closed November 06, 2015
  • Theory & Data Analysis Tools
700 To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development. This FOA will support short courses to facilitate the development of a sophisticated cadre of investigators with the requisite knowledge and skills in computational neuroscience perspectives and techniques for analyzing and interpreting complex, high-dimensional neuroscience data to advance the BRAIN Initiative. For the purposes of this FOA, computational neuroscience encompasses theoretical neuroscience, computational and mathematical modeling of neural systems, and/or statistical perspectives and techniques. Each short course is expected to include both didactics and in-person/hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.
Pre-Applications for Industry Partnerships to Provide Early Access to Devices for Stimulation and Recording in the Human Central Nervous System PAR-15-345 Closed November 18, 2015
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

This FOA is intended to facilitate partnerships between clinical investigators and manufacturers of latest-generation stimulating and/or recording devices that are FDA-designated as Class III (invasive, posing significant risk of harm), to conduct clinical research in the central nervous system. As part of The BRAIN InitiativeSM, NIH has initiated a Public-Private Partnership program (BRAIN PPP) to reduce barriers to negotiating such partnerships, and to ensure that new clinical studies leverage manufacturers’ existing data demonstrating safety and utility of these devices. Safety and utility data for invasive devices are costly to obtain, yet they are necessary for regulatory approval of human research, and therefore pose a substantial barrier to research progress. For this program, NIH has entered into agreements with a number of manufacturers to make available next generation devices that can stimulate and/or record from the central nervous system and have sufficient data to enable new Non-Significant Risk (NSR) or Investigational Device Exemption (IDE) without the need for significant additional testing.

Technology Sharing and Propagation RFA-MH-16-725 Closed January 06, 2016
  • Monitor Neural Activity
  • Interventional Tools
  • Theory & Data Analysis Tools
The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Funding Opportunity Announcement (FOA) is to encourage the transfer of new technologies and new data analysis techniques into a research laboratory. One of the key goals of the BRAIN Initiative is to develop new technologies to improve our understanding of the brain. In order for those technologies to be useful, they need to be broadly disseminated beyond the laboratory or company where they originated. This FOA promotes this goal by providing funds to enable the incorporation of new technologies or data analysis techniques into research programs that further the aims of the BRAIN initiative.
Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain RFA-NS-16-008 Closed January 13, 2016
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity

Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system. The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. In the interest of iterative models of discovery, support for complementary animal studies may be allowed if they validate or inform these empirical studies of human physiology or dysfunction. Applicants are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate.

Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities RFA-MH-16-750 Closed January 13, 2016
  • Monitor Neural Activity
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts that will revolutionize our understanding of the biological activity underlying, and bioinformatic content of, data collected using contemporary non-invasive functional brain imaging techniques. The hope is that these transformative discoveries will lead to breakthroughs in understanding the dynamic activity of the human brain.
Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01) RFA-MH-16-775 Closed February 02, 2016
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
Non-Invasive Neuromodulation – New Tools and Techniques for Spatiotemporal Precision RFA-MH-16-810 Closed February 18, 2016
  • Interventional Tools
  • Human Neuroscience
This Funding Opportunity Announcement (FOA) solicits grant applications in two related but distinct areas. The first area is in the development and testing of novel tools and methods of neuromodulation that go beyond the existing variations on magnetic or electrical stimulation, and that represent more than an incremental advance over existing electromagnetic approaches. The second distinct area that this FOA seeks to encourage is the optimization of existing electrical and magnetic stimulation methods.
Non-Invasive Neuromodulation – Mechanisms and Dose/Response Relationships for Targeted CNS Effects RFA-MH-16-815 Closed February 18, 2016
  • Interventional Tools
  • Human Neuroscience
The focus of this Funding Opportunity Announcement (FOA) is to better understand how existing non-invasive neuromodulation devices affect brain circuity. This information should shed light on dose/response relationships that could be used for neuroscience applications and clinical interventions.
New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System RFA-NS-16-006 Closed February 24, 2016
  • Monitor Neural Activity
  • Interventional Tools
Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large-scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system. In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Where appropriate, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System RFA-NS-16-007 Closed February 24, 2016
  • Monitor Neural Activity
  • Interventional Tools
Although invention and proof-of-concept testing of new technologies is a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
New Concepts and Early-Stage Research for Large-Scale Recording and Modulation in the Nervous System RFA-EY-16-001 Closed March 15, 2016
  • Monitor Neural Activity
  • Interventional Tools
A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-16-006) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-16-007) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.
Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-16-009 Closed April 26, 2016
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study.

Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-16-010 Closed April 26, 2016
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.

Next-Generation Invasive Devises for Recording and Modulation in the Human Central Nervous System (SBIR) RFA-NS-16-011 Closed April 26, 2016
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain. The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical study (e.g., Early Feasibility Study). Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

SBIR Direct to Phase II - Next-Generation Invasive Devises for Recording and Modulation in the Human Central Nervous System RFA-NS-16-018 Closed April 26, 2016
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and thereby better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.

Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities RFA-MH-17-235 Closed November 23, 2016
  • Monitor Neural Activity
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative®, aims to support transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts that will revolutionize our understanding of the biological activity underlying, and bioinformatic content of, data collected using contemporary non-invasive functional brain imaging techniques. The hope is that these transformative discoveries will lead to breakthroughs in understanding the dynamic activity of the human brain.
New Concepts and Early-Stage Research for Large-Scale Recording and Modulation in the Nervous System RFA-EY-17-001 Closed December 07, 2016
  • Monitor Neural Activity
  • Interventional Tools
A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-16-006) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-16-007) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. It is expected that this research would be at a very early stage where preliminary data would not be available. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.
Proof of Concept Development of Early Stage Next Generation Human Brain Imaging RFA-EB-17-001 Closed January 21, 2017
  • Monitor Neural Activity
  • Interventional Tools
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small scale, proof of concept development based on exceptionally innovative, original and/or unconventional concepts.
Development of Next Generation Human Brain Imaging Tools and Technologies (Phase II) RFA-EB-17-002 Closed January 21, 2017
  • Monitor Neural Activity
  • Interventional Tools
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the timeframe of the BRAIN Initiative (“BRAIN 2025: A Scientific Vision,” https://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200.
BRAIN Initiative Cell Census Network (BICCN) Brain Cell Data Center RFA-MH-17-215 Closed January 24, 2017
  • Cell Type
  • Circuit Diagrams
  • Theory & Data Analysis Tools

This Funding Opportunity Announcement (FOA) intends to support a Brain Cell Data Center (BCDC) that will work with other BICCN Centers and interested researchers to establish a web-accessible information system to capture, store, analyze, curate, and display all data and metadata on brain cell types, and their connectivity. The BCDC is expected to: (1) lead the effort to establish spatial and semantic standards for managing heterogeneous brain cell census data types and information; (2) lead the effort to collect and register multimodal brain cell census data to common brain coordinate systems; (3) generate searchable 2D and 3D digital brain atlases for cell census data; and (4) generate a unified and comprehensive brain cell knowledge base that integrates all existing brain cell census data and information across diverse repositories. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)

BRAIN Initiative Cell Census Network (BICCN) Comprehensive Center on Mouse Brain Cell Atlas RFA-MH-17-225 Closed January 24, 2017
  • Cell Type
  • Circuit Diagrams

This Funding Opportunity Announcement (FOA) intends to assemble a group of Comprehensive Centers that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)

Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science RFA-MH-17-260 Closed January 30, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements in research and development supported by the BRAIN Initiative. The hope is that efforts supported under this FOA might be both complimentary and integrative with the transformative, breakthrough discoveries being supported through the BRAIN Initiative.

Targeted BRAIN Circuits Projects - TargetedBCP RFA-NS-17-014 Closed March 08, 2017
  • Integrated Approaches

This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.

Exploratory Targeted BRAIN Circuits Projects - eTargetedBCP RFA-NS-17-015 Closed March 08, 2017
  • Integrated Approaches

This FOA solicits applications for exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. Applications should offer a limited scope of aims and an approach that will establish feasibility, validity or other technically qualifying results that, if successful, would support a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-17-014).

BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship RFA-MH-17-250 Closed March 15, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

The purpose of the BRAIN Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that complements their predoctoral research. Formal training in quantitative perspectives and analytical tools is expected to be an integral part of the proposed research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 6 months of postdoctoral training. Watch an informational Webinar: https://youtu.be/zVgsrsKb92s (Please copy and paste the url in your browser)

Research Career Enhancement Award for Investigators to Build Skills in a Cross-Disciplinary Area RFA-DA-17-022 Closed April 14, 2017
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
  • Theory & Data Analysis Tools
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for the BRAIN Initiative, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate’s ability to significantly contribute to or lead projects that investigate questions central to the goals of the BRAIN Initiative. Eligible candidates are independent investigators at any faculty rank or level.
Standards to Define Experiments Related to the BRAIN Initiative RFA-MH-17-256 Closed October 11, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of the BRAIN Initiative. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.

BRAIN Initiative Cell Census Network (BICCN) - Specialized Center on Human and Non-Human Primate Brain Cell Atlases RFA-MH-17-210 Closed October 13, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience

This Funding Opportunity Announcement (FOA) intends to assemble a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing reference cell atlases of human brain and/or non-human primate brains. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)

Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain RFA-MH-17-220 Closed October 13, 2017
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
BRAIN Initiative Cell Census Network (BICCN) - Specialized Center on Mouse Brain Cell Atlas RFA-MH-17-230 Closed October 13, 2017
  • Cell Type
  • Circuit Diagrams

This Funding Opportunity Announcement (FOA) intends to support Specialized Collaboratory that will adopt scalable technology platforms and streamlined workflows to generate a comprehensive 3D brain cell reference atlas encompassing molecular, anatomical, and physiological annotations of brain cell types in mouse, and incorporate additional genetic and other advanced cell-specific targeting approaches and tools to facilitate this goal. A central goal of this and the three companion FOAs is to build a brain cell census resource that can be widely used throughout the research community. Watch an informational Webinar: https://youtu.be/Zd0JWzBJH5Q (Please copy and paste the url in your browser)

Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision RFA-MH-17-240 Closed October 13, 2017
  • Monitor Neural Activity
  • Interventional Tools
  • Human Neuroscience
This Funding Opportunity Announcement (FOA) solicits grant applications in two related but distinct areas. The first area is in the development and testing of novel tools and methods of neuromodulation that go beyond the existing variations on magnetic or electrical stimulation, and that represent more than an incremental advance over existing approaches. The second distinct area that this FOA seeks to encourage is the optimization of existing electrical and magnetic stimulation methods.
Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects RFA-MH-17-245 Closed October 13, 2017
  • Monitor Neural Activity
  • Interventional Tools
  • Human Neuroscience
The focus of this Funding Opportunity Announcement (FOA) is to better understand how existing non-invasive neuromodulation devices affect brain circuity. This information should shed light on dose/response relationships that could be used for neuroscience applications and clinical interventions.
Team-Research BRAIN Circuit Programs - TeamBCP RFA-NS-17-018 Closed October 17, 2017
  • Integrated Approaches

This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise – including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.

New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System RFA-NS-17-003 Closed October 18, 2017
  • Interventional Tools
Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for largescale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system. In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Where appropriate, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System RFA-NS-17-004 Closed October 18, 2017
  • Monitor Neural Activity
  • Interventional Tools
Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-17-005 Closed October 18, 2017
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational and clinical studies for recording and/or stimulating devices to treat nervous system disorders and better understand the human brain. The program will utilize a cooperative agreement mechanism to support the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and a subsequent small clinical study (e.g., Early Feasibility Study). The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional nonclinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. As part of the BRAIN InitiativeSM, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see https://braininitiative.nih.gov/BRAIN_PPP/. Individuals, institutions or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this FOA or RFA-NS-17-006.

Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-17-006 Closed October 18, 2017
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device. As part of the BRAIN InitiativeSM, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without need for significant additional non-clinical data. For more information on the BRAIN PPP, see https://braininitiative.nih.gov/BRAIN_PPP/. Individuals, institutions or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to RFA-NS-17-005 or this FOA.

Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (SBIR) RFA-NS-17-007 Closed October 18, 2017
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue translational non-clinical studies and clinical studies for recording and/or stimulating devices to treat nervous system disorders and thereby better understand the human brain. The program will utilize a cooperative agreement mechanism to support the non-clinical studies necessary for the submission of an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or to obtain Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, and the subsequent small clinical study (e.g., Early Feasibility Study). Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, and pursuit of regulatory approval for, and implementation of, a single small clinical study. The small clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

SBIR Direct to Phase II Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System RFA-NS-17-008 Closed October 18, 2017
  • Human Neuroscience
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small business concerns (SBCs) to pursue a small clinical study to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and thereby better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical study should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical study is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical study to answer key questions about the function or final design of a device.

Data Archives for the BRAIN Initiative RFA-MH-17-255 Closed October 19, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.

New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System RFA-EY-17-002 Closed October 26, 2017
  • Monitor Neural Activity
  • Interventional Tools
A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization. In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models. Invasive or non-invasive approaches are sought that will ultimately enable or reduce the current barriers to large-scale recording or manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individuals, including physicists, engineers, theoreticians, and scientists, especially those not typically involved with neuroscience research.
Integration and Analysis of BRAIN Initiative Data RFA-MH-17-257 Closed October 26, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This Funding Opportunity Announcement (FOA) solicits applications to develop informatics tools for analyzing, visualizing, and integrating data related to the BRAIN Initiative or to enhance our understanding of the brain.

Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science RFA-MH-18-500 Closed December 07, 2017
  • Cell Type
  • Circuit Diagrams
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity
  • Theory & Data Analysis Tools

This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. The hope is that efforts supported under this FOA might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.

Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP RFA-NS-18-008 Closed December 15, 2017
  • Integrated Approaches

This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several FOAs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” this FOA specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. The hope is that efforts supported under this FOA might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.

Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain RFA-NS-18-010 Closed January 19, 2018
  • Human Neuroscience
  • Integrated Approaches
  • Interventional Tools
  • Monitor Neural Activity

Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience. The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. In addition, projects that aim to implement novel methods of temporally-linked brain-behavior quantification in laboratory and real-world settings are encouraged. Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice as well as supplemental opportunities to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

Research Resource Grants for Technology Integration and Dissemination - Clinical Trial Not Allowed RFA-NS-18-005 Closed February 09, 2018
  • Cell Type
  • Circuit Diagrams
  • Monitor Neural Activity
  • Interventional Tools
  • Theory & Data Analysis Tools
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document "BRAIN 2025: A Scientific Vision." They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users are allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.
Targeted BRAIN Circuits Projects- TargetedBCP - Clinical Trial Not Allowed RFA-NS-18-009 Closed March 15, 2018
  • Integrated Approaches

This FOA solicits applications for research projects that use innovative and methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.

Tools to target, identify and characterize non-neuronal cells in the brain - Clinical Trial Not Allowed RFA-DA-18-018 Closed October 04, 2018
  • Cell Type
  • Circuit Diagrams
  • Interventional Tools
  • Monitor Neural Activity

The purpose of this Funding Opportunity Announcement [FOA] submitted through the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to stimulate the development and validation of novel tools and analytical methods to target, identify and characterize non-neuronal cells in the brain. This FOA complements previous and ongoing cell-census and tool development efforts initiated under BRAIN, RFA-MH-14-215 and RFA-MH-14-216, that have focused almost exclusively on neuronal cells. The cutting-edge tools and methods developed under this opportunity should focus specifically on providing improved points of entry into non-neuronal cell-types (glial and vascular) to enable their inventory and characterization within the CNS and help define how these cells interact among each other and with neuronal cells to impact functional circuitries. Plans for validating the utility of the tool/technology/method and demonstrating its advantage over currently available approaches will be an essential feature of a successful application. Tools that can be used in several species or model organisms rather than in a single species are especially desirable.

Tools to Facilitate High-Throughput Microconnectivity Analysis RFA-MH-18-505 Closed November 13, 2018
  • Cell Type
The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate tools and resources to facilitate the detailed analysis of brain microconnectivity. Novel and augmented techniques are sought that will ultimately be broadly accessible to the neuroscience community for the interrogation of microconnectivity in healthy and diseased brains of model organisms and humans. Development of technologies that will significantly drive down the cost of connectomics would enable routine mapping of the microconnectivity on the same individuals that have been analyzed physiologically, or to compare normal and pathological tissues in substantial numbers of multiple individuals to assess variability. Advancements in both electron microscopy (EM) and super resolution light microscopic approaches are sought. Applications that propose to develop approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged. Proof-of-principle demonstrations and/or reference datasets enabling future development are welcome, as are improved approaches for automated segmentation and analysis strategies of neuronal structures in EM images.
Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (Clinical Trials Not Allowed) RFA-EB-17-003 Closed December 11, 2018
  • Monitor Neural Activity
  • Interventional Tools
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support early stage development of entirely new and novel noninvasive human brain imaging technologies and methods that will lead to transformative advances in our understanding of the human brain. The FOA solicits unusually bold and potentially transformative approaches and supports small-scale, proof-of-concept development based on exceptionally innovative, original and/or unconventional concepts.
Development of Next Generation Human Brain Imaging Tools and Technologies (Clinical Trials Not Allowed) RFA-EB-17-004 Closed December 11, 2018
  • Monitor Neural Activity
  • Interventional Tools
  • Integrated Approaches
  • Human Neuroscience
This funding opportunity announcement (FOA), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, aims to support full development of entirely new or next generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. The FOA seeks innovative applications that are ready for full-scale development of breakthrough technologies with the intention of delivering working tools within the timeframe of the BRAIN Initiative (“BRAIN 2025: A Scientific Vision,” http://braininitiative.nih.gov/). This FOA represents the second stage of the tool/technology development effort that started with RFA-MH-14-217 and RFA-MH-15-200.