Project Summary
Brain-wide correlation of single-cell firing properties to patterns of gene expression
Every neuron expresses thousands of proteins which, through their interactions with each other
and with other small molecules, imbue the neuron with its functional properties.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBrain-wide correlation of single-cell firing properties to patterns of gene expression
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
TitleBreaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and Neuroenergetics
Investigator
Wei Chen, Xiao-Hong Zhu
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how neural circuits operate and interconnect at mesoscopic (sub-millimeter) scale, and how
neuroenergetic metabolism and neurotransmitters support brain&nb
TitleBuilding analysis tools and a theory framework for inferring principles of neural computation from multi-scale organization in brain recordings
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Summary
The BRAIN initiative is enabling ground-breaking techniques for brain recordings that
will permit a unique view onto the dynamics of neural activity. However, inferring brain
function from multi-channel physiological recordings is challenging.
TitleC-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparative
Investigator
Richard Cameron Craddock, Michael Peter Milham
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording,
and macroscale neuroimaging techniques in human and non-human animal models in order to develop a
multilevel understanding of human brain function.
TitleCausal mapping of emotion networks with concurrent electrical stimulation and fMRI
Investigator
Ralph Adolphs, Matthew A. Howard, Russell A Poldrack
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Understanding human brain function requires knowledge of its connectivity: how one structure
causally influences other components of the network.
TitleCausally linking dendritic Ca2+ dynamics to CA1 circuit function and spatial learning using novel tools to precisely manipulate an endogenous Ca2+ buffering process
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
In dendrites, Ca2+ is critical in determining how neurons respond to incoming excitation.
TitleCell atlas of mouse brain-spinal cord connectome
Investigator
Hong-Wei Dong, Huizhong Whit Tao, Li I Zhang
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Although great efforts have been dedicated to characterizing neuronal cell types in the brain, systematic
studies on the brain-spinal cord connectome and associated spinal neuronal types are lacking.
TitleCircuit and Synaptic Mechanisms of Visual Spatial Attention
Investigator
Bilal Haider
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Sensory processing is a way to understand neural circuits and their functions during behavior.
Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is
easier to detect if it appears in a predictable spatial location.
TitleCircuit mechanisms for encoding naturalistic motion in the mammalian retina
Investigator
Wei Wei
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Motion detection, a fundamental computation of the visual system, begins in the retina. In the
mammalian retina, the direction of moving objects is computed by the direction-selective circuit.
The retinal output of this circuit is provided by direction-selective ganglion cells (DSGCs).
TitleCircuit mechanisms underlying learned changes in persistent neural activity
Investigator
Emre Aksay, Mark S Goldman, Hyunjune Sebastian Seung
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Persistent neural activity, a sustained response following brief stimuli that is observed in many
brain networks, needs to be appropriately tuned to meet the exacting demands of various motor
and cognitive tasks.
TitleCircuitry underlying response summation in mouse and primate: Theory and experiment
Investigator
Nicolas Brunel, Kenneth D Miller, John H Reynolds
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Despite the enormous complexity of the brain, it is becoming increasingly apparent that structures like the
cerebral cortex are modular, relying on a set&nbs
TitleCoarse-graining approaches to networks, learning, and behavior
Investigator
William Bialek, Stephanie E Palmer, David Jason Schwab
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The theory hub put forward in this proposal will work to translate successful and powerful approaches to
describing emergent collective behavior in physical systems so they can be applied to the brain.
TitleCollaborative Standards for Brain Microscopy
Investigator
Carol Marie Hamilton
Institute
research triangle institute
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Fast microscopy techniques, coupled with recent advances in tissue clearing, are now able to efficiently
produce cellular-resolution images of intact brain samples.
TitleCombined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Investigator
Darin D Dougherty, Alik S Widge
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
This project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD
is a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms
after being treated with medication or talk therapy.
TitleComputational and Circuit Mechanisms Underlying Rapid Learning
Investigator
Elizabeth A Buffalo
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The mammalian brain has a remarkable ability to store and retrieve information. Detailed memories can
be formed after as little as one exposure, and those memories can be retained for decades.
TitleConnectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Investigator
Peter J. Basser, Susie Yi Huang, Bruce R Rosen, Lawrence L Wald, Thomas Witzel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
We present Connectome 2.0, the next-generation human MRI scanner for imaging structural anatomy and
connectivity spanning the microscopic, mesoscopic and macroscopic scales.
TitleContext-dependent processing in sensorimotor cortex
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even
for seemingly simple tasks, a variety of sensory inputs are integrated to create a motor plan to complete a task.
Take the example of picking up a glass.
TitleControlling the spatial extent of light-based monitoring and manipulation of neural activity in vivo
Investigator
John Assad, Massimo Devittorio, Ferruccio Pisanello, Wade G Regehr, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract/Summary
The brains of mammals contain an extraordinarily large number of neurons whose activity and interconnections
determine the function of circuits that monitor our sensory environment, dictate our motor choices, form
memories, and guide all behavior.
TitleCortical Interactions Underlying Sensory Representations
Investigator
Jerry L Chen
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Sensory perception involves processing incoming sensory input and interpreting that information through rules
generated from prior experience.
TitleCortical Signature and Modulation of Pain
Investigator
Zhigang He, Fan Wang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Cortical Signature and Modulation of Pain
Abstract/Project Summary
Pain perception contains two main dimensions: the sensory-discriminative and the affective-cognitive
aspects.
Last reviewed on July 02, 2025