[{"title":"1 mm resolution single-photon spectral imaging of the brain","field_investigator":"Ling-Jian  Meng, Scott Dean Metzler","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034715-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EAbstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,\u003C\/p\u003E"},{"title":"3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform","field_investigator":"Huanan  Zhang","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1R56NS131084-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10883867\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10883867\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY: Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for ma\u003C\/p\u003E"},{"title":"A Dry Electrode for Universal Accessibility to EEG","field_investigator":"Walid Soussou","field_institution":"Quasar, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43NS132644-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761609\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EElectroencephalography (EEG) measures the brain\u2019s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.\u003C\/p\u003E"},{"title":"A germline- and promoter-independent strategy to gain access to all cell types in the brain","field_investigator":"Huaiyu  Hu, Yingxi  Lin, Baisong  Lu","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130782-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject summary The heterogeneity from the vast number of cell types in the brain presents a major challenge in our understanding of how brain works and in our treatment of neurological disorders.\u003C\/p\u003E"},{"title":"A multi-foci objective lens for large scale brain activity recording","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731905\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract The goal of this project is to develop a novel bifocal catadioptric objective that will allow large-scale recording of neural circuits in vivo.\u003C\/p\u003E"},{"title":"A scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology","field_investigator":"Bing-Xing  Huo","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.\u003C\/p\u003E"},{"title":"A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy","field_investigator":"David A Boas, Xiaojun  Cheng","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034710-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EAbstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring\u003C\/p\u003E"},{"title":"A visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays","field_investigator":"Maximilian  Haeussler","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT The BRAIN Initiative\u2019s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.\u003C\/p\u003E"},{"title":"Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology","field_investigator":"Fuyixue  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572005\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572005\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.\u003C\/p\u003E"},{"title":"All holographic two-photon electrophysiology","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131075-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616937\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616937\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY Achieving a detailed understanding of the neural codes of sensation, action, and cognition will require technologies that can both sample and perturb neural activity with millisecond precision and cellular resolution across large populations of neurons.\u003C\/p\u003E"},{"title":"An Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation","field_investigator":"Mark A Foster","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739050\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739050\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Multiphoton microscopy of cells labeled with genetically encoded calcium indicators (GECIs) enables detection and correlation of fine neuronal structure to functional activity with cellular resolution.\u003C\/p\u003E"},{"title":"An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease","field_investigator":"Dennis Alan Turner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS129898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10571952\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10571952\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDBS therapy for Parkinson Disease [PD], the primary, FDA-approved surgical approach, has proven efficacious in clinical trials.\u003C\/p\u003E"},{"title":"An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates","field_investigator":"Karl A. Deisseroth, Eyal J Seidemann","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH133047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650669\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.\u003C\/p\u003E"},{"title":"Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability","field_investigator":"Loren D Peeters","field_institution":"East Tennessee State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130827-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754809\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754809\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.\u003C\/p\u003E"},{"title":"Beyond dopamine: dual neuromodulator regulation of motor variability and learning","field_investigator":"Drew Clinton Schreiner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132152-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10605853\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10605853\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.\u003C\/p\u003E"},{"title":"Biophysical Mechanisms of Cortical MicroStimulation","field_investigator":"Sydney S Cash, Mark Thomas Harnett","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS132784-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10711723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10711723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDirect local electrical stimulation (DLES) is an increasingly important therapeutic tool for treating brain disorders such as Parkinson\u2019s, epilepsy, and OCD.\u003C\/p\u003E"},{"title":"Boss: A cloud-based data archive for electron microscopy and x-ray microtomography","field_investigator":"Brock A. Wester","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114785-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664562\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EABSTRACT The generation of scienti\ufb01cally rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.\u003C\/p\u003E"},{"title":"Bottom-Up, Top-Down, and Local Interactions in the Generation and Consolidation of Cortical Representations of Sequential Experience","field_investigator":"Bruce L Mcnaughton","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132041-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658227\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658227\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EYears of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132250-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665380\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665380\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electron microscopy pipeline that could scale to a whole mouse brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132253-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665386\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665386\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural basis of brain function are cell type composition and the wiring diagram between those cells.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for Mesoscale Connectomics","field_investigator":"Taner  Akkin, Damien A Fair, Sarah Rachel Heilbronner, Christophe  Lenglet, Kamil  Ugurbil, Essa  Yacoub, Jan  Zimmermann","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132207-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EPROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Comprehensive regional projection map of marmoset with single axon and cell type resolution","field_investigator":"Guoping  Feng, Partha Pratim Mitra, Xiao  Wang","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132173-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664170\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664170\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY This ambitious proposal will establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate, the common marmoset (Callithrix jacchus),.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping brain-wide connectivity of neuronal types using barcoded connectomics","field_investigator":"Xiaoyin  Chen, Justus M Kebschull, Ian R Wickersham","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132161-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary Mapping the brain-wide connections of neurons provides a foundation for understanding the structure and functions of a brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate System","field_investigator":"Bruce  Fischl, Patrick R Hof, Hui  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664289\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664289\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract (30 lines of text limit) The ~1 billion neurons that form the human brainstem are organized at multiple scales, ranging from their cell type-specific patterns of dendritic arborization, to local circuits embedded within large-scale projection systems spanning the brainste\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Multi-beam transmission electron microscopy of iteratively milled semi-thick tissue sections","field_investigator":"Andreas  Schaefer, Adrian Andreas Wanner","field_institution":"Paul Scherrer Institut Psi","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10669305\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10669305\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract Volume electron microscopy is the only technique to-date that provides both sufficient resolution (100 \u03bcm) for the dense reconstruction of neuronal wiring diagrams.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes","field_investigator":"Tim M Jarsky, Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665493\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665493\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary \/ Abstract Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Rapid and Cost\u2010effective Connectomics with Intelligent Image Acquisition, Reconstruction, and Querying","field_investigator":"Jeff W Lichtman, Hanspeter  Pfister, Aravinthan D. Samuel, Nir  Shavit, Brock A. Wester","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132158-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY High-throughput connectomics is needed to generate the TB-, PB- and EB-scale wiring diagrams of mammalian brains, but is limited to the few research institutes (e.g., Janelia, Allen, Max Planck) with suf\ufb01cient infrastructure.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus","field_investigator":"Andreas  Tolias, Anthony M Zador","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132353-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672786\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672786\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EABSTRACT Single-cell transcriptomics has revolutionized our understanding of neuronal diversity and enabled high-throughput characterization of molecular cell types across brain areas and species.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)","field_investigator":"Suzanne N Haber, Elizabeth M. C. Hillman, Anastasia  Yendiki","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132358-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672681\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject summary: This project will develop and validate a comprehensive toolset of novel technologies for imaging axonal projections across scales, and will deploy this toolset to map a complex system of cortico- subcortical projections in the macaque and human brain.\u003C\/p\u003E"},{"title":"Brain dynamics underlying long-term memory consolidation","field_investigator":"Priya  Rajasethupathy","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658311\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658311\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.\u003C\/p\u003E"},{"title":"Brain-wide mapping of neuronal inhibition by novel inverse activity markers","field_investigator":"Li  Ye","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132570-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10639977\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10639977\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EAbstract This project aims to develop the first Inverse Activity Marker (IAM) for detecting neuronal inhibition (broadly defined as the decrease of neuronal activities).\u003C\/p\u003E"},{"title":"Capturing the neural signature of the paraventricular thalamus that underlies individual variability in cue-motivated behavior","field_investigator":"Shelly Beth Flagel","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132808-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.\u003C\/p\u003E"},{"title":"Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex","field_investigator":"Deepa L Ramamurthy","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129753-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739223\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Sensory representations are influenced by an animal\u2019s external context, internal state, past experiences, expectations, and future goals.\u003C\/p\u003E"},{"title":"Center for Advanced Muscle BioElectronics (CAMBER)","field_investigator":"Muhannad   Bakir, Samuel  Sober","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS126936-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10573637\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10573637\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EA central goal of neuroscience is to discover how neural circuits control the body\u2019s muscles to produce behavior.\u003C\/p\u003E"},{"title":"Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke","field_investigator":"Jasmine Jamilah Cash","field_institution":"Medical University Of South Carolina","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829133\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.\u003C\/p\u003E"},{"title":"Characterizing odor motion detection in flies","field_investigator":"Damon Alistair Clark, Thierry  Emonet","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EMany animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.\u003C\/p\u003E"},{"title":"Chemigenetic voltage indicators for far-red and two-photon imaging in vivo","field_investigator":"Ahmed  Abdelfattah","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133755-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY DESCRIPTION (provided by applicant): Changes in membrane potential are the fundamental language of the nervous system, but these voltage signals are not directly visible.\u003C\/p\u003E"},{"title":"Circuit architecture and dynamics of the insular cortex underlying motivational behaviors","field_investigator":"Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.\u003C\/p\u003E"},{"title":"Circuit mechanisms of arbitration between distinct reinforcement learning systems","field_investigator":"Margaret Louise Demaegd","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132176-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608739\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608739\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?\u003C\/p\u003E"},{"title":"Circuit-specific, chemogenetic neuromodulation in nonhuman primates.","field_investigator":"Serge E Przedborski, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH129381-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651371\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651371\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT \u2012 UG3\/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.\u003C\/p\u003E"},{"title":"cloudSLEAP: Maximizing accessibility to deep learning-based motion capture","field_investigator":"Talmo D. Pereira","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EcloudSLEAP \u2013 PROJECT SUMMARY\/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.\u003C\/p\u003E"},{"title":"Cognitive and Neural Strategies for Latent Feature Inference","field_investigator":"Tahra  Eissa","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99NS127855-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662877\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.\u003C\/p\u003E"},{"title":"Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits","field_investigator":"Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44NS134432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761217\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761217\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.\u003C\/p\u003E"},{"title":"Contextual modulation of visual decision-making across the visual hierarchy","field_investigator":"Pamela  Reinagel","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132037-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658176\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658176\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract In sensory decision-making, choices are influenced by non-sensory factors such as motivation, attention, and recent trial history.\u003C\/p\u003E"},{"title":"Continuous development of nTracer2 and its deployment at NIH image repositories","field_investigator":"Dawen  Cai, Yan  Yan","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726178\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726178\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EAbstract In response to the BRAIN Initiative \u201cIntegration and Analysis of BRAIN Initiative Data\u201d FOA, we propose further developing nTracer2, a cloud-based platform for brain image visualization and neuron tracing in the web browser.\u003C\/p\u003E"},{"title":"CONVERGENT PROCESSING ACROSS VISUAL AND HAPTIC CIRCUITS FOR 3D SHAPE PERCEPTION","field_investigator":"Charles E Connor, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132848-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10720137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10720137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ETHEORETICAL FRAMEWORK: Vision and touch share a critical function\u2014perception of 3D object shape.\u003C\/p\u003E"},{"title":"Cortical assembly formation through excitatory\/inhibitory circuit plasticity","field_investigator":"Brent D. Doiron, Anne-Marie Michelle Oswald","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729689\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ECortical assembly formation through excitatory\/inhibitory circuit plasticity. Project Summary Throughout the brain, sensory information is thought to be represented by the joint activity of neurons that form functionally connected assemblies.\u003C\/p\u003E"},{"title":"Cortical circuit dynamics underlying multisensory decision making","field_investigator":"Christopher R Fetsch","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132910-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721255\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721255\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary To navigate and guide locomotion in a complex 3D environment, humans and animals must make countless judgments of their direction of self-motion, or heading.\u003C\/p\u003E"},{"title":"CRCNS US-German Research Proposal: Quantitative and Computational Dissection of Glutamatergic Crosstalk at Tripartite Synapses","field_investigator":"Ghanim Ullah","field_institution":"University of South Florida","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130916-01  ","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612169\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Project Grants","field_priority_area":"","field_program":"Understanding Circuits","field_research_area":"Data Science \u0026amp; Informatics, Systems Neuroscience","body":"\u003Cp\u003ECRCNS US-German Research Proposal: Quantitative and computational dissection of glutamatergic crosstalk at tripartite synapses (1) Christine R Rose, Heinrich Heine University, D\u00fcsseldorf, Germany (2) Christian Henneberger, University of Bonn, Germany (3) Ghanim Ullah, University of South Florida,\u003C\/p\u003E"},{"title":"Cross-modal sensory interactions, processing, and representation in the Drosophila brain","field_investigator":"Itai  Cohen, Noah John Cowan, Jessica  Fox, Sung Soo  Kim","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645611\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645611\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ERobust navigation, which is critical for an animal\u2019s survival, requires the processing of complex sensory information spanning different modalities and time scales.\u003C\/p\u003E"},{"title":"DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal Analysis","field_investigator":"Terrence J Sejnowski","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary The goal of this proposal is to develop DDALAB, a software platform that will make it possible for researchers to identify latent cortical states and analyze the flow of information in large populations of neurons using Delay Differential Analysis (DDA).\u003C\/p\u003E"},{"title":"Deconstructing the sertonin system in the mouse brain","field_investigator":"Liqun  Luo, Scott Warren Linderman","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656870\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Serotonin is an evolutionarily conserved neurotransmitter that modulates the activity of excitatory and inhibitory neurons throughout the entire mammalian brain and is thus essential for diverse aspects of physiology and behavior.\u003C\/p\u003E"},{"title":"Developing an Optogenetics Technology Based on Natural Potassium-selective Channelrhodopsins","field_investigator":"John Lee Spudich, Francois  St-Pierre, Mingshan  Xue","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731153\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731153\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESUMMARY Mapping individual on channelrhodopsins types inhibitory transporting as presynaptic objective temporally propose gated whose the function of neural circuits in the brain crucially relies on the ability to both activate and silence circuit components to subsequently assess their impact on\u003C\/p\u003E"},{"title":"Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits","field_investigator":"Christopher  Versteeg","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132175-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10752956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10752956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?\u003C\/p\u003E"},{"title":"Developing Novel Trans-Synaptic Viral Vectors for Orthogonal or Rapid Circuit Tracing","field_investigator":"Euiseok J Kim","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132591-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640622\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary To determine the anatomical basis of complex neural behavior, it is critical to have the ability to trace more than one circuit simultaneously in the same animal.\u003C\/p\u003E"},{"title":"Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes","field_investigator":"Kip A Ludwig","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129955-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572029\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572029\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDespite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.\u003C\/p\u003E"},{"title":"Development of a combined Gamma\/Positron system for molecular imaging of the human brain at sub-500 micron spatial resolution","field_investigator":"Shiva  Abbaszadeh, Lars R Furenlid, Michael A King","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034686-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722205\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY We are proposing a new approach to a hybrid imaging modality that has been called \u201cb+g\u201d or \u201cpamma-positron\u201d Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two differ\u003C\/p\u003E"},{"title":"Development of Quantum Magnetic Tunneling Junction Sensor Arrays for Brain Magnetoencephalography (MEG) under Natural Settings","field_investigator":"Jerome N Sanes, Gang  Xiao","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034695-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10723802\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10723802\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary The long-term objective of this project is to develop a revolutionary quantum mechanical solid-state magnetometer designed to non-invasively detect femtoTesla (fT) scale magnetic fields derived from the brain\u2019s electrical activities during natural human experiences.\u003C\/p\u003E"},{"title":"DIrectional and SCalable (DISC) Microelectrode Array for Speech Decoding","field_investigator":"John P Seymour, Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS125487-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10513043\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10513043\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract Currently, the brain-computer interface (BCI) field has demonstrated two distinct device strategies - macroelectrodes (e.g., surface grids and depth) versus microelectrode arrays, and some are even pushing the field to smaller, higher density arrays hoping to address the general signal d\u003C\/p\u003E"},{"title":"Dissecting modular and redundant organization of cortical circuits","field_investigator":"Shaul  Druckmann, Nuo  Li","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657919\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657919\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract In many cognitive processes, information is processed in a parallel manner across many brain regions.\u003C\/p\u003E"},{"title":"Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG\/EEG","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129945-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726032\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726032\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EHNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09\/2016\u201306\/2020) to meet the Initiative\u2019s goal to \u201cdevelop innovative technologies to understand brain circuits and ensembles of circuits th\u003C\/p\u003E"},{"title":"Distinct contributions of converging neural pathways to auditory learning","field_investigator":"Santiago  Jaramillo, James  Murray","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131993-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657285\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657285\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.\u003C\/p\u003E"},{"title":"Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony","field_investigator":"Zoe Rebecca Donaldson, Yevgenia  Kozorovitskiy, John  Rogers","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10644475\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10644475\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis.\u003C\/p\u003E"},{"title":"Electrophysiology-Compatible Wearable Transcranial Focused Ultrasound Neuromodulation Array Probes","field_investigator":"Bin  He","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131069-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616201\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616201\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Noninvasive high precision neuromodulation technologies are crucial for probing mechanisms of neural circuits and enabling the non-pharmacological treatment of brain disorders.\u003C\/p\u003E"},{"title":"ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO","field_investigator":"Laurent  Bourdieu, Francois  St-Pierre","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739579\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.\u003C\/p\u003E"},{"title":"Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization","field_investigator":"Christopher  Rorden","field_institution":"University Of South Carolina At Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.\u003C\/p\u003E"},{"title":"Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales","field_investigator":"Jeremiah Yaacov Cohen, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131984-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656752\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656752\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ESUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.\u003C\/p\u003E"},{"title":"Functions of the Cortical Amygdala in social behavior","field_investigator":"Antonio V Aubry","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA058213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641270\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.\u003C\/p\u003E"},{"title":"Gulf Coast Consortia (GCC) Research Evaluation and Commercialization Hub","field_investigator":"Peter J Davies, Suzanne Marie Tomlinson, Stanley J Watowich","field_institution":"Texas A\u0026amp;M University Health Science Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-OD-23-005","field_project_number":"1U01GM152516-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10783414\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10783414\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003EIn recent years, the NIH has awarded over $850M annually to the numerous research institutions and hospitals within the Texas Medical Center (TMC; Houston, TX), producing ever-increasing numbers of biomedical discov- eries.\u003C\/p\u003E"},{"title":"High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging","field_investigator":"Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43MH133544-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10695784\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10695784\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EWhole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.\u003C\/p\u003E"},{"title":"High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioids","field_investigator":"Andre  Berndt, Michael R Bruchas","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130391-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10635413\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10635413\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Neuropeptide modulation of neuronal circuits is strongly linked to many crucial behaviors such as exploration, stress, memory formation, learning, and many pathophysiological conditions.\u003C\/p\u003E"},{"title":"High-throughput measurement of neuronal projections and synapses using Synapse-seq","field_investigator":"Evan Z Macosko","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130468-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640361\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640361\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003ESUMMARY The brain is composed of thousands of highly specialized cell types that form very specific synaptic connections with each other. Together, these connections form neural circuits that are the structural basis of brain function.\u003C\/p\u003E"},{"title":"Highly multiplexed circuit mapping using barcoded rabies viruses and in situ sequencing.","field_investigator":"Ian R Wickersham, Shenqin  Yao","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640501\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640501\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Understanding the function of neural circuits requires thorough investigation of two circuit elements: cell types and connectivity.\u003C\/p\u003E"},{"title":"Hybrid TMS\/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity","field_investigator":"Berkin  Bilgic, Susie Yi Huang, Aapo  Nummenmaa, Jason P Stockmann","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730783\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730783\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary. We propose a new coil array that will enable next-generation causal brain mapping with unprecedented flexibility, resolution and precision.\u003C\/p\u003E"},{"title":"Identifying human-specific neural progenitors and their role in neurodevelopment","field_investigator":"Sumin  Jang","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130892-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662868\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662868\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).\u003C\/p\u003E"},{"title":"Identifying the neural mechanisms of goal-directed decision-making in Parkinson\u0026#039;s disease using closed-loop deep brain stimulation","field_investigator":"Colin  Hoy","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132174-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ETITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON\u2019S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson\u2019s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c\u003C\/p\u003E"},{"title":"Implantable 3D fluorescence imaging with high-speed, addressable laser scanning in moving mice","field_investigator":"Kenn R Oldham","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131063-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10614795\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10614795\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary The goal of this work is to achieve high-speed optical fluorescence imaging of 3D brain volume in moving, behaving mice, using miniature scanning mirrors in an implantable, fiber-coupled microscope.\u003C\/p\u003E"},{"title":"Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior","field_investigator":"Gabriela  Manzano Nieves","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH132082-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.\u003C\/p\u003E"},{"title":"Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)","field_investigator":"Susie Yi Huang, Jonathan David Jackson, Francis X Shen","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH134144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary \/ Abstract Although BRAIN 2.0 called for the BRAIN Initiative to \u201cprioritize diversity and inclusion as a fundamental pillar,\u201d research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.\u003C\/p\u003E"},{"title":"Improving the Speed of Galvo-Scanners","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034809-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract Optical methods provide high-resolution, non-invasive measurement of neural function, ranging from single neurons to entire populations, in the intact brain. Nevertheless, limited penetration depth, spatial scale and temporal resolution remain the main challenges for optical imaging.\u003C\/p\u003E"},{"title":"Integrating single-cell connectivity, gene expression, and function in zebra finches","field_investigator":"Justus M Kebschull","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657971\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657971\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The courtship song of male zebra finches is a classical model for learning complex motor behaviors and shows important parallels to human speech and communication. Male zebra finches learn a song from an adult tutor and then reproduce this song throughout adulthood.\u003C\/p\u003E"},{"title":"Integrative Analysis of Adaptive Information Processing and Learning-Dependent Circuit Reorganization in the Auditory System","field_investigator":"Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715925\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715925\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Decades of research have revealed the principles of information processing that give rise to auditory spatial tuning and experience-dependent adaptive plasticity in the owl auditory system.\u003C\/p\u003E"},{"title":"Integrative circuit dissection in the behaving nonhuman primate","field_investigator":"Wyeth Daniel Bair, Farran  Briggs, Anitha  Pasupathy, Anqi  Wu","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10653435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10653435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EIn natural vision, recognizing objects based on the retinal image is challenging and is often an ill-posed problem because a single image is compatible with multiple interpretations.\u003C\/p\u003E"},{"title":"Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents","field_investigator":"William John Mitchell","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134208-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828675\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828675\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others\u0027 beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes.\u003C\/p\u003E"},{"title":"Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes","field_investigator":"Leighton Hosea Duncan","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135816-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EHypothalamic tanycytes have limited postnatal neurogenic competence, but the extrinsic and intrinsic factors that promote this are not well understood. My predoctoral research identified a defined developmental window during which neurogenic competence is lost from hypothalamic tanycytes.\u003C\/p\u003E"},{"title":"Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy","field_investigator":"Christopher  Hughes","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130022-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Intracortical microstimulation (ICMS) of the sensory cortices is an emerging approach to restore sensation to people who have lost it due to neurological injury or disease.\u003C\/p\u003E"},{"title":"Investigations of cAMP-dependent brain-barrier permeability in choroid plexus","field_investigator":"Dario Xavier Figueroa Velez","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132178-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753098\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The choroid plexus (ChP) comprises a network of cells that form a critical brain barrier that can mediate secondary damage in certain brain disorders and trauma. The Lehtinen lab has developed a suite of tools to study the ChP across development ex vivo and in vivo.\u003C\/p\u003E"},{"title":"Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience","field_investigator":"Michelle  Redinbaugh","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753172\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary: The majority of lived experience depends on neural activity conveying sensory information about the world.\u003C\/p\u003E"},{"title":"Live spike sorting for multichannel and high-channel recordings","field_investigator":"Tim Chifong Lei, Achim Klug","field_institution":"Popneuron, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-178","field_project_number":"1R41NS132700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10759767\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10759767\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes.\u003C\/p\u003E"},{"title":"Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus","field_investigator":"Attila  Losonczy, Ivan  Soltesz","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725714\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725714\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract Neural representations supporting spatial and episodic learning form, and transform rapidly in the mammalian hippocampus.\u003C\/p\u003E"},{"title":"Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex","field_investigator":"Lee O Vaasjo","field_institution":"Tulane University Of Louisiana","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134203-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10755203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10755203\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Sub-Cerebral Projection Neurons (SCPNs) are a clinically relevant neuron class that controls voluntary movement and whose loss in Amyotrophic Lateral Sclerosis and Fronto-temporal dementia or injury (e.g., damaged by spinal cord injury) leads to paralysis.\u003C\/p\u003E"},{"title":"Massively Parallel Optoacoustic Retinal Stimulation at Micrometer-Resolution","field_investigator":"Chen  Yang","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035437-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731795\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731795\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Retinal degenerative diseases are the leading cause of irreversible vision loss. There is no approved medical intervention that could cure or reverse the courses of retinal degenerative diseases.\u003C\/p\u003E"},{"title":"Mechanisms of experience-dependent plasticity in an innate social behavior circuit","field_investigator":"Emma E Boxer","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10751542\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10751542\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Many social behaviors, such as defense and aggression, are innate- requiring no prior experience to be expressed and presumably \u2018hardwired\u2019 into neural circuits.\u003C\/p\u003E"},{"title":"Mechanisms of neural circuit dynamics in working memory and decision-making","field_investigator":"Carlos D Brody, Ila R. Fiete, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"1U19NS132720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705962\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705962\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract: Overall The overarching goal of this U19 program is to determine how neural computations across brain regions produce two core cognitive processes, working memory and decision-making, and thus to derive fundamental principles of brain function.\u003C\/p\u003E"},{"title":"Mechanoluminescent nanomaterials for optogenetic neuromodulation","field_investigator":"Jin  Nam, Yadong  Yin","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034806-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616188\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616188\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThe exponential surge in the prevalence of neurological diseases\/disorders, partly due to the rapid growth in the aged population, poses a significant challenge to the prevention and treatment of impairments in cognitive, sensory, and motor functions.\u003C\/p\u003E"},{"title":"Modeling and Mapping Human Action Regulation Networks","field_investigator":"Vasileios N Christopoulos, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-041","field_project_number":"1U01NS132788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10712708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10712708\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"\u003Cp\u003EAbstract Humans can rapidly regulate actions according to updated demands of the environment.\u003C\/p\u003E"},{"title":"Models for accumulation of evidence through sequences in a navigation-based, decision-making task","field_investigator":"Lindsey Shoemaker Brown","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608293\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608293\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EDecision making is a fundamental cognitive process, and many decisions are based on gradually accumulated evidence. Thus, it is critical to understand the mechanistic basis underlying this accumulation process.\u003C\/p\u003E"},{"title":"Multiphon imaging for understanding social brain function in tadpoles","field_investigator":"Na  Ji, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132841-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717610\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717610\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Mother-infant bonding is a key relationship that lays a foundation for wellness throughout life. Social recognition is an important component of this relationship, as infants imprint on the smell of their mothers and use olfaction to distinguish their mother from others.\u003C\/p\u003E"},{"title":"Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET\/FLIM-based Sensors","field_investigator":"Daniel A Dombeck, Oliver  Griesbeck, Ryohei  Yasuda","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128655-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516813\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516813\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Plasticity is a fundamental aspect of neuronal circuits across all species. It is at the base of learning and memory, sensory adaption, and many disease-related processes such as addiction, chronic pain or regeneration.\u003C\/p\u003E"},{"title":"Multiplexed Sensing and Control of Neuromodulators and Peptides in the Awake Brain","field_investigator":"Mark L Andermann","field_institution":"Beth Israel Deaconess Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035436-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731789\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESummary Imbalanced levels of neuromodulators and other chemical signals contribute to a host of neurological disorders.\u003C\/p\u003E"},{"title":"Multisensory integration and self-motion perception in primate vestibular cortex","field_investigator":"Alejandra  Gomez","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134455-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753017\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753017\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary In vertebrate animals, the vestibular system (primarily known as the \u201cbalance system\u201d of the brain) interprets head-movement and orientation signals to provide organisms with a sense of self-motion.\u003C\/p\u003E"},{"title":"Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode Site","field_investigator":"Nathaniel P Williams","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132145-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract Microelectrode arrays (MEAs) have great potential for therapeutic use in direct brain-computer interface (BCI) control of robotic prostheses to improve the lives of patients suffering from debilitating conditions related to loss of limbs or limb function.\u003C\/p\u003E"},{"title":"Neural basis of collective behavior during environmental stress","field_investigator":"Tara  Raam","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH133159-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10740543\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10740543\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Social interactions are critical to the physical and emotional health of a wide variety of species.\u003C\/p\u003E"},{"title":"Neural circuits for social modulation of a persistent negative emotional state","field_investigator":"Weizhe  Hong, Li I Zhang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132912-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721276\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721276\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY In social species, social relationships can exert profound influences on individuals\u2019 behavioral and physiological states.\u003C\/p\u003E"},{"title":"Neural Mechanisms for Flexible Vocal Communication","field_investigator":"Arkarup  Banerjee","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658308\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary: Whether to laugh at a joke or to engage in a lively debate, we flexibly modify our vocalizations based upon social contexts. Such adaptive behavior requires real-time adjustments of motor outputs in response to rapidly changing sensory inputs.\u003C\/p\u003E"},{"title":"Neural Recording and Simulation Tools to Address the Mesoscale Gap","field_investigator":"John Compton Mosher, Charles E Schroeder, John P Seymour","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739544\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739544\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract We have designed a novel approach to perform multi-scale recordings in the brain across regions and depths.\u003C\/p\u003E"},{"title":"Neuronal and Network Mechanisms of Electrocortical Stimulation","field_investigator":"Marc W. Slutzky","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS125026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724958\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724958\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrocortical stimulation (ECS) has been used for functional mapping for many decades to identify brain areas that are \u201ccritical\u201d for speech and language (i.e., that impair function when stimulated) prior to epilepsy or tumor surgery.\u003C\/p\u003E"},{"title":"Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology","field_investigator":"Joshua H Siegle, Karel  Svoboda","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133760-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731991\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731991\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY Within every brain region, neurons can be classified into dozens or hundreds of different cell types, each with unique functional roles and unique impacts on disease states.\u003C\/p\u003E"},{"title":"NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination","field_investigator":"Alexander  Beckett, David Alan Feinberg, An T Vu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129949-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725586\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003ESUMMARY The \u0022NexGen\u0022 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.\u003C\/p\u003E"},{"title":"Next generation axonal quantification and classification using AI","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"2R44MH128076-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10698843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10698843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis Phase II project describes the commercial development of HyperAxon\u2122, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional \u003C\/p\u003E"},{"title":"Next Generation Opto-GPCRs for Neuromodulatory Control","field_investigator":"Andre  Berndt, Michael R Bruchas, Moran  Shalev-Benami, Ofer  Yizhar","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128537-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515612\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515612\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary\/Abstract: The field of optogenetics \u2014 utilizing light to engage biological systems \u2014 is widely used for the dissection of neural circuits, cellular signaling and manipulating neurophysiological systems in awake, behaving animals.\u003C\/p\u003E"},{"title":"Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation","field_investigator":"Andrei G Pakhomov","field_institution":"Old Dominion University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034803-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10615485\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10615485\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrostimulation (ES) is a versatile and efficient tool for interrogating, altering, and manipulating neural activities in health and disease.\u003C\/p\u003E"},{"title":"O-GlcNac Modulation of GABAergic Transmission","field_investigator":"Shekinah  Phillips","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134163-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754746\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754746\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EChanges in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.\u003C\/p\u003E"},{"title":"OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH117179-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.\u003C\/p\u003E"},{"title":"Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation","field_investigator":"Lan  Luan, Chong  Xie","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS131086-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10617092\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10617092\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.\u003C\/p\u003E"},{"title":"Oxytocin Modulation of Neural Circuit Function and Behavior","field_investigator":"Richard W Tsien","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"2U19NS107616-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705986\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705986\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various \u2018non-social\u2019 aspects of internal state and physiological processes.\u003C\/p\u003E"},{"title":"Parameterizing the relationship between motor cortical reactivation during sleep and motor skill acquisition in the freely behaving marmoset","field_investigator":"Nicholas G Hatsopoulos, Jason Neil Maclean","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132033-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658109\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658109\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract This project will provide a more nuanced and mechanistic model of the role of sleep in memory consolidation, particularly as it pertains to procedural motor skill acquisition in a non-human primate model.\u003C\/p\u003E"},{"title":"Peptidergic neurons in error computations and behavioral flexibility","field_investigator":"Emily L Sylwestrak","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003E\uf077PROJECT SUMMARY Survival in dynamic environments demands that behaviors are flexible and adaptive. An organism must make predictions about which actions lead to rewards, calculate how outcomes differ from those predictions (prediction errors), and adapt a behavioral strategy accordingly.\u003C\/p\u003E"},{"title":"Portable Intraoperative MRI for Neurosurgery","field_investigator":"Hung-Yu Lin","field_institution":"Neuro42, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-282","field_project_number":"1U44NS136026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10728737\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10728737\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003EMagnetic Resonance Imaging (MRI) is the gold-standard method for the detection and diagnosis of brain disease and surgical planning.\u003C\/p\u003E"},{"title":"Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research","field_investigator":"Joseph J. Fins, Gabriel  Lazaro-Munoz","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722437\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI\u003C\/p\u003E"},{"title":"Postnatal experience shapes gene expression and connectivity development in the cortex","field_investigator":"Alexander  Nevue","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10749679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10749679\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.\u003C\/p\u003E"},{"title":"Pre-motor neural circuits enable versatile and sequential limb movements","field_investigator":"Julie H Simpson","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132900-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.\u003C\/p\u003E"},{"title":"Probing form and function of memory representations in the hippocampus of memory expert birds","field_investigator":"Emily Lambert Mackevicius","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS131256-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641392\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary\/Abstract Mental disorders that affect the hippocampus disrupt people\u2019s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.\u003C\/p\u003E"},{"title":"Processing of visual information by spatial memory circuits in the avian brain","field_investigator":"Hannah L Payne","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10570644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10570644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT. Research Project: Spatial memory \u2013 memory of where an event happened or an object was located \u2013 depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.\u003C\/p\u003E"},{"title":"Psych-DS: A FAIR data standard for behavioral datasets","field_investigator":"Melissa  Kline","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-145","field_project_number":"1RF1MH132747-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645923\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645923\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.\u003C\/p\u003E"},{"title":"Reconfigurable 3D Origami Probes for Multi-modal Neural Interface","field_investigator":"Gyorgy  Buzsaki, Michael Patrick Flynn, Euisik  Yoon","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10738994\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10738994\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Over the decades, various neurotechnologies have made significant advancements to meet the highest priority goals enumerated in the BRAIN 2025 Report.\u003C\/p\u003E"},{"title":"Responsive Neurostimulation for Treatment Resistant Depression","field_investigator":"Andrew D Krystal","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS123310-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10513243\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10513243\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY This UH3 application seeks to address the major public health burden of treatment-resistant major depression (trMDD) by developing a novel form of Deep Brain Stimulation (DBS).\u003C\/p\u003E"},{"title":"Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.","field_investigator":"Maksim V Bazhenov, Joshua D Berke, Karunesh  Ganguly","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721280\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721280\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.\u003C\/p\u003E"},{"title":"Role of cortical connections to higher-order thalamic nuclei in visual decision-making","field_investigator":"Ariana R Andrei","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034699-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739488\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739488\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.\u003C\/p\u003E"},{"title":"Role of multi-regional neuronal reactivations in reward-based memories","field_investigator":"Celine  Drieu","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA059024-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722635\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722635\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.\u003C\/p\u003E"},{"title":"Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality","field_investigator":"Gianfranco  Doretto, Michael David Morehead, George A Spirou","field_institution":"Istovisr","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"2R44MH125238-03","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604786\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604786\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EOver the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.\u003C\/p\u003E"},{"title":"Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative","field_investigator":"Kaitlyn  Casimo, Jeremy A Miller","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS133077-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724950\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724950\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.\u003C\/p\u003E"},{"title":"Sensing and manipulating neuromodulatory signaling in vivo","field_investigator":"Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130784-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650681\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EPROJECT SUMMARY Neuromodulation, such as that mediated by the neuromodulators norepinephrine, acetylcholine, and dopamine, imposes powerful control over brain function. It regulates the excitability, synaptic plasticity, and other aspects of neuronal function.\u003C\/p\u003E"},{"title":"SensiTrak: Automated Assessment of Forelimb Sensation","field_investigator":"Camilo Andres Sanchez","field_institution":"Vulintus, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"2R44NS120748-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10603956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10603956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Abstract Current common methods for measuring somatosensory function in preclinical rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli.\u003C\/p\u003E"},{"title":"Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior","field_investigator":"Brandon  Logeman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108801-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10661884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10661884\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.\u003C\/p\u003E"},{"title":"State-dependent modulation of taste and temperature integration in Drosophila","field_investigator":"Fumika  Hamada","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132843-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10718009\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10718009\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY: Animals constantly detect different environmental stimuli and change their behavior or physiology based on their internal state. How animals integrate the external multiple sensory information with the internal state is largely unclear.\u003C\/p\u003E"},{"title":"Systematic characterization of spinal cord stimulation effects on dorsal horn populations","field_investigator":"Andrei D Sdrulla","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS124557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558269\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558269\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThere is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).\u003C\/p\u003E"},{"title":"Thalamic Coordinated Reset Deep Brain Stimulation for Upper Extremity Essential Tremor: Proof of Principle Study","field_investigator":"Jerrold L Vitek, Jing  Wang","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS125162-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10575895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10575895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EEssential tremor (ET) is a common neurologic disorder affecting over 10 million people in the United States. Pathologic synchrony in the cerebello-thalamo-cortical (CTC) network has been considered to underlie the development of ET.\u003C\/p\u003E"},{"title":"The development of multimodal dynamics in a short-term memory system","field_investigator":"Gregory Patrick Davis","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753261\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.\u003C\/p\u003E"},{"title":"The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia","field_investigator":"David  Narvaiz","field_institution":"Baylor University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134141-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary \/ Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.\u003C\/p\u003E"},{"title":"The Neuroimaging Brain Chart Software Suite","field_investigator":"Christos  Davatzikos, Yong  Fan, Ilya M Nasrallah, Haochang  Shou","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS130411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10581015\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10581015\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EThis study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.\u003C\/p\u003E"},{"title":"Thermal-plex: fluidic-free, rapid sequential multiplexed imaging of RNA and protein in brain tissues","field_investigator":"Peng  Yin","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary Multiplexed imaging of brain cells and tissues can reveal critical details about the abundance and spatial organization of molecular targets.\u003C\/p\u003E"},{"title":"Time-varying spatiotemporal causal interactions in the functional brain networks","field_investigator":"Nan  Xu","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS123113-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590411\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590411\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThis proposal describes a five-year career development program to prepare the candidate, Dr.\u003C\/p\u003E"},{"title":"Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas","field_investigator":"Panagiotis  Roussos, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133703-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu\u003C\/p\u003E"},{"title":"Tracking Flow of Attention in Visual Circuits Across the Brain","field_investigator":"Bilal  Haider","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132288-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.\u003C\/p\u003E"},{"title":"Trans-synaptic optical control of user-defined synaptic connections","field_investigator":"Bryan  Copits, Patrick Ross O\u0026#039;neill","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1UF1NS133763-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10732081\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10732081\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract The human brain is estimated to contain over 100 billion neurons that are wired together by more than 100 trillion synapses.\u003C\/p\u003E"},{"title":"Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception","field_investigator":"Todd P Coleman, Duygu  Kuzum, Lyle Edward Muller, John H Reynolds, Mark J Schnitzer","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10655101\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10655101\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT An important longstanding goal in neuroscience research is to understand how large-scale spatiotemporal patterns of neural activity emerge in the brain and whether they have a direct role in shaping the brain\u2019s computational processes and thereby mammalian behavior.\u003C\/p\u003E"},{"title":"UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents","field_investigator":"Gordon J Fishell, Xiangmin  Xu","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-180","field_project_number":"1U24MH133236-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664193\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664193\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Monitor Neural Activity","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary Gaining genetic access to specific cell types in rodents, non-human primates and other vertebrate species is critical for enabling targeted circuit manipulations to understand normal brain function and brain.\u003C\/p\u003E"},{"title":"Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform","field_investigator":"Patrick Goodwill","field_institution":"Magnetic Insight, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44EB035078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761613\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EIn this SBIR grant proposal, \u201cUltra-low distortion and noise electronics to enable a clinical MPI imaging platform,\u201d we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen\u003C\/p\u003E"},{"title":"Ultrasonic-tagged remote interferometric flowmetry for brain activity","field_investigator":"Min  Xu","field_institution":"Hunter College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035400-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731255\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731255\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EOptical monitoring of brain activities is intrinsically associated with various operational advantages, including low-cost and portable noninvasive bedside continuous monitoring capabilities.\u003C\/p\u003E"},{"title":"Understanding the Conceptual Priority Map Guiding Naturalistic Visual Attention for Autistic Individuals","field_investigator":"Amanda J Haskins","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829114\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).\u003C\/p\u003E"},{"title":"UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL","field_investigator":"Elizabeth  Medina","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829011\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.\u003C\/p\u003E"},{"title":"Unified, Scalable, and Reproducible Neurostatistical Software","field_investigator":"Scott Warren Linderman, Alexander Henry Williams","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725500\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725500\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).\u003C\/p\u003E"},{"title":"Validation and Optimization of Two-Photon Dendritic Voltage Imaging in Vivo","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132045-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658307\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658307\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Understanding information flow in cortical circuits requires understanding both the anatomical connectivity between neurons and the way in which inputs to a neuron are integrated to generate a spiking output.\u003C\/p\u003E"},{"title":"Voltage dynamics of distinct cortical ensembles in visually guided behavior","field_investigator":"Madhuvanthi  Kannan","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524557\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524557\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EABSTRACT BRAIN Initiative-funded, large-scale approaches to classify neurons based on transcriptomic, morphological and electrical properties have unveiled dozens of unique cell classes in the mouse brain.\u003C\/p\u003E"},{"title":"Wireless Implantable COrtical Neuroprosthetic System (W-ICONS)","field_investigator":"Francesco V Tenore","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS130131-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10576751\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10576751\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThe goal of this project is to develop a Wireless, fully Implantable, bidirectional Cortical Neuroprosthetic System (W-ICONS) for restoring sensorimotor function through an interface with intact upper limb areas of primary motor and sensory cortex.\u003C\/p\u003E"},{"title":"A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive","field_investigator":"Anup  Mahurkar, Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114788-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447478\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447478\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative\npromotes the development and application of technologies to describe the temporal and spatial\ndynamics of cell types and neural circuits in the brain."},{"title":"A Community Resource for Single Cell Data in the Brain","field_investigator":"Michael  Hawrylycz, Carol Lynn Thompson","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10521124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10521124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe BRAIN Initiative Cell Atlas Network (BICAN) will generate comprehensive molecular taxonomies and\norganizational principles of cell type diversity in the human and non-human primate extending comprehensive\nBICCN work in the mouse."},{"title":"A Confocal Fluorescence Microscopy Brain Data Archive","field_investigator":"Marcel P Bruchez, Alexander J Ropelewski, Alan Michael Watson","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114793-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451277\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Brain image data collected by the neuroscience community will continue to grow\ndramatically in the next 5-10 years as the push to image physically larger volumes, such as\nwhole brains from humans and other primates, becomes a focus."},{"title":"A multi-modal wireless oscillator array for high-resolution mapping of neurovascular coupling","field_investigator":"Chunqi  Qian","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128611-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516470\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nAn outstanding challenge of brain research is to link the cross-scale functional perspectives from the cellular and molecular level to the circuit and systems level."},{"title":"A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell Atlases","field_investigator":"Aparna  Bhaduri, Marcel  Daadi, Hao  Huang, Arnold  Kriegstein, Jon E Levine, Tomasz  Nowakowski, Alexander A Pollen, Nenad  Sestan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130991-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523935\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523935\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe ultimate product of our Center will be a series of comprehensive developing human and non-human primate\n(NHP) brain atlases of unprecedented cellular, spatial, and anatomical resolution."},{"title":"A Novel Wireless and Subcellular Device for Neuromodulation","field_investigator":"Deblina  Sarkar","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034283-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Implantable interfaces for neuromodulation is necessary to advance fundamental neuroscience research,\ndevelop new treatments for neurological disorders, and create efficient breakthrough neuroprosthetics.\nHowever, modern implants based on multi-electrode arrays suffer from low spatial resolution, hi"},{"title":"A robotic multi-armed two-photon microscope for imaging neural interactions across multiple brain areas","field_investigator":"Mark J Schnitzer","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401607\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401607\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nAmong the BRAIN Initiative\u2019s most important achievements are the genetic identification of many new neurons- types and the creation of genetic tools to access these cell types."},{"title":"A Shared Neuroscience Platform for National Dissemination and Training  in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies","field_investigator":"William T Newsome, Sergiu  Pasca, Mehrdad  Shamloo, Gordon X Wang","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out\nfunctional and mechanistic studies accompanied by advanced imaging techniques."},{"title":"A staged, comprehensive investigation for developing insular deep brain stimulation to treat refractory chronic pain","field_investigator":"William Jeffrey Elias, Chang-Chia  Liu","field_institution":"University Of Virginia","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS123308-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10437978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10437978\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nPatients with refractory chronic pain typically do not respond to traditional analgesics or weak opioids\nas these agents do not directly address the cause for their pain."},{"title":"A versatile approach for highly multiplexed, high-resolution imaging of endogenous molecules","field_investigator":"Linnaea E Ostroff","field_institution":"University Of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130472-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505946\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505946\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n The quest to understand the brain\u2019s complex structure has become more challenging as the high\ndegree of molecular heterogeneity among brain cells has become evident in recent years."},{"title":"Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments","field_investigator":"Kaysaw C Tuy","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129129-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610104\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610104\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nPerturbations in redox signaling are associated with multiple neurological disorders, ranging from\nneurodegenerative diseases to brain tumors."},{"title":"Accelerating connectomic proofreading for larger brains and multiple individuals","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129268-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413515\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413515\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Technology for automating the segmentation of neurons from electron microscopic (EM) data has improved\ndramatically, making it now possible to obtain accurate reconstructions of neural circuits from large EM\nvolumes."},{"title":"Accelerating discovery of the human foveal microconnectome with deep learning","field_investigator":"Dennis Michael Dacey","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129260-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10411154\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10411154\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe human retina is one of the most complex microcircuits of the central nervous system (CNS) and is a model\nof CNS neurodegenerative disease with unique advantages for microconnectomics technology advancement.\nThe central retina or fovea mediates high acuity vision, drives activity "},{"title":"Acoustic modulation of forebrain aggression network in miniature, transparent vocal fish","field_investigator":"Andrew H Bass","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524567\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524567\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters,\nincluding the potential to win a fight or prevent escalation resulting in physical injury."},{"title":"Advancing epilepsy diagnosis with flexible, high-resolution thin-film electrodes","field_investigator":"Robert Kyle Franklin, Daniel  Friedman, Bijan  Pesaran, Florian  Solzbacher, Jonathan  Viventi","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS120172-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10297290\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10297290\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTo advance the development of next-generation personalized therapies for long-term seizure freedom, we\nurgently need technologies that improve seizure diagnostics while reducing risks associated with invasive\nneurosurgical procedures."},{"title":"An acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scanners","field_investigator":"Kawin  Setsompop","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033206-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481056\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481056\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nFunctional MRI (fMRI) is the most widely-used tool to noninvasively measure brain function and has produced\nmuch of our current knowledge about the functional organization of the human brain."},{"title":"An Atlas of Human Brain Cell Variation","field_investigator":"Evan Z Macosko, Steven Andrew Mccarroll","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130966-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523654\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nThe human brain exhibits profound diversity in biological function and vulnerability to disease. Despite the\nbiomedical and cultural importance of inter-individual variation, we know relatively little about its underlying\ncellular and molecular substrates."},{"title":"An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans","field_investigator":"Peter  Brunner, Kai  Miller, Gregory A Worrell","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128612-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516471\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516471\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\n Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce\na third of all health care costs."},{"title":"An extensible brain knowledge base and toolset spanning modalities for multi-species data-driven cell types","field_investigator":"Satrajit Sujit Ghosh, Michael  Hawrylycz, Shoaib  Mufti, Lydia Lup-Ming Ng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520941\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520941\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nBRAIN Initiative Cell Census Network (BICCN) is completing a comprehensive cell census of the adult mouse\nbrain, and BRAIN Initiative Cell Atlas Network (BICAN) will extend this work with emphasis on human and non-\nhuman primates."},{"title":"An Integrated Neurochemical\/Electrophysiological Recording and Neuromodulation System for Basic and Clinical Research","field_investigator":"Kevin Elliott Bennet, Kendall  Lee","field_institution":"Wincs International, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"1R42NS125895-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10477708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10477708\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nWINCS International LLC, in partnership with Mayo Clinic, proposes to develop and demonstrate a highly\ninnovative next-generation clinical instrument together with custom user-friendly display and analysis software.\nFor the first time, the Multifunctional Apparatus for Voltammetry, E"},{"title":"Anatomical connectivity and activity in primary visual cortex of mouse","field_investigator":"Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505662\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505662\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nEstimates of the total length of axonal \u0022wiring\u0022 in the human brain are on the order of hundreds of thousands\nof kilometers."},{"title":"Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion","field_investigator":"Alesa Hughson Netzley","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129171-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610655\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610655\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTraumatic brain injury (TBI) is a leading health concern for both children and adults worldwide."},{"title":"Automated microfluidic hyperpolarization reactor for neurometabolic imaging","field_investigator":"Patrick Tomhon, Carlos Dedesma","field_institution":"Vizma life Sciences, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-819","field_project_number":"1R43MH129007-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10383423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10383423\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EBrain function is regulated by molecular signaling and metabolism, however, our ability to track neurometabolic transformations deep in the brain is very underdeveloped compared to the central role of neurometabolism in neurodegenerative disease or brain function in general.\u003C\/p\u003E"},{"title":"Basic neural processing mechanisms of live human face viewing","field_investigator":"Megan  Kelley","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129174-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n  Significance. The human brain has a dedicated neural system for processing other humans. However relatively\n  little is known about the basic mechanisms of this processing."},{"title":"BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework","field_investigator":"Karen G Hirsch, Holly K Tabor","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130518-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508135\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe objective of \u201cBrain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-\nDEF)\u201d is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to\nassess and analyze diverse, critical stakeholder perspective"},{"title":"Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients","field_investigator":"Ken  Bruener, Damien A Fair, Jarod  Roland","field_institution":"Turing Medical Technologies Inc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS129521-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10546990\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10546990\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Abstract\/Summary\nThe objective of this psychological technology SBIR\/STTR Fast-Track proposal is to provide an innovative\ngamified biofeedback solution (software-only) to improve the effectiveness of functional Magnetic Resonance\nImaging (fMRI) for pediatric pre-neurosurgical planning."},{"title":"Bidirectional circuits of locus ceruleus and motor cortex neurons","field_investigator":"Gordon M Shepherd","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447235\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447235\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nPrimary motor cortex (M1) and the locus ceruleus (LC) both contribute in essential ways to the generation of\npurposive movements \u2013 with M1 and its pyramidal tract (PT) neurons involved in action planning and execution,\nthe and LC and its noradrenergic axonal projections involved in a"},{"title":"Biophysical and Neural Basis of Focused Ultrasound Stimulation","field_investigator":"Charles F Caskey, Li Min  Chen","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10415733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10415733\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"This proposal responds to BRAIN Initiative RFA-NS-20-006 and aims to elucidate the neural and biophysical mechanisms of noninvasive focused ultrasound (FUS) neuromodulation."},{"title":"BRAIN Initiative: Hierarchical Event Descriptors (HED): a system to characterize events in neurobehavioral data","field_investigator":"Scott  Makeig, Kay A Robbins, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1RF1MH126700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10480619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10480619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"This two-year project will advance, integrate, document, and promote the use of the Hierarchical\nEvent Descriptor (HED) system to describe events in human neuroimaging and behavioral data\nfrom research experiments and other sources in sufficient detail to support comparative analysis\nof human brain "},{"title":"BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology","field_investigator":"Dominique  Duncan, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nIntracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly\naccess, study, and learn about both normal human brain function and neuropsychiatric disease."},{"title":"Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons","field_investigator":"Anton  Arkhipov, Marina E. Garrett","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130907-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10519964\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10519964\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons\nThe versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and\ncomputations, and their evolution over time due to learning, homeostatic plasticity, and other processes."},{"title":"Broadening access with an Armamentarium Vector Core Powered by Inclusive Research Experiences","field_investigator":"Viviana  Gradinaru, Timothy Francis Shay","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-180","field_project_number":"1U24MH131054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10531723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10531723\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Monitor Neural Activity","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe AAV BRAIN Safe and Effective Neuromodulator and Sensor Utilization across Species (SENSUS, led by\nCaltech) of the NIH BRAIN Initiative Armamentarium Project will develop, validate, and disseminate integrated\n(capsid and genome) engineered adeno-associated virus (AAV) tools to mon"},{"title":"Broadly Accessible Technologies for Single-cell Joint Analysis of Transcriptome and Epigenome","field_investigator":"Bing Ren","field_institution":"Epigenome Technologies, inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"Opportunity Number PA-20-265","field_project_number":"1R41MH128993-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10383385\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10383385\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EHistone modifications carry rich information of cellular memory and gene regulatory mechanisms.\u003C\/p\u003E"},{"title":"CAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells","field_investigator":"Pablo  Gonzalez Camara","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130553-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509196\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nMorphology is an essential phenotype in the characterization of cells and their states. It reflects the progression\nof functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be\nindicative of disease."},{"title":"Caring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials","field_investigator":"Sara  Goering, Eran  Klein","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130457-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506303\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project abstract\nBRAIN pioneers are people who take on significant risk as participants in first-in-human or early\nneurotechnology studies for the sake of helping to further science."},{"title":"Cell type specific AAVs to study reward and cognition","field_investigator":"Leah  Byrne, Andreas Robert Pfenning, Afonso C Silva, William Richard Stauffer","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130881-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Adeno-Associated Viruses (AAVs) are potent gene delivery vectors for neuroscience studies and gene therapy\napplications."},{"title":"Cell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems","field_investigator":"Wei  Xu","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505702\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505702\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Cell Type-specific Anterograde Circuit Mapping and Functional Control by\n Optimizing YFV-17D Transneuronal Systems\nSummary\nTo elucidate the functional organization of brain circuitry we need to delineate neuronal\nconnectivity and control the activity of neurons with specific connectivity."},{"title":"Center for Multiomic Human Brain Cell Atlas","field_investigator":"M Margarita Behrens, Joseph R Ecker, Bing  Ren, Ting  Wang, Xiangmin  Xu","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130994-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523973\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523973\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nUnderstanding cell identities and their spatial distributions throughout different regions of the human brain is a\nfundamental step when trying to integrate physiological, behavioral, neurochemical and molecular data."},{"title":"Circuit dynamics of structuring episodic memories in humans","field_investigator":"Jie  Zheng","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126233-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590796\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590796\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nOur lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.\nHowever, we remember this as a series of discrete events. For example, the memory of a two-hour movie\nconsists of a few memorable moments tied to the main story."},{"title":"Circuits for spontaneous behavior and phototaxis in a simple model chordate","field_investigator":"William  Smith","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127106-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446697\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"This proposal will investigate neural circuits driving negative phototaxis in an emerging model for neural circuit\nanalysis: larvae of the primitive chordate Ciona. Ciona larvae have a number of features that make them\nideally suited for this project."},{"title":"Closed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals","field_investigator":"Daniel  Aharoni, Hugh T Blair, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401560\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401560\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nA major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Adding to this challenge is the fact that neural function does not operate in isolation but rather within living, behaving animals."},{"title":"Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology","field_investigator":"Loren M Frank, Mattias Peter Karlsson, Chong  Xie, Jan  Zimmermann","field_institution":"Spikegadgets, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS127692-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481712\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nExamining how behavior arises from the complex interconnected activity of the brain is a\ncornerstone of neuroscience research. A recent technological advance in neurotechnology is\nenabling studies where the parallel activity of thousands of neurons can be studied in rodent\nbrains."},{"title":"Comprehensive single-cell atlas of the developing mouse brain","field_investigator":"Paola  Arlotta, Tomasz  Nowakowski, Hongkui  Zeng","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130962-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523550\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe developing mouse brain is a foundational experimental model for investigation of the origins of cell types in\nthe mammalian brain."},{"title":"Computational dynamics in neural populations of freely foraging vs. restrained monkeys","field_investigator":"Dora  Angelaki","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127122-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447347\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nThis proposal will investigate the neural dynamics underlying three-dimensional foraging behavior, with three\noverarching goals. The first is to evaluate the neural computations of foraging in dynamic environments in\nnaturalistic settings."},{"title":"Computational foundations of active visual sensing","field_investigator":"Mackenzie Weygandt Mathis, Cristopher M Niell, Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126566-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10431247\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10431247\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nVision is an active process: we move our head and eyes to explore the sensory world."},{"title":"Computational Tools for assessing mechanisms and functional relevance of divisive normalization","field_investigator":"Ruben  Coen-Cagli","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056400-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488972\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488972\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDivisive normalization (DN) is a well-established theory of how interactions between neurons in a circuit\nmodulate the activity of individual neurons."},{"title":"Cortical circuits for the integration of parallel short-latency auditory pathways","field_investigator":"Hiroyuki  Kato, Paul B Manis","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524362\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524362\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nHow our brain achieves coherent perception by integrating information from parallel sensory pathways\ndistributed across space and time remains a central question in neuroscience."},{"title":"CRCNS: Circuit mechanisms of priors and learning during decision making","field_investigator":"Guangyu Yang","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132172-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhen learning a new task, both rats and humans exhibit suboptimal behaviors plagued with superstitious ticks and idiosyncratic biases.\u003C\/p\u003E"},{"title":"CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior","field_investigator":"Paul Nuyujukian","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610495\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610495\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhat operations are performed by the mammalian central nervous systems to coordinate and conduct voluntary movement? Motor systems neuroscience seeks to understand these neural mechanisms.\u003C\/p\u003E"},{"title":"CRCNS: Dynamics of thalamocortical networks during sensory discrimination","field_investigator":"Mark Allan Reimers","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612202\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612202\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Evidence-based modeling of neuromodulatory action on network properties","field_investigator":"Yangyang Wang","field_institution":"University of Iowa","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DA057767-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610566\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610566\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Heterogeneous effects of cognition on perception: unique leverage on circuit mechanisms","field_investigator":"Marlene Rochelle Cohen, Brent D. Doiron","field_institution":"University of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01EY034723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608553\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608553\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multifocal causal mapping of brain networks supporting human cognition","field_investigator":"Aapo Nummenmaa","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DC020891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612128\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612128\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENeuroimaging methods such as functional MRI and magneto- \/ electroencephalography (MEG\/EEG) cannot directly reveal causal relationships between regional brain activity and behavior.\u003C\/p\u003E"},{"title":"CRCNS: Neural Representations of Time Across Scales in Natural and Artificial Networks","field_investigator":"Marc W Howard","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610084\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization","field_investigator":"Fabrizio Gabbiani, Matthias Heinkenschloss","field_institution":"Baylor College of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612187\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612187\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EMotivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?\u003C\/p\u003E"},{"title":"DataJoint SciOps: A Managed Service for Neuroscience Data Workflows","field_investigator":"Dimitri  Yatsenko","field_institution":"Vathes Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS129492-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10547509\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10547509\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project summary\nThis SBIR proposal aims to address current challenges in data-driven neuroscience by implementing DataJoint\nSciOps: a commercial service to help research labs implement computational work\ufb02ows for data-intensive science\nexperiments."},{"title":"Deciphering the genomic mechanisms underlying the physiology of human brain stimulation","field_investigator":"Genevieve  Konopka, Bradley C Lega","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126143-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10559426\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10559426\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The underlying mechanisms of brain stimulation in humans are poorly understood, especially at the level of gene expression."},{"title":"Deep Analysis of Brain Chemistry at Enhanced Spatial and Temporal Resolution using Microscale Sampling and Analysis","field_investigator":"Robert T Kennedy","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128522-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515445\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515445\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The objective of this project is to develop new bioanalytical methods for exploring brain chemistry dynamics in vivo. Monitoring the concentration dynamics of neurochemicals in vivo is vital for studying brain function, diseases, and treatments."},{"title":"Deep and fast imaging using adaptive excitation sources","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128660-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516870\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Optical recordings of activity are critical to probe neural systems because they provide high-resolution,\nnon-invasive measurements, ranging from single neurons to entire populations in intact nervous systems, and\nare readily combined with genetic methods to provide cell type-specific reco"},{"title":"Defining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo","field_investigator":"Justin  O\u0026#039;hare","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10502363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10502363\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCandidate Goals and Mission Relevance: The applicant\u2019s broad, long-term objective is to investigate how high-\n(circuit\/behavioral) and low- (subcellular\/molecular) level organizational principles of the brain cooperate to drive\nlearning."},{"title":"Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest","field_investigator":"Wiley Thomas Waddell, Maik Huettemann, Thomas Hudson Sanderson","field_institution":"Mitovation, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-022","field_project_number":"1U44NS125160-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515831\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515831\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Human Neuroscience, Interventional Tools","field_program":"Dissemination, Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003ECardiac arrest in infants is a medical emergency requiring rapid resuscitation to restore circulation. However, resuscitation often results in significant brain injury, caused by ischemia\/reperfusion injury.\u003C\/p\u003E"},{"title":"Development and Validation of a Genetically Encoded Method to Trace and Manipulate Neuronal Circuits in Zebrafish","field_investigator":"Carlos  Lois, David Aaron Prober","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130420-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505822\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505822\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIdentifying how neurons are connected to each other in the brain is an important and necessary step towards\nunderstanding how brain activity gives rise to behavior, and how it is perturbed by disease."},{"title":"Development of a Miniaturized Wearable Ultrasonic Beam-forming Device for Localized Targeting of Brain Regions in Freely-moving Experimental Subjects","field_investigator":"Kevin A Snook","field_institution":"Actuated Medical, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43NS126007-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10483847\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10483847\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"This Phase I SBIR will further develop, validate, and initiate commercialization of the miniature ultrasound\nbeamforming array (MUBA) system for transcranial focused ultrasound (tFUS)."},{"title":"Development of a sample preparation protocol for brain ultrastructural analysis, immunolabeling, and neuronal tracing by light microscopy","field_investigator":"Ons  M\u0026#039;saad","field_institution":"Panluminate Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43MH128999-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10483978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10483978\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThe brain is the most complex organ in the human body. Understanding its neural connections and molecular\nanatomy requires imaging technology that is capable of mapping the 3D nanoscale distribution of specific\nproteins in the context of brain ultrastructure."},{"title":"Development of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving mice","field_investigator":"Richard L Huganir, Jin  Zhang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH126707-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505852\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nCell signaling pathways in the brain are an essential part of a complex system regulating the activity and\ncoordination of neuronal networks."},{"title":"Development of opioid and ketamine probes for in vivo photopharmacology","field_investigator":"Matthew Ryan Banghart, Conor M Liston","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126073-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401573\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401573\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nPharmacological probes are widely used to study the nervous system. Despite often exhibiting exquisite specificity for target receptors, due to diffusion, traditional small molecule drugs act slowly and with spatial imprecision."},{"title":"Dissecting circuit and cellular mechanisms for limb motor control","field_investigator":"John  Tuthill","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128785-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10522108\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10522108\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Motor neurons connect to muscles and comprise the major output of the nervous system. Patterns of\nneural activity in motor neurons cause temporally precise muscle contractions, producing coordinated\nand flexible behavior."},{"title":"Dissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement","field_investigator":"Alice  Mosberger","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126307-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTo learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to\ncausally link previously performed movements to their resulting outcomes."},{"title":"Dissection of Cell Type Specific Contributions to Motor Learning Circuits","field_investigator":"Lina Marcela Carmona","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505229\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505229\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\nWhether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our\ndaily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must\nfirst be learned through the process of motor learning."},{"title":"Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.","field_investigator":"Gyorgy  Buzsaki, Zhe Sage Chen","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488900\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ ABSTRACT\nAdvances in neurotechnologies are producing large and complex datasets at unprecedented rate."},{"title":"Dissemination of FlyWire, A Whole-Brain Connectomics Resource","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126935-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439970\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439970\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We\nused advances in AI to segment all neurons from a whole brain EM volume called FAFB."},{"title":"Dissemination of MAPseq and BARseq for high-throughput brain mapping","field_investigator":"Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126938-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience\ncommunity. These are novel methods developed in my laboratory based on high-throughput DNA\nsequencing for determining neuronal circuitry."},{"title":"Distributed Neural Activity Patterns Underlying Practice-Based Learning","field_investigator":"Kimberly  Reinhold","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH127471-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447345\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nTo survive, animals must learn appropriate associations between sensory cues and motor actions through a\nprocess of trial and error."},{"title":"Early-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors","field_investigator":"Brianna Elyse George","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129177-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541392\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nStress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to\ncompulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple\nclasses of drugs."},{"title":"Efficient Two-Photon Voltage Imaging of Neuronal Populations at Behavioral Timescales","field_investigator":"Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516906\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding how information is processed in the mammalian neocortex has been a longstanding\nquestion in neuroscience. While the action potential is the fundamental bit of information, how these\nspikes encode representations and drive behavior remains unclear."},{"title":"Elucidating Principles of Sensorimotor Control using Deep Learning","field_investigator":"Shreya  Saxena","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056377-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488409\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488409\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHow do distributed neural circuits drive purposeful movements from the complex musculoskeletal system?"},{"title":"Empirical Power Analysis Tool for fMRI","field_investigator":"Stephanie  Noble","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10503064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10503064\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nFunctional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain\nfunction and disease and is flourishing under unprecedented international funding, including dedicated support\nfrom the BRAIN Initiative."},{"title":"Enabling precise cell-type-specific dissection of orientation and memory circuits in retrosplenial cortex","field_investigator":"Omar Jamil Ahmed","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127101-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446099\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446099\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nIn humans, damage to a brain region called the retrosplenial cortex leads to pronounced spatial disorientation\nand severe retrograde and anterograde memory deficits."},{"title":"Engagement and outreach to achieve a FAIR data ecosystem for the BICAN","field_investigator":"Hua  Xu, Guo-Qiang  Zhang, Wenjin Jim Zheng","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130988-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523908\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523908\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"As a part of BRAIN 2.0, the BRAIN Initiative Cell Atlas Network (BICAN) is expected to advance fundamental knowledge and enabling technology for classifying human brain cell types, understanding their organizational principles, and providing open-access digital brain cell reference atlases, emphasiz"},{"title":"Engineering the Neuronal Response to Electrical Microstimulation","field_investigator":"Mark E. Orazem, Kevin J. Otto","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126052-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401586\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nOur proposed efforts align directly with a goal of RFA-NS-18-019: optimization of transformative technologies for modulation in the nervous system."},{"title":"Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.","field_investigator":"Ludovica Labruna","field_institution":"Magnetic Tides, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-266","field_project_number":"1R44NS127667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481976\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481976\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003ENon-invasive brain stimulation (NIBS) has attracted considerable interest in the cognitive neuroscience community, providing an important basic research tool to study brain function, with emerging clinical applications to enhance function in individuals with neurological disorders.\u003C\/p\u003E"},{"title":"Fast Multichannel Magneto-thermal Genetics","field_investigator":"Jacob T. Robinson","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126063-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401691\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401691\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Precisely timed activation of genetically targeted cells is a powerful tool for studying neural circuits. Neuronal modulation (activating or inhibiting select neurons) allows us to investigate how neural activity causes changes in animal behavior."},{"title":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop","field_investigator":"Garrett B. Stanley","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128896-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop\nNearly all sensory experience begins in the periphery, generating sensory signals travelling through the thalamus\nbefore reaching neocortex."},{"title":"Fluorescence-based methods for microconnectivity analysis in neocortex","field_investigator":"Alison L Barth","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413555\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413555\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nA comprehensive census of neural cell types in the brain, together with molecular-genetic\nresources for cell-type specific labeling, is revolutionizing our ability to detect and monitor age,\ndisease, and experience-dependent changes in neural connectivity."},{"title":"Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project","field_investigator":"Tristan  Mcintosh","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130519-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nNeurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,\nmonitor brain activity, and collect and transmit personal health data."},{"title":"From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampus","field_investigator":"Mark E J Sheffield","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127123-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447353\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447353\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Memory enables animals to acquire, store, and recall knowledge of the world\nthrough experience and use this knowledge to maximize reward and avoid danger."},{"title":"Functional connectivity of a brain-scale neural circuit for motion perception","field_investigator":"Eva Aimable Naumann","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128895-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524593\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524593\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe transformation of visual cues into appropriate behavior requires the collaboration of diverse neurons across\ndistant brain areas."},{"title":"Functional dissection of cerebellar output circuits that orchestrate limb motor control","field_investigator":"Eiman  Azim, Albert  Chen","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524627\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524627\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe cerebellum is essential for coordinating motor behavior through rapid adjustments of ongoing movements.\nTo refine movement, the cerebellum processes motor and sensory information, and transmits output that\nultimately modulates motor neuron activity to ensure successful execution."},{"title":"Functional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states","field_investigator":"Jane  Yi","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467357\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467357\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\/SUMMARY\nThe mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep\nand pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably\noverlooked due to their sparsity in the total neuronal population."},{"title":"Functional Mapping of the Suprachiasmatic Nucleus","field_investigator":"Karen Jill Tonsfeldt","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119291-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and\nprovide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow\nsingle cell recording at 1024 contacts simultaneously."},{"title":"Functionally guided adult whole brain cell atlas in human and NHP","field_investigator":"Ed  Lein, Hongkui  Zeng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130981-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523848\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523848\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Progress in treating brain disorders has been frustratingly slow, in large part due to the extraordinary complexity of the\nhuman brain and its inaccessibility to study."},{"title":"Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.","field_investigator":"Claudia Z Han","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH129983-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThe prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis,\nneuronal migration, and formation of neural networks."},{"title":"Hierarchy of the vocalization motor patterning circuits","field_investigator":"Kevin  Yackle","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446346\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446346\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"How are complex behaviors that require the coordination of multiple muscle systems produced? How does the\nbrain suddenly turn them \u201con\u201d?\n Vocalizations are seemingly simple, yet to occur, ~100 muscles must be coordinated, such as those for\narticulation (laryngeal and tongue) and breathing."},{"title":"High-resolution bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals","field_investigator":"Robert E. Campbell, Daniel  Razansky, Shy  Shoham","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10407380\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10407380\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nAcoustic technologies such as optoacoustic (OA) imaging and ultrasound neuromodulation (USNM) are poised to revolutionize deep tissue, high-resolution, large-scale, in vivo imaging, and neurostimulation in mammalian organisms."},{"title":"High-throughput mapping of synaptic connectivity between transcriptomically defined cell types","field_investigator":"Michael Nicholas Economo","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH126882-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413540\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413540\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIdentifying the cell types that make up each region of the brain and the patterns of synaptic connections\nthrough which they are linked is key to understanding how neural circuits give rise to all perception, cognition,\nand behavior."},{"title":"High-throughput sequencing of synaptic partnerships and gene expression at single-cell resolution in vivo","field_investigator":"Arpiar B Saunders","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130464-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506110\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506110\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nBrain function depends on forming and maintaining synaptic connections between neurons of specific types,\nyet systematic descriptions of cell-type connectivity and the molecules that instruct these relationships remain\nchallenging because we lack some necessary tools."},{"title":"Highly parallel long wavelength heterodyne diffuse correlation spectroscopy for brain functional imaging","field_investigator":"Stefan Alexandru Carp","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033202-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10479451\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10479451\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nNon-invasive imaging of human brain function plays an important role in advancing neuroscience research and\nunderstanding neurological diseases. This need has been met primarily by functional magnetic resonance\nimaging (fMRI)."},{"title":"Hippocampo-cortical contributions to world building in freely behaving macaques","field_investigator":"Kari  Hoffman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWhen learning in complex, realistic, or even real worlds, we have the benefit of using different\nstrategies adaptively. For most primate brains, adaptive means adjusting as a function of where we\nare, who we are with, and what things of use are in view or in reach."},{"title":"Hormonal regulation of sensory processing during parental care","field_investigator":"Kristina O. Smiley","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n Does the way we hear sounds change when we become parents?"},{"title":"Identifying prefrontal signatures of successful and dysfunctional attention","field_investigator":"Brielle  Ferguson","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349347\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Attention is comprised of several component processes, including sustained attention, selective\nattention, and attentional flexibility."},{"title":"Imaging at the speed of spikes: An electro-optical multiphoton microscope","field_investigator":"Aaron Michael Kerlin","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128658-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nSignals in the brain are transmitted and transformed on a millisecond timescale. The precise timing of activity can carry unique information, correlate perceptual decisions, and powerfully influence synaptic plasticity."},{"title":"Implementation and dissemination of cloud-based retrospective hemodynamic analysis tools to enhance HCP data interpretation","field_investigator":"Blaise Debonneval Frederick","field_institution":"Mclean Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130637-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509534\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509534\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Summary\nFunctional Magnetic Resonance Imaging data has been a mainstay of neuroscience research for more than two\ndecades, as it allows rapid, continuous, noninvasive monitoring of neuronal function."},{"title":"Improving the robustness of neuroimaging through exploitation of variability in processing pipelines","field_investigator":"Gregory  Kiar, Michael Peter Milham","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130859-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516830\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nReproducible findings are essential to scientific advancement. Unfortunately, when fields lack consensus\nstandards for methods, or their implementations, reproducibility tends to be more of an ideal than a reality."},{"title":"In situ Single-Cell Multi-Omic and Morphological Profiling in Mammalian Brains","field_investigator":"Chongyuan  Luo","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130461-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506297\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nSingle-cell technologies have revolutionized the characterization of mammalian brains allowing unbiased census\nof cell types and their transcriptomic and epigenomics signatures."},{"title":"Integrated functional and structural analysis of an entire column in mouse primary visual cortex","field_investigator":"Reza  Abbasi Asl","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128672-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505417\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nNeurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The\nstructural and morphological organization of the neurons is known to constrain its functional properties."},{"title":"Integration of social and nonsocial information in the primate brain","field_investigator":"Joseph  Simon","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125826-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPrimate species frequently use social information to inform their decisions, for instance, to help make inferences\nabout potential threats or rewards in the environment."},{"title":"Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots","field_investigator":"Gregory John Gage, Christopher Aiden Harris","field_institution":"Backyard Brains, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-07-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"2R44NS108850-03A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10385012\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10385012\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EUnderstanding the brain is a profound and fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes training the next generation of neuroscientists, engineers and physicians a key concern.\u003C\/p\u003E"},{"title":"Investigating descending control of walking","field_investigator":"Helen Horan Yang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129759-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10568039\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10568039\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCircuits in the brain control motor output to generate the precise behaviors required for survival. Dysfunction of\nthese circuits results in devastating movement disorders such as Parkinson\u2019s disease and amyotrophic lateral\nsclerosis."},{"title":"Investigating the microcircuit determinants of neural population activity through comparative analysis of latent dynamics across cortical areas in the mouse","field_investigator":"Audrey  Sederberg","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505552\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505552\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nA key goal in neuroscience is determining how microcircuit structure predicts circuit function. An intriguing idea,\nsupported by some theoretical models, is that variation in microcircuit composition supports functional\nspecialization."},{"title":"Investigating the pathomechanisms underlying Charcot-Marie-Tooth Disease","field_investigator":"Julia Alexis Jones","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129169-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541701\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541701\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nCharcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of\ninherited peripheral neuropathies that is characterized by damage to long motor and sensory\naxons."},{"title":"Investigating the Role of Microglia in Methamphetamine Use Disorder","field_investigator":"Samara Jo Vilca","field_institution":"University Of Miami School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130871-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nSubstance use disorder is a chronic relapsing disease that is characterized by repeated drug use despite\nnegative consequences."},{"title":"Kilohertz volumetric imaging of neuronal action potentials in awake behaving mice","field_investigator":"Liang  Gao, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128488-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515267\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515267\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"High-speed volumetric imaging of dynamic neuronal activity over long periods is a challenging but essential goal in neuroscience. Conventional optical measurements of neuronal activity mostly rely on calcium signals."},{"title":"Locus coeruelus-prefrontal interactions for flexible decision-making","field_investigator":"Joshua I Gold","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128974-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10532047\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10532047\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nHigher brain functions include the ability to learn expectations about the world, update those expectations\nappropriately when given new sensory information, and use those continually updating expectations to guide\nbehavior."},{"title":"Long-term consequences of visual working memory","field_investigator":"Megan Teresa Debettencourt","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99MH128893-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523326\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523326\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe ability to remember information, whether after short or long delays, is a fundamental human ability."},{"title":"Machine learning analyses of single-cell multi-modal data for understanding cell-type functional genomics and gene regulation","field_investigator":"Daifeng  Wang","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128695-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505191\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505191\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nUnderstanding cell-type-specific gene functions, expression dynamics, and regulatory\nmechanisms in complex brains is still challenging."},{"title":"Machine Learning Augmented Discovery of AAV Capsids for Cell Type Specific Access into Human Neurons and Glia","field_investigator":"Tomasz  Nowakowski, David V Schaffer, Vikaas Singh Sohal","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512547\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512547\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe human brain contains an astonishing diversity of neuronal and glial cell types distributed across dozens of\nfunctional areas."},{"title":"Mechanisms of Transplanted Cortical Interneuron Survival and Function","field_investigator":"Benjamin  Rakela","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425147\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal\ntimepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to\nsurvive."},{"title":"Mesh electronics for understanding space encoding in the amphibian brain","field_investigator":"Lisa  Giocomo, Guosong  Hong, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446284\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446284\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nMany animals rely on spatial cognition for daily survival in order to recognize familiar places and process movements\nthrough or between locations. A variety of space-encoding cells in the hippocampus are important for spatial behaviors\nin mammals."},{"title":"Mesoscale bidirectional two-photon holographic optogenetics","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516934\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516934\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nAchieving a detailed understanding of the neural codes of sensation, action, and cognition requires technologies that can causally perturb each of the major dimensions of population coding one at a time with extremely high precision across multiple brain areas."},{"title":"Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"1R44MH129023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10384932\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10384932\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis project aims to develop the 2P-ActivityScope\u2122, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr.\u003C\/p\u003E"},{"title":"Miniaturized silicon neurochemical probe to monitor brain chemistry","field_investigator":"Yurii A Vlasov","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126061-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401696\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401696\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nMiniaturized silicon neurochemical probe to monitor brain chemistry."},{"title":"Modeling the development of orientation selectivity, maps, and the associated recurrent circuit","field_investigator":"Kenneth D Miller","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056397-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nMuch evidence suggests that the development of orientation selectivity and maps in primary visual cortex (V1)\nis instructed by spontaneous patterns of input activity, without the necessity of visual experience."},{"title":"Modulation of Cerebellar Activity by Electrical and Focused Ultrasound Stimulation","field_investigator":"Eric J Lang, Omer  Oralkan, Mesut  Sahin","field_institution":"New Jersey Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS122741-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429656\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429656\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The cerebellum has been overlooked for its potential for neuromodulation for decades."},{"title":"Molecular and circuit mechanisms of nausea-associated behaviors","field_investigator":"Chuchu  Zhang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129758-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10569466\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10569466\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nNausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.\nNausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that\navoid or expel toxins which may cause peripheral tissue damage."},{"title":"Molecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish","field_investigator":"Dena  Goldblatt","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541342\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant\nneural circuit assembly. However, the developmental logic that dictates circuit organization, function, and\nultimately behavior remains unresolved due to the complexity of most circuits."},{"title":"Monitoring presynaptic release of neuropeptides in awake behaving animals","field_investigator":"Sung  Han","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128680-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517245\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nNeuromodulators, such as neuropeptides and biogenic amines are produced and released by neurons to communicate with each other."},{"title":"Motor Recovery through Plasticity-Inducing Cortical Stimulation","field_investigator":"Steven C. Cramer, Jeffrey G Ojemann","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS121565-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10357993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10357993\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Limited recovery of function after stroke remains a major problem for millions. Disability persists in\nmany, especially when hand function is limited. Existing therapies are limited and many have difficulties with\nactivities of daily living, even after rehabilitation."},{"title":"Multi-probe minimally invasive endomicroscope","field_investigator":"Antonio Miguel Caravaca Aguirre","field_institution":"Modendo Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43NS127710-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThis project seeks to develop a multi-probe ultrathin endomicroscope to enable high-resolution imaging and\nphoto-stimulation at multiple sites within currently inaccessible regions of the brain."},{"title":"Multimodal dissociation of posterior cingulate cortex contributions to episodic memory","field_investigator":"Seth Ryan Koslov","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467220\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nEpisodic memory is the ability to recall details about prior experiences. Researchers have historically relied on\ncontrolled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the\nbiological substrates of episodic memory."},{"title":"Network based neuro-modulation for mesial temporal lobe epilepsy","field_investigator":"Behnaam  Aazhang, Sandipan Pati  Bankim Behari Pati, Nitin  Tandon, Gregory A Worrell","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10113342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10113342\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":""},{"title":"Neural basis of facial individual recognition in paper wasps","field_investigator":"Michael J Sheehan","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524286\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524286\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neural circuits of animals, including humans, are the combined product of adaptation by natural selection\nand the evolutionary history of a species."},{"title":"Neural circuit control of fluid and solute clearance during sleep","field_investigator":"Patrick James Drew, Hajime  Hirase, Douglas H Kelley, Laura Diane Lewis, Maiken  Nedergaard","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS128613-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516497\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516497\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Program abstract: This proposal aims to identify the neural circuit mechanisms that control periarterial\ncerebrospinal fluid (CSF) pumping and glymphatic clearance of fluid and solutes."},{"title":"Neural circuit mechanisms for multisensory associative learning","field_investigator":"Roudabeh  Behnia, Ashok  Litwin-Kumar","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524400\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524400\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe brain uses sensory representations to assess risk and predict reward in order to adjust behavior. Per\u00ad\nception is a multisensory process. To make reliable predictions, it is advantageous for the brain to combine\nmore than one sensory modality to represent the world."},{"title":"Neural coding of natural stimuli in freely moving macaque","field_investigator":"Valentin  Dragoi","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524592\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524592\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Despite the fact that visual perception represents such a fundamental aspect of our everyday life, our knowledge\nof the underlying neural coding of natural stimuli is woefully lacking."},{"title":"Neural mechanisms of behavioral coordination in Hydra","field_investigator":"Alison  Hanson","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127851-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505359\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505359\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nHow do animals coordinate their many parts to generate coherent, adaptive behavior?"},{"title":"Neural mechanisms of taste and metabolic state integration in the brainstem","field_investigator":"Nilay  Yapici","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe taste of food is a critical factor that determines whether an organism will accept or reject a food source."},{"title":"Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin Optoelectronic Materials","field_investigator":"Ertugrul  Cubukcu","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY033676-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401044\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401044\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin\n Optoelectronic Materials\n Recording electrical activity of neural populations with high resolution is essential to\ninvestigate neural circuits and cognitive functions."},{"title":"NEURODEVELOPMENTAL FUNCTION OF HCFC1","field_investigator":"Victoria L Castro","field_institution":"University Of Texas El Paso","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125690-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541351\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541351\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nMutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin\nmetabolism, intractable epilepsy, intellectual disability, and motor dysfunction."},{"title":"Neurodevelopmental role of a tRNA methyltransferase underlying intellectual disability","field_investigator":"Kimberly Rose R. Madhwani","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10540878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10540878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nGene regulation at multiple levels is critical for nervous system development and function."},{"title":"Neurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson\u0026#039;s disease","field_investigator":"Helen  Bronte-Stewart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS128150-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510424\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Cognitive decline begins in early stages of Parkinson\u2019s disease (PD) and progresses to dementia in 75% of\npeople with PD after ten years."},{"title":"New Methodologies for Connectomics","field_investigator":"Xiaotang  Lu","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10345620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10345620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT ABSTRACT\nThe nervous systems of animals are comprised of neurons connected by a large number of synapses.\nThe resulting neural networks underlie animal behavior and contribute to the storage of learned\ninformation in many species."},{"title":"New strategies for molecular cell-type labeling in volume electron microscopy","field_investigator":"Linnaea E Ostroff","field_institution":"University Of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413454\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413454\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n Recent years have seen major breakthroughs in methodology for studying two complex yet\nfundamental aspects of brain structure: synaptic connectivity patterns and the heterogeneous distribution of\nmolecules."},{"title":"Noninvasive Targeted Neuromodulation","field_investigator":"Jan  Kubanek","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128569-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515789\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nNeurological and psychiatric disorders absorb one-third of the total health care expenditures; more than cancer, cardiovascular diseases, and diabetes combined. On average, approximately one in three patients fails to respond to medication treatments or has intolerable side e\ufb00ects."},{"title":"Odor trail tracking: a new paradigm to unveil algorithms and neural circuits underlying active sensation and continuous decision making","field_investigator":"Catherine  Dulac, Venkatesh N Murthy, Massimo  Vergassola","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524245\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nAnimals actively sample sensory information, which they combine with prior knowledge to make\ndecisions in a sensorimotor feedback loop."},{"title":"ONIX: A Neural Acquisition System for Unencumbered, Closed-Loop Recordings in Small, Freely Moving Animals","field_investigator":"Jonathan  Newman","field_institution":"Open Ephys, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS127725-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10482182\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10482182\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nOver the last century, extracellular recording technologies have progressed from handmade needle electrodes\nand vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip\ndigitization circuits."},{"title":"Open-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging","field_investigator":"Daniel  Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman  Golshani, Alcino J. Silva, Alipasha  Vaziri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516900\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract:\nSingle-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors\nhas allowed investigators to record the activity of large populations of identified neurons over days to weeks in\nfreely behaving animals, answering fundamental questions in neurosci"},{"title":"Optical neural motes to enable high density recording through intact dura in a nonhuman primate","field_investigator":"David  Blaauw, Cynthia Anne Chestek","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516965\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\nIR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless\n Motes for Large Scale Implantation Into Nonhuman Primate Cortex\n In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes\nnear-infrared (NIR) light for "},{"title":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation","field_investigator":"Xue  Han","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558965\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes."},{"title":"Optimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures","field_investigator":"Meng  Cui, Scott M Sternson","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401603\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401603\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nA central goal of neuroscience is to understand animal behavior in the context of the information processing properties of neuron ensembles."},{"title":"Optimization of Flexible Neural Probe Arrays for Multi-Region Recordings in Rodents and Nonhuman Primates","field_investigator":"Ellis  Meng, Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401221\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401221\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"A core goal of the BRAIN Initiative is to link neural activity to behavior which requires technology to acquire high-quality recordings of dynamic neural activity from different brain regions over time."},{"title":"Optimization, application, and dissemination of imaging modules for high-speed mesoscopic volumetric recording of neuroactivity in scattering brains","field_investigator":"Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401689\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\nA number of recent observations suggest that complex brain functions in the mammalian brain emerge from highly parallel computation in which information about sensory inputs, internal states, and behavioral parameters are mapped onto highly distributed brain-wide neuronal "},{"title":"Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)","field_investigator":"Dion  Khodagholy","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nA major obstacle to understanding how the dynamic activity of brain circuits permits the emergence of cortical function is the insufficient capability to acquire and manipulate this activity across the course of brain maturation."},{"title":"Pinpointing the Cerebellum\u0026#039;s Contribution to Social Reward Processing","field_investigator":"Haroon Skander Popal","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541308\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nThe cerebellum has long been thought to solely process motor information. Yet, there is a growing literature\nthat points to a role of the cerebellum in processes across multiple domains."},{"title":"PREFRONTAL CIRCUITS OF WORKING MEMORY","field_investigator":"Christos  Constantinidis, Boris V Zemelman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127100-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446082\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446082\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWorking memory, the ability to maintain and manipulate in formation in memory over a period of seconds, is a\ncritical component of higher cognitive functions."},{"title":"Probing Neural Circuits of Zebrafish Sleep with Electrophysiology and Calcium Imaging","field_investigator":"David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS126800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10436734\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10436734\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe zebrafish has emerged as a useful model system to discover and characterize genetic and neuronal circuits\nthat regulate vertebrate sleep."},{"title":"Protein ticker-tapes for brain-wide neural recordings","field_investigator":"Adam Ezra Cohen","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY033669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10399721\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10399721\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nProtein ticker-tapes for brain-wide neural recordings\nBehavior emerges from the interacting activity of widely distributed ensembles of neurons; but all existing tools\nfor measuring brain activity sample only a small subset of these dynamics."},{"title":"Rapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light source","field_investigator":"Kim  Butts-Pauly, Xiaoke  Chen, Guosong  Hong","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126076-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nOptogenetics provides a precise deconstruction of neural circuits by optically manipulating the activity of opsin-expressing neurons with fast temporal responses and neuron-type specificity."},{"title":"Real Time NEURON Simulation for Experimental Applications","field_investigator":"Mark W Nowak","field_institution":"Cytocybernetics, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"1R43NS125749-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10384810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10384810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this proposal is to combine the power of the NEURON mathematical modeling software with the Cybercyte \u201cplug and play\u201d dynamic clamp system.\u003C\/p\u003E"},{"title":"Real-time mapping and adaptive testing for neural population hypotheses","field_investigator":"John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056376-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10486197\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10486197\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Recent advances in neural recording technologies have made it possible to study increasingly large and di-\nverse subsets of neurons, producing a growing interest in the collective computational properties of neural pop-\nulations."},{"title":"Revealing the mechanisms of primate face recognition with synthetic stimulus sets optimized to compare computational models","field_investigator":"Winrich  Freiwald, Nikolaus  Kriegeskorte","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128897-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524626\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524626\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nNeuroscience is entering a new era, where large-scale neural network models can be tested with unprecedent-\nedly rich measurements of neural activity."},{"title":"Ribo-STAMPEDE: novel tools for molecular profiling of brain cell types","field_investigator":"Giordano  Lippi, Eugene Wei-Ming Yeo","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH126719-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506300\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506300\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nA detailed and comprehensive census of central nervous system (CNS) cell types and states is essential to our\nunderstanding of the neural substrates of cognition and behavior."},{"title":"Robot assisted brain-wide neural recordings and comprehensive behavioral monitoring in freely behaving mice","field_investigator":"Timothy J Ebner, Suhasa B Kodandaramaiah","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126044-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401192\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401192\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nThe brain processes sensory inputs and contextualizes this information with internal brain states, generating the signals that drive motor and cognitive behaviors. The underlying computations are distributed across several anatomically and functionally distinct brain regions."},{"title":"Role of Endocannabinoid System in Seizure Sensitivity in Eclampsia","field_investigator":"Maria  Jones-Muhammad","field_institution":"University Of Mississippi Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPreeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother\ndisplays novel seizures. The mechanisms that cause some preeclampsia patients to advance to\neclampsia are unknown."},{"title":"Role of neuronal ensembles in cortical plasticity during learning and development","field_investigator":"Alejandro  Akrouh","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033974-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523350\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523350\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar\nchanges recur throughout life during learning in a more narrowly constrained manner."},{"title":"Scalable electron tomography for connectomics","field_investigator":"Mark H Ellisman, Wei-Chung Allen Lee","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129261-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10410742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10410742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary \/ Abstract\nA fundamental goal in neuroscience is understanding how neural network function arises from circuit structure.\nHowever, the immense complexity of most brain networks has been a significant barrier to progress."},{"title":"Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data","field_investigator":"Jesse  Gillis, Timothy L Tickle, Owen R White","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130968-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523659\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523659\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThis project will create scalable resources that will be critical to the development of BRAIN Initiative Cell Atlas\nNetwork (BICAN) consortium brain atlases. This team will focus on the development of common molecular\ndata processing pipelines that are cloud-native and FAIR."},{"title":"Scalable technologies for brain-wide connectomics of transcriptomic cell types: focus on brainstem","field_investigator":"Jayaram  Chandrashekar, Karel  Svoboda","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128841-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369309\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369309\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project summary, Scalable technologies for brain-wide connectomics of\ntranscriptomic cell types: focus on brainstem\nThis proposal is to develop a scalable pipeline to combine high-resolution morphology and molecular\nclassification of individual neurons to define morpho-molecular cell types in the br"},{"title":"Scalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease","field_investigator":"Li Sun","field_institution":"Topogene, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-025","field_project_number":"1R41MH130299-01   ","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10484888\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10484888\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EA fundamental goal of the BRAIN Initiative and other neuroscience projects is to map cell types in the brain and study their changes associated with function, disease, and drug treatment.\u003C\/p\u003E"},{"title":"Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of\nhuman brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts."},{"title":"Sensory-motor strategies for odor-guided navigation","field_investigator":"Ian Gordon Davison","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128975-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10531982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10531982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAnimals interact with the world through dynamic, iterative sensory-motor processes that guide their\nongoing movement."},{"title":"Simultaneous high-throughput functional, transcriptomic and connectivity profiling using FUNseq","field_investigator":"Andreas  Tolias, Anthony M Zador","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH126883-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413650\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413650\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nRecent advances in technology driven by the BRAIN Initiative have yielded new methods for characterizing the ac-\ntivity, transcriptome, and microscale anatomy of neurons throughout the brain, and have increased the throughput\nof these techniques by orders of magnitude."},{"title":"Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brains","field_investigator":"Chongyuan  Luo","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523974\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523974\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe adult human brain is comprised of numerous cell types exhibiting specific transcriptomic and epigenomic\nsignatures associated with their spatial location, connectivity, and function."},{"title":"Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke Hemiplegia","field_investigator":"Marco Capogrosso, Douglas J Weber","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS123135-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512143\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512143\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESUMMARY Motivation: In the US, almost 800\u2019000 people have a stroke every year. Unfortunately, despite intense physio- therapy stroke survivors retain permanent arm motor deficits, some complete hemiparesis.\u003C\/p\u003E"},{"title":"Statistical machine learning tools for understanding neural ensemble representations and dynamics","field_investigator":"Uri Tzvi Eden, Loren M Frank, Alan David Kaplan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510107\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510107\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The brain is a massively interconnected network of specialized circuits."},{"title":"Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator","field_investigator":"Ji-Xin  Cheng","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034275-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516429\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516429\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\n Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet\nbiomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed\nwireless neuromodulation methods."},{"title":"Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex","field_investigator":"Paola  Arlotta, Benjamin E Deverman, Gordon J Fishell, Yating  Wang","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512459\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512459\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIn this proposal we aim to identify gene regulatory elements that permit the targeting and\nmanipulation of brain circuit models of human brain function."},{"title":"Targeted Neuromodulation by Nanosecond Pulsed Electric Fields","field_investigator":"Andrei G Pakhomov","field_institution":"Old Dominion University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034258-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515459\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515459\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Nanosecond pulsed electric field (nsPEF) is a new modality for neuromodulation, with unique capabilities\nqualitatively different from the conventional electrostimulation."},{"title":"Thalamus in the middle: computations in multi-regional neural circuits","field_investigator":"Adam G Carter, Jayaram  Chandrashekar, Jorge H Jaramillo, Karel  Svoboda, Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294397\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294397\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary, Overall (Thalamus in the middle: computations in multi-regional neural\ncircuits)\nThis collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex\nthrough the thalamus."},{"title":"The Disadvantage Exposome as a Driver of Alzheimer\u2019s Disease Pathology","field_investigator":"Margo  Heston","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"1 PROJECT SUMMARY\n 2 Alzheimer\u0027s disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare\n 3 burden of $1 trillion in the United States alone by 2060."},{"title":"The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish","field_investigator":"Florian  Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"2U19NS104653-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10525427\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10525427\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The heart and the mind: an integrative approach to brain-body interactions in the\nzebrafish\nOur current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience\noriginating from events in the outside world."},{"title":"The interaction of cortical and subcortical processing in natural sensory behavior","field_investigator":"Cristopher M Niell, Michael  Wehr","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127305-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10455297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10455297\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nOur brains have evolved to extract relevant sensory information from rich and complex natural environments in\norder to drive appropriate behavior."},{"title":"The Neural Circuit Basis of Olfactory Navigation in Adult Drosophila","field_investigator":"Katherine  Nagel","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127129-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447440\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447440\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nIn order to forage effectively for food, the brain must integrate innate and learned information about the\nvalue of different food odors and use this information to select navigational motor programs."},{"title":"The Neural Code and Dynamics of the Reading Network","field_investigator":"Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS128921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10526168\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10526168\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Reading involves complex transformations of word forms, with visual input mapped to lexical, semantic and\nphonological systems in less than a second."},{"title":"The Spatial and Temporal Scale of Neuromodulation in Mouse Sensory Cortex","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128901-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524638\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neuromodulators acetylcholine (ACh) and norepinephrine (NE) are associated with an\nactivated cortical brain state characterized by an increase in the reliability of cortical responses\nto external stimuli and enhanced performance on behavioral tasks."},{"title":"Tools for gene editing in marmosets","field_investigator":"Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin  Wang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA056556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508541\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508541\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Tools for Gene Editing in Marmosets\nSUMMARY\n The goal of this proposal is to create an efficient new set of tools and techniques for the generation of\ngenetically modified marmosets suitable for use as models of brain physiology and function."},{"title":"Tracking the emergence of internal models","field_investigator":"Elizabeth A Buffalo, Adrienne L Fairhall","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126485-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429372\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429372\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nCentral to human and animal cognition is the idea of internal models: an internal repository of\nknowledge about the structure of the world and its affordances that enables prediction and\nplanning. The existence of such models is fundamental to experience."},{"title":"Two-photon all-optical electrophysiology in behaving mice","field_investigator":"Adam Ezra Cohen","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126043-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401180\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nTwo-photon all-optical electrophysiology in behaving mice Neurons communicate through electrical signals, so the ability to record membrane potential from dozens or hundreds of points simultaneously within the brain of a behaving animal would be a transformative capability f"},{"title":"Ultra-fast cerebral blood flow imaging for quantifying brain dynamics","field_investigator":"Jia  Guo","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033210-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481324\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481324\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\/Project Summary\nBlood oxygenation level dependent (BOLD) fMRI is widely used in neuroscience studies."},{"title":"Ultrafast high-contrast voltage imaging in freely moving animals","field_investigator":"Jerome  Mertz","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127098-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10445419\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10445419\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nWe propose to develop a targeted illumination confocal (TICO) microscope to enable high speed,\nlarge-scale voltage imaging in the brain. This microscope will be based on the combination of two\nkey strategies. The first strategy is high-speed confocal microscopy based on line scanning."},{"title":"Understanding feedforward and feedback signaling between neuronal populations","field_investigator":"Adam  Kohn, Christian  Machens, Byron M. Yu","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446820\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446820\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nMost perceptual, cognitive, and motor functions rely on neuronal activity distributed across multiple networks,\noften located in different brain areas."},{"title":"Understanding how cortex supports flexible sensory representations","field_investigator":"Katherine Charlotte Wood","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019504-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nLearning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in\nenvironmental demands and experience, thus allowing us to adapt to the world around us."},{"title":"Unlocking the potential of High-speed widefield Imaging","field_investigator":"Luke Satish Kumar Theogarajan","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034291-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517241\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517241\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nWidefield imaging and spatial multiplexing are crucial to advancing the field of\nneuroscience. Current imagers do not offer the speed and versatility needed for\ncalcium or voltage imaging experiments."},{"title":"Virtual observatory of the cortex: organelles, cells, circuits, and dynamics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120053-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440183\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440183\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,\nCircuits, and Dynamics."},{"title":"Wearable modular high-density diffuse optical tomography","field_investigator":"Jason Wayne Trobaugh","field_institution":"Esperimage Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"1R41MH131449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10547630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10547630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary:\nEsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable,\noptical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance\nimaging (MRI) tools to provide naturalistic brain imaging in adults a"},{"title":"Wearable RF-EEG Cap for closed loopTMS\/fMRI\/EEG Applications","field_investigator":"Lucia Isabel Navarro De Lara","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EB032749-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520726\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520726\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nFunctional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in\nhumans."},{"title":"Whole-Brain Functional Imaging and Analysis of Zebrafish Sleep","field_investigator":"Geoffrey J Goodhill, David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126562-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10430595\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10430595\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nSleep occupies a third of our lives and sleep-related ailments cost an estimated $100 billion per year, yet the\nmechanisms governing its regulation remain poorly understood."},{"title":"3D Functional Photoacoustic Imaging of Human Brain with a Stretchable Ultrasound Matrix Array","field_investigator":"Yun  Jing","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB031629-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252441\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252441\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nMany scientific efforts have been devoted to understanding the brain functions, and the relevance of its dynamics\nduring development, aging, and in diseased conditions. Alterations of the brain functions can result from\nmultifactorial processes and be reflected by various biomarkers."},{"title":"A 3D multimodal micron-scale human brain atlas bridging single cell data, neuropathology and neuroradiology","field_investigator":"Partha Pratim Mitra, Jiangyang  Zhang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370064\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Digitized reference brains, also referred to as Common Coordinate Frameworks (CCFs), together\nwith superposed atlas annotations, are of central importance to neuroscience. They bear the\nsame relation to neuroscience as do reference genomes and genome annotations to cellular and\nmolecular biology."},{"title":"A cellular atlas of the primate and human basal ganglia","field_investigator":"Jason Daniel Buenrostro, Fei  Chen, Gordon J Fishell, Evan Z Macosko","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-149","field_project_number":"1U01MH124602-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088048\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088048\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe human basal ganglia (BG) are a collection of subcortical regions whose diverse, specialized cell types\ninfluence motor control, emotional regulation, habit formation, and higher cognition."},{"title":"A community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections","field_investigator":"Franco  Pestilli","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126699-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253558\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253558\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\n The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)\ncommunity-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool\ndevelopment."},{"title":"A Computational Framework for Distributed Registration of Massive Neuroscience Images","field_investigator":"Matthew  Mccormick","field_institution":"Kitware, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH126732-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nNeuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent\nadvances in imaging data acquisition technologies such as light-sheet \ufb02uorescence microscopy (LSFM)."},{"title":"A Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models","field_investigator":"Guoping  Feng","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10286437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10286437\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n While mice are essential models for many areas of neuroscience, there are also many aspects of\nhigher brain function and dysfunction that cannot be adequately modeled in rodents. Thus, there is a need for\nnew genetic models that have brain structure and function closer to humans."},{"title":"A harmonized vendor-agnostic environment for multi-site functional MRI studies","field_investigator":"Jon-Fredrik  Nielsen, Maxim  Zaitsev","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120056-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-\nderstanding of the human brain. Functional MRI may be used to observe brain function during a speci\ufb01c motor\nor cognitive task, or at \u201crest\u201d (resting-state fMRI)."},{"title":"A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration","field_investigator":"Janelle Claire Shane","field_institution":"Boulder Nonlinear Systems, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41MH125556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139220\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations\nin holographic photostimulation."},{"title":"A multi-plane 3-photon microscope for volume imaging in NHP cortex","field_investigator":"Jack  Waters","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121766-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205806\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205806\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nRecent advances in microscopy permit volume imaging - the near-simultaneous imaging of many neurons in a circuit -\nwith 2-photon (2P) excitation, yielding new insights into the circuits underlying relatively simple behaviors."},{"title":"A regulome and transcriptome atlas of fetal and adult human neurogenesis","field_investigator":"Long  Cai, Patrick R Hof, Panagiotis  Roussos, Nenad  Sestan, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128970-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10377713\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10377713\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nDynamic changes in the spatiotemporal patterning of transcription factor binding on cis-regulatory DNA\nelements drives the developmental transition of cell lineages during neurogenesis."},{"title":"A robotic fiber platform for large area deep brain interfacing","field_investigator":"Itai  Cohen, Xiaoting  Jia","field_institution":"Virginia Polytechnic Inst And St Univ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033080-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294007\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294007\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding the functional network in the brain is critical to the development of neural\nprostheses and effective treatment of neurological diseases."},{"title":"A robust, low-cost platform for EM connectomics","field_investigator":"Daniel Joseph Bumbarger, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123398-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10273540\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10273540\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nOver the past decade, serial-section electron microscopy has come into its own as a method to study the\nconnectivity of neural circuits, from local circuits in mammals to entire invertebrate brains."},{"title":"A scalable mass spectrometry platform for proteome mapping of brain tissues","field_investigator":"Tujin  Shi","field_institution":"Battelle Pacific Northwest Laboratories","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128885-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370198\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370198\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe brain is the most complex organ in the mammalian body. Bulk analysis obscures heterogeneity of cell\ntypes present even in the smallest brain regions."},{"title":"A Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH123386-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271724\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271724\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe goal of this work is to facilitate synaptic level analysis of neurons and their interconnecting microcircuits in\nneurosurgical cerebral cortex biopsies from human patients."},{"title":"A web-based framework for multi-modal visualization and annotation of neuroanatomical data","field_investigator":"David  Kleinfeld, Samuel Sheng-Hung Wang","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nModern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal\nvia different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.\nUnfortunately, viewing and analysis methods have "},{"title":"Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy","field_investigator":"Nuri Firat Ince","field_institution":"University Of Houston","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS117944-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290984\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290984\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nHigh frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection\narea\/seizure onset zone (SOZ) in patients with drug resistant epilepsy."},{"title":"Adaptive optical microscopy for high-accuracy recording of neural activity in vivo","field_investigator":"Na  Ji","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS118300-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048013\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048013\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTo understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy,\nwhich requires methodologies with high spatial and temporal resolution."},{"title":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format","field_investigator":"Anton  Arkhipov, Emad  Tajkhorshid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306896\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format\nOne of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks\nvia theory\/modeling."},{"title":"Advancing brain health research through male germline editing in marmosets","field_investigator":"Brian Peter Hermann, Jenny  Hsieh, John R Mccarrey, Christopher  Navara","field_institution":"University Of Texas San Antonio","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054170-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nNeuropsychiatric disorders represent a leading cause of disability, affecting nearly 19% of the US population.\nOnly 9% of neuropsychiatric drugs entering clinical trials reach the market, which is one of the lowest success\nrates across all therapeutic areas."},{"title":"Advancing Standardization of Neurophysiology Data Through Dissemination of NWB","field_investigator":"Benjamin K Dichter, Oliver  Ruebel","field_institution":"University Of Calif-Lawrenc Berkeley Lab","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116139\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nLack of standards for neurophysiology data and related metadata is the single greatest impediment to fully\nextracting return on investment from neurophysiology experiments."},{"title":"AI based system for longitudinal, repeated measure analyses of freely moving C. elegans worms","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH126834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10258638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10258638\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThis project aims to develop WormInvestigator\u2122, a novel, highly innovative system for performing automated,\nhigh-throughput and longitudinal studies of the behavior of C."},{"title":"AI-driven biomarker analysis of intact whole brains imaged at micron and sub-micron resolution","field_investigator":"Katherine Cora Ames, Dominic  Mangiardi","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH125512-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139966\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139966\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract. Whole-organ 3D immunohistochemistry is revolutionizing the field of neuroscience, enabling\nunprecedented insight into the distribution of neural cells and neurological markers throughout the brain in health\nand disease."},{"title":"An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species","field_investigator":"Ting  Xu","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360863\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360863\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows\nresearchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying\nmeso- and microscale phenomena that cannot be fully investigated in huma"},{"title":"An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition","field_investigator":"Ziv  Williams","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121616-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10200517\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10200517\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"An integrated single-neuronal, population-, local network- and stimulation-based\nprefrontal investigation of human social cognition\nThis proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-\nbased evaluation of the role that the dorsal prefrontal co"},{"title":"AnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations","field_investigator":"Jason M Christie, Adam  Hantman, Michael Roland Williams","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH126706-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10258693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10258693\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nA goal of the BRAIN initiative is to develop and validate novel tools to map and manipulate neural circuits. The\ndefinition and control of behaviorally relevant circuits requires both retrograde and anterograde trans-synaptic\ntechnologies that perform well in vivo."},{"title":"Anticipating ethical challenges and disparities in the dissemination of novel neurotechnologies","field_investigator":"Winston  Chiong, Daniel P. Dohan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10283140\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10283140\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\/ABSTRACT\nA central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for\nbrain diseases."},{"title":"Behavioral Analysis and Modeling Core","field_investigator":"Jonathan William Pillow","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294672\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294672\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\/Abstract, Core D: Behavioral Analysis and Modeling\nThis proposal\u2019s overarching goal is to understand how internal states influence decisions and to identify the\nunderlying neural mechanisms."},{"title":"Big-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)","field_investigator":"William R Gray Roncal","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126684-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252257\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nIn an effort to better understand structural organization and anatomy of nervous systems at\nunprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have\ncollected increasingly larger datasets using Electron Microscopy (EM) and X-Ray\nMicrotomograp"},{"title":"BRAIN Initiative: Assessing development of event-related cortical network dynamics","field_investigator":"Scott  Makeig, Michael Peter Milham, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125934-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190670\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190670\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe Child Mind Institute\u2019s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and\nsharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children\nand adolescents (ages 5-21)."},{"title":"BRAIN Viral Vector Services and Distribution Core","field_investigator":"Kimberly  Ritola","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,\npropagation, and distribution of viral vectors that are used by neuroscientists for neural circuit\nidentification and manipulation, as well as for preclinical translational studies."},{"title":"BRAINShare: Sharing Data in BRAIN Initiative Studies","field_investigator":"Amy L Mcguire, Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126937-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10281874\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10281874\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\nData sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN\nInitiative."},{"title":"Capturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe","field_investigator":"Nelson  Totah","field_institution":"University Of Helsinki","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123876-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300345\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nSystems neuroscience has viewed the brainstem noradrenergic nucleus, Locus Coeruleus (LC), as the\nsource of a global arousal signal, which modulates cognitive functions by altering operations throughout\nthe entire central nervous system."},{"title":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment","field_investigator":"Anton  Arkhipov, Li-Huei  Tsai","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS122742-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10275301\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10275301\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment\nPatterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,\ntypically employing periodic light flicker or auditory tones presented at regular intervals."},{"title":"Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis","field_investigator":"Elizabeth M. C. Hillman, Pavel  Osten, Zhuhao  Wu","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128969-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10377810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10377810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary (Abstract)\nGaining a comprehensive understanding of brain-wide cellular organization in the human brain has long been\nrecognized as a critical foundation for understanding complex brain functions, including who we are as humans.\nIn this project we propose to take on this challenge an"},{"title":"Cellular and Neural Network Mechanism of Transcranial Electric Stimulation","field_investigator":"Dominique M Durand","field_institution":"Case Western Reserve University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124592-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10338804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10338804\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006)."},{"title":"Cellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex","field_investigator":"Padmavathi Sundaram Patel","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS112183-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10178967\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10178967\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)\nmay activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro\nturtle Cb, (ii) computational modeling of the induced electric (E) fields in the"},{"title":"Changing the neuromodulation game: ultrasound fenestration of the blood brain barrier for noninvasive viral transfection of primate CNS neurons","field_investigator":"Arnaud Y Falchier, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122272-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10235811\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10235811\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nGenetic technologies have revolutionized the way scientists can dissect out brain circuitry by inserting G\nprotein-coupled receptors that enable selective modulation of neurons in target structures."},{"title":"Characterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound","field_investigator":"Bin  He","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124564-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10337754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10337754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures."},{"title":"Circuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation","field_investigator":"Alik S Widge","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120851-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10339086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10339086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders."},{"title":"Circuit basis of social behavior decision-making in a subcortical network","field_investigator":"David J Anderson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300937\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300937\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This proposal responds to an FOA (RFA-NS-18-030) calling for 1) \u201cnovel approaches to understand neural\ncircuitry associated with well-defined social behaviors;\u201d 2) Distributed circuits that contribute to the coordination\nof motivational states and reward behavior;\u201d 3) \u201cEmpi"},{"title":"Circuits underlying threat and safety","field_investigator":"Donald B Arnold, Scott E Fraser, Nancy  Kopell, Carl  Kesselman","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122082-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10218722\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10218722\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Classical conditioning has been studied in many different animal models, and even in humans. However, the\nlarval zebrafish with its transparent brain offers a unique opportunity to observe large scale changes in\nsynaptic structure that accompany this form of learning."},{"title":"Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging","field_investigator":"Raag D Airan","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS114438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9879539\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9879539\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY .\nThere are numerous clinical needs for a technology that can modulate nervous system activity noninvasively\nand focally, with clinically-relevant spatial and temporal precision, with a robust and predictable mechanism of\naction, and that could act on any of the varied modes of neura"},{"title":"Combined Mechanistic and Input-Output Modeling of the Hippocampus During Spatial Navigation","field_investigator":"Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263699\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263699\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nLarge-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive\nfunctions. It integrates multi-scale neurobiological mechanisms\/processes identified through diverse hypotheses\nand experimental data into a single platform."},{"title":"Comparative Neuroanatomy at single-neuron resolution","field_investigator":"Roger L Clem, Peter  Rudebeck","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10216577\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10216577\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nAlthough single neurons occasionally project to a single downstream target, it is more often the case that their\naxons collateralize and project to multiple distinct anatomical areas."},{"title":"Comprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomography","field_investigator":"Alexandra Teodora  Joita Pacureanu, Wei-Chung Allen Lee","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128949-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10376584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10376584\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary \/ Abstract\nA fundamental goal in neuroscience is understanding how information is processed in neuronal circuits.\nHowever, the immense complexity of most brain networks has been a significant barrier to progress."},{"title":"Computational neuroscience of language processing in the human brain","field_investigator":"Evelina  Fedorenko, Robert Mark Richardson","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121471-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10199330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10199330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":""},{"title":"Conformable, Expandable Neural Interface Device for the developing brain","field_investigator":"Jennifer  Gelinas, Dion  Khodagholy","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY032381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156858\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156858\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nA major obstacle to identifying neural network mechanisms responsible for emergence of cognitive function is\ninsufficient capability to acquire large-scale electrophysiologic signals across the course of brain maturation.\nThere is urgent need to develop the technology and ex"},{"title":"Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression","field_investigator":"Alex  Leow, Yichao  Wu, Liang  Zhan","field_institution":"University Of Illinois At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190424\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Recently, several lines of evidence have supported that synaptic dysfunction represents one of\nthe earliest brain changes in Alzheimer\u2019s disease (AD), leading to hyper-excitation in neuronal\ncircuits."},{"title":"Control of the time course of dopamine release through optimized electrical brain stimulation.","field_investigator":"Stephen Leigh Cowen, Michael L Heien, Timothy  Lewis","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS123424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285860\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nElectrical stimulation of deep brain structures is an essential tool for the causal investigation of neural systems\nthat regulate learning and decision making."},{"title":"Converting Value into Action: Computations in Corticostriatal Circuits for Flexible Decision Making","field_investigator":"Linda  Amarante","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127780-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314166\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314166\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nTo flexibly execute behavior, choices are made based on previous outcomes that will maximize reward.\nCrucially, learning the value of each action to obtain a reward is thought to drive this decision making process.\nIn a value-based decision making framework, these values are first co"},{"title":"Coordinating Structure and Function for Neuronal Computations Mediating Context-Dependent Behavior","field_investigator":"Bijan  Pesaran","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122123-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10225166\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10225166\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThis proposal explores an emergent computational framework for understanding the neural population codes\nthat support flexible, context-dependent behavior. The current state of the field is based on two competing\nviews."},{"title":"Correlating molecular behavioral phenotypes in a marmoset model of Huntingtons disease","field_investigator":"Ali H Brivanlou","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10287090\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10287090\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe common marmoset provides a very relevant primate model for understanding the organization of the human\nnervous system and the diseases that affect it."},{"title":"Cortical basis of complex motor sequences in humans for neural interfaces","field_investigator":"Jaimie M Henderson, Krishna V Shenoy","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123101-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289711\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289711\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\nIntracortical brain-computer interfaces (iBCIs) can restore lost function for people with severe\nspeech and motor impairment (SSMI) due to neurological injury or disease. Despite tremendous\nrecent progress, iBCI performance remains well below that of able-bodied people."},{"title":"Cortical information integration as a model for pain perception and behavior","field_investigator":"Zhe Sage Chen, Jing  Wang","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205303\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Sensory processing requires the interaction between external inputs and an internal brain state. Pain is a unique\nsensory experience that is triggered by external signals, but is also strongly shaped by internal cognitive and\nemotional variables."},{"title":"Cortical visual processing for navigation","field_investigator":"Michael  Goard, Cristopher M Niell, Spencer Lavere Smith","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nVision plays a key role in our ability to navigate through the environment, from identifying landmarks and obstacles\nto determining location and heading."},{"title":"CRCNS: A mechanistic theory of serotonergic modulation of cortical processing","field_investigator":"Luca Mazzucato, Cristopher M Niell","field_institution":"University of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DA055439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396147\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESerotonergic neuromodulation is a crucial factor in regulating several aspects of brain function, from mood disorders to appetite, reward and motivation, and in maintaining balance of sensory perception. However, the network mechanisms by which it modulates brain dynamics are elusive.\u003C\/p\u003E"},{"title":"CRCNS: Computational Modeling of Microvascular Effects in Cortical Laminar fMRI","field_investigator":"Jonathan Rizzo Polimeni","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032746-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10398277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10398277\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EToday, the most widespread tool for measuring whole-brain activity noninvasively is functional magnetic resonance imaging (fMRI).\u003C\/p\u003E"},{"title":"CRCNS: Computational principles of mental simulation in the entorhinal and parietal cortex","field_investigator":"Mehrdad Jazayeri, Ila R. Fiete","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396142\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans make rich inferences about the relationships between entities in the world from scarce information. For example, we can find a novel destination after seeing a few street numbers, or find a page in a dictionary by glancing at a few words in other pages.\u003C\/p\u003E"},{"title":"CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep Brain","field_investigator":"Kim Butts-Pauly","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EB032743-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397709\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397709\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENumerous neuroscience and clinical applications exist for a noninvasive neuromodulation technology that can reach deep in the brain with high resolution. One compelling clinical application is the treatment of drug addiction, a major public health challenge in the US.\u003C\/p\u003E"},{"title":"CRCNS: Diverse effects of GABAergic inputs on a basal ganglia output center","field_investigator":"Jonathan E. Rubin, Aryn hilary Gittis","field_institution":"University of Pittsburgh at Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125814-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395793\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe basal ganglia are a collection of subcortical nuclei studied for their contributions to movement, action selection, habit formation, and reward learning as well as their dysfunction in movement disorders.\u003C\/p\u003E"},{"title":"CRCNS: Functional Brain Networks with Tensioned Stability for Optimal Processing","field_investigator":"Paul Laurienti, Erik Bollt","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01AA029926-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EUnderstanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. Human brain imaging has greatly contributed to our current understanding of AUD, but much more remains to be understood.\u003C\/p\u003E"},{"title":"CRCNS: Integrating gray and white matter data to understand the organization of human visual cortex","field_investigator":"Jonathan A Winawer, Noah C Benson","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033628-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396141\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396141\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging","field_investigator":"Sergey Plis","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ECRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An acc\u003C\/p\u003E"},{"title":"CRCNS: Multiple clocks for the encoding of time in corticostriatal circuits","field_investigator":"Sotiris Masmanidis, Dean V Buonomano","field_institution":"University of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01NS125877-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396146\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396146\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to predict when external events will occur, such as anticipating the actions of a predator or the availability of food, is critical for survival.\u003C\/p\u003E"},{"title":"CRCNS: Multiple Time Scale Memory Consolidation in Neural Networks","field_investigator":"Alex D Reyes, Stefano Fusi","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129031-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10395852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10395852\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDetailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used; Dissociated, primary cultures will be prepared from the cortex of new born mice of either sex (mus musculus, Postnatal day 0-1).\u003C\/p\u003E"},{"title":"CRCNS: Regulation of assembly and disassembly of the postsynaptic density during synaptic plasticity and its effect on AMPAR trapping","field_investigator":"Terrence J Sejnowski, Mary B Kennedy","field_institution":"Salk Institute for Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01MH129066-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397182\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397182\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EFast glutamatergic synaptic transmission is based on a precise and complex molecular organization which requires the control of the number of AMPA-type glutamate receptors (AMPARs) at the postsynaptic sites of glutamatergic synapses on dendritic spines.\u003C\/p\u003E"},{"title":"CRCNS: Resolving human face perception with novel MEG source localization methods","field_investigator":"Dimitrios Pantazis","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01EY033638-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10397180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10397180\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EA brief glimpse at a face quickly reveals rich multi-dimensional information about the person in front of us. How is this impressive computational feat accomplished? A recently revised neural framework for face processing suggests perception of face form information, i.e.\u003C\/p\u003E"},{"title":"CRCNS: The Role of Statistical Structure for Natural Sound Recognition in Noise","field_investigator":"Monty A Escabi","field_institution":"University of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-005","field_project_number":"1R01DC020097-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10396135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10396135\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.\u003C\/p\u003E"},{"title":"Decoding and Selective Modulation of Human Memory During Awake\/Sleep Cycles","field_investigator":"Itzhak  Fried","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nEpisodic memories integrate the content of human experience in space and time and constitute the core of one\u0027s\nidentity."},{"title":"Defining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro access","field_investigator":"Tulsi  Patel","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121136-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n In order to understand neurological diseases, it is essential to identify the affected neuronal cell types,\ncreate model systems that accurately recapitulate normal function and disease phenotypes, and develop tools\nthat allow cellular manipulations."},{"title":"Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation","field_investigator":"Christopher R Butson, Aysegul  Gunduz, Michael S Okun","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119844-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290544\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290544\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe\ncases, physically injurious."},{"title":"Developing A Transition MicroElelectrode Array for Large-scale Brain Recording","field_investigator":"Yantao  Fan","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033082-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294077\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294077\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\n The brain\u2019s functions are determined by its neural circuits, which consist of approximately 85 billion\nneuronal cells."},{"title":"Developing cell type-specific enhancers and connectivity mapping pipelines for marmosets","field_investigator":"Guoping  Feng, Partha Pratim Mitra","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126869-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n Although genetic tools have dramatically advanced our understanding of brain function, they have\nlargely been confined to mice."},{"title":"Development of 3D-FAST Optical Interface for Rapid Volumetric Neural Sensing and Modulation","field_investigator":"Emily  Gibson, Cristin G Welle","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS123665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294019\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294019\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTo further our understanding of the function of neural circuits, there is a need for new tools that can\ncollect simultaneous measurements from large populations of neurons involved in a common neural\ncomputation and provide precise functional modulation."},{"title":"Development of a high throughput system for molecular imaging of different cell types in mouse brain tissues","field_investigator":"Gaurav  Chopra, Julia  Laskin","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128866-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369883\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369883\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Development of a high throughput system for molecular imaging of different cell types in mouse brain\ntissues\nMass spectrometry imaging (MSI) is a powerful tool for developing detailed molecular maps of biological\ntissues with high specificity and sensitivity."},{"title":"Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets","field_investigator":"Z Josh Huang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189902\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nUnderstanding the biological principles of cell type diversity and organization is necessary for deciphering\nneural circuits underlying brain function."},{"title":"Disentangling hippocampal and cortical contributions to episodic memory","field_investigator":"Alexa  Tompary","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126427-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188803\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188803\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThis application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,\nintegrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain\nstimulation techniques (TMS)."},{"title":"Dissecting active neural circuits regulating sensory and affective pain","field_investigator":"Akihiko  Ozawa","field_institution":"Florida Atlantic University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206401\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206401\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nOpioids as a pain medication has been the most preferred pain treatments in order to provide quick relief from\nsevere pain. Decades of opioid abuse have triggered negative impact on pain therapies."},{"title":"Dissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-types","field_investigator":"Mark J Schnitzer, Ivan  Soltesz","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124590-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10338619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10338619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings."},{"title":"Dissecting sodium appetite circuits in the mammalian brain","field_investigator":"Yuki  Oka","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300953\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300953\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nInternal sodium balance is critical for many physiological functions, including osmoregulation and action\npotentials. Deciphering the mechanisms that control sodium intake is essential for understanding the\nprinciples of appetite regulation and sodium homeostasis in the body."},{"title":"Dissecting the role of neuronal-astroglial interactions in sleep homeostasis","field_investigator":"Ashley Miranda Ingiosi","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119293-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10299917\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10299917\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nInsufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common\nin the United States."},{"title":"Dissecting the roles of timing in a canonical neural computation","field_investigator":"Damon Alistair Clark","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121773-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205535\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205535\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary [30 lines max]\nTiming is critical to neural processing. Nowhere is that clearer than in visual motion detection. To detect\nmotion, neurons transmit visual information with different latencies, or delays, allowing the circuit to compare\nvisual scenes over time."},{"title":"Effects of abnormal early experience on IT circuitry","field_investigator":"Margaret S Livingstone","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10296415\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10296415\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific\nmanipulations of early visual experience."},{"title":"Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species","field_investigator":"Andrew S Fox, Viviana  Gradinaru, Timothy Francis Shay, Lin  Tian","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH128336-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10350260\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10350260\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY:\nThis team initiative will provide the broad neuroscience community with a cell type-specific adeno-\nassociated virus (AAV) armamentarium for easy and non-invasive implementation of novel and\nemerging molecular tools for anatomical and functional analysis of the nervous system in rod"},{"title":"Enhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference","field_investigator":"John Gustaf Wilhelm Samuelsson ","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316652\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316652\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nElectromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no\nimplanted hardware or injected biochemical agents."},{"title":"Ethical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study","field_investigator":"Peter David Zuk","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"7F32MH127776-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10507898\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10507898\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nBrain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions\nsuch as mobility, communication, and visual perception."},{"title":"Ethologically relevant short term memory in the olfactory bulb","field_investigator":"Matthew C Smear","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS123903-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300826\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300826\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nShort-term memory is an essential component of cognition. Here, we will investigate an ethologically\nrelevant form of short-term memory that guides navigation behavior: memory of odor concentration across\nsniffs."},{"title":"Flexible normalization in ferret V1: computational modeling and 2-photon imaging","field_investigator":"Theoden I Netoff, Cheryl A. Olman, Gordon Brawn Smith","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123842-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10299683\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10299683\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe remarkable efficiency of human perception derives from the fact that we do not process each stimulus as a\nnovel event. Instead, past experiences and scene context inform internal, working models of the world that\nallow us to generate predictions for our physical environment."},{"title":"fMRI physiological signatures of aging and Alzheimer\u0026#039;s Disease","field_investigator":"Catherine Elizabeth Chang","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125931-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361105\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361105\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nThe growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new\ninvestigations into functional systems of the human brain."},{"title":"From diverse dynamics to diverse computation via neural cell types","field_investigator":"Stefan  Mihalas, Eric Todd Shea-Brown","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263658\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA prominent feature of biological neuronal networks is the astonishing diversity of their cell types."},{"title":"From synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125932-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360840\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360840\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe goal of this project is to create a unified framework for understanding the relationship between\nneuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key\nlinking modality."},{"title":"Functional and cell-type specific axonal pathways in the primate brain","field_investigator":"R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126864-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10272370\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10272370\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nOver the past decade, there have been transformative advances in three areas of mammalian neuroscience.\nFirst, our ability to record from large populations of neurons has dramatically increased with the advent of new\nelectrode technologies and improved multiphoton imaging."},{"title":"Genetic and neural mechanisms underlying emerging social behavior in zebrafish","field_investigator":"Florian  Engert, Mark C Fishman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS124017-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306905\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Genetic and neural mechanisms underlying emerging social behavior in zebrafish\nOur goal is to understand emerging collective behaviors of groups, such as schooling and shoaling in fish.\nOur approach is to dissect basic sensorimotor transformations in the zebrafish, which we believe play a\nfundamenta"},{"title":"Harmonizing and Archiving of Large-scale Infant Neuroimaging Data","field_investigator":"Gang  Li","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123202-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189251\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189251\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Abstract\nThe first postnatal years are an exceptionally dynamic and critical period of structural and functional development\nof the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development\nduring this stage."},{"title":"Hemogenetic imaging technology for circuit-specific analysis of primate brain function","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271639\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271639\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Primate brains contain cortical areas that exhibit selective engagement in high-level sensory or behavioral\noperations. The functional specialization of these regions is thought to be central to primate-specific cognitive\nfaculties and to associated disorders."},{"title":"Heritability and cognitive implications of structural-functional connectome coupling","field_investigator":"Amy  Kuceyeski","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123232-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189014\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189014\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex\nthought, emotion and behavior."},{"title":"High Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging","field_investigator":"Roger J Zemp","field_institution":"University Of Alberta","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10293940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10293940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract Section\n\nEnter the text here that is the new abstract information for your application."},{"title":"High-content single-cell epigenetic technologies scalable to the human brain","field_investigator":"Andrew  Adey","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128842-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369335\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369335\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT ABSTRACT\nTo meet the goal of the BRAIN Initiative Cell Census Network to catalogue and produce molecular profiles of\nevery cell type in the human brain; order-of-magnitude improvements in single-cell assay throughput and\ncoverage are required."},{"title":"High-density optical tomography of cerebral blood flow and metabolism in small animals","field_investigator":"Guoqiang  Yu","field_institution":"Biopticstechnology, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41NS122722-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10323090\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10323090\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"ABSTRACT\nMany clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot\nmaintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to\ncerebral ischemic\/hypoxic stresses and neurological disorders."},{"title":"High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequence","field_investigator":"Andrew Michael Seeds","field_institution":"University Of Puerto Rico Med Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121911-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208363\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The ability to generate complex motor behaviors by assembling sequences of movements is essential for\npurposeful actions and survival. Defects in the brain regions thought to drive such movement selection can lead\nto behaviors becoming abnormally repetitive (e.g. autism spectrum disorder)."},{"title":"Highly scalable and sensitive spatial transcriptomic and epigenomic sequencing of brain tissues from human and non-human primate","field_investigator":"Rong  Fan, Nenad  Sestan","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128876-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370074\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370074\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nThe human nervous system is possibly the most complex biological tissue, organized into multiple functionally\ndistinct regions and comprised of over 200 billion neural and non-neural cells, requiring novel scalable tools to\nprofile cell types and relationships in the tissue context with high"},{"title":"Hippocampal neural dynamics driving affiliation and attachment","field_investigator":"Zoe Rebecca Donaldson, Peyman  Golshani, Weizhe  Hong, Michael Moshe Yartsev","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122124-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10225059\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10225059\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract:\nAttachment powerfully shapes our development and remains a primary driver of health and well-being in\nadulthood; disruption of attachments is highly traumatic."},{"title":"Imaging Dynamics in Anxiogenic Serotonin Circuitry","field_investigator":"Emily Clarissa Wright","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125597-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316027\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316027\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSerotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-\nspecific dynamics are little understood."},{"title":"Influence of task complexity and sensory feedback on cortical control of grasp force","field_investigator":"Jennifer L. Collinger","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289762\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289762\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"ABSTRACT\nHumans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,\nand as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve\nand maintain an appropriate grasp force."},{"title":"Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation","field_investigator":"Shadi  Dayeh","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS123655-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10293899\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10293899\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nWe propose to develop novel neurorecording devices using sequential thin-film transistors that are capable of\nrecording and stimulating brain activity with thousands of channels using only 8 wires and to demonstrate\nbroadband recordings with large area coverage in fully awake, chronically i"},{"title":"Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources","field_investigator":"Mark Bender Gerstein, Avram J Holmes","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123245-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190025\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190025\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Constructing an integrated picture of human brain function requires understanding how the effects of molecular\nand genetic factors propagate upwards, through many intervening layers of structure and interaction, to\ninfluence behavioral, psychiatric and cognitive traits."},{"title":"Integrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks","field_investigator":"Mikail  Rubinov","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125933-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10361057\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10361057\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"SUMMARY\nBrain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic\u2014\ne.g. genomic and transcriptomic\u2014datasets."},{"title":"Interferometric Speckle Visibility Spectroscopy for Brain Activity Associated Cerebral Blood Flow Monitoring","field_investigator":"Changhuei  Yang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033086-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294139\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Optical monitoring of brain activities is intrinsically associated with a range of operational advantages:\na. non-ionizing and safe radiation, b. simple and relatively lightweight apparatus, c. readily available\ncommercial optical advanced systems that can be cross adapted for our usage."},{"title":"Interrogating the propagation of electrical stimulation across scales in vivo","field_investigator":"Daniel James Denman","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120850-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10175648\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10175648\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nIntracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in\nseveral animal model systems. However, little is actually known about the ensembles of neurons activated by\ntypical and clinical intracranial EBS protocols."},{"title":"Intersectional transgenic targeting of discrete neuronal and glial subtypes","field_investigator":"Jeffrey  Mumm","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH126731-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259997\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259997\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nTools for exclusively targeting neuronal and glial subtypes are needed to advance our understanding of the brain.\n\u201cIntersectional\u201d systems improve targeting by restricting \u201creporter\/effector\u201d transgenes to a subdomain defined\nby the expression overlap between two activating factors."},{"title":"Investigating Functional Ependymal Cell Heterogeneity in the Ventricular System","field_investigator":"Stephanie  Redmond","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121273-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10189131\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10189131\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract:\nGlial cells collectively outnumber neurons in the vertebrate brain, but mechanistic understanding of their\nmolecular subtypes and functions is lacking."},{"title":"iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains","field_investigator":"Hong  Chen, Ilya E. Monosov","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH126861-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10270569\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10270569\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nCritical advances in the treatment of human brain disorders are hindered by our inability to specifically target\ndysfunctional circuitry in a safe and noninvasive manner."},{"title":"Linking Fast Timescale Neuron-Astrocyte Communication to Neural Circuit Function and Behavior","field_investigator":"Axel  Nimmerjahn","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123719-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294804\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Project 2 - Linking Fast Timescale Neuron-Astrocyte Communication to Neural\nCircuit Function and Behavior\nA fundamental yet unresolved question in neuroscience is how non-neuronal cells communicate with the\nsurrounding neurons, influence their function, and potentially affect animal"},{"title":"Linking function, structure, and molecular identity of lateral habenula neurons","field_investigator":"Steven  Shabel","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206846\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206846\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT:\nThe lateral habenula (LHb) impacts motivated behavior through dense direct and indirect projections to midbrain\ndopaminergic and serotonergic neurons."},{"title":"Long-range neuronal projections: circuit blueprint or stochastic targeting?  Rigorous classification of brain-wide axonal reconstructions","field_investigator":"Giorgio A Ascoli","field_institution":"George Mason University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128693-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT (PROJECT SUMMARY)\nThe classification of neurons in the mammalian brain has long been a focus of intensive investigation in\nneuroscience."},{"title":"Map Manager: Longitudinal image analysis with online editing and sharing.","field_investigator":"Robert Harry Cudmore","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123206-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The increasing availability and ease of use of confocal, two-photon, and light-sheet microscopes coupled with\nrapid developments in fluorescent protein reporters have made 3D and functional imaging and its analysis a\ncentral component of modern Neuroscience research."},{"title":"Mapping Algorithmic State Space in the Human Brain","field_investigator":"Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121472-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10199622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10199622\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Abstract\nHumans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this\ncognitive flexibility is our ability to respond correctly to novel contextual situations on the first attempt, without\nprior rehearsal."},{"title":"MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS","field_investigator":"Xin  Duan, Massimo  Scanziani","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123912-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300917\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300917\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n The precise assembly of neural circuits ensures accurate neurological function and behavior."},{"title":"Mapping thalamo-striatal neuronal circuits underlying motivational drive","field_investigator":"Sofia Beas","field_institution":"National Institute of Mental Health ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126429-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EMotivational drive is an adaptive process that helps individuals overcome obstacles to obtain essential needs and hence ensure survival. Motivation is composed of two major components.\u003C\/p\u003E"},{"title":"Mechanism and Modulation of the homeostatic setpoint for protein feeding","field_investigator":"Qili  Liu","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300667\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300667\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAll animals share motivated behaviors to fulfill their basic needs for survival, including food, water,\nsleep, and social interactions, etc. The homeostatic regulatory system energizes behaviors to defend a\ntarget level for these needs (the homeostatic setpoint)."},{"title":"Mechanisms of basal forebrain control over sensory processing","field_investigator":"Elizabeth Hanson Moss","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019505-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10187890\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10187890\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA key problem in neuroscience is understanding how internal and external information are integrated in the brain to produce\nsensory experiences, cognition, and behavioral responses."},{"title":"Midbrain circuits for perceptual decision-making","field_investigator":"Martha E Bickford, Michele A Basso, Jianhua  Cang, Alev  Erisir, Per Benjamin Sederberg","field_institution":"University Of Virginia","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122040-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10216482\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10216482\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Perceptual decision-making is a fundamental cognitive ability that is vital to healthy, daily functioning and is\nimpaired in many diseases."},{"title":"Minimally Invasive Ultrasonic Brain-Machine Interface","field_investigator":"Richard A Andersen, Mikhail  Shapiro, Mickael  Tanter","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS123663-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294005\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294005\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nBrain-machine interfaces (BMIs) are one of the key motivating applications for the BRAIN Initiative\u2019s drive to develop\ninnovative technologies for large-scale recording of neural activity, benefiting not only BMI, but many other neuroscience\nstudies."},{"title":"Molecular identity, cellular physiology, and in vivo functions of nucleus accumbens astrocytes","field_investigator":"Kay Elizabeth Linker","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125598-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316907\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316907\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\n Astrocytes are pervasive throughout the CNS and are the most abundant non-neuronal cell type. They\nare an essential component of neural circuits, and increasing evidence demonstrates they are specialized for\nspecific brain regions."},{"title":"Molecular recording to predict cell fate decisions and animal behavior","field_investigator":"Joseph D Dougherty, Robi D Mitra","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH126723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10260139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10260139\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\n The brain is remarkably complex, and our understanding of this organ is still in its infancy. Many\nfundamental questions about brain development and function remain."},{"title":"mRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes","field_investigator":"Melissa Mckenzie Campbell","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH126430-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188959\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188959\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nAlternative splicing of pre-mRNAs is extensively employed by the nervous system to expand the transcriptomic\nmanifold."},{"title":"Multi-color optical voltage imaging of neural activity in behaving animals","field_investigator":"Mark J Schnitzer, Ganesh  Vasan","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS120822-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10166236\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10166236\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nGroundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their\ngenetic signatures."},{"title":"Multi-feature, Multi-scale Atlas","field_investigator":"Paul S Katz","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U01NS123972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10302203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10302203\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY \/ ABSTRACT \u2013 Project 1. Multi-feature, Multi-scale Atlas\nProject 1 of the Berghia Brain Project is to create a multi-scale, multi-feature atlas of the Berghia brain and\nperipheral neural plexus."},{"title":"Multimodal probes for multiscale calcium imaging","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY032369-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10154098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10154098\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"A major goal of the BRAIN Initiative is to promote the development of neural activity measurement tools that\nbridge between spatial scales, so that the processing roles of individual neurons and microcircuits can be related\nto broader regional or brain-wide dynamics."},{"title":"Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution","field_investigator":"Lin  Tian, Mark E Vonzastrow","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS120820-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10166304\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10166304\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nThe dynamic adaptability of the mammalian brain to environmental changes is remarkable, as it is the complexity\nof the networks of neurons underlying the operations that allow for such adaptations."},{"title":"Multiscale computational frameworks for integrating large-scale cortical dynamics, connectivity, and behavior","field_investigator":"Tatiana  Engel","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055666-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263628\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263628\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nA central problem in neuroscience is to understand how activity arises from neural circuits to drive animal\nbehaviors. Solving this problem requires integrating information from multiple experimental modalities and\norganization levels of the nervous system."},{"title":"Multiscale theory of synapse function with model reduction by machine learning","field_investigator":"Eric D Mjolsness","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055668-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263653\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263653\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This project constructs a unifying model that links synaptic morphodynamics, the fundamental process of\nlearning and memory in the brain, to the underlying molecular signaling pathways that regulate it."},{"title":"NABOR: A Sustainable, High-quality Neuroscience Antibody Open Resource","field_investigator":"Melina  Fan","field_institution":"Addgene, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS119916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10114049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10114049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThe goal of this project is to build an open-access recombinant antibody\/affinity reagent resource for the\nneuroscience community called NABOR (Neuroscience AntiBody Open Resource)."},{"title":"Nanosensors for sensitive brain-wide neurochemical imaging","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS120592-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10154138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10154138\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The large-scale dynamics of neural circuitry depend on interactions among numerous neurochemical spe-\ncies that play functionally distinct roles throughout the brain."},{"title":"National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource","field_investigator":"Mark H Ellisman","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116087\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116087\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\/ABSTRACT\nThis project aims to disseminate validated technologies and resources of the National Center for Microscopy\nand Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN\nInitiative."},{"title":"Neural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networks","field_investigator":"Preeya  Khanna","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS124748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349317\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349317\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years."},{"title":"Neural mechanisms of multisensory auditory-olfactory integration in the auditory cortex","field_investigator":"Nathan  Vogler","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316690\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316690\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nLiving organisms interact with complex environments that are inherently multisensory. Within these\nenvironments, the brain must integrate information from multiple sensory modalities, including the auditory and\nolfactory systems, for perception and behavior."},{"title":"Neural Mechanisms of Social Communication in Parrots","field_investigator":"Jesse Heymann Goldberg","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10207958\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10207958\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nWhen Confucius said, \u201cTell me who are your friends, and I\u2019ll tell you who you are,\u201d he was noticing that how we\nbehave and communicate is shaped by who we choose to hang out with every day. We constantly mimic the\nmannerisms and behaviors of friends and loved ones."},{"title":"Neural Mechanisms of Transcranial Current Stimulation","field_investigator":"Bart  Krekelberg, Pierre- Olivier  Polack","field_institution":"Rutgers The State Univ Of Nj Newark","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120289-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10274328\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10274328\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTranscranial current stimulation (TCS) creates small electrical fields in the brain through electrodes placed on\nthe scalp."},{"title":"Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural Interfaces","field_investigator":"Hui  Fang, Jonathan  Viventi","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS123668-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294053\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294053\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\n The purpose of this project is to optimize circuit and system architectures of active electrode arrays which will\nprovide low-noise, multiplexed acquisition of neural signals from thousands of electrodes."},{"title":"NeuroExM","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R42MH124566-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156966\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156966\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThis project describes the development of NeuroExM\u2122, a highly innovative system for performing\ncomprehensive spatial distribution analysis of populations of messenger RNAs (mRNAs) and proteins in tissue\nprocessed for expansion microscopy (ExM))."},{"title":"NeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform","field_investigator":"Qianqian  Fang","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308329\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308329\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Traditional file-based neuroimaging data management and integration strategies have shown\nincreasing limitations in accommodating the meteoric growth in both the scale and complexity of today\u2019s\nneuroimaging data."},{"title":"Next-generation MORF Mice for Scalable Brainwide Morphological Mapping and Genetic Perturbation of Single Neurons","field_investigator":"Hong-Wei  Dong, Xiangdong William Yang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128888-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370248\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370248\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n A major challenge in studying the mammalian brain is to characterize the integrative properties of\nindividual neurons, such as molecular profiles, complete morphology (dendrites, axons, synapses),\nconnectivity, and activity; furthermore, this must be done at a scale that is commensu"},{"title":"NIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species","field_investigator":"Oscar  Esteban, Michael Peter Milham, Russell A Poldrack, Ariel Shalom Rokem, Theodore  Satterthwaite","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121867-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10260312\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10260312\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nDespite the rapid advances in the neuroimaging research workflow over the last decade, the enormous\nvariability between and within data types and specimens impedes integrated analyses."},{"title":"Novel high-field MRI compatible subdural electrode and acquisition system for recording and stimulation in small animals","field_investigator":"Hernan  Millan","field_institution":"Emri Systems Llp","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R43MH128138-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10325694\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10325694\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\n Preclinical small animal imaging makes valuable contributions to improving\nour understanding of human brain."},{"title":"Open-Access AAV\u00a0Toolbox for Basal Ganglia Cell Types and Circuits","field_investigator":"Trygve  Bakken, Tanya Lynn Daigle, Boaz Pirie Levi, Jonathan T Ting, Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH128339-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10350021\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10350021\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nWe propose to leverage new and existing transcriptomic and epigenetic datasets from mouse, marmoset,\nmacaque and human brain to develop refined approaches for brain cell type enhancer selection for creating cell-\ntype specific enhancer adeno-associated viruses (AAVs), and to make inr"},{"title":"OpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function","field_investigator":"Christof  Koch, Jerome Anthony-Jean Lecoq","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113646-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967446\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967446\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Project summary\nOver the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and\noptical-physiology: together they form the Allen Brain Observatory."},{"title":"Optical gearbox for high speed neural recording","field_investigator":"Meng  Cui, Guang  Yang","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY032382-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10157026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10157026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The rapid advance of genetically encoded functional indicators allows the scientists to visualize\nneuronal activities with light in the living brain at high spatiotemporal resolutions."},{"title":"Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice","field_investigator":"Robert E. Campbell, Hod Michael Dana, Marie-Eve  Paquet","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS123658-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10293936\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10293936\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nThe goal of this proposed research is to optimize a dual-use calcium ion sensor for recording single-cell activity\nfrom the entire dorsal cortex or hippocampus of freely-moving mice."},{"title":"Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulation","field_investigator":"Samuel Andrew Hires, Yulong  Li","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS120824-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10166173\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10166173\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Neuromodulators regulate addiction, attention, cognition, mood, memory, motivation, sleep, and more through\ntheir influence on brain circuits. Classic tools for measuring neuromodulation in the brain have poor spatial and\ntemporal resolution."},{"title":"Platform technologies for scalable highly multiplexed proteomic phenotyping of the brain","field_investigator":"Kwanghun  Chung, Hong-Wei  Dong, Matthew P Frosch, Guoping  Feng, Peng  Yin","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128861-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369777\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369777\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"The complexity of the mammalian brain is unparalleled by any other organs, and understanding its cellular\ncomposition and their brain-wide organization is essential to understand the brain functions and dysfunctions.\nExtensive efforts have been made toward mapping brain cells through various lenses,"},{"title":"Principles of sensorimotor processing in zebrafish thermosensation","field_investigator":"Martin  Haesemeyer","field_institution":"Ohio State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123887-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300619\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nIt is our long-term goal to understand computations that underlie sensori-motor transformations in the context\nof thermoregulatory behaviors. Generating appropriate behaviors in response to sensory stimuli is critical for\nthe survival of any animal."},{"title":"Project 2","field_investigator":"Anna  Devor","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294713\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294713\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nWe propose to investigate the role of neuromodulation in the phenomenon of \u201cwhole-cortex\u201d activity of\nthe pial neurovascular circuit."},{"title":"Quantitative Diffuse Correlation Spectroscopy for Assessing Human Brain Function","field_investigator":"Ulas  Sunar","field_institution":"Wright State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB031759-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10265818\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10265818\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nAcute brain injuries can lead to secondary brain damage that worsens the outcome. Reduced cerebral blood\nflow can induce ischemia, while excess blood flow can cause hemorrhage."},{"title":"Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain","field_investigator":"Steven Graham Adie","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS120819-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10166305\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10166305\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nOptical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges\nfor optical brain imaging are depth and speed."},{"title":"Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning","field_investigator":"Peter V. Kochunov, Paul M Thompson","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123163-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10186960\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10186960\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nThis application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-\nrelated patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing\nNeuroimaging Genetics through Meta-Analysis (ENIGMA)."},{"title":"Representation and modulation of social information in the ant chemosensory system","field_investigator":"Daniel  Kronauer","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123899-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300789\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nSocial insects show robust and complex behaviors, and have served as important study systems in ethology\nfor decades."},{"title":"Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods","field_investigator":"Genevieve Lauren Stein-O\u0026#039;brien","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS122085-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188106\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188106\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nHigh-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently\nunderway."},{"title":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)","field_investigator":"Maisie Ky Lo","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118284-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Resource Core 3 - Teaching\/Training\/Dissemination Core (TTDC)\n Leads: Maisie Lo PhD and Kristin Overton PhD\nSummary\n The TTDC\u2019s teaching mission specifically leverages our educational infrastructure for advancing the\napplication of modern neurotechnology methods in short (3-day) or extended-format ("},{"title":"Revealing neural circuits underlying zebrafish behavior using mesoscopic light field microscopy","field_investigator":"Oliver Strides Cossairt, Geoffrey J Goodhill","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300922\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300922\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nA critical step towards understanding how neural circuits drive behavior is the ability to record the activity of all\nneurons in an organism while it interacts with its environment in an unconstrained manner."},{"title":"RNA-programmable cell type targeting and manipulation across vertebrate nervous systems","field_investigator":"Z Josh Huang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH128337-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10350096\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10350096\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Systematic experimental access to diverse neuronal cell types is a prerequisite to deciphering brain circuit\norganization, function, and dysfunction."},{"title":"Robotically-actuated, low-noise, concurrent TMS-EEG-fMRI system","field_investigator":"Chunlei  Liu, Michael  Lustig, Angel V Peterchev","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-310","field_project_number":"1R01MH127104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10286708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10286708\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Therapeutic Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nThe ability to noninvasively modulate and image the brain with spatial and temporal precision is highly desirable\nfor understanding brain circuits in health and disease."},{"title":"Robust modeling of within- and across-area population dynamics using recurrent neural networks","field_investigator":"Lee  Miller, Chethan  Pandarinath","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Over the past several decades, the ability to record from large populations of neurons (e.g., multi-electrode\narrays, neuropixels, calcium imaging) has increased exponentially, promising new avenues for understanding\nthe brain."},{"title":"Scalable 3D molecular imaging and data analysis for cell census generation","field_investigator":"Steve  Presse, Douglas  Shepherd","field_institution":"Arizona State University-Tempe Campus","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128867-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369885\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369885\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThis project is a collaboration across two universities and multiple scientific disciplines to develop new scalable\n3D molecular imaging and analysis approaches for cell type identification within human brain tissue."},{"title":"Scalable integration of cell types and connectivity in the motor cortex of rodents and non-human primates","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369307\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369307\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe BICCN has recently completed a broad survey of the cellular components of motor cortex, including\ntranscriptomic profiling, patch-seq, multiplexed FISH, inter-areal connectivity, and single neuron morphology.\nMissing from this view is a detailed picture of how individual neurons "},{"title":"Scalable tools for consistent identification of neuronal cell types in mouse and human","field_investigator":"Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365216\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365216\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by\ndeveloping machine learning algorithms and cloud-based software for the integration of multiple modality\ncharacterizations large and growing datasets of cortical neurons in mou"},{"title":"Secondary analysis of functional MRI and resting state connectivity in white matter","field_investigator":"John C Gore, Bennett A. Landman","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123201-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190338\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract \/ Summary\nThis proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI\nstudies in order to quantify the functional characteristics of white matter (WM) and their changes during\nnormal aging and in the progression to Alzheimer\u2019s Disease (AD)."},{"title":"Selective Control of Synaptically-Connected Circuit Elements by Interluminescence","field_investigator":"Ute H Hochgeschwender, Christopher I Moore","field_institution":"Central Michigan University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS120832-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10165226\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10165226\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nA wealth of new tools can directly control output of specific neurons on fast (e.g., optogenetic) or sustained (e.g.,\nchemogenetic) time scales."},{"title":"SensiTrak: Automated Assessment of Forelimb Sensation","field_investigator":"Andrew Michael Sloan","field_institution":"Vulintus, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41NS120748-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259383\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259383\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Abstract\nIn this Phase I STTR project, Vulintus, Inc., in collaboration with Columbia University, proposes\nto develop and test \u2018SensiTrak,\u2019 an automated, high-throughput behavioral system designed to\nfinely measure somatosensory function in rodent models."},{"title":"Sensory motor transformations in human cortex","field_investigator":"Richard A Andersen","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS123127-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10289879\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10289879\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Abstract: The long-term objective of this application is to understand cortical processing of sensory to\nmotor transformations within the human cerebral cortex. A vast number of computations must be\nperformed to achieve sensory-guided motor control."},{"title":"Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding","field_investigator":"Brandy A. Briones","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10313129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10313129\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through\nmapping of Lateral Habenula (LHb) circuits."},{"title":"Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation","field_investigator":"Ilknur  Ay, Giorgio  Bonmassar, Xin  Yu","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS120594-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10154562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10154562\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\n Micromagnetic stimulation (\u00b5MS) has several advantages over electrical stimulation. First, \u00b5MS does not\nrequire charge-balanced stimulation waveforms as in electrical stimulation. In \u00b5MS, neither sinks nor sources\nare present when the time-varying magnetic field induces a current."},{"title":"Simultaneous, Cell-Resolved, Bioluminescent Recording From Microcircuits","field_investigator":"Nozomi  Nishimura, Chris B Schaffer","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033085-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294095\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294095\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nMeasuring the activity of many individual neurons at once while knowing their wiring diagrams would provide\nexciting information on how the components of a network interact."},{"title":"Small molecule regulation of endogenous transcription factors for circuit-specific neuromodulation","field_investigator":"Gerald R. Crabtree","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH126720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10260250\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10260250\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nMethods for regulating cellular processes within distinct populations of neurons are needed to elucidate\nrelationships between molecular mechanisms, circuits, and behavior; and to develop cell type- or circuit-\nselective treatments for neurological disorders."},{"title":"Stability and Robustness of Hippocampal Representations of Space","field_investigator":"John C Doyle, Carlos  Lois, Evgueniy Vassilev Lubenov, Athanassios  Siapas","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS121918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208522\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nHow does the brain balance the need to preserve prior knowledge with the necessity to continuously learn\nnew information? The tradeo\ufb00 between stability and plasticity is inherent in both biological and arti\ufb01cial\nlearning systems constrained by \ufb01nite resources and capacity."},{"title":"Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.","field_investigator":"Daniel  Lu","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10112480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10112480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nRespiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure\nis the leading cause of death in patients with SCI."},{"title":"Strategy to map electrical synaptic connectivity in neural networks","field_investigator":"Sue A Aicher, Stephen C Massey, Catherine W Morgans, Christophe P. Ribelayga","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH127343-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nElectrical synapses, also known as gap junctions, occur frequently in all nervous systems, including the human\nbrain. They are composed of connexins, arranged to form intercellular channels between adjacent, coupled\ncells. Connexin36 (Cx36) is the predominant connexin in the CNS."},{"title":"Structural variation in neuronal circuits as a basis for functional and behavioral individuality","field_investigator":"Bassem A Hassan, Wei-Chung Allen Lee, Benjamin  De Bivort","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS121874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10206473\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10206473\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA fundamental gap in our knowledge of the nervous system is understanding how variations in wiring and\nconnectivity of neuronal circuits relate to variability in neural computations and behavior."},{"title":"Structure and function of spontaneous network activity during circuit formation","field_investigator":"Arnaldo  Carreira-Rosario","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119295-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10103918\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10103918\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nTowards the end of nervous system development, neural circuits are extremely plastic. Small perturbations\nduring this time can cause lifelong circuit and behavioral changes."},{"title":"SWITCH trial: Early feasibility study of Stentrode BCI for augmentative communication","field_investigator":"Nicholas Lachlan Opie, Thomas J Oxley, David Francis Putrino, Douglas J Weber","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS120191-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123759\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123759\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"7. Project Summary\nMultiple early feasibility trials in humans have demonstrated that implantable Brain-Computer Interfaces (BCIs) can enable\npeople with severe paralysis to use neural signals to control remote and digital communication technologies, including\nmessaging and email."},{"title":"Thalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome","field_investigator":"Martha J Morrell","field_institution":"Neuropace, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9958791\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9958791\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\n Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive\ndysfunction and very frequent generalized onset seizures (GOS) often leading to injury."},{"title":"The encoding of uncertainty in the Drosophila compass system","field_investigator":"Jan  Drugowitsch, Rachel  Wilson","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123819-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10298651\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10298651\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nStrategic behaviors often take account of uncertainty. For example, if we are presented with two conflicting\npieces of information, we give less weight to the more uncertain source of information \u2013 i.e., the source of\ninformation that leads to lower accuracy overall."},{"title":"The first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases","field_investigator":"Oliver  Graudejus","field_institution":"Bmseed, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43NS124469-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10324053\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10324053\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThe proposed work aims at the development of an enhanced organoid-based in vitro pre-clinical drug\nscreening platform for neurological and neurodegenerative brain diseases."},{"title":"The laminar organization of \u0026#039;index\u0026#039; versus \u0026#039;attribute\u0026#039; coding in neocortex","field_investigator":"Bruce L Mcnaughton","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205913\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205913\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"We propose a circuit-level principal underlying how brains acquire \u0027episodic\u0027 memories and reprocess\nthem into compact, efficient \u0027schemas\u0027: The attributes or \u0027contents\u0027 of experience are represented primarily in\nthe deeper layers of neocortex (NC), whereas the superficial layers are dedicated to en"},{"title":"The origins of neuronal correlations in cerebral cortex","field_investigator":"David J Heeger, Jason Neil Maclean, John H.r. Maunsell","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205571\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205571\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHere, we propose to thoroughly characterize the origins of pairwise correlations in cortex using a synergistic mix\nof experimental methodologies, behavior, and computation in mice and macaques."},{"title":"The power of positivity: a novel class of voltage indicators for high-fidelity brain activity imaging","field_investigator":"Michael Z. Lin","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS123681-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294164\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294164\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nTo understand how the brain functions in health, and how sensory, motor, and cognitive functions are affected in disease, it\nis crucial to be able to record the activities of large numbers of individual neurons in real time."},{"title":"The representation and modulation of sensory information in the learning and memory center of the Drosophila brain","field_investigator":"Andrew M Davidson","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH125582-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10314793\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10314793\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The brain uses the combined physiology of many cells to transform incoming sensory signals into internal\nrepresentations."},{"title":"The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior","field_investigator":"Sarah D Ackerman","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS121137-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10188928\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10188928\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nSignificance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.\nplasticity) to produce stereotyped behavior."},{"title":"Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy","field_investigator":"Shadi  Dayeh","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS123723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294893\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294893\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\n The goal of this project is to significantly advance the field of acute and semichronic epilepsy monitoring\nusing novel, high-resolution electrocorticography (ECoG) record\/stimulate grids (4096\/256 channels,\nrespectively) and stereoelectroencephalography (sEEG) depth electrodes (120\/8 micr"},{"title":"Topological bridges between circuits, models, and behavior","field_investigator":"Marlene Rochelle Cohen, Chengcheng  Huang, Alessandro  Rinaldo, Caroline Anne Runyan","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208403\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208403\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nThe plight of the neuroscientist trying to understand the brain using linear analysis methods is akin to studying\nthe makeup of the ocean using the bits you find with a metal detector."},{"title":"Toward functional molecular neuroimaging using vasoactive probes in human subjects","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB031641-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253338\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253338\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"We propose to develop a probe technology for monitoring human brain function with molecular precision;\nin conjunction with magnetic resonance imaging (MRI) or other imaging modalities, the probes will provide a\ncombination of sensitivity and resolution that could permit unprecedented noninvasive stu"},{"title":"Ultra High-density Optomechanic Neural Interfaces","field_investigator":"Maysamreza  Chamanzar, Gianluca  Piazza","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033084-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294080\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294080\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nA multi-scale, mechanistic understanding of neural circuits that includes both local- and whole-brain\ninterconnections still remains elusive."},{"title":"Ultra-high Throughout Single Cell Multi-omic Analysis of Histone Modifications and Transcriptome in Mouse and Human Brains","field_investigator":"M Margarita Behrens, Bing  Ren","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128838-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369242\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369242\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Histone modification carries rich epigenetic information that constitutes a mechanism of cellular memory.\nSingle cell analysis of histone modification in conjunction with transcriptome could help uncover this critical\nlayer of cellular memory and lead to better definition of cell types and states in"},{"title":"Ultrasonic Genetically Encoded Calcium Indicators for Whole-Brain Neuroimaging","field_investigator":"Mikhail  Shapiro","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS120828-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10166018\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10166018\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nA major goal of the BRAIN initiative is to develop neural imaging technologies enabling whole-brain imaging of\nspecific molecular signals such as neuronal calcium."},{"title":"Understanding the regulation of neuron cell number and arbor size","field_investigator":"Jennifer A Malin","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY032269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104237\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104237\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nHow the brain generates the correct number of neurons and how these neurons determine the size of their\narbors to innervate the receptor field is a critical question in neurobiology."},{"title":"Understanding the role of quantitative internal signals in behavioral flexibility","field_investigator":"Gaby  Maimon","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS121904-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10208212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10208212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nThis grant focuses on how very recent experiences\u2013\u2013over the past few seconds to minutes\u2013\u2013allow brains to\nupdate expectations about the world and then use these expectations to guide behavior."},{"title":"Use of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data","field_investigator":"Marc N Potenza, Yihong  Zhao","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128614-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10358692\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10358692\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nGrowing up in a media-saturated world, the current generation of children and adolescents spend on average 6-\n9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the\nUSA and elsewhere."},{"title":"Using large scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behaviors","field_investigator":"Kurt M Fraser","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127792-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10316450\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10316450\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA core feature of a number of psychiatric illnesses is the disordered estimation of the predictive relationship\nbetween a given cue and an outcome. This failure to appraise and generate appropriate behavioral responses\nis true for cues that both are rewarding and aversive."},{"title":"Waking up the nervous system: Molecular characterization of neuronal leader cells and their role in brain development","field_investigator":"Nicole Ann Aponte-Santiago","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH127777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10315708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10315708\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nLearning how spontaneous neuronal activity shapes embryonic brain development is critical for understanding\nneurodevelopmental processes, with implications in neurological or neuropsychiatric disorders."},{"title":"\u0026quot;Building a robust organoid platform to study the developmental potential and physiology of human specific cortical cell types\u0026quot;","field_investigator":"Jia  Liu, Sharad  Ramanathan, David A Weitz","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-140","field_project_number":"1RF1MH123948-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10049141\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10049141\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nThe goal of this proposal is to develop robust in vitro human cell-derived microphysical systems which faithfully\nrepresent key features of the developing human neocortex in vivo."},{"title":"4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007275\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007275\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT\nThe overarching goal of this project is to optimize, validate and implement a revolutionary and safe modality\nfor noninvasive functional imaging of neural currents deep in the human brain through the skull at\nunprecedented spatial and temporal resolution."},{"title":"A Community Framework for Data-driven Brain Transcriptomic Cell Type Definition, Ontology, and Nomenclature","field_investigator":"Michael  Hawrylycz, Ed  Lein, Christopher J Mungall, Helen Elizabeth Parkinson, Richard H Scheuermann","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH123220-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: A Data-driven Framework for Brain Transcriptomic Cell Type Definition, Ontology, and\nNomenclature\nDefining the complete census of neuronal and non-neuronal cell types in the brain is a major priority for the NIH BRAIN\nInitiative, since cellular complexity is a major barrier to under"},{"title":"A Comparative Framework for Modeling the Low-Dimensional Geometry of Neural Population States","field_investigator":"Eva  Dyer","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029852-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007243\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007243\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAdvances in neural recording technology now provide access to neural activity at high temporal resolutions, from\nmany brain areas, and during complex and naturalistic behavior."},{"title":"A high-resolution molecular and lineage atlas of the mouse brain using Slide-seq","field_investigator":"Fei  Chen, Evan Z Macosko","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH124598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088261\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe mouse brain is composed of thousands of highly specialized cell types, distributed across hundreds of\nanatomical regions."},{"title":"A neuroethological model of sensorimotor processing in animal-animal interactions","field_investigator":"Joseph  Parker","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053664\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053664\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project\u0026nbsp;Summary\u0026nbsp;\nAnimals\u0026nbsp; interact\u0026nbsp; with\u0026nbsp; members\u0026nbsp; of\u0026nbsp; their\u0026nbsp; own\u0026nbsp; or\u0026nbsp; other\u0026nbsp; species\u0026nbsp; in\u0026nbsp; the\u0026nbsp; context\u0026nbsp; of\u0026nbsp; social\u0026nbsp; and\u0026nbsp; defensive\u0026nbsp;\nbehaviors,\u0026nbsp;predator-\u00adprey\u0026nbsp;relationships\u0026nbsp;and\u0026nbsp;symbiose"},{"title":"A new theory of population coding in the cerebellum","field_investigator":"Reza  Shadmehr","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028156-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A theory of population coding in the cerebellum\nIn order to move accurately, the brain relies on internal models that predict the sensory consequences of motor\ncommands."},{"title":"A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop system","field_investigator":"John H Byrne, Hillel J Chiel, Elizabeth C Cropper, Cynthia Anne Chestek, Avy  Susswein, Peter John Thomas","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118606-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10058915\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10058915\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nAdaptive behaviors emerge from neuronal networks by dynamically regulating functional connectomes."},{"title":"A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging","field_investigator":"Chenming  Chang, Craig S Levin","field_institution":"Petcoil, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41MH123253-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007289\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007289\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\nMedical imaging technologies such as magnetic resonance imaging (MRI) and positron emission tomography\n(PET) have been widely used in studying the underlying mechanisms of mental illnesses and neurological\ndisorders such as brain tumors, Alzheimer\u2019s disease, epilepsy, and depression,"},{"title":"Accelerating Dissemination of Implantable Neurotechnology for Clinical Research","field_investigator":"David Allenson Borton, Timothy  Denison, Philip Andrew Starr, Gregory A Worrell","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113637-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967390\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967390\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Summary\nInvasive neurostimulation is an established technique in the therapy of movement disorders and epilepsy, and\nshows promise for amelioration of psychiatric and cognitive disorders."},{"title":"Active sensing at the sensory surface: glomerular signals for olfactory navigation by freely-moving mice","field_investigator":"Matthew C Smear","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116731-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Our senses aren\u2019t passive. Rather, we actively seek relevant information via sampling movements.\nHowever, experiments in sensory systems often restrict sampling movements to simplify stimulus delivery\nand allow large scale imaging and electrophysiology."},{"title":"Activity-dependent mechanisms for memory circuit maturation.","field_investigator":"Sarah  Leinwand","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DC018779-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952093\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952093\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nAdult behavior is the product of neural circuits that have been sculpted during development by\ngenetic programs and experience in the form of neural activity."},{"title":"Adaptive Neurostimulation to Restore Sleep in Parkinson\u0026#039;s Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair","field_investigator":"Aviva  Abosch, Casey Harrison Halpern, Clete A Kushida, John A Thompson","field_institution":"University Of Nebraska Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS113769-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9960743\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9960743\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nParkinson\u2019s disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms.\nWhile there is as yet no cure for PD, medical and surgical therapies have been developed that effectively target\nthe motor symptoms of PD."},{"title":"An Ethical Approach to Detecting Covert Consciousness","field_investigator":"Michael J Young","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAlarming shortcomings of the bedside behavioral examination in reliably detecting consciousness generate\nprofound dilemmas for clinicians and families facing decisions about continuation of life-sustaining therapy, pain\ncontrol, prognostication, and resource allocation in patients wi"},{"title":"An integrated platform for studying sensory networks in the vertebrate brain","field_investigator":"Ethan Kime Scott","field_institution":"University Of Queensland","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10051317\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10051317\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"7. Project Summary\/Abstract\nHuman experience is shaped by our senses, which receive diverse inputs from our\nenvironment. These varied inputs, however, all contribute to a single integrated\nrepresentation in our minds of the outside world."},{"title":"Application of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome","field_investigator":"Hernan  Makse, Manuel  Zimmer","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028157-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n The broad, long-term objective of this grant is to advance a new theoretical approach to identify\nsynchronized building blocks of neural circuits based on group theory and its application to understand the\npermutation symmetries of these circuits."},{"title":"Bicoastal Marmoset Breeding Center","field_investigator":"Xiaoqin  Wang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-145","field_project_number":"1U24MH123423-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10029350\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10029350\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the\nUnited States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of\nscientific discovery."},{"title":"Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection","field_investigator":"Allison Elizabeth Girasole","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156658\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156658\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSelecting future actions based on previous experiences is key to an animal\u0027s survival. This process, known as\naction selection, depends on the proper function of cortical and subcortical basal ganglia circuits."},{"title":"Biology and Biophysics of the Cortical Response to Transcranial Magnetic Stimulation","field_investigator":"Angel V Peterchev, Marc A Sommer","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS117405-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10031284\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10031284\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"The use of transcranial magnetic stimulation (TMS) as a therapeutic intervention is FDA-cleared for treating\ndepression, obsessive-compulsive disorder, and migraine, and shows promise for a host of other brain disorders.\nThe appeal of TMS is its safety, non-invasiveness, and well-established capacit"},{"title":"Biophysical modeling of the functional MRI signal through parametric variations in neuronal activation and blood vessel anatomy using realistic synthetic microvascular networks","field_investigator":"Grant  Hartung","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156061\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156061\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The most widespread tool for measuring brain activity noninvasively in humans is functional magnetic resonance\nimaging (fMRI), which typically tracks changes in blood flow and oxygenation using the blood-oxygenation-level-\ndependent (BOLD) signal."},{"title":"Brain States and Flexible Behavior","field_investigator":"Santiago  Jaramillo, David  Mccormick, Cristopher M Niell","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118461-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053588\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053588\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nTo survive in dynamic environments, the nervous system must be able to generate flexible behavior \u2014\nseamlessly weaving together past experience with the present context to achieve future goals."},{"title":"Brainstem circuits of corticospinal neurons","field_investigator":"Gordon M Shepherd","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116713-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977340\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977340\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nCorticospinal axonal projections are critical for mammalian motor control."},{"title":"Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitry","field_investigator":"Franck K Kalume, Ed  Lein, Boaz Pirie Levi, Jonathan T Ting","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH120095-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025520\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025520\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract:\nMany cell types together assemble the functional circuitry of the human brain. For over a century, neuroscientists\nhave categorized brain cell types by their features, including shape, position, physiology, molecules, and\nfunction."},{"title":"Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature","field_investigator":"Lily Y Jan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116588-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9970898\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9970898\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic\nfeedback regulation based on monitoring the temperature of internal organs as well as the environment.\nHomeostatic thermoregulation in response to changes of brain temp"},{"title":"Characterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces","field_investigator":"Karen Elizabeth Schroeder","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952827\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952827\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in\nneural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish\nan independent nonhuman primate (NHP) laboratory with two primary aims."},{"title":"Circuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.","field_investigator":"Brandon J Mark","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125443-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10137601\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10137601\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise\ncontrol of large numbers of motor neurons."},{"title":"Circuit dynamics of sensorimotor integration and decision making in octopus","field_investigator":"Galit  Pelled","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115817-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9949982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9949982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\n The goal of this proposal is to identify fundamental sensorimotor circuits associated with\ngoal-oriented gripping movement by using high-dimensional biological, analytical and robotics\ntechnologies."},{"title":"Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI","field_investigator":"Jonathan D Cohen, Kenneth A Norman","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125318-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123207\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123207\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary: (30 lines of text max)\n We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback\nexperiments."},{"title":"Collaborative Expansion of Marmoset Colonies for Neuroscience Research","field_investigator":"Jon E Levine, Jeffrey A. Rogers, Corinna Nicole Ross","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-145","field_project_number":"1U24MH123422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10029227\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10029227\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\nDemand for the common marmoset (Callithrix jacchus) in biomedical research has increased tremendously over\nthe past five years, as they have emerged as a critical biomedical model system in a variety of study disciplines.\nThe increased use of marmosets has been most acute in neuroscience, wh"},{"title":"Combined Topological and Machine Learning Tools for Neuroscience","field_investigator":"Michael  Hawrylycz, Partha Pratim Mitra, Yusu  Wang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH125317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10123310\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10123310\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Two major recent advances have raised the possibility of fundamental breakthroughs in both\nbasic and clinical neuroscience: the development of new tools to probe the nervous system with\nsingle-cell resolution as well as brain-wide scope, and breakthroughs in machine learning\nmethods for handling com"},{"title":"Connecting neural circuit architecture and experience-driven probabilistic computations","field_investigator":"Zachary Peter Kilpatrick","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029847-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007281\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007281\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Organisms\u0027 actions and decisions are guided by experience. Models of such behavior often\nappeal to the formalism of probabilistic inference, in which expectations about the world build up sequentially\ndue to past observations."},{"title":"Context-dependent neural processing of leg proprioception in Drosophila","field_investigator":"Sweta  Agrawal","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039477\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039477\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair\nbalance, motor coordination, and motor learning."},{"title":"Coordinating center for collaborative marmoset research","field_investigator":"Donald F. Conrad, Jon E Levine, Corinna Nicole Ross","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-150","field_project_number":"1U24MH123696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044896\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nThe common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human\nprimate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding.\nSeveral barriers to the adoption of marmoset models by the neuroscie"},{"title":"Cortical circuitry supporting flexible audiovisual interactions and behaviors","field_investigator":"Andrea Rayne Hasenstaub","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971394\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971394\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nInteractions between the auditory and visual systems are among the most well-established cases of\ncrossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining\nprocessing confined to a single modality and we understand comparatively l"},{"title":"Cortical-Basal Ganglia Speech Networks","field_investigator":"Robert Mark Richardson","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS117836-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044852\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\nActions are not mediated solely by cortical processes but rely on communication within basal ganglia-\nthalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely\nhuman behavior is not clear, due to a lack of empirical data."},{"title":"Corticostriatal contributions to motor exploration and reinforcement","field_investigator":"Timothy James Gardner, Carlos  Lois, Richard D. Mooney, John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053204\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053204\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nComplex motor sequences are fundamental to many highly skilled behaviors, ranging from athletics to musical\nand vocal expression."},{"title":"Corticostriatal mechanisms of causal inference and temporal credit assignment.","field_investigator":"Hyojung  Seo","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118463-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053605\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053605\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Learning desired actions from experience requires evaluating alternative actions by integrating the\nconsequences assigned to each action over time."},{"title":"Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis","field_investigator":"Daniel Maxim Iascone","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125600-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10155930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10155930\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCircadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in\nmammals [1-3]."},{"title":"Critical Technology Development for 16 Tesla Head-only MRI Superconducting Persistent Magnets: V2","field_investigator":"Minfeng  Xu","field_institution":"General Electric Global Research Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-001","field_project_number":"1R01EB029814-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006952\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006952\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nAdvanced brain research demands ultra-high field MRI systems. The 11.7 T Neurospin CEA MRI magnet\npushed the use of superconducting NbTi materials to the limit by using superfluid helium to cool."},{"title":"Cross-frequency coupling: its role in brain function and dysfunction","field_investigator":"Andrei V Medvedev","field_institution":"Georgetown University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123192-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10008042\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10008042\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\n One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the\nbrain network dynamics across time and space from human electrophysiological recordings."},{"title":"Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activity","field_investigator":"Shella D Keilholz, Garrett B. Stanley","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007011\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The brain is a complex dynamical system, with a hierarchy of spatial and temporal scales ranging from microns\nand milliseconds to centimeters and years. Activity at any given scale contributes to activity at the scales above\nit and can influence activity at smaller scales."},{"title":"Data Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience","field_investigator":"Chun Chieh  Fan, Wesley Kurt Thompson","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH120025-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10011169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10011169\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nPopulation neuroscience requires investigation of brain-behavioral relationships within epidemiological\nsamples studied in longitudinal designs, including a large number of assessment modalities and with subjects\nenrolled at many data collection sites to achieve a large sample and br"},{"title":"DataJoint Pipelines for Neurophysiology","field_investigator":"Dimitri  Yatsenko","field_institution":"Vathes Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS116470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967639\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967639\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data."},{"title":"Decision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics","field_investigator":"Sharlene  Flesher","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-813","field_project_number":"1K99NS112412-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977403\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977403\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nThe long-term goal of my research is to gain a holistic understanding of how movement commands are\ngenerated- including their relationship to sensory feedback and movement context- in order to restore movement\nto those who have lost it."},{"title":"Defining the role of a prefrontal-midbrain circuit in exploratory behavior","field_investigator":"Victoria L Corbit","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125546-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10146550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10146550\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nInvestigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.\nExploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving\nrodent experiments."},{"title":"Determining computational principles governing neural circuits responsible for feedback and movement control of D. melanogaster flight","field_investigator":"Itai  Cohen","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116595-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971313\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nA principle aim of the NINDS is to determine how motor control is successfully implemented by\nthe nervous system. Locomotion and balance are complex motor functions that are largely\ncontrolled by complex microcircuits that reside outside the brain."},{"title":"Developing A Mouse Chronic Pain Scale by 3D Imaging and Measurement of Mouse Spontaneous Behaviors","field_investigator":"Long  Ding, Wenqin  Luo, Hyun Soo  Park","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10051598\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10051598\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nRodent models are highly valuable for elucidating the molecular and cellular mechanisms of chronic pain.\nBecause rodents cannot articulate their sensation, \u201cpain-like\u201d behaviors have been used as the proxy.\nHowever, sensitivity and specificity of many existing methods for measuring r"},{"title":"Developing a novel therapeutic for treating tinnitus","field_investigator":"Luisa L Scott","field_institution":"Cognosetta, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43DC018487-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9907138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9907138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\nTinnitus or \u201cringing in the ears\u201d is a hearing disorder that disproportionately impacts those who are or have served\nin the military. There is currently no effective cure for tinnitus."},{"title":"Developing Molecular and Computational Tools to Enable Visualization of Synaptic Plasticity In Vivo","field_investigator":"Richard L Huganir","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH123212-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10009886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10009886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nDeveloping new methodological and analytical tools to address currently insurmountable experimental questions\nis crucial to the future of neuroscience."},{"title":"Development of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brain","field_investigator":"Dawen  Cai, Meng  Cui, Yan  Yan, Peng  Yin","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH124611-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nIn order to fully understand the structural substrates underlying the brain function, it is central to curate\nmultiple attributes of the same neurons."},{"title":"Development of multi-color, bright chemigenetic indicators to image synaptic transmission","field_investigator":"Lin  Tian","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031858-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048014\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048014\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nActivity of the brain across structures is an orchestrated process that spans a broad range of time\nand space scales. Highly coordinated communication is what activate responses to stimuli, makes\nbehavior possible, and generates memories."},{"title":"Development of the Human Dynamic Neurochemical Connectome Scanner","field_investigator":"Ciprian  Catana","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007205\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nWe seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible\npositron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution\n(HSTR-BrainPET)."},{"title":"Developmental cell census of human and non-human primate brain","field_investigator":"Nenad  Sestan","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-149","field_project_number":"1U01MH124619-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe human brain is a highly complex biological tissue organized into hundreds of regions composed of a myriad\nof cell types with distinct molecular, morphological, and physiological properties."},{"title":"Dissecting the neural circuit for discrete cue representation in the Dentate Gyrus","field_investigator":"Sebnem Nur Tuncdemir","field_institution":"New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH122226-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10125693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10125693\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this project is to provide the building blocks for an independent research program focused on\nthe mechanisms by which neural networks incorporate multisensory cues into episodic memories.\nDiscrimination of different contexts composed of distinct constellations of multisensory cues is a h"},{"title":"Dissemination of 3-photon imaging for chronic cellular imaging across species","field_investigator":"Jack  Waters","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS115585-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nActivity-sensitive fluorescent indicators and microscopy have proven valuable tools for measuring neuronal\nactivity, but most forms of cellular microscopy can produce images of neurons only near the brain surface and\ngenerally only after removal of tissues overlying the brain surface, such "},{"title":"Distributional reinforcement learning in the brain.","field_investigator":"Jan  Drugowitsch, Naoshige  Uchida","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS116753-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe field of artificial intelligence (AI) has recently made remarkable advances that resulted in new and\nimproved algorithms and network architectures that proved efficient empirically in silico."},{"title":"Dopamine neuronal microcircuits controlling methamphetamine seeking behavior","field_investigator":"Sergio  Dominguez Lopez","field_institution":"Oklahoma Medical Research Foundation","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DA049719-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9977578\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9977578\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to\nan independent investigator in the neurobiology of drug addiction, specifically studying the dopamine\nmicrocircuits controlling drug-seeking behavior. Dr."},{"title":"Dynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study","field_investigator":"Marsa  Taheri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123010-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991579\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n Astrocytes comprise up to half of mammalian brain cells."},{"title":"Eliminating the human factor from stereotaxic surgeries","field_investigator":"Achim  Klug","field_institution":"Popneuron Llc","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41NS119079-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10080673\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10080673\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary:\nThe main goal of this research project is to develop a new line of new stereotaxic devices for small animal\nresearch that outperforms existing devices in terms of accuracy, reproducibility, and ease of use."},{"title":"Elucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology","field_investigator":"Takashi Daniel Yoshida Kozai","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS115707-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10132019\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10132019\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\n Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an\nincreasingly prevalent clinical therapy."},{"title":"Engineering of organoid-based brain circuits","field_investigator":"Andre  Levchenko, Flora M Vaccarino","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-140","field_project_number":"1RF1MH123978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10049681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10049681\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"The human induced pluripotent stem cell (hiPSC) technology promises major advances in disease modeling\nand personalized medicine."},{"title":"Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse Brains","field_investigator":"James C Gee, Yongsoo  Kim, Lydia Lup-Ming Ng","field_institution":"Pennsylvania State Univ Hershey Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH124605-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088508\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088508\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nBrain development is characterized by a diverse set of cell types that are born and connected into rapidly growing\ncomplex 3D structures across time."},{"title":"Ethics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders\u0026#039; Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control","field_investigator":"Cynthia M. S. Kubu","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123407-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10026287\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10026287\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"ABSTRACT\nA fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of\ncontrol."},{"title":"Focused ultrasound-mediated disruption of blood plasma protein binding with pharmacological molecules","field_investigator":"Wonhye  Lee","field_institution":"Brigham And Women\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031807-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10046533\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10046533\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nRegion-specific enhancement of drug delivery to the brain, without increasing systemic drug dose or actively\ndisrupting the blood-brain barrier, has been sought after for effective pharmacological treatment of various\ncentral nervous system disorders."},{"title":"From ion channels to graph theory in sensorimotor learning","field_investigator":"Genevieve  Konopka, Daniel  Margoliash, Jason Neil Maclean, Todd F Roberts","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115821-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9950584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9950584\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nMechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of\nindividuals is an overarching goal of neuroscience."},{"title":"Functional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning","field_investigator":"Shogo  Ohmae","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053429\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053429\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nThe cerebellum performs information processing for motor control and various cognitive functions in\ncooperation with the cerebral neocortex."},{"title":"Generation of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system","field_investigator":"Seth  Blackshaw","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH123237-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012468\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012468\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nNew tools are urgently needed to selectively target constructs that monitor and manipulate the activity of\nindividual cell types without having to rely on genetic manipulation."},{"title":"Genetic access and connectional assays of mouse inhibitory cortical cell types","field_investigator":"Edward M Callaway","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116885-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9985641\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9985641\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe function of the nervous system is dependent on complex interactions between networks of neurons\ncomposed of multiple neuron types."},{"title":"Genetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening","field_investigator":"Edward M Callaway","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH123394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025622\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe function of the nervous system is dependent on complex interactions between networks of neurons\ncomposed of multiple neuron types."},{"title":"Genetic mechanisms specifying astrocyte functional diversity and their role in sleep","field_investigator":"Margaret  Ho","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS117654-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nAstrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our\nunderstanding of their identities and functions is far less comprehensive than for neurons."},{"title":"Genetic-assisted, full brain scale integrated activity mapping with MRI","field_investigator":"Mazahir T. Hasan","field_institution":"Achucarro Basque Center For Neuroscience","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031256-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9922415\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9922415\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTo understand the cellular basis of cognition, behavior and pathology, it is necessary to map the different\nparticipating brain regions and circuits that participate during the different biological processes and do so I the\nsame animals."},{"title":"Graspy: A python package for rigorous statistical analysis of populations of attributed connectomes","field_investigator":"Carey  Priebe, Joshua T Vogelstein","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123233-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012519\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012519\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nOverview: We will extend and develop implementations of foundational methods for analyzing populations of\nattributed connectomes."},{"title":"Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals","field_investigator":"Vladislav  Verkhusha, Junjie  Yao","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS115581-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924909\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924909\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nTo capture the normal brain functions, it is critically important to record the neural activities in freely-behaving\nanimals, with high resolution, high speed, and high throughput."},{"title":"High throughput assaying of circuit activity and connectivity in brain organoids","field_investigator":"Paola  Arlotta, Edward S. Boyden, Jennifer A. Lewis","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-140","field_project_number":"1RF1MH123977-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10049677\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10049677\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Experimental models of the human developing brain are needed to investigate human-specific aspects of\nbrain development, evolution, and neurological disease."},{"title":"High-throughput approaches to local and long-range synaptic connectivity","field_investigator":"Edward S. Boyden, Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123403-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025780\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025780\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe overarching objective of this proposal is to develop a robust approach to map the brain\u0027s connections\nquickly, accurately, and cost-effectively."},{"title":"Highly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations","field_investigator":"Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH123698-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10035136\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10035136\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary \/ Abstract\n This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national\nWorking Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and\ngenerate evidence-based consensus recommendations for the ethical conduct "},{"title":"Hormonal regulation of value-based decision-making","field_investigator":"Carla  Golden","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125448-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10140910\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10140910\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nIndividuals decide between alternatives based on their perceived value of the reward associated with each\noption."},{"title":"How do parvalbumin interneuron-generated gamma oscillations organize prefrontal networks to promote behavioral adaptation?","field_investigator":"Vikaas Singh Sohal","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS116594-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971310\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971310\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nRhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many\ncases these oscillations are synchronized across brain regions."},{"title":"Identifying mediators of sex hormone uptake and signaling","field_investigator":"Nicole Yishi Leung","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125593-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10158076\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10158076\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nSex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes\nacross our lifespan."},{"title":"Improving Brain Organoid Models by Mediating Metabolic Dysregulation","field_investigator":"Madeline  Andrews","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH125329-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10104263\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10104263\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThere is currently an unmet need for accurate model systems of the human brain to study its cellular and\nmolecular features."},{"title":"Innovative biostatistical approaches to network level analyses of connectome-behavior relationships","field_investigator":"Muriah D Wheelock","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EB029343-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10055480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10055480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nDetermining the mechanisms by which the human brain generates cognition, perception, and emotion hinges\nupon quantifying the relationships between coordinated brain activity and behavior."},{"title":"Integrative labeling, imaging, and reconstruction tools for high-throughput inhibitory microconnectivity analysis in the mouse brain","field_investigator":"Dawen  Cai, Yan  Yan","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123402-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025817\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025817\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nNeural circuits composed of interconnected neurons with distinct properties lay the physical foundation\nof any brain function. Identifying connections between individual neurons is central to understand how\ninformation is processed and propagated in the brain."},{"title":"Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury","field_investigator":"Claudia  Angeli, Maxwell  Boakye","field_institution":"University Of Louisville","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS116238-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9962062\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9962062\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY ABSTRACT\nMore than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000\nnew cases."},{"title":"Investigation of the Cortical Communication (CORTICOM) System","field_investigator":"Nathan E Crone, Nicolas Franciscus Ramsey","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS114439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9879474\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9879474\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"For many years brain-computer interfaces (BCI\u0027s) have been explored as a means of restoring communication\nto patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which\ncognition is intact but nearly all motor output from the brain is interrupted, eff"},{"title":"kHz frequency Spinal Cord Stimulation: Novel Temperature-Based Mechanisms of Action","field_investigator":"Marom  Bikson","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112996-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9960245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9960245\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project(Summary(\/(Abstract!\nThere is a need to understand the mechanisms of neural stimulation technologies (RFA-NS-18-018). The impact\nof such research increases with both the clinical relevance of a neuromodulation technology and the extent\nmechanisms are unknown."},{"title":"Large-field-of-view high-throughput two-photon endoscope to image neuronal activity","field_investigator":"Weijian  Yang","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS118289-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047830\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nLarge-field-of-view high-throughput two-photon endoscope to image neuronal activity\nDevelopment of miniaturized optical endoscopes have enabled visualization and recording of neural activity\nin freely-behaving animals."},{"title":"Large-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex","field_investigator":"Jordan Marie Ross","field_institution":"Georgia State University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139328\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139328\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still\nmaintaining the ability to detect change in the environment is critical to biological success."},{"title":"Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and Attention","field_investigator":"Tirin  Moore, Krishna V Shenoy, Joni D Wallis","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9972475\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9972475\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Prefrontal cortex (PFC) is critical for a range of high-level cognitive functions, such as attention and decision-\nmaking. Studying these processes is difficult, since they are covert, dynamic and under the control of the\nsubject, rather than the experimenter."},{"title":"Lateral habenula circuit in reward\/conflict mediation","field_investigator":"Christian Emmanuell Bravo-Rivera","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH123495-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952906\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nReward is often present in risky environments, requiring individuals to weigh the benefits of rewards against\nthe associated risks. There are several psychiatric disorders in which patients are unable to choose an\nappropriate response during risky reward opportunities."},{"title":"Light-Induced Targeted Recombination Strategies For Genetic Access to Recently Active Neurons","field_investigator":"Aaron J Norris, Chandra L Tucker","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924856\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924856\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nA fundamental challenge in neuroscience is in understanding which circuits and cells in the brain contribute to\nspecific behaviors, perceptions, and functions."},{"title":"Linking Hippocampal Replay Content to Learning and Decision-Making","field_investigator":"Michael Edward Coulter","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123003-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nMemory is an integral component of human cognition, and when memory processes go awry, the result is\ndevastating neurological disorders of memory loss including Alzheimer\u0027s disease and other forms of dementia.\nOne essential role of normal memory processes is to use previou"},{"title":"Linking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampus","field_investigator":"Sara J Aton","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118440-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053374\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053374\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary: Synaptic plasticity in brain structures like the hippocampus has been hypothesized to\nunderlie an essential brain function - consolidating transient experiences into long-lasting memories."},{"title":"Linking molecular and anatomical features of brain cell identity through computational data integration","field_investigator":"Joshua  Welch","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123199-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10009608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10009608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Linking molecular and anatomical features of brain cell identity through computational data integration\nAbstract\nThe brain contains diverse cell types that vary widely in characteristic properties and function in complex,\ninterconnected circuits."},{"title":"Magnetic Particle Imaging for High-Resolution Functional Brain Imaging","field_investigator":"Steven M Conolly","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-001","field_project_number":"1R01EB029822-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007168\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007168\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary \/ Abstract\nMagnetic Particle Imaging (MPI) is a novel tomographic imaging modality, with unprecedented contrast,\ndepth of penetration and sensitivity (1 micromolar sensitivity today; 100 nM soon)."},{"title":"Mapping human brain perivascular space in lifespan using human connectome project data","field_investigator":"Jeiran  Choupan","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123223-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012731\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012731\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nPerivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble\nwaste."},{"title":"Mapping the neural circuitry underlying walking","field_investigator":"Sumaira  Zamurrad","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123012-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991417\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nWalking is an essential and conserved behavior across the animal kingdom."},{"title":"Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema","field_investigator":"Kyle Scott Severson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH122995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9987939\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9987939\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this proposed research is to reveal the sensory origins underlying the body schema\nrepresentation. Body schema is the brain\u0027s internal model of the body\u0027s spatial configuration."},{"title":"Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain","field_investigator":"Danny Jj Wang, Lihong  Wang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029823-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007184\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007184\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT (30 Lines)\nThe BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation\nnoninvasive human brain imaging tools and methods that will lead to transformative advances in our\nunderstanding of the human brain."},{"title":"Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordings","field_investigator":"Loren M Frank, Chong  Xie","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS115588-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9925027\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9925027\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"The brain is a massively interconnected network of specialized circuits."},{"title":"Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan","field_investigator":"Elizabeth  Johnson","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS115918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9952838\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9952838\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nMemory is core to human cognition, undergoes protracted developmental maturation and age-related decline,\nand is disrupted in numerous neurological and neuropsychiatric disorders."},{"title":"Metastable dynamics in cortical circuits","field_investigator":"Braden  Brinkman, Alfredo  Fontanini, Giancarlo  La Camera, Arianna  Maffei, Il Memming Park, Jin  Wang","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS115779-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9949119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9949119\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n Cortical circuits generate dynamic patterns of activity. One of the great challenges of modern neuroscience is to\ndetermine the circuit architectures that generate such dynamics patterns, and understand their genesis and functional\nsignificance."},{"title":"Metasurface-Dressed Nanophotonic Neural Interfaces for Multipoint Concurrent Optogenetic Modulation and Calcium Mapping","field_investigator":"Xingjie  Ni","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031853-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047885\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047885\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Metasurface-Dressed Nanophotonic Neural Interfaces for Multipoint Concurrent Optogenetic\nModulation and Calcium Mapping\n Large-scale recording of neural activity while manipulating arbitrary neurons in freely behaving animals are\nimportant for answering many key questions in neuroscience."},{"title":"Modeling developmental gradients and supportive tissue signaling networks using iPSC-derived forebrain organoids embedded in fluidic hydrogels","field_investigator":"Leon Marcel Bellan, Vivian  Gama","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-140","field_project_number":"1RF1MH123971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10049470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10049470\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nUnderstanding of many aspects of the human brain is currently limited due to the lack of appropriate model\nsystems that recapitulate the heterogenous nature of the human brain and the ethical and practical limitations\nof working with human brain tissue from patients."},{"title":"Modeling the structure-function relation in a reconstructed cortical tissue","field_investigator":"Anton  Arkhipov, Stefan  Mihalas","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029813-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005712\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\n How is connectivity between neurons related to patterns of activity exhibited by these neurons in vivo? This\nquestion of structure-function relations in brain circuits is of fundamental importance."},{"title":"Molecular Engineering of Natural Light-Gated Chloride Channels for Optogenetic Inhibition","field_investigator":"John Lee Spudich, Francois  St-Pierre, Mingshan  Xue","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS118288-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047808\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047808\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nTargeted modulation of neural activity is an essential approach in basic and clinical neuroscience research.\nOptogenetic proteins, such as light-activated ion channels or pumps, enable optical control of neuronal activity\nwith exquisite spatiotemporal precision."},{"title":"Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin States","field_investigator":"Thomas  Theis","field_institution":"North Carolina State University Raleigh","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-001","field_project_number":"1R01EB029829-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007222\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007222\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Molecular MRI of Brain Metabolism enabled by Long-Lived Spin States\nAbstract:\nBrain function is regulated by molecular signaling and metabolism, however our ability to track metabolic\ntransformations of individual metabolites deep in the brain pales compared to their central relevance to life."},{"title":"Molecular Multi-Species Approach for Trans-Synaptic Labeling of Neural Circuits","field_investigator":"Gilad  Barnea, Marnie E Halpern, Jennifer Mengbo Li, Drew  Robson","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH123213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10009743\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10009743\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nIt is estimated that the human brain contains an overwhelming 1015 synapses, structures essential for the normal\nfunctioning of neural circuits."},{"title":"Moving MRI: Imaging a Moving Body with a Moving MRI Magnet","field_investigator":"Jerome L Ackerman","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-001","field_project_number":"1R01EB029818-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007118\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007118\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"In response to BRAIN RFA-EB-19-001 we propose to demonstrate a novel noninvasive brain imaging method,\nMoving MRI (mMRI). In mMRI, a high resolution, high field, superconducting MRI magnet moves such that the\nsubject\u0027s head and body effectively remain stationary with respect to the magnet."},{"title":"MPS-TMS: Modular Pulse Synthesizer for Transcranial Magnetic Stimulation with Fully Adjustable Pulse Shape and SequenceTBD","field_investigator":"Angel V Peterchev","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-310","field_project_number":"1RF1MH124943-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10108525\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10108525\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Therapeutic Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nWe will develop a novel technology for noninvasive transcranial magnetic stimulation (TMS) of the human brain.\nTMS is a standard tool in experimental brain science and is FDA cleared for treatment of depression, obsessive-\ncompulsive disorder, and migraine as well as pre-sur"},{"title":"Multi-modal, large-scale characterization of cellular and cell-type-specific effects with electric stimulation in rodent and human brain","field_investigator":"Soo Yeun  Lee","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120300-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10132674\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10132674\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nThe application of electric stimulation (ES) to the brain has been widely used to perturb the physiological and\npathological dynamics of neuronal circuits, with established applications including therapeutic interventions for\nneurological disorders such as epilepsy, dementia, and Pa"},{"title":"Multimodal study of infra-slow propagating brain activity","field_investigator":"Xiao  Liu","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH123247-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nThe highly-organized intrinsic brain activity, as measured by resting-state functional magnetic resonance imaging\n(rsfMRI), is being widely used to measure functional brain connectivity in both healthy subjects and patient\ngroups, despite the underlying neural mechanisms remain large"},{"title":"Multiplexed Nanoscale Protein Mapping Through Expansion Microscopy and Immuno-SABER","field_investigator":"Edward S. Boyden, Peng  Yin","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH124606-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088537\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088537\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Tools for surveying brain cell types and circuits must be scalable, both in the number of molecular targets\nvisualizable at once, and in the size of the tissues that can be assessed."},{"title":"Multiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.","field_investigator":"Dean V Buonomano, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116589-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971022\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971022\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nA general principle of brain function is the ability to store information about the past to better predict and prepare for the\nfuture."},{"title":"Multiscale imaging of marmoset cortex during visual object recognition and learning","field_investigator":"Elias  Issa","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116739-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978313\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\/ABSTRACT\nAnthropoid primates (monkeys, apes, and humans) are distinguished from their phylogenetically nearest\nrelatives (lemurs, tree shrews, and rodents) by an elaboration of the cerebral cortex including changes in\ncellular composition of the cortical circuit."},{"title":"Neural basis of causal inference: representations, circuits, and dynamics","field_investigator":"Gregory C Deangelis","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS118246-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047607\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047607\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe same pattern of neural activity can correspond to multiple events in the world. Signals sweeping across\nthe retina, for instance, might be generated by a moving object or by the animal\u0027s self-motion."},{"title":"Neural circuit computations for visual motion during natural primate behaviors","field_investigator":"Lawrence Kevin Cormack, Gert  Cauwenberghs, Mary M Hayhoe, Alexander C Huk, Cory T Miller, Cristopher M Niell","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS116377-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9964469\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9964469\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY \/ ABSTRACT\nOur current understanding of primate motion perception is often lauded as one of the great achievements of\ncomputational systems neuroscience."},{"title":"Neural circuitry for observational learning of maternal behavior","field_investigator":"Amy  Lemessurier","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123016-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991218\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991218\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nBehaviors essential for survival, including parenting behaviors, are driven by neural circuits that arise from\ncombinations of genetics and experience-dependent learning."},{"title":"Neural coding and functional organization of the octopus visual system","field_investigator":"Cristopher M Niell","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118466-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053626\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053626\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nCephalopods have large and complex brains, and in particular a highly capable visual system.\nHowever, their brains evolved independently from vertebrates, and very little is known about how neural\ncircuits in the cephalopod brain process visual information."},{"title":"Neural Electrodes with Enhanced Charge Injection and Reduced Interfacial Impedance Using Graphenated Carbon Nanotubes Coated With Atomic Layer-Deposited Platinum Nanoparticles","field_investigator":"Charles Bernard Parker","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031271-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924896\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The objective of this project is to evaluate graphenated carbon nanotubes (gCNTs) as lower impedance,\nsmaller electrodes for neurostimulation, using deep brain stimulation (DBS) as a test case, with the long-term\ngoal of developing a new type of neural electrode with lower impedance and smaller size"},{"title":"Neural mechanisms linking need to reward","field_investigator":"Joshua D Berke, Zachary A. Knight","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116626-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9972733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9972733\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nBehavior is motivated by reward, and the most powerful rewards are those that satisfy a physiologic need. For\ndecades, neuroscientists have studied the midbrain dopamine system to understand reward and hypothalamic\ncircuits to understand sensing of internal needs."},{"title":"Neurobiology of Social Behavior: Circuit Analysis in Early Life","field_investigator":"Maya  Opendak","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH124434-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10039031\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10039031\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n My long-termcareer goal is to establish a research laboratory that dissects functional microcircuits supporting\nflexible social behavior in typical and perturbed development."},{"title":"NeuroEthics  of Non-Therapeutic Invasive Human Neurophysiologic Research","field_investigator":"Ashley L Feinsinger, Nader  Pouratian","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121373-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10038224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10038224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe BRAIN Initiative has made a significant investment in invasive human neuroscientific studies that take\nadvantage of unique neurosurgical opportunities to study basic human neuroscience without therapeutic intent.\nThese non-therapeutic studies are of particular ethical in"},{"title":"NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of Neurochemistry","field_investigator":"Richard E. Carson, Hongdi  Li, Jinyi  Qi","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029811-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10005604\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10005604\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Research applications of brain Positron Emission Tomography (PET) have been in place for over 40 years.\nThe combination of quantitative PET systems with novel radiotracers has led to a numerous imaging para-\ndigms to understand normal brain physiology including neurotransmitter dynamics and receptor"},{"title":"Neuronal mechanisms of human episodic memory","field_investigator":"Adam Nathaniel Mamelak, Ueli  Rutishauser","field_institution":"Cedars-Sinai Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS117839-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044948\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044948\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\nThe rapid formation of new memories and the recall of old memories to inform decisions is essential for human\ncognition, but the underlying neural mechanisms remain poorly understood."},{"title":"Neuronal mechanisms of visually-driven aggressive behavior","field_investigator":"Andr\u00e9s  Bendesky","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116734-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978478\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978478\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\n Aggression is a fundamental social behavior. Though widespread, the stimuli that modulate aggression\ndiffer between species. Primates rely strongly on visual cues, while in rodents and insects olfactory stimuli are\nessential."},{"title":"NeuroPhIBER: A Nimble Fiber-Optically Read Silicon Microelectrode Array","field_investigator":"Amy Carole Foster, Mark A Foster","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031854-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047889\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047889\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/ Abstract\nAdvancements in microelectrode array (MEA) neural probes have allowed the number of neurons that can be\nsimultaneously recorded by implantable electrodes to roughly double every 7 years since the 1970s, with present\nstate of the art devices allowing for simultaneous recordi"},{"title":"Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and Primates","field_investigator":"Timothy D Harris","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS115587-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924965\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"1 Project Summary: The BRAIN 2025 Report, with the goal to \u201cproduce a dynamic picture of the functioning brain\n 2 by developing and applying improved methods for large-scale monitoring of neural activity\u201d is directly\n 3 addressed by this application."},{"title":"Neurostimulation and Recording of Real World Spatial Navigation in Humans","field_investigator":"Nanthia A Suthana","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS117838-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044930\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\nDecades of research and clinical observations have established that successful spatial navigation and memory\ndepend on the hippocampus and associated structures in the medial temporal lobe (MTL), including entorhinal,\nperirhinal and parahippocampal cortices [1, 2]."},{"title":"Neurostimulation by Ultrasound: Physical, Biophysical, and Neural Mechanisms","field_investigator":"Stephen A Baccus, Kim  Butts-Pauly, Butrus T Khuri-Yakub, Merritt C Maduke","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112152-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9957860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9957860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\n The goal of this project is to understand the neurobiological underpinnings of the effects of ultrasound\n(US) on neural activity. US can modify action potential activity in neurons in vitro and in vivo without damaging\nneural tissue."},{"title":"New approaches for chemical-genetic targeting of specific circuits and cell types in the mammalian brain","field_investigator":"Anton  Maximov","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH123224-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012597\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012597\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"The goal of this research is to establish new robust methods for manipulation of specific circuits and genetically\ndefined neuron types in brains of model organisms with small molecules."},{"title":"Nobrainer: A robust and validated neural network tool suite for imagers","field_investigator":"Satrajit Sujit Ghosh","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121885-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10021957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10021957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"There is an increasing need for efficient and robust software to process, integrate, and offer insight across the\ndiversity of population imaging efforts underway across the BRAIN Initiative and other projects."},{"title":"Non-invasive Radio Frequency Stimulation of Neurons and Networks","field_investigator":"Gyorgy  Buzsaki, Daniel K Sodickson","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS113782-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10030860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10030860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nNonivasive stimulation of the brain in health and disease is an important goal of the Brain Initiative. Current\nmethods include Transcranial Magnetic Stimulation (TMS), Transcranial Electric Stimulation (TES) and\nTranscranial Focused Ultrasound Stimulation (TFUS)."},{"title":"Non-invasive, Deep Brain, and Focal Neuromodulation in Nonhuman Primates","field_investigator":"Taylor D Webb","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123019-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991119\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The ability to non-invasively perturb speci\ufb01c regions deep in the human brain would enable researchers and clinicians\nto study the causal relationships between speci\ufb01c brain structures and behavior."},{"title":"Noninvasive low-intensity focused ultrasound-enabled sonogenetic method to induce plasticity in adult visual cortex.","field_investigator":"Grace M Hwang, Hey-Kyoung  Lee","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031265-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924788\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924788\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\n Development of non-invasive tools for activating deep brain structures is critical for causally\nmanipulating neural function in humans. Furthermore, such method, if able to elicit long-term plastic changes in\nneural circuits, will aid in functional recovery of neural function."},{"title":"Novel transparent, ultra-soft neuroelectrode arrays based on nanomeshing conventional electrode materials","field_investigator":"Michela  Fagiolini, Hui  Fang, Wentai  Liu","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS118301-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048033\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048033\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n There is a growing interest to effectively combine optical approaches with electrophysiology at large scale\nand with great precision to fully leverage the complementary spatial and temporal resolution advantages of\nboth techniques."},{"title":"Open-source software for multi-scale mapping of the human brain","field_investigator":"Bruce  Fischl, Juan Eugenio Iglesias Gonzalez","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH123195-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10008355\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10008355\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary (maximum 30 lines)\nThe BRAIN initiative seeks to develop and apply technologies in order to understand of how brain cells interact\nin both time and space to give rise to brain function."},{"title":"Optical control of neuromodulatory GPCRs","field_investigator":"Ehud  Isacoff, Dirk Hartwig Trauner","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH123246-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012228\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012228\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\/ABSTRACT\nA major goal of neuroscience is to understand how neuromodulatory systems regulate core processes of brain\nand behavior, from motor function and learning to reward, aversion, attention, and sleep."},{"title":"Optical interrogation of neural circuits in Manduca","field_investigator":"Barry A Trimmer, Bing  Ye","field_institution":"Tufts University Medford","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118412-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10051684\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10051684\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"R34 BRAIN Initiative. Optical interrogation of neural circuits in Manduca\nProject Summary \/ Abstract\nThis BRAIN Circuits Planning Project will help to bridge the gap between well-established brain studies\non the fruit fly, Drosophila, and complex behaviors exhibited more generally by other species."},{"title":"Optical methods for imaging and manipulating dendritic spines in vivo","field_investigator":"Roberto  Etchenique, Rafael  Yuste","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116740-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978285\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978285\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Dendritic spines cover dendrites of most mammalian neurons and receive almost\nall excitatory connections in the cortex."},{"title":"Optical tools to probe neural circuits in the echolocating bat","field_investigator":"Kishore V Kuchibhotla, Melville J Wohlgemuth","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118462-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053600\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053600\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT:\n A major goal in neuroscience is to dissect the neural circuits that support complex behaviors."},{"title":"Optimization of Clear Optically Matched Panoramic Access Channel Technique (COMPACT) for large-scale deep-brain neurophotonic interface","field_investigator":"Meng  Cui, Guang  Yang","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS118302-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Optimization of Clear Optically Matched Panoramic Access Channel Technique (COMPACT)\n for large-scale deep-brain neurophotonic interface\nWith the advance of sensitive molecular indicators and actuators, neurophotonics has become a powerful\nparadigm for discovering the principles underlying neural ci"},{"title":"Optimization, application and dissemination of high-speed hybrid multiphoton volumetric imaging technologies","field_investigator":"Attila  Losonczy, Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS115530-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9921918\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9921918\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY \/ ABSTRACT\nUnderstanding how cognitively-relevant behavioral functions emerge from activity patterns of identified cell-\ntypes is predicated on the ability to record large-scale ensemble dynamics from genetically-identified and\nlongitudinally-tracked neuronal populations across multi"},{"title":"Optimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areas","field_investigator":"Karunesh  Ganguly, Jeffrey A Roberts","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS117406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10031331\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10031331\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nStroke is the leading cause of motor disability in the United States. While brain stimulation to enhance motor\nfunction after stroke has shown promise in small studies, two recent large stroke trials did not find evidence for\nsignificant benefits."},{"title":"Optogenetic manipulation of cortical feedback to examine network function and behavior","field_investigator":"Valentin  Dragoi","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116829-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9984742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9984742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nThe brain transforms raw sensory input into perception and cognition, and this transformation relies on\ncomputations performed across neuronal circuits. Fortunately, the anatomy of cortical microcircuits in non-\nhuman primate models is much better understood today than decades ago."},{"title":"Organization of inhibition in the cerebellar cortex","field_investigator":"Jason M Christie, Adam  Hantman","field_institution":"Max Planck Florida Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS118401-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10050669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10050669\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nOur long-term goal is to generate a complete understanding of how the cerebellum learns to improve movement\nin response to motor errors. Climbing fibers are thought to play an essential role in this process because they\nfire during erroneous movement."},{"title":"Photoactivatable systems for controlling transcription and ablating synapses.","field_investigator":"Donald B Arnold","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS115610-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9927247\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9927247\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The advent of optogenetic tools for controlling neuronal function with light has led to dramatic\nadvances in the understanding of the anatomy and function of neural circuits."},{"title":"Population codes and sensory discrimination","field_investigator":"Dario L Ringach","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116471-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9967687\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9967687\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nHow do cortical populations represent sensory input and support perceptual decision making?"},{"title":"Prefrontal contributions to contextual representation","field_investigator":"Cybelle Marguerite Smith","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123002-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9990118\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9990118\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\/Summary\nThis application describes a 3-year training plan that will enable me, a cognitive neuroscientist with prior\ntraining in electroencephalography (EEG), to conduct research on contextual memory representation using\nneuroimaging (fMRI) and computational modeling."},{"title":"Re-engineering Connectivity in the Drosophila Brain","field_investigator":"Marco  Gallio","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031849-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10047820\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10047820\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding how our brain\u0027s 100 billion neurons process information to produce complex\nfeelings, decisions, and behaviors is a daunting task. A single neuron in the human brain may\ncommunicate with more than a hundred thousand partners."},{"title":"Real-time manipulations to understand and improve memory processes","field_investigator":"Anna Kathleen Gillespie","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AG068425-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9953551\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9953551\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nThe hippocampus is critical for capturing rich, multimodal representations of experience and facilitating\nthe long-term storage and later recall of these experiences."},{"title":"Real-time, all-optical interrogation of neural microcircuitry in the pretectum","field_investigator":"Eva Aimable Naumann, John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS116738-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9978318\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9978318\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nOne of the major barriers to understanding how neural circuits give rise to behavior is that typical\nexperimental preparations make it difficult to study these circuits across different brain areas."},{"title":"Relating structure and function in synapse-level wiring diagrams","field_investigator":"Ashok  Litwin-Kumar","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB029858-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10006999\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10006999\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary:\nModern electron-microscopy (EM) imaging and analysis methods now permit the comprehensive reconstruction\nof all neurons and synapses in large volumes of brain tissue or the entire brains of individual organisms. However,\nrelating this structure to function is difficult."},{"title":"Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses","field_investigator":"Noelle  Stiles","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY031987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10041440\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10041440\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \u2013 Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses\n Retinal prostheses restore sight to the blind by electrically stimulating still viable cells in the\nretina."},{"title":"Robust circuit computation in freely behaving animals.","field_investigator":"Keith B. Hengen","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118442-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053390\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053390\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nSleep is necessary for all brain function and ultimately life. The core function by which sleep contributes to\nhealthy cognition remains one of the great questions facing neuroscience."},{"title":"Shedding light on brain circuits mediating navigation of the odor plume in a natural environment","field_investigator":"Emily  Gibson, Diego  Restrepo","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS116241-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9961270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9961270\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nNavigating within an odor plume is a complex task due to unpredictable changes in odor concentration."},{"title":"Significance of excitatory and inhibitory synaptic integration by interneurons for local circuit dynamics and behavior","field_investigator":"Brandon David Turner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123017-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991142\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Localized structuring of neuronal output by inhibitory microcircuits is a fundamental component of\nneuronal information processing."},{"title":"Single-cell computation in auditory brainstem and its impact on cortical coding and behavior","field_investigator":"Nace L Golding, Lisa  Goodrich, Philip  Joris, Matthew J Mcginley","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS118402-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10050683\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10050683\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Abstract\nUnderstanding how neuronal computations build up a perception of the external world is fundamental to our\nunderstanding of how the brain works."},{"title":"Sliced human neocortical organoids for modeling cortical laminar and columnar organization and function","field_investigator":"Guo-Li  Ming","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-140","field_project_number":"1RF1MH123979-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10049693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10049693\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nThe modular organization of the cerebral cortex is defined by anatomically and functionally segregated cortical\ncolumns, as well as layer-specific anatomical and functional connections that span multiple columns.\nDysregulation of the developmental processes governing cortical formation can r"},{"title":"Sonogenetic control of neurons in a large volume of the rodent brain","field_investigator":"Sreekanth H. Chalasani","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS115591-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9925113\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9925113\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nA key challenge in neuroscience is the development of methods to non-invasively manipulate specific neuronal\ncell types in vivo."},{"title":"Spatial exploration and navigation in the primate hippocampus","field_investigator":"Cory T Miller, Kechen  Zhang","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118457-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053557\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053557\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary.\nHuman and nonhuman primates are highly visual animals that are predominantly active during the daylight hours.\nYet our understanding of the neural mechanisms supporting spatial navigation is largely based on studies of\nnocturnal, burrowing rodents with poor vision."},{"title":"Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate Pain","field_investigator":"Jan  Drugowitsch, David D Ginty, Clifford J Woolf","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01AT011447-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053529\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053529\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nOur goal is to generate a predictive model of the spinal cord nociceptive circuits that underlie the initiation of\npain perception and behavior. Nociceptive signals are conveyed from the periphery to the spinal cord dorsal\nhorn via highly specialized primary sensory neuron subtypes."},{"title":"Streamlining Volumetric Imaging, Analysis and Publication Using Immersive Virtual Reality","field_investigator":"Gianfranco  Doretto, Michael David Morehead, George A Spirou","field_institution":"Istovisr","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R44MH125238-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10011054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10011054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Over the past 15 years, new imaging technologies and methods for high throughput imaging\nhave revolutionized structural biology by extending the resolution and scale of collected images\nin 3 dimensions."},{"title":"Structure and Function of a Cubic Millimeter of Cortex: Crowdsourcing for Proofreading and Discovery","field_investigator":"Hyunjune Sebastian Seung","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123400-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025901\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025901\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"At the end of 2020, the IARPA MICrONS program will conclude with an automated reconstruction of all\nneurons in a cubic millimeter of mouse visual cortex, along with the neurons\u2019 synaptic connectivity and\ncalcium-imaged responses to video stimuli."},{"title":"Studying how the hippocampal-prefrontal-hypothalamic circuit encodes social dominance","field_investigator":"Nancy  Padilla Coreano","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH124435-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10041744\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10041744\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nSocial deficits are common in psychiatric disorders and available treatments are limited. Our lack of basic\nknowledge on how the brain controls social behaviors makes it challenging to develop therapeutics for social\ndeficits."},{"title":"Synaptic mechanisms of temporal pattern separation","field_investigator":"James Mcclure Jeanne","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116584-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9970802\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9970802\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n Pattern separation is the process by which the brain distinguishes between similar or overlapping\nfeatures of the external world."},{"title":"Systems-level and in situ transcriptomics deconstruction of neural circuits underlying sensorimotor transformation in an innate behavior","field_investigator":"Catherine  Dulac, Venkatesh N Murthy, Xiaowei  Zhuang","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS116593-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9971196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9971196\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nIn order to control specific behavioral responses, transcriptionally distinct cell types assembled\ninto dynamic brain circuits integrate environmental information with internal states and generate\npurposeful motor actions."},{"title":"The behavioral microstructure of a memory-guided food-caching behavior and its relationship to hippocampal replay","field_investigator":"Selmaan  Chettih","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123015-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe hippocampus is a critical site for rapid memory formation and retrieval, with extensively documented\nfunctions representing spatial and navigational variables, yet less is known of the means by which it guides\nbehavior."},{"title":"The Emergence, Persistence and Plasticity of Neural Codes for Self-Selected Goal-Directed Navigation","field_investigator":"Michael Moshe Yartsev","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053126\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053126\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nGoal-directed navigation often occurs in complex, large environments where the same goal can be reached\nfrom different starting point and through different routes which are often self-selected."},{"title":"The experience of human subjects with brain organoid research","field_investigator":"Kate E. Macduffie","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH125328-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10101989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10101989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nEfforts to understand the mechanisms of brain-based disease have been hindered by the limited\nability of animal models to reflect the full complexity of human brain and behavior."},{"title":"The neural coding of speech across human languages","field_investigator":"Edward  Chang","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS117765-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10044400\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10044400\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"PROJECT SUMMARY\nThe basic mechanisms underlying comprehension of spoken language are unknown. We are only beginning to\nunderstand how the human brain extracts the most fundamental linguistic elements (consonants and vowels)\nfrom a complex and highly variable acoustic signal."},{"title":"The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function","field_investigator":"David A Boas, Swathi  Kiran","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-19-002","field_project_number":"1U01EB029856-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10007021\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10007021\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Innovations in human neuroimaging tools have driven profound advances in our understanding\nof brain function under well-controlled and constrained conditions."},{"title":"The planning of new compositional action sequences guided by interpretation of ambiguous sensory data in a novel drawing task","field_investigator":"Lucas Y. Tian","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH125573-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10151223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10151223\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nAnimals exhibit a remarkable array of creative, adaptive, and flexible behaviors."},{"title":"Tracking Changes in High-Dimensional Circuit Behaviors over Long-Term Neural Recordings","field_investigator":"Alexander Henry Williams","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH122998-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9989472\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9989472\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nRecent breakthroughs in neural recording technologies suggest the possibility of understanding the\ncollective dynamics of large-scale brain circuits."},{"title":"Transgenic tools for revealing the contributions of electrical synapses to neural circuits","field_investigator":"Adam C Miller, John  O\u0026#039;brien, Alberto E Pereda","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120016-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10012410\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10012410\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nWhile current efforts in the analysis of neural circuits focus on interneuronal connectivity mediated by chemical\nsynapses, less is known about the contribution of electrical synapses."},{"title":"Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain Networks","field_investigator":"Alexander  Opitz","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-310","field_project_number":"1RF1MH124909-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10107530\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10107530\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Therapeutic Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nTranscranial alternating current stimulation (TACS) non-invasively alters neuroelectric activity in the human\nbrain by applying weak, time-varying electric currents to the scalp."},{"title":"Two-photon Line Excitation Array Detection (2p-LEAD) microscopy for volumetric monitoring neuronal activity at 120,000 frames per second","field_investigator":"Adela  Ben-Yakar","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY031863-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048099\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048099\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nTo understand how the brain processes information and generates behaviors, we must record neural activity of\nthree-dimensionally distributed circuits at millisecond timescales."},{"title":"Ultra-high resolution, multiplexed single molecule nanoscopy and functional characterization of neural circuits","field_investigator":"Alexander  Chubykin, Fang  Huang, Peng  Yin","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123401-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10025878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10025878\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"The complex behaviors of all vertebrates are determined by the brain where neurons are connected by\nsynapses. The average volume of synapses corresponds to a sphere of ~400 nm radius\u2014a size scale that can\nbarely be resolved using conventional optical microscopy methods."},{"title":"Understanding Multi-Layer Learning in a Biological Circuit","field_investigator":"Laurence F. Abbott, Nathaniel  Sawtell","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1RF1NS118448-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10053457\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10053457\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Work on learning in neural systems has focused largely on the effects of plasticity at synapses\nthat provide direct input to the neurons being studied."},{"title":"Understanding overlap in resting state fMRI networks at the single cell level: a cross-species approach","field_investigator":"Janine Diane Bijsterbosch, Lawrence H Snyder","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS118618-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10059107\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10059107\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Understanding overlap in resting state fMRI networks at the single cell level: a cross-species\napproach\nAbstract\nResting state functional connectivity MRI (rsfcMRI) is a popular tool to investigate the intrinsic\nfunctional organization of the brain into large scale networks."},{"title":"Using multiple species, stimuli, and tasks to study the neural basis of visually guided behavior","field_investigator":"Amy Meesun Ni","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-813","field_project_number":"1K99NS118117-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10040904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10040904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n The visual system must constantly extract behaviorally relevant stimulus information from an abundance of\nirrelevant inputs from the environment, using cognitive phenomena such as attention and learning to guide this\ncontinuously adapting process."},{"title":"Using perceptual decision-making to understand the role of selective inhibitory activity in cortical computation","field_investigator":"James Patrick Roach","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH123011-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9991423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9991423\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Cortical circuits perform computations to generate appropriate behaviors based upon diverse\nsensory inputs. These computations are central to an animal maintaining its health and long-\nterm survival."},{"title":"Wireless Magnetomechanical Neuromodulation of Targeted Circuits","field_investigator":"Polina O Anikeeva","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222020-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2020\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1R01NS115576-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9924842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9924842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nScalable approaches to modulate neural activity during complex behaviors are essential to basic study of normal\nand aberrant brain function."},{"title":"3D neonatal Photoacoustic Tomography (3D-nPAT) to detect Hypoxic-Ischemic brain injury in preterm neonates","field_investigator":"Kamran  Avanaki","field_institution":"Wayne State University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB028661-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837229\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837229\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT:\nHypoxic-Ischemic brain Injury (HII) is a severe injury caused by oxygen deprivation to the brain at or near time of birth\nin preterm and\/or low birth weight newborns. It is very important to recognize HII as soon as possible because early\nintervention improves outcomes."},{"title":"3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology","field_investigator":"Suhasa B Kodandaramaiah, Michael  Mcalpine","field_institution":"Applied Universal Dynamics Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R42NS110165-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9774492\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9774492\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThis proposal responds to PAR-18-870 titled \u201cBRAIN Initiative: Development Optimization, and Validation of\nNovel Tools and Technologies for Neuroscience Research (STTR).\u201d This project is a Fast Track STTR with a\nphase I and phase II."},{"title":"4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB028662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837231\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837231\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT\nThe overarching goal of this project is to develop, validate and implement a new modality for noninvasive\nfunctional imaging of neural currents deep in the human brain through the skull at unprecedented spatial and\ntemporal resolution."},{"title":"A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology","field_investigator":"Emily  Gibson, Karl  Kilborn","field_institution":"3 I","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH119879-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9777036\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9777036\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Good methods to interrogate, and ideally perturb, neural systems at the network level have been elusive until\nrecently."},{"title":"A Computational Miniature Mesoscope for Large-Scale Brain Mapping in Behaving Mice","field_investigator":"David A Boas, Ian Gordon Davison, Lei  Tian","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030016-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9693533\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9693533\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\n Scale is a fundamental obstacle in linking neural activity to behavior. While perception and cognition arise\nfrom interactions between diverse brain areas separated by long distances, neural codes and computations are\nimplemented at the scale of individual neurons."},{"title":"A data science toolbox for analysis of Human Connectome Project diffusion MRI","field_investigator":"Ariel Shalom Rokem","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH121868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9886761\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9886761\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nThe connections between different brain regions play an important role in normal brain function. This project\nproposes to create an end-to-end pipeline for analysis of human white matter connections using \u201ctractometry\u201d\nmethods."},{"title":"A Fully Ultrasonic Approach for Combined Functional Imaging and Neuromodulation in Behaving Animals","field_investigator":"Charles F Caskey, Omer  Oralkan, Gianmarco  Pinton","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113285-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829276\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829276\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTwo very recent advancements have been transforming the field of medical ultrasound. First, the revolutionary\ndiscovery of ultrasound neuromodulation, which non-invasively targets and modulates activity in specific regions\nof the brain."},{"title":"A Functional and Selective Toolkit for Choroid Plexus Networks","field_investigator":"Maria  Lehtinen, Christopher I Moore","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048790-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9798116\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9798116\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe choroid plexus (ChP) is a vital tissue located in each ventricle in the brain."},{"title":"A genetically Encoded Method to Trace Neuronal Circuits in the Zebrafish Brain","field_investigator":"Carlos  Lois, David Aaron Prober","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111661-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9746823\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9746823\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nIt is widely thought that identifying how neurons are connected to each other in a brain circuit, its wiring\ndiagram, is a necessary step towards understanding how brain activity gives rise to behavior, and how it is\nperturbed by disease."},{"title":"A Massive Library of AAVs to Target Transcriptionally-Defined Primate Cell Types","field_investigator":"William Richard Stauffer","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH120094-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9804256\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9804256\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Here we will identify nonhuman primate (NHP) neuron types and build an extensive toolbox of vectors for circuit-\nbased neuroscience studies."},{"title":"A multimodal platform to bridge the experimental gap between behavioral, neuronal, and molecular studies","field_investigator":"Dawen  Cai, Meng  Cui","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120005-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9794177\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9794177\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\n Depicting the specific neuronal identity and connectivity underlying particular brain function remains\na central goal for neuroscience."},{"title":"A Neural Systems Approach to Understanding the Dynamic Computations Underlying our Sense of Direction","field_investigator":"Jeffrey Steven Taube, Matthijs  Van Der Meer","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS111695-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9749522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9749522\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nThe Research Plan describes a series of experiments that will examine how spatial information is\nprocessed in the mammalian brain."},{"title":"A new approach to biological recording of lineage hierarchy in primate brains","field_investigator":"Ali H Brivanlou","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120026-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795184\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795184\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\n!\n Most genetic recorders described so far utilize the CRISPR\/Cas9 system to leave a unique genetic scar in\n each cell that can be traced in daughter cells."},{"title":"A novel platform for the investigation of human microglia","field_investigator":"Mathew Mark Blurton-Jones, Robert C Spitale","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048813-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800505\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800505\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nTo accomplish their diverse maintenance and protective roles, microglia must be extremely plastic, dynamically\nsensing and responding to specific local challenges throughout the brain."},{"title":"A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM","field_investigator":"Ravi  Srinivasan","field_institution":"Advanced Imaging Research, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R44MH122273-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9897423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9897423\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"NIH SBIR PA-18-871 w\/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System\nThe intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using\nmagnetic resonance imaging (MRI)."},{"title":"A system for whole-brain recording and control of activated neurons with near-infrared light","field_investigator":"Daria  Shcherbakova","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030705-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829308\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT:\nThe brain simultaneously processes tremendous amount of information using billions of neurons.\nTechnologies for large scale recording and modulation of neurons in the brain of behaving animals\nsought by this RFA should provide researchers with tools to correlate neural circuits with behavi"},{"title":"A Technology Resource for Polymer Microelectrode Arrays","field_investigator":"Ellis  Meng, Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS113647-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9845414\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9845414\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their\nintegrated into neuroscience research practice."},{"title":"A unified framework to study history dependence in the nervous system","field_investigator":"Fidel  Santamaria","field_institution":"University Of Texas San Antonio","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026939-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The brain uses its own previous activity to adapt to an ever-changing environment. This history\ndependent adaptation takes place at all scales of organization of the nervous system."},{"title":"A wearable functional-brain-imaging system with full-head coverage and enhanced spatiotemporal-resolution to study complex neural circuits in human subjects","field_investigator":"Peter D. D. Schwindt","field_institution":"Sandia Corp-Sandia National Laboratories","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB028656-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837083\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837083\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nTo develop maps at multiple scales of neuronal circuits in the human brain and study the brain dynamics, there\nis a need for non-invasive functional brain imaging with high spatiotemporal resolution operating in natural\nenvironments."},{"title":"A wearable high-density MEG system with uOPMs","field_investigator":"Orang  Alem","field_institution":"Fieldline, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH118154-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9778503\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9778503\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThis Phase I project will focus on developing key elements needed to achieve a wearable, high-density,\nmagnetoencephalography (MEG) device based on optically-pumped atomic magnetometers (OPMs).\nOPM sensors have progressed to be comparable in sensitivity to liquid-helium-cooled superconducti"},{"title":"Accessible technologies for high-throughput, whole-brain reconstructions of molecularly characterized mammalian neurons","field_investigator":"Michael I Miller, Ulrich  Mueller","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121539-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9868000\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9868000\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nThe BRAIN Initiative seeks to accelerate the development and application of innovative technologies that\nultimately will revolutionize our understanding of the human brain."},{"title":"Accurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation","field_investigator":"Luis Javier Gomez","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9751045\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9751045\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Transcranial magnetic stimulation (TMS) is a noninvasive technique used for neuroscience research and\ntreatment of psychiatric and neurological disorders. During TMS, a current-carrying coil placed on the scalp\ninduces an electric field that modulates targeted neuronal circuits."},{"title":"Acoustically targeted molecular control of cell type specific neural circuits in non-human primates","field_investigator":"Mikhail  Shapiro, Doris Ying Tsao","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH120102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9804641\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9804641\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nControlling specific neural circuits across large areas of the brain is a major technology goal of the BRAIN\nInitiative."},{"title":"ADVANCED NEXT GEENRATION RADIO FREQUENCY COILS FOR MAGNETIC RESONANCE IMAGING","field_investigator":"Ravi  Srinivasan","field_institution":"Advanced Imaging Research, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R44MH119843-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9842998\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9842998\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Magnetic resonance imaging (MRI) is a safe, non-ionizing diagnostic tool. The overall goal of this\nproject is to arrive very close to the ultimate intrinsic signal to noise ratio (UISNR) for a given MRI\nmagnet field strength by combining innovations in very advanced transceiver technology."},{"title":"An open software solution to integrate non-invasive brain stimulation with functional imaging data","field_investigator":"Alexander  Opitz","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH117428-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9793745\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9793745\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nNoninvasive tools capable of selectively manipulating neural systems in the human brain are needed to\nadvance our neuroscientific understanding of brain function and develop novel non-pharmacologic\npsychotherapeutics and are a major focus of Brain Initiative funding."},{"title":"An optogenetic brain implant with EEG monitoring and response for mice","field_investigator":"Kevan Sayed Hashemi","field_institution":"Open Source Instruments, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH119880-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9909902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9909902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract: Optogenetics can be used to selectively stimulate or suppress the \ufb01ring of genetically\ntargeted and spatially targeted mammalian neurons. It is used to study neuropsychiatric\ndiseases in vivo with mouse models of conditions including epilepsy, schizophrenia, and\nParkinson\u0027s."},{"title":"Automating whole brain connectomics: development, validation, and application of an open toolkit","field_investigator":"Davi  Bock","field_institution":"University Of Vermont \u0026amp; St Agric College","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH120679-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9822552\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9822552\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nWe have recently published a 3D electron microscopy volume of the whole fruit fly brain. However mapping of\nsynaptic `wiring diagrams\u0027 or connectomes of neuronal circuits from this volume is currently completely manual\nand therefore slow."},{"title":"Axonal connectomics: dense mapping of projection patterns between cortical areas","field_investigator":"R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117820-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9822860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9822860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nConnectomics is a new field, created with the goal of densely or completely mapping the connections in the\nbrain. Because this goal is at present only achievable for small organisms, connectomics has taken on two forms\nin the study of larger brains."},{"title":"BCI2000: Software Resource for Adaptive Neurotechnology Research","field_investigator":"Peter  Brunner, Gerwin  Schalk","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9645884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9645884\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The central nervous system (CNS) changes throughout life, and its interactions with the world produce activity-\ndependent plasticity that enables it to acquire and maintain useful behaviors."},{"title":"Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic Feedback","field_investigator":"Helen  Bronte-Stewart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS107709-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9729333\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9729333\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Gait impairment and Freezing of gait (FOG), lead to falls, injury (even death), loss of independent living, and are\ncommon in neurodegenerative diseases such as Parkinson\u2019s Disease (PD), affecting over 7 million people\nworldwide."},{"title":"BRAIN INITIATIVE RESOURCE: DEVELOPMENT OF A HUMAN NEUROELECTROMAGNETIC DATA ARCHIVE AND TOOLS RESOURCE (NEMAR)","field_investigator":"Amitava  Majumdar, Scott  Makeig, Russell A Poldrack, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-145","field_project_number":"1R24MH120037-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795341\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795341\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"To take advantage of recent and ongoing advances in intensive and large-scale computational methods,\nand to preserve the scientific data created by publicly funded research projects, data archives must be\ncreated as well as standards for specifying, identifying, and annotating deposited data."},{"title":"Breaking the Barriers to Microscale fMRI","field_investigator":"An  Vu","field_institution":"Northern California Institute\/Res\/Edu","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB028670-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837381\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837381\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"SUMMARY\n The goal of this proposal is to develop technology that is both novel and disruptive in order to achieve\nanatomical quality, dynamic B0 corrected, whole brain, microscale (\u2264 500 \u00b5m isotropic) fMRI."},{"title":"Bridging structure, dynamics, and information processing in brain networks","field_investigator":"Hannah  Choi","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY030840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9804370\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9804370\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The mammalian brain is believed to be optimally designed for robust and adaptable computation of the\nsensory inputs from the world, with respect to both its hardware (network structure) and software (network\ndynamics)."},{"title":"Building a Complete, Predictive, Data-Driven Model of Action Selection During Olfactory Navigation","field_investigator":"Matthieu R. P. J. C. G. Louis","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113048-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9817551\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9817551\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nTo survive, living organisms must collect information about their environment and use it to select appropriate\nbehaviors. However, information from the environment is often noisy, incomplete and ambiguous."},{"title":"Canonical computations for motor learning by the cerebellar cortex micro-circuit","field_investigator":"Nicolas  Brunel, Court A Hull, Stephen G Lisberger, Javier F Medina","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS112917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9814049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9814049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe cerebellum is critical for learning and executing coordinated, well-timed movements. The cerebellar\ncortex seems to have a particular role in learning to time movements."},{"title":"Cell class- or type-specific viruses for brain-wide labeling and neural circuit examination","field_investigator":"Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121274-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852868\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852868\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nExperimental access to specific cell classes or types in the brain is essential for elucidating their roles in neural\ncircuit function."},{"title":"Cell-Specific Visualization of Endogenous Proteins","field_investigator":"Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9805046\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9805046\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT\u0026nbsp;SUMMARY\u0026nbsp;\nA\u0026nbsp;major\u0026nbsp;goal\u0026nbsp;of\u0026nbsp;the\u0026nbsp;BRAIN\u0026nbsp;initiative\u0026nbsp;is\u0026nbsp;to\u0026nbsp;understand\u0026nbsp;neuronal\u0026nbsp;connectivity\u0026nbsp;and\u0026nbsp;plasticity\u0026nbsp;in\u0026nbsp;the\u0026nbsp;context\u0026nbsp;of\u0026nbsp;\nanimal\u0026nbsp;behavior.\u0026nbsp;The\u0026nbsp;functions\u0026nbsp;and\u0026nbsp;connectivity\u0026amp;"},{"title":"Cellular mechanisms of hippocampal network neuroplasticity generated by brain stimulation","field_investigator":"John F Disterhoft, Joel L Voss","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS113804-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9867989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9867989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\nThe distributed brain network of the hippocampus supports memory and related cognitive abilities. Disruptions\nof this network occur in many neurological disorders such as epilepsy, brain injury, and neurodegenerative\ndisease."},{"title":"Chromatin Plasticity, Transcriptional Activity and Kinetics in Developing and Adult Human Astrocyte and Oligodendroglial Lineages","field_investigator":"Nadejda Mincheva Tsankova","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800190\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800190\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\nWhile glial research has advanced in rodent models, significantly less progress has been made in\nunderstanding human-specific diversity of glia at a molecular and a functional level, both during development\nand in adulthood."},{"title":"Circuit Dynamics for encoding and remembering sequence of events","field_investigator":"Anna  Jafarpour","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120048-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9753679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9753679\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"We experience the world as a continuous sequence of events, but we remember the events as segmented\nepisodes (e.g., my sister\u2019s wedding). During encoding, we associate a sequence of relevant events and segment\ndeviant events."},{"title":"Circuit principles of demotivation in the decision to switch behaviors","field_investigator":"Michael A Crickmore","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS111441-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9737617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9737617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: The decision to commence a new behavior often requires termination of the ongoing\nbehavior. This implies that the many drive states produced by an animal impact not only the neural circuits\nunderlying their directly associated behaviors, but also those of many other behaviors."},{"title":"Close-loop, spatially addressable multiphoton functional imaging","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113281-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829233\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829233\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\n A major goal of brain research is to image the dynamics of groups of neurons during behavior."},{"title":"Cognitive Restoration: Neuroethics and Disability Rights","field_investigator":"Joseph J. Fins","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121378-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9861790\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9861790\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nApproximately, 40% of TBI patients discharged from the hospital will develop long-term disability with 70%\nexperiencing chronic cognitive impairments that disrupt vocational, social, and emotional functioning."},{"title":"Comprehensive Analysis of a Decision Circuit","field_investigator":"Cengiz  Pehlevan, Aravinthan D. Samuel, Paul Warren Sternberg, Mei  Zhen","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS111697-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9749555\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9749555\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAnimal brains integrate information to make crucial developmental and behavioral decisions."},{"title":"Computational and circuit mechanisms of decision making","field_investigator":"Michael Neil Shadlen","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113113-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9820088\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9820088\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe neurobiology of perceptual decision-making elucidates fundamental neural mechanisms of higher cognitive\nfunction, the understanding of which will inspire new strategies to treat neurological and psychiatric diseases\naffecting thought, perception and awareness."},{"title":"Cortical dynamics underlying visual working memory","field_investigator":"Arbora  Resulaj","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99EY030415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754448\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754448\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Playing a game of chess, driving a car, or even reading this sentence all require that the brain retain and integrate information over short periods of time. This retaining and integration of information is accomplished by working memory."},{"title":"Cortical Spatial Processing for Solving the Cocktail Party Problem","field_investigator":"Xue  Han, Kamal K Sen","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111742-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9753613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9753613\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The ability of our auditory systems to recognize target sounds in a mixture of other sounds is fundamental\nto normal healthy function and communication."},{"title":"Cortico-striatal representations of multisensory decision-making","field_investigator":"Xiaonan  Sun","field_institution":"Feinstein Institute For Medical Research","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120888-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834241\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834241\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Perceptual decision-making is a complex cognitive function critical for health, reproductive success, and\nsurvival. In this process, an informed choice based on sensory evidence is made through engagement of\ncircuits across the brain."},{"title":"Cracking the Olfactory Code","field_investigator":"Dmitry  Rinberg","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS112953-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9814744\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9814744\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary (Overall: Cracking the Olfactory Code)\n Sensation drives perception, which informs decisions and actions. Olfaction is the main sense used by\nmost animals to interact with the environment."},{"title":"CRCNS: Closed-Loop Computational Neuroscience for Causally Dissecting Circuits","field_investigator":"Christopher John Rozell, Garrett B. Stanley","field_institution":"Georgia Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01NS115327-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9916954\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9916954\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Interventional Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDespite substantial progress characterizing neural responses, it is particularly challenging to determine causal interactions within recurrently connected circuits due to the confounding influence of the interconnections.\u003C\/p\u003E"},{"title":"CRCNS: Neurocomputational Study of Reward-Related Decision-Making \u0026amp; Uncertainty","field_investigator":"Angela Yu","field_institution":"University of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01DA050373-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9916054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9916054\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans and animals often make decisions under uncertainty, whereby each decision affects not only the immediate reward gain but also longer-term information gain.\u003C\/p\u003E"},{"title":"CRCNS: Optimization of closed-loop control of gamma oscillations","field_investigator":"Satish S Nair","field_institution":"University of Missouri - Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01MH122023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9914633\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9914633\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThroughout the brain, specialized systems carry out different but complementary functions, sometimes independently but often in cooperation. However, we do not understand how their activity is dynamically coordinated, and dysregulation of this is associated with many mental health conditions.\u003C\/p\u003E"},{"title":"CRCNS: Processing speed in the human connectome across the lifespan","field_investigator":"Dora Hermes","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01MH122258-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9927841\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9927841\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Interventional Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Reward and motivation in neural networks","field_investigator":"Alexei Koulakov, Bo Li","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-19-002","field_project_number":"1R01DA050374-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9916069\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9916069\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Interventional Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe overall goal of this project is to develop a reinforcement learning (RL) theory of motivation, understood here as motivational salience, and to test the conclusions of this theory using experimental observations obtained in the ventral pallidum (VP).\u003C\/p\u003E"},{"title":"Customizable, Ultra-high Density Optic Fiber-paired Multielectrode Array by 3D Nanoparticle Printing","field_investigator":"Rahul  Panat","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS110483-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9698508\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9698508\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Recent technological advances have led to the realization recording devices that can sample neuronal\nactivity from up to a few hundred channels in a limited area."},{"title":"DANDI: Distributed Archives for Neurophysiology Data Integration","field_investigator":"Satrajit Sujit Ghosh, Yaroslav O Halchenko","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-145","field_project_number":"1R24MH117295-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795271\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795271\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Neuroscientific data contain information from an incredible diversity of species, are generated by a plethora of\ndevices, and encapsulate the results of scientific thinking and decision making."},{"title":"Deep brain live imaging of cAMP and protein kinase A activities underlying synaptic- and circuit-level mechanisms during learned behaviors","field_investigator":"Shana M Augustin","field_institution":"National Institute on Alcohol Abuse and Alcoholism","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AA027740-01A1","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ENeuromodulation is crucial for information processing throughout the brain. Neuromodulators influence neuronal function by acting through G protein-coupled receptors (GPCRs) to alter neuronal excitability and synaptic transmission, which can then affect circuit functions.\u003C\/p\u003E"},{"title":"Defining the anatomical, molecular and functional logic of internal copy circuits involved in dexterous forelimb behaviors","field_investigator":"Eiman  Azim","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS111479-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9739115\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9739115\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nBehavior is movement, and the effective and efficient execution of movement has served as a fundamental\nevolutionary force shaping the form and function of the nervous system."},{"title":"Dendritic Computation and Representation of Head Direction in Retrosplenial Cortex","field_investigator":"Mark Thomas Harnett","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113079-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9818860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9818860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The mammalian cortex plays a critical role in integrating multiple streams of information to guide adaptive\nbehavior. For example, head direction (HD) information is combined with visual and spatial input in the mouse\nretrosplenial cortex (RSC)."},{"title":"Designing and deploying an expanded color palette of voltage indicators engineered for multiphoton microscopy","field_investigator":"Francois  St-Pierre, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113294-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829382\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829382\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nThe ability to track electrical activity in genetically defined neurons deep in the brain has long been sought by neuroscientists\nto unravel the functions of neuronal circuits in health and disease."},{"title":"Determining the role of muscle afferent signals in cortical proprioceptive representation","field_investigator":"Kyle  Blum","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe overall premise of this proposal is to understand how the transformation of the signals from proprioceptive\nafferents within muscles leads to the representation of movements in somatosensory cortex."},{"title":"Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber array","field_investigator":"Xin  Yu","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113278-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829194\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829194\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Brain dynamic low-frequency ("},{"title":"Developing genetically-encoded detectors for neuropeptide release based on class B G-protein coupled peptide receptors","field_investigator":"Zhiping P. Pang","field_institution":"Rbhs-Robert Wood Johnson Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9805402\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9805402\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nSynaptic transmission is mainly mediated by classical neurotransmitters such as glutamate and g-amino butyric\nacid (GABA) which transduce fast information flow in the brain. This process is tightly regulated by neuromodu-\nlators including monoamines and neuropeptides."},{"title":"Developing new tools for high throughput analysis of microcircuits and synapse ultrastructure using tagged vesicular transporters and deep learning.","field_investigator":"Daniela  Boassa, Thomas  Hnasko","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH120685-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9822844\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9822844\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nSynaptic dysfunction is a common feature of neuropsychiatric disease. For example, a hallmark of age-related\nneurodegenerative diseases such as Alzheimer\u2019s and Parkinson\u2019s is synaptic fibrilization and aggregation of\nkey proteins that participate in synapse and cell loss."},{"title":"Developing novel chemo-optogenetic tools for in vivo applications","field_investigator":"Pui Ying  Lam","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS112599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9805989\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9805989\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Optogenetics and chemo-optogenetics are powerful tools for modulating cell activities with light."},{"title":"Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.","field_investigator":"Benjamin E Deverman, Jordane  Dimidschstein, Gordon J Fishell","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH120096-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9804329\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9804329\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIn this proposal we aim to identify gene regulatory elements that permit the targeting and manipulation of brain\ncircuit models of human brain function."},{"title":"Development of new photo-releasable neuropeptide nano-vesicles for studying modulation in the brain","field_investigator":"Zhenpeng  Qin, Paul A Slesinger","field_institution":"University Of Texas Dallas","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS110499-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9698714\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9698714\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neuropeptides are important signaling molecules that regulate brain states, modify neural activity and control\nvascular tone in the nervous system."},{"title":"Dissecting circuits for local and long-range competitive inhibition in the mouse superior colliculus","field_investigator":"Shreesh P Mysore","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9746311\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9746311\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nThe SCid, a sensorimotor hub in the midbrain, plays a fundamental role in stimulus-guided behavior as well as spatial\nattention control."},{"title":"Dissecting distributed representations by advanced population activity analysis methods and modeling","field_investigator":"Shaul  Druckmann","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9776022\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9776022\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA central goal of systems neuroscience is to relate behavior to its underlying circuit dynamics. This task is\ncomplicated by the complex and circuitous paths along which information flows as it is encoded and processed\nin the many steps between sensory inputs and motor outputs."},{"title":"Dissecting the dual role of dopamine in context-dependent and learned behaviors","field_investigator":"Vanessa  Ruta","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9819947\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9819947\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDopamine plays a central role in motivation and reinforcement learning, allowing animals to take advantage of\ntheir current circumstances to optimize both present and future behavior."},{"title":"Dissecting the inhibitory architecture governing basal ganglia output","field_investigator":"Rebekah C Evans","field_institution":"National Institute of Neurological Disorders and Stroke","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS112417-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThe initiation and maintenance of organized movement through the basal ganglia is strongly influenced by its feed-forward and feedback inhibitory architecture. The substantia nigra pars compacta (SNc) and pedunculopontine nucleus (PPN) contribute to the overall output of the basal ganglia.\u003C\/p\u003E"},{"title":"Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor","field_investigator":"Kelly D Foote, Karim G Oweiss","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109845-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9663679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9663679\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\n Essential Tremor (ET) is a progressive disease that leads to significant disability and\nmarkedly diminished quality of life."},{"title":"Dynamic Neural Mechanisms of Audiovisual Speech Perception","field_investigator":"Michael S Beauchamp, Charles E Schroeder","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS113339-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829909\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829909\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\nSpeech perception is inherently multisensory: when conversing with someone that we can see,\nour brains combine auditory information from the voice with visual information from the face.\nSpeech perception lies at the heart of our interactions with other people and is thus one"},{"title":"Effects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers","field_investigator":"Ikbal  Sencan-Egilmez","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120053-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754481\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754481\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"This proposed project focuses on quantifying the spatial and temporal diversity in cortical oxygen metabolism and neurovascular coupling, and informing next generation of biophysical models of the Blood Oxygen Level Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) measurements by integr"},{"title":"Efficiency and Safety of Microstimulation Via Different Electrode Materials","field_investigator":"Xinyan Tracy Cui","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110564-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9713886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9713886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Microstimulation has been an invaluable tool for neuroscience researchers to infer functional connections\nbetween brain structures or causal links between structure and behavior."},{"title":"Efficient resource allocation and information retention in working memory circuits","field_investigator":"Shinung  Ching, Lawrence H Snyder","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028154-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9774513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9774513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nShort-term working memory is critical for all cognition. It is important to fluid intelligence by definition and is\ndisordered in many psychiatric conditions. It is also an ideal model system for studying the link between the\ndynamics and functions of neural circuits."},{"title":"Epigenomic cell-type classification and regulatory element identification in the human brain","field_investigator":"M Margarita Behrens, Joseph R Ecker","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-149","field_project_number":"1U01MH121282-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852895\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\u0026nbsp;\nUnderstanding\u0026nbsp;the\u0026nbsp;exact\u0026nbsp;cell-\u00adtype\u0026nbsp;composition\u0026nbsp;in\u0026nbsp;the\u0026nbsp;different\u0026nbsp;regions\u0026nbsp;of\u0026nbsp;the\u0026nbsp;human\u0026nbsp;brain\u0026nbsp;is\u0026nbsp;a\u0026nbsp;fundamental\u0026nbsp;step\u0026nbsp;\nwhen\u0026nbsp;trying\u0026nbsp;to\u0026nbsp;integrate\u0026nbsp;physiological,\u0026nbsp;behavioral,\u0026nbsp;neur"},{"title":"Expanding access to open-source data acquisition software for next-generation silicon probes","field_investigator":"Joshua H Siegle","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109043-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9645567\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9645567\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We plan to provide software support services for Neuropixels probes, a groundbreaking new tool for recording\nelectrical signals from the brain."},{"title":"Expanding field-of-view with reduced tissue displacement in micro-endoscopic computational imaging","field_investigator":"Steven M Blair, Rajesh  Menon, Jason D Shepherd","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829467\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829467\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nOptical imaging methods are well-established in neuroscience, but high-speed, high-\nresolution volumetric imaging of neural activity in deep tissue remains a challenge."},{"title":"Exploring the role of reactive astrocytes in brain inflammation using a novel combinatorial strategy","field_investigator":"Todd A Fiacco, Martin Miguel Riccomagno, Emma H Wilson","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1R01DA048815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800733\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nWhile numerous transgenic tools and approaches exist to enable manipulation of gene expression in\nmany cell types in the healthy brain, tools designed to target and study cells present only in the dis-\neased or damaged brain are lacking."},{"title":"Flexible active electrodes for frequency-multiplexed large-scale neural recording","field_investigator":"Matthew L Johnston, Ethan D Minot","field_institution":"Oregon State University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030007-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9693438\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9693438\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nState-of-the art neural recording technologies for in vivo applications can record simultaneously from a few\nhundred microelectrode recording sites. These recording sites are passive electrodes wired to read-out circuitry\noutside the brain."},{"title":"Functional Dissection of Neural Circuitry Underlying Parenting Behavior","field_investigator":"Weizhe  Hong","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113124-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9820188\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9820188\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nImpairments in social functioning is a prominent, debilitating symptom in many neuropsychiatric disorders, such\nas autism spectrum disorders, schizophrenia, and major depressive disorder."},{"title":"Functional dissection of thalamocortical interactions through genetically-defined TRN subnetworks","field_investigator":"Guoping  Feng, Michael M Halassa","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113245-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9827675\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9827675\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, plays essential roles in\nsensory processing, arousal and cognition."},{"title":"Functional implications of a patch\/matrix-like compartmental organization in the mouse inferior colliculus","field_investigator":"Alexandria Marie Lesicko","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834188\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834188\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nA major unresolved question in systems neuroscience is whether specialized anatomical structures support\nspecific functions in behavior. Therefore, this proposal will bridge the gap between anatomical circuit diagrams\nand their predicted functional roles."},{"title":"Generating a formal set of collaborative standards for sharing behavioral data and task designs to enable reproducibility in neuroscience","field_investigator":"Stephen Anthony Edwards, Adam  Kepecs","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH120034-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795228\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795228\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Abstract\nThe goal of this project is to develop an archival data format and a formal task specification\nlanguage to serve as standards for describing behavioral experiments."},{"title":"Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysis","field_investigator":"Gregory D Horwitz, Rozanne M Sandri-Goldin, Bert L Semler, Xiangmin  Xu","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120020-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795116\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795116\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe development of trans-synaptic viral tracers is an important component of the BRAIN Initiative. At present,\nthe lack of viral-based anterograde monosynaptic tracing tools with high signal strength and low toxicity is a gap\nin neuroscience."},{"title":"Genetically targeted high sensitivity voltage sensitive dyes","field_investigator":"Leslie M Loew","field_institution":"University Of Connecticut Sch Of Med\/Dnt","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030712-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829421\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829421\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nA primary focus of the NIH BRAIN Initiative is to develop new technologies for large scale high\nresolution imaging of brain activity. Imaging, as opposed to traditional electrode array based\nmeasurements, promise much greater spatial resolution and specificity."},{"title":"Head-mounted miniature microscopes for combined calcium imaging and electrophysiological measurement of neural circuit function in deep brain regions of behaving macaques","field_investigator":"Jonathan J Nassi","field_institution":"Inscopix, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R44MH122084-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9909084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9909084\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nA consensus has emerged in the Neurosciences over the last decade regarding the critical importance of\nunderstanding brain function at the level of neural circuits."},{"title":"High-density microgrid development for human neural interface devices","field_investigator":"Daniel R Cleary","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120886-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834280\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834280\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Abstract\nBrain-computer interfaces (BCI) offer hope to treat otherwise intractable neurological disease. However, the\ncurrent state of BCI is still short of the potential; solutions to fundamental biological and engineering problems\nmust be found before BCIs can be broadly used for patient care."},{"title":"High-throughput Physiological Micro-connectivity Mapping in Vivo","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH120680-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9822746\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9822746\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nMapping the synaptic connectivity of brain circuits is essential for obtaining a mechanistic understanding of the\nneural basis of behavior, learning, and cognition."},{"title":"Highly specific control of neurons with photoswitchable bioluminescent optogenetics.","field_investigator":"Nathan Christopher Shaner","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829466\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829466\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nHere, we will generate photoswitchable and photoactivatable bioluminescent (PS-BL and PA-BL) light\nsources. These constructs will be implemented to facilitate highly selective and \u201creprogrammable\u201d modulation of\nneural ensembles."},{"title":"Highly specific, renewable, and cost-effective antibody toolbox for 3D proteomic phenotyping of the brain","field_investigator":"Kwanghun  Chung, Daniel J Eichinger, Ignacio  Pino, Heng  Zhu","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121270-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852828\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852828\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nSystem-wide analysis of cell types in the brain is essential for understanding how complex cellular interactions\ngive rise to various brain functions."},{"title":"Imaging Brain Function with Biomechanics","field_investigator":"Samuel  Patz, Ralph  Sinkus","field_institution":"Brigham And Women\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB028664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837265\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837265\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\n Methods that improve upon the temporal resolution of current fMRI techniques are urgently needed to better\nunderstand the temporal characteristics of healthy brain function and to better identify the drivers of brain\ndysfunction."},{"title":"Implantable Microarray Probe for Real-Time Glutamate and GABA Detection","field_investigator":"Nicolaie Andrei Moldovan","field_institution":"Alcorix","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41NS115282-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9909493\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9909493\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\n There is an enormous need for the development of a new class of neurotransmitter (NT) sensors that are versatile,\nselective, sensitive and reliable to allow investigation of the neurobiological mechanisms of behavior and disease symptoms.\nThis STTR proposal will focus on implementin"},{"title":"Implantable Recording and Integrated Stimulation (IRIS) device for cortical experiments","field_investigator":"Andrew  Wilder","field_institution":"Ripple, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R44NS112072-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9776691\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9776691\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nWe propose to build a hermetically sealed implantable stimulation and recording system to enable\nclosed-loop experiments while mitigating the need for percutaneous leads."},{"title":"In vivo Imaging of Neuroactivity in the Deep Forward Scattering Regime Using Speckle Identification and Demixing (SPID) Microscopy","field_investigator":"Sylvain  Gigan, Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113251-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9828367\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9828367\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nOptical imaging of neuronal activity in the mammalian brain at depth and at high spatial and temporal resolution\nremains a key challenge in neuroscience."},{"title":"Input-specific imaging and manipulation of synaptic plasticity underlying social memory","field_investigator":"Mary L Phillips","field_institution":"Max Planck Florida Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832833\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832833\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nAscertaining the neural basis of behavior has been a cornerstone goal since the conception of neurobiology.\nWhile activity recording and loss-of-function studies have shed light on brain regions involved and necessary for\nthe expression of certain behaviors, they are unabl"},{"title":"Integrated Biophysical and Neural Model of Electrical Stimulation Effects","field_investigator":"Maksim V Bazhenov, Eric  Halgren","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109553-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800559\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800559\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Abstract\nElectrical stimulation is widely used to activate and\/or disrupt neuronal activity."},{"title":"Intercellular TWEAK\/Fn14 Cytokine Signaling in Sensory-Dependent Circuit Refinement","field_investigator":"Lucas M Cheadle","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120051-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754316\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754316\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"During postnatal brain development, newly assembled neural circuits are refined through the strengthening of a subset of synaptic connections and the concurrent elimination of others."},{"title":"Interneurons differentially regulate discrete pathways from ventral hippocampus","field_investigator":"Jennifer  Donegan","field_institution":"University Of Texas Hlth Science Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH121355-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9806339\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9806339\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Hippocampal microcircuits are comprised of excitatory pyramidal cells, which integrate information and innervate\ndownstream brain regions, and inhibitory interneurons, which function locally to regulate pyramidal cell activity\nand synchronicity."},{"title":"Interrogating Biophysical Mechanisms of Magnetogenetic Cell Stimulation at Radio Frequencies","field_investigator":"Chunlei  Liu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110554-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9712554\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9712554\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nMagnetogenetics is a recently proposed method for stimulating cells using electromagnetic fields. In one\napproach, radio-frequency (RF) electromagnetic fields are applied to stimulate membrane channel proteins such\nas TRPV1 and TRPV4 that are attached to ferritins."},{"title":"Investigating the molecular, cellular and circuit effects of transcranial magnetic stimulation","field_investigator":"Arnaud Y Falchier, Alexander  Opitz, Andreas  Vlachos","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109498-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9793736\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9793736\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nTranscranial magnetic stimulation (TMS) is a non-invasive brain stimulation method which can alter brain\nactivity in humans in a safe manner."},{"title":"Investigating the response of CNS neurons to electric and magnetic stimulation","field_investigator":"Shelley  Fried","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110575-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9716798\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9716798\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Our long-term goals are to better understand the response of neurons to artificial stimulation, and, to use this\nknowledge to develop new and more effective strategies for stimulating non- or improperly-functioning neurons\nof the CNS."},{"title":"Lensless, high-speed and multi-region volumetric Ca2+ imaging of up to 1cm2 brain surface across model animals","field_investigator":"Jacob T. Robinson, Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS110501-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9698734\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9698734\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY \/ ABSTRACT\nTo understand the highly integrated cognitive processes in the mammalian brain, and the neuronal basis of com-\nplex and ethologically relevant behavior, one requires fast, depth-penetrating and volumetric imaging techniques\nthat are compatible with free behavior such as du"},{"title":"Leveraging ethical dissension among capacity, beneficence and justice in clinical trials of neurotherapeutics in the severely disabled: lessons from schizophrenia","field_investigator":"Rachel A Davis, Judith Morse Gault, Elyn R. Saks","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121362-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9863120\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9863120\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nEthical concerns raised from both current and historically controversial psychosurgeries are driving disparities in\naccessibility to emerging BRAIN Initiative technology for those with severe, disabling, chronic mental illness like\nindividuals with treatment-refractory schiz"},{"title":"Mapping cerebellar granule cell function with novel genetic and optical tools","field_investigator":"Gerard Joey Broussard","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120887-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nRecent evidence from multiple laboratories in both human and animal models supports a role for the granule cell (GrC)\npathway of the cerebellum in representing a wide range of sensory, motor, and internal information."},{"title":"Mapping Developmental Lineage Relationships in the Cerebral Cortex","field_investigator":"Tomasz  Nowakowski","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121268-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852810\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\/Abstract\n The cerebral cortex contains an astonishing diversity of neuronal cell types distributed across dozens of\nfunctional areas, which emerge during early development for an apparently uniform neuroepithelium, and the\nradial glia cells, which act as neural stem cells."},{"title":"Mapping the neuronal circuitry underlying indirect striatal to hypothalamicconnectivity and its role in feeding","field_investigator":"Miriam E Bocarsly","field_institution":"National Institute on Alcohol Abuse and Alcoholism","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99AA027750-01","field_link":"","field_funded_status":"Active","field_grant_mechanism":"Training Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EFood consumption is fundamental to species survival and understanding the neuronal circuitry underlying feeding behaviors is of the utmost importance. Amassing evidence supports the idea that control of caloric intake is complex and involves calculations of hedonic value, reward and motivation.\u003C\/p\u003E"},{"title":"Massively Multiplexed Gold Microprobe Arrays for Whole-Mouse-Brain Recording","field_investigator":"Hui  Fang, Ross M Walker","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030710-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829405\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829405\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Understanding brain function requires the ability to record simultaneously from thousands or tens-of-\nthousands of neurons contributing to the dynamic activity in a neural circuit."},{"title":"Mechanism underlying Nerve Conduction Block by High Frequency (kHz) Biphasic Stimulation","field_investigator":"Changfeng  Tai","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109198-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795292\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795292\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nBased on the gate-control theory of pain, traditional spinal cord stimulation (SCS) to treat chronic back\/leg pain\nutilizes 40-60 Hz stimulation that activates spinal dorsal columns to elicit paresthesia over a patient\u2019s painful\nregion."},{"title":"Mechanisms of Active Sensing in Drosophila","field_investigator":"Marie  Suver","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS114179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9871513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9871513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The goal of this project is to study the cellular basis of active sensation. A crucial function of all nervous systems is to distinguish between sensory stimuli originating from the external world and that generated by our own movements."},{"title":"Mechanisms of Information Routing in Primate Fronto-striatal Circuits","field_investigator":"Thilo  Womelsdorf","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028161-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775812\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775812\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY \/ ABSTRACT\n This project focuses on developing new analysis tools to investigate the mechanisms of information\nrouting in primate fronto-striatal circuits during goal-directed behavior."},{"title":"Mechanisms underlying large-scale coordination of cortical activity during perceptual decisions","field_investigator":"Lucas  Pinto","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"It has become increasingly clear that both spontaneous and trained behaviors engage activity throughout the cortex. However, at least in the case of perceptual decisions, task complexity critically modulates the underlying large- and mesoscale cortical dynamics."},{"title":"Motion Sequencing for All: pipelining, distribution and training to enable broad adoption of a next-generation platform for behavioral and neurobehavioral analysis","field_investigator":"Sandeep R Datta","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9654850\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9654850\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Understanding the function of the nervous system requires a sophisticated understanding of its main\noutput, behavior."},{"title":"Multi-region \u0026#039;Network of Networks\u0026#039; Recurrent Neural Network Models of Adaptive and Maladaptive Learning","field_investigator":"Kanaka  Rajan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028166-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775964\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775964\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The massive neural activity data collected through transformative new technologies present an incredible\nopportunity in facilitating the mission of the BRAIN Initiative and the wider neuroscience community: to\nunderstand brain function."},{"title":"Multi-regional neural circuit dynamics underlying short-term memory","field_investigator":"Shaul  Druckmann, Nuo  Li","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113110-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9820011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9820011\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe focus of this BRAIN Initiative funding opportunity is to use \u201cinnovative approaches to understand how\ncircuit activity gives rise to a specific behavior\u201d. Cognitive behaviors arise from collective interactions of\nmultiple brain systems."},{"title":"Multielectrode Arrays for Neurotransmitter Detection with Fast Scan Cyclic Voltammetry","field_investigator":"Alexandros George Zestos","field_institution":"Microprobes For Life Science, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41NS113702-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9846413\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9846413\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\/Abstract\nThe brain is by far the most complex and heterogeneous organ in the human body. For years, there has\nbeen a growing and unmet need to develop multielectrode arrays for neurotransmitter sensing in\nmultiple brain regions simultaneously."},{"title":"Multilevel Analysis of Neuronal Computations Underlying the Robust Encoding of Sensory Information in the Mammalian Olfactory System","field_investigator":"Benjamin R Arenkiel, Paul  Pfaffinger","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-029","field_project_number":"1UF1NS111692-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9749471\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9749471\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A key problem in neuroscience is to uncover fundamental principles and algorithms that allow\nneuronal networks to perform the complex calculations that underlie normal behavior effectively and\nefficiently."},{"title":"Multimodal Stainless Steel Neural Interfaces for Large-scale Recording and Modulation in Large Animals","field_investigator":"Maysamreza  Chamanzar","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113303-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829431\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829431\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nIn this proposal a course of research is proposed to design and implement high-density multimodal (electrical\nand optical) neural probes on stainless steel for robust, reliable and large-scale recording from thousands of\nneurons in large animal (primate) brains."},{"title":"Multiscale analysis of how the basal ganglia impact cortical processing in behaving mice","field_investigator":"Dieter  Jaeger","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS111470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9738272\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9738272\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nThe overall goal of this project is to determine how output from the basal ganglia influences cerebral cortical\nactivity in the processes of decision making, motor planning, and movement execution."},{"title":"Neural Computation for Innate Behaviors in the Superior Colliculus","field_investigator":"Markus  Meister","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS111477-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9738880\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9738880\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Neural computation for innate behaviors in the superior colliculus\nThe long-term goal of the proposed research is to understand how the brain makes sense of the onslaught of\nsensory data to extract just the few bits of relevant knowledge needed to make a decision."},{"title":"Neural Computations Underlying Vocal Sensorimotor Transformations","field_investigator":"Michael A Long","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113071-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9818181\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9818181\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor\ntransformation."},{"title":"Neural representation of mating partners by male C. elegans","field_investigator":"Scott Warren Linderman, Aravinthan D. Samuel, Paul Warren Sternberg","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9820157\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9820157\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nUnderstanding how neural circuits create animal behavior requires knowing the system-wide activity patterns\nthat connect sensory experience to motor activities, all within the full set of feedback loops by which actuated\nmotor decisions modulate the animal\u0027s perceptions of itself and"},{"title":"Neural signatures of learning complex environments in the amygdala-prefrontal network","field_investigator":"David  Barack","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99DA048748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754494\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754494\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The ability to learn and think about complex situations is central to a range of human cognitive\nfunctions, including navigation, reasoning, and decision making."},{"title":"Neuro-glio-vascular interactions in vivo probed with optical imaging","field_investigator":"Congwu  Du, Yingtian  Pan","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048808-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9799749\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9799749\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"This application, \u0022Neuro-glio-vascular interactions in vivo probed with optical imaging\u0022, will address the\nbroad challenge of the BRAIN Initiative (Innovative Neurotechnologies) and the targeted challenge\n(tools to target, identify and characterize non-neuronal cells in the brain)."},{"title":"Neuromodulation approaches for restoring dexterous control following cortical stroke.","field_investigator":"Preeya  Khanna","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9834150\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9834150\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years.\nDespite physical therapy, about 50% of stroke survivors have impaired hand function, which strongly impacts\nactivities of daily living and independence; novel treatment methods a"},{"title":"Neuronal circuits for context-driven bias in auditory categorization","field_investigator":"Yale E Cohen, Maria Neimark Geffen, Konrad P. Kording","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113241-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9827841\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9827841\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"NEURONAL CIRCUITS FOR CONTEXT-DRIVEN BIAS IN AUDITORY CATEGORIZATION\n In everyday life, because both sensory signals and neuronal responses are noisy, important cognitive tasks, such\nas auditory categorization, are based on uncertain information."},{"title":"NeuropixelsUltra: Dense arrays for stable, unbiased, and cell type-specific electrical imaging","field_investigator":"Timothy D Harris, Shawn R. Olsen, Nicholas  Steinmetz","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113252-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9828472\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9828472\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Summary\/Abstract\nUnderstanding the neural mechanisms underpinning cognition and behavior requires the\nability to measure the dynamics and interactions of populations of neurons spread across\nmany brain regions."},{"title":"New approaches for single cell tagging, editing and profiling of glial cells in vivo","field_investigator":"Weizhe  Hong","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048811-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800386\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800386\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\nThe mammalian central nervous system supports a multitude of cognitive and behavioral functions through\ncoordinated action of different neural circuits that are composed of diverse sets of differentiated cell types,\nincluding both neurons and non-neuronal cells."},{"title":"New methods and theories to interrogate organizational principles from single cell to neuronal networks","field_investigator":"Mara  Dierssen, Bing  Ye","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028159-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775774\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775774\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nUnderstanding how individual neurons contribute to network functions is fundamental to neuroscience. Recent\nyears have seen exciting progresses in the reconstructions of single-neuron morphologies and wiring diagrams\nat the level of individual synapses."},{"title":"Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuits","field_investigator":"Matthew Ryan Banghart, Bernardo L Sabatini, Lin  Tian","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113295-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829386\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829386\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project summary\nThe mammalian brain is remarkably dynamic and can quickly adjust its functional state in response to changes\nin the environment. For example, when a salient event occurs, the brain enters a mode that enhances memory\nformation."},{"title":"Next Generation Cell-Type-Specific Viral Vectors for Non-Neuronal Brain Cell Types","field_investigator":"Michael Eldon Greenberg","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048787-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9798697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9798697\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary:\nWhile traditionally conceived as passive support elements for neuronal networks, non-neuronal brain cells are\nnow appreciated as dynamic integral components of central nervous system (CNS) circuitry."},{"title":"Next-generation high-resolution diffusion MRI resolving cortical columns and layers in vivo","field_investigator":"Allen W Song, Trong-Kha  Truong","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB028644-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9833660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9833660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nIn response to the NIH RFA-EB-17-003 on \u201cProof of Concept Development of Early Stage Next Generation\nHuman Brain Imaging\u201d, we propose a two-year plan to develop the much needed hardware and software\nsolutions for ultrahigh resolution diffusion MRI to delineate cortical columns and layers in"},{"title":"Non-Invasive Nanoparticle Platform for Tool Delivery to the Brain","field_investigator":"Ute H Hochgeschwender, Julien  Rossignol, Ajit  Sharma","field_institution":"Central Michigan University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030012-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9693489\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9693489\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nThe goal of this proposal is to assess the feasibility of a non-invasive nanoparticle platform for tool delivery to\nthe brain."},{"title":"Novel fluorescent sensors for imaging neuromodulation","field_investigator":"Yang  Dan, Jun  Ding, Yulong  Li, Dayu  Lin","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113358-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832339\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832339\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"SUMMARY\n Animal behaviors are orchestrated by the sophisticated nervous system, which is\ndynamically regulated by neuromodulators including lipids and neuropeptides."},{"title":"Novel tools for spatiotemporal modulation of astrocytes in neuronal circuits","field_investigator":"Mriganka  Sur","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA049005-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9810860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9810860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Astrocytes are a major class of non-neuronal cells in the brain whose crosstalk with neurons at the synaptic\nand circuit levels remains poorly understood."},{"title":"Optimization and Delivery of Bioactive Coating for High Yield and Stable Neural Recording","field_investigator":"Xinyan Tracy Cui","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113279-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829195\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829195\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nThe ability to monitor activity of ensembles of neurons at single-cell resolution, chronically, over long time\nperiods is greatly desired by neuroscientists. A variety of multi-electrode arrays (MEAs) have been developed\nfor in vivo studies."},{"title":"Optimization and dissemination of non-linear Acousto-Optic Lens two-photon microscopy for high speed multiscale 3D imaging","field_investigator":"Jessica A Cardin, Jeffrey S Diamond, Darcy S Peterka, Robin Angus Silver","field_institution":"University College London","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS113273-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTo understand brain function, it is essential to identify how information is represented in neuronal population\nactivity and how it is transformed by individual neurons as it flows through microcircuits."},{"title":"Opto-Crown: Transparent skulls with embedded optics for cortex-wide cellular resolution imaging in freely moving mice","field_investigator":"Edward S. Boyden, Suhasa B Kodandaramaiah, John L Sherwood","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113287-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829281\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829281\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nThe activity patterns of millions of neurons organized in circuits distributed across multiple brain regions\nmediate our interaction with the outside world."},{"title":"Pediatric Deep Brain Stimulation: Neuroethics and Decision Making","field_investigator":"Jennifer  Blumenthal-Barby, Gabriel  Lazaro-Munoz, Eric A. Storch","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1RF1MH121371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9862214\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9862214\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\n Deep brain stimulation (DBS) and adaptive DBS systems are currently used in children with dystonia,\nepilepsy, and Tourette Syndrome, and its use is expanding to other neuropsychiatric conditions."},{"title":"Proprioceptive Coding of Jaw Movement during Orofacial Behavior","field_investigator":"William Paul Olson","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832792\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832792\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nIntegration of sensory information with motor commands allows movement to be adaptable. For example,\nmany survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement\ntrajectories based on interaction with objects (e.g."},{"title":"Quantifying causality for neuroscience","field_investigator":"Konrad P. Kording","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028162-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775861\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775861\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract:\nCausality is central to neuroscience. For example, we might ask about the causal effect of a neuron on another\nneuron, or its influence on perception, action, or cognition. Moreover, any medical approaches aim at\nproducing a causal effect \u2013 effecting improvements for patients."},{"title":"Rapid and Agile Multi-Photon Optical Imaging Over Large Neural Volumes","field_investigator":"Mark A Foster","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030011-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9693482\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9693482\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/ Abstract\nMulti-photon, depth-sectioning microscopes are of paramount importance in capturing neural activity with cellular\nresolution."},{"title":"Rapid Evaluation of Neuronal Activity in the Intact Whole-Brain at Single Cell Resolution","field_investigator":"Damian G. Wheeler","field_institution":"Translucence Biosystems, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH119989-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9776196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9776196\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\nNew imaging tools are needed for brain-wide visualization of the neural activity underlying defined\nbehaviors. Live imaging techniques such as fMRI and MEG measure activity across the brain, but\nthese methods cannot resolve single cell activity."},{"title":"Rapid, single-cell level molecular phenotyping of intact brains via active immunohistochemistry","field_investigator":"Adam C Hall, Frank  He, Jeffrey  Stirman","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH121158-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9845254\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9845254\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract. Cell-level analysis and a growing appreciation of cell-type diversity have transformed our\nunderstanding of the brain."},{"title":"Re-engineering Rabies Virus","field_investigator":"Ian R Wickersham","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH120017-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795068\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795068\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nEvery part of the brain is composed of dense tangles of heavily-interconnected neurons of many different types,\neach playing completely different roles in the circuitry."},{"title":"Relating functional MRI to neuronal activity: accounting for effects of microarchitecture","field_investigator":"Anna I Blazejewska","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754470\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits."},{"title":"Responsive Neurostimulation for Loss of Control Eating","field_investigator":"Casey Harrison Halpern, James D Lock, Robert C Malenka, Tara L Skarpaas (Crowder)","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103446-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588174\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588174\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nBackground\/Description."},{"title":"Responsive Neurostimulation for Post-Traumatic Stress Disorder","field_investigator":"Jean-Philippe  Langevin","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS107673-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9730252\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9730252\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\nPost-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its\nbiological substrate, amygdala reactivity to trauma reminders13,14."},{"title":"Revealing neural computations through combined optical and electrical recordings","field_investigator":"Gregory Darin Field, Alexander  Sher","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111645-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9745392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9745392\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA major limitation to understanding the brain is a shortage of technologies for tracking the\nactivity of large populations of individual neurons across multiple layers of synaptic processing.\nIdeally, these measurements of population activity would be compatible with both optogenetic"},{"title":"Revealing the transcriptional and developmental mechanisms of interneuron identity","field_investigator":"Megan  Crow","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH120050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Cortical GABAergic interneurons are critical components of neural circuitry, and their dysfunction has been\nlinked to neurodevelopmental diseases."},{"title":"Scaling up spatial RNA profiling with compressed sensing","field_investigator":"Fei  Chen, Yonina  Eldar","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121289-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852697\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Single cell RNA-Seq (scRNA-Seq) and Imaging Transcriptomics (IT) methods have put a systematic\nunderstanding of the brain and brain diseases through comprehensive 3-dimensional map of its constituent\ncell types within reach."},{"title":"Self-Image-Guided Flexible Ultrasonic Interrogation Platform for Neural Dust","field_investigator":"Mehdi  Kiani","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829145\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829145\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nDynamic mapping of complex brain circuits by monitoring and modulating brain activity at a large scale will\nenhance our understanding of brain functions, such as sensation, thought, emotion, and action."},{"title":"Sensory recruitment by working memory: neuronal basis and neural circuitry","field_investigator":"Behrad  Noudoost","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113073-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9818609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9818609\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Working memory maintenance is fundamental for the orderly pursuit of goals in the\nface of irrelevant, distracting stimuli."},{"title":"Single cell isoform expression across mouse brain regions and development","field_investigator":"Hagen Ulrich Tilgner","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-148","field_project_number":"1RF1MH121267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852789\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Single cell isoform expression across mouse brain regions and development\nMuch of the mouse brain\u0027s biology is defined by the action of long RNA and protein isoforms in distinct cell\ntypes and brain regions."},{"title":"Single cell transcriptional and epigenomic atlas of the macaque brain across the lifespan","field_investigator":"Michael L Platt, Jay Ashok Shendure, Noah  Snyder-Mackler","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-149","field_project_number":"1U01MH121260-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9852073\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9852073\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT \/ SUMMARY\nNew technologies are enabling molecular profiling of single brain cells at remarkable throughput."},{"title":"Single Neuron Analyzer for Multi-modal, Cross-dataset (Epi)genomic Cell Type Datasets","field_investigator":"Eran A Mukamel","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH120015-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795063\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795063\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nOur project will create a computational resource, the Single Neuron Analyzer, to support the neuroscience\ncommunity\u2019s efforts to build a reproducible, comprehensive, data-driven atlas of brain cell types."},{"title":"Spinal Circuits for the Control of Dextrous Movement","field_investigator":"Martyn D Goulding","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS112959-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9815384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9815384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Overall\nLocal networks within the spinal cord represent an essential computational layer for the control of limb-driven\nmotor behaviors, integrating descending and sensory inputs to coordinate dexterous motor output."},{"title":"Spinal Effects of Cortical Stimulation: Mechanisms and Functional Impact","field_investigator":"Jonathan Saul Carp, Yu  Wang, Jonathan Rickel Wolpaw","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS110577-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9868054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9868054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\n Because activity-dependent plasticity is ubiquitous in the CNS, brain stimulation may have long-term effects on\nareas to which the stimulated area connects. These effects have received little attention."},{"title":"Structural and functional connectivity of the social decision-making network","field_investigator":"Adam Steven Smith","field_institution":"University Of Kansas Lawrence","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9819957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9819957\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nHumans and numerous other species live in complex social environments, requiring many of our most important\ndecisions to be made in the context of social interactions."},{"title":"Structural, single-cell transcriptomic, and functional 3-photon mapping of spinal pain circuits","field_investigator":"Prakash  Kara, Suhasa B Kodandaramaiah, Lyudmila H Vulchanova","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111654-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9746442\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9746442\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nSpinal dorsal horn interneurons (IN) integrate somatosensory inputs and control their access to spinal\nprojection neurons (PrN) that transmit nociceptive information to supraspinal components of pain pathways.\nThe heterogeneity of dorsal horn neurons, limited knowledge on their conne"},{"title":"Subcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During Behavior","field_investigator":"Mai-Anh  Vu","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9833927\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9833927\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\nThe basal ganglia are a group of deep brain nuclei that play a central role in motivating, selecting, and learning\nactions."},{"title":"Technology development for closed-loop deep brain stimulation to treat refractory neuropathic pain","field_investigator":"Edward  Chang, Philip Andrew Starr","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS109556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9655963\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9655963\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nMany pain syndromes are notoriously refractory to almost all treatment and pose significant costs to patients\nand society. Deep brain stimulation (DBS) for refractory pain disorders showed early promise but\ndemonstration of long-term efficacy is lacking."},{"title":"Thalamic stimulation to prevent impaired consciousness in epilepsy","field_investigator":"Hal  Blumenfeld","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS112826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9811685\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9811685\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY \/ ABSTRACT\nImpaired consciousness during seizures has a major negative impact on quality of life for people with epilepsy.\nConsequences include risk of motor vehicle accidents, drowning, poor work and school performance, and\nsocial stigmatization."},{"title":"The cerebro-cerebellar-basal-gangliar network for visuomotor learning","field_investigator":"Stefano  Fusi, Michael E. Goldberg, Peter  Strick","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS113078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9818745\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9818745\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nVisual learning is critical to the lives of human and non-human primates. Visuomotor association, the\nassignment of an arbitrary symbol to a particular movement (like a red light to a braking movement), is a well-\nstudied form of visual learning."},{"title":"The glial mechanism for electrical brain stimulation","field_investigator":"Hai-Long  Wang, Gregory A Worrell, Long-Jun  Wu","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS112144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795519\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795519\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT:\nElectrical brain stimulation (EBS) is a FDA-approved neuromodulation therapy applied to several\nneurological disorders. However, the molecular basis of its efficacy remains unclear."},{"title":"The Neural Mechanism of Interval Timing in Drosophila","field_investigator":"Ashley Danielle Smart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH120865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9832447\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9832447\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n There is no dedicated sensory organ for time, and yet our brains are able to use time to anticipate the\nenvironment and adapt."},{"title":"The Neuroimaging Data Model: FAIR descriptors of Brain Initiative Imaging Experiments","field_investigator":"David Bryant Keator","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-146","field_project_number":"1RF1MH120021-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9795124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9795124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nReuse of existing neuroscience data relies, in part, on our ability to understand the experimental design and\nstudy data."},{"title":"Time-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain","field_investigator":"Maria Angela  Franceschini","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB028660-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9837223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9837223\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nFunctional near-infrared spectroscopy (fNIRS) is a well-established neuroimaging method which enables\nneuroscientists to study brain activity by non-invasively monitoring hemodynamic changes in the cerebral cortex.\nIn the last decade, the use of fNIRS has increased significa"},{"title":"Tools for modeling state-dependent sensory encoding by neural populations across spatial and temporal scales","field_investigator":"Stephen V David, Nima  Mesgarani","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB028155-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9774688\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9774688\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThroughout life, humans and other animals learn statistical regularities in the natural acoustic environment.\nThey adapt their hearing to emphasize the features of sound that are important for making behavioral\ndecisions."},{"title":"Tools to broaden access to high-throughput functional connectomics","field_investigator":"Wei-Chung Allen Lee, Thomas  Macrina, Hyunjune Sebastian Seung, John  Tuthill","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117808-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9822460\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9822460\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe goal of this proposal is to develop a widely adoptable, high-throughput, functional connectomics platform to\nsemi-automatically reconstruct and analyze the synaptic connectivity of functionally characterized neuronal\nmicrocircuits."},{"title":"Towards a unified framework for dopamine signaling in the striatum","field_investigator":"John  Assad, Sandeep R Datta, Samuel J Gershman, Scott Warren Linderman, Bernardo L Sabatini, Naoshige  Uchida, Linda E Wilbrecht","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS113201-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9823712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9823712\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project abstract\nAnimals, including humans, interact with their environment via self-generated and continuous actions that\nenable them to explore and subsequently experience the positive and negative consequences of their actions.\nAs a result of their interactions with the environment, animals alter"},{"title":"Transparent neural interface for in vivo interrogation of human organoids","field_investigator":"Anna  Devor","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY030727-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9836984\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9836984\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Recent advances in pluripotent stem cell technology have enabled generation of neuronal cell lines and\ncerebral organoids from human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells\n(hiPSCs) derived from peripheral tissues."},{"title":"Ultra-flexible \u03bcLED Optoelectrode Platform for Brain Circuit Mapping: a Longitudinal, Minimally Invasive Tool","field_investigator":"Gyorgy  Buzsaki, John P Seymour, Kensall David Wise, Euisik  Yoon","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS113283-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9829259\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9829259\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nSignificance: Neuroscientists have set ambitious goals for electrophysiology and stimulation technology but\nthese tools continue to lag behind."},{"title":"Unbiased Epigenomic and Transcriptomic Profiling of Non-Neuronal Cells in the Mouse Brain","field_investigator":"Nicola J Allen, Joseph R Ecker","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048816-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9800781\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9800781\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe mammalian brain is composed of 50% neurons and 50% non-neuronal glial cells, including astrocytes\n(20%) which regulate synaptic transmission and provide metabolic support for neurons, oligodendrocytes\n(25%) that speed up neuronal action potential conduction, and microglia (5-15%) which "},{"title":"Uncovering Population-Level Cellular Relationships to Behavior via Mesoscale Networks","field_investigator":"David E Carlson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026937-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9775689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9775689\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract:\nThere is significant current interest in understanding how neurons relate to whole-brain\nnetworks and how these networks coordinate to give rise to behavior."},{"title":"Understanding Brain Development Through the Lens of Metabolism","field_investigator":"Aparna  Bhaduri","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS111731-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9754464\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9754464\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"The human cerebral cortex is a complex structure comprised of distinct areas with specialized functions and connectivity patterns."},{"title":"Understanding how post-translational palmitoylation influences in vivo molecular and circuit dynamics during learning","field_investigator":"Jessica C Nelson","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99NS111736-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9892327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9892327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Habituation is a simple form of learning in which animals reduce responsiveness to repetitive stimuli. Habituation forms a foundation for normal cognition; without the ability to filter irrelevant stimuli, animals are unable to perform more complex cognitive tasks."},{"title":"Understanding the logic of the brain-wide olfactory bulb projectome","field_investigator":"Dinu Florentin Albeanu, Alexei  Koulakov","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS111673-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9747001\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9747001\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nTo date, fundamental understanding of which features of odorants are decoded by the brain, and how\ninformation about these features is channeled through the olfactory system is still lacking."},{"title":"Using Direct Brain Stimulation to Study Cognitive Electrophysiology","field_investigator":"Michael Jacob Kahana","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS113198-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9823648\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9823648\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Abstract\n Our project aims to form a multi-site consortium that will carry out fundamental exper-\niments to elucidate the mesoscopic and microscopic neural dynamics underlying human\nmemory and use direct brain stimulation as a manipulative tool to study those dynamics.\nAdditionally, we seek "},{"title":"Validated tools for identifying, characterizing, and targeting all non-neuronal cells in the brain and determining the neuro-glio-vascular connectome","field_investigator":"Chenghua  Gu","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1RF1DA048786-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9798582\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9798582\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract:\nProper function of precisely wired neural circuits depends on a close physical and functional relationship with an\nequally complex and overlapping vascular network."},{"title":"Ventromedial prefrontal cortex regulation of fear memory expression","field_investigator":"Kirstie Alyssa Cummings","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-814","field_project_number":"1K99MH122228-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9871708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9871708\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Anxiety disorders such as post-traumatic stress disorder (PTSD) typically nucleate when individuals experience a highly traumatic event. One hallmark of PTSD is pronounced expression of fear and resistance to fear-suppressing behavioral therapies."},{"title":"Visual coding in freely moving behavior","field_investigator":"Cristopher M Niell","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222019-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2019\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS111669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9747079\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9747079\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nVision is an active sense that we use to explore the world around us."},{"title":"3D-Fast Optical Interface for Rapid Volumetric Neural Sensing and Modulation","field_investigator":"Emily  Gibson, Cristin G Welle","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029458-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591501\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591501\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTo further our understanding of the function of neural circuits, there is a need for new tools that can collect\nsimultaneous measurements from large populations of neurons involved in a common neural computation and\nprovide precise functional modulation."},{"title":"A 100\u03bcm Scale Single Unit Neural Recording Probe Using IR-Based Powering and Communication","field_investigator":"David  Blaauw","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029452-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591356\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591356\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\n In this research proposal, we present a new approach for recording and transmitting neural signals at the level of\nsingle neurons using micron-scale distributed implants referred to as micro-probes (mProbes)."},{"title":"A 5-dimensional connectomics approach to the neural basis of behavior","field_investigator":"Paul S Katz","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-008","field_project_number":"1U01NS108637-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9614766\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9614766\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nThis project is a collaboration between researchers at four universities to examine how the brain makes\ndecisions. When a human or any animal moves through the world, it must make constant decisions about what\nto do next."},{"title":"A Biomimetic Approach Towards a Dexterous Neuroprosthesis","field_investigator":"Michael L. Boninger","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS107714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9587834\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9587834\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nCervical spinal cord injury results in the loss of arm and hand function, which significantly limits independence\nand results in costs over the person\u2019s lifespan."},{"title":"A Facility to Generate Connectomics Information","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9645829\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9645829\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The goal of this proposal is to disseminate high resolution large volume serial section electron\nmicroscopy data to neuroscientists."},{"title":"A Fast, Accurate and Cloud-based Data Processing Pipeline for High-Density, High-Site-Count Electrophysiology","field_investigator":"Nathan G Clack, Bruce  Kimmel","field_institution":"Vidrio Technologies, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH114811-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9414851\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9414851\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The past decade has seen major advances in the tools available to neuroscientists, making it possible to ask\nincreasingly specific questions regarding which neurons and circuits are correlated with, necessary for, and\nsufficient for, specific behavioral or computational functions."},{"title":"A fully biological platform for monitoring mesoscale neural activity","field_investigator":"Kafui  Dzirasa","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591349\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591349\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"A fully biological platform for monitoring mesoscale neural activity\n One of the barriers to understanding the human brain is due to its geometry. Accessing\nbrain tissue at single cell resolution has classically involved implanting electrodes (metallic or\noptical) directly into the brain."},{"title":"A high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs","field_investigator":"Jose Luis Contreras-Vidal, Svenja  Knappe","field_institution":"University Of Houston","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB027004-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617587\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617587\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG\nsystem that can operate without external shielding that will lead to Advances in Human Neuroscience and\ntransformative advances in our understanding of the Human Brain \u2018in Action and in Context\u2019,"},{"title":"A method for anterograde trans-synaptic tracing","field_investigator":"Donald B Arnold","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH116989-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583942\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583942\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Although considerable information about neuronal circuits has been generated from experiments where\nretrograde transsynaptic tracing has been performed using Rabies Virus, there is no comparable technique for\ntranssynaptic tracing in the anterograde direction."},{"title":"A TOF, DOI, MRI compatible PET detector to support sub-millimeter neuroPET imaging","field_investigator":"Sergei  Dolinsky, Robert S Miyaoka","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB026964-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9616697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9616697\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nThe overall goal of this research is to develop next generation positron emission tomography (PET) detector\ntechnology to support non-invasive, quantitative brain imaging at spatial and temporal resolutions currently not\nachievable with human neuro-PET systems."},{"title":"AChMRNS: Nanosensors for Chemical Imaging of Acetylcholine Using MRI","field_investigator":"Heather A Clark, Christopher A Flask","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107713-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588063\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588063\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nThe neurotransmitter acetylcholine is widely distributed in the central nervous system and brain,\nand is a key signaling molecule involved in neural function."},{"title":"Advanced MOTEs: Injectable Microscale Optoelectronically Transduced Electrodes","field_investigator":"Jesse Heymann Goldberg, Paul  Mceuen, Alyosha Christopher Molnar, Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107687-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588702\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588702\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nOur goal is to develop a new class of electrophysiological recording devices, on the same physical scale as the\nneurons they record, by combining modern imaging with implanted optoelectronics."},{"title":"An open source, wireless, miniature microscope for monitoring neuronal activity","field_investigator":"Michele A Basso, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107668-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588792\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588792\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nRecent years have seen a boon in the development of new molecular, genetic and imaging tools designed to\ndissect brain circuits that give rise to behavior in live animals."},{"title":"An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal Neural Recordings","field_investigator":"Duygu  Kuzum","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029466-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591591\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591591\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal\n Neural Recordings\n A major goal of neuroscience is to record the activity of all neurons in an area of\nan intact brain and understand the relationship between neural activity and behavior.\nHowever, with current technologies"},{"title":"Assessing the Effects of Deep Brain Stimulation on Agency","field_investigator":"Adina L Roskies","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-500","field_project_number":"1RF1MH117813-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9609947\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9609947\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nRecent advances in neurotechnologies have provided us with the ability to modulate brain function by\ndirect and indirect interventions."},{"title":"Auditory brain-computer interface for communication","field_investigator":"Daniel James Thengone","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118709-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668360\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668360\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n A fundamental end-goal of brain-computer interfaces (BCI) is to enable communication in individuals\nwith severe motor paralysis. BCIs decode the neural signals and accomplish the intended goal via an effector,\nsuch as a computer cursor or a robotic limb."},{"title":"Autonomously-activating bioluminescent reporters to enable continuous, real-time, non-invasive brain cell imaging","field_investigator":"Gary S Sayler","field_institution":"490 Biotech, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43MH118186-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9621526\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9621526\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Autonomously-activating bioluminescent reporters to enable continuous, real-time, non-\n invasive brain cell imaging\nProject Summary\nThis Small Business Innovation Research (SBIR) Phase I project proposes to develop a set of genetically encoded,\nself-exciting bioluminescent (autobioluminescent) optic"},{"title":"Bidirectional Hybrid Electrical-Acoustic Minimally Invasive Implants for Large-Scale Neural Recording and Modulation","field_investigator":"Mehdi  Kiani","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9590465\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9590465\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nDynamic mapping of complex brain circuits by monitoring and modulating brain activity at large scale will\nenhance our understanding of brain functions, such as sensation, thought, emotion, and action."},{"title":"Bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals","field_investigator":"Daniel  Razansky, Dmitry  Rinberg, Shy  Shoham","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107680-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588727\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588727\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nNeuroscience has an essential requirement for large-scale neural recording and\nperturbation technologies for the understanding of brain function, as well as in the\ndiagnosis and treatment of neurological disorders."},{"title":"Boss: A cloud-based data archive for electron microscopy and x-ray microtomography","field_investigator":"Brock A. Wester","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-255","field_project_number":"1R24MH114785-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588690\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588690\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Abstract\nDue to recent technological advances, it is possible to image the high-resolution structure of brain volumes at\nspatial extents that are much larger than was previously possible."},{"title":"Brain-wide correlation of single-cell firing properties to patterns of gene expression","field_investigator":"Adam Ezra Cohen","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH117042-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584464\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584464\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nBrain-wide correlation of single-cell firing properties to patterns of gene expression\nEvery neuron expresses thousands of proteins which, through their interactions with each other\nand with other small molecules, imbue the neuron with its functional properties."},{"title":"Breaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and Neuroenergetics","field_investigator":"Wei  Chen, Xiao-Hong  Zhu","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB026978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617144\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617144\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT\u0026nbsp;SUMMARY\u0026nbsp;\n\u0026nbsp; Understanding\u0026nbsp;how\u0026nbsp;neural\u0026nbsp;circuits\u0026nbsp;operate\u0026nbsp;and\u0026nbsp;interconnect\u0026nbsp;at\u0026nbsp;mesoscopic\u0026nbsp;(sub-\u00admillimeter)\u0026nbsp;scale,\u0026nbsp;and\u0026nbsp;how\u0026nbsp;\nneuroenergetic\u0026nbsp; metabolism\u0026nbsp; and\u0026nbsp; neurotransmitters\u0026nbsp; support\u0026nbsp; brain\u0026amp;nb"},{"title":"Building analysis tools and a theory framework for inferring principles of neural computation from multi-scale organization in brain recordings","field_investigator":"Friedrich T Sommer","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026955-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615743\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615743\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nThe BRAIN initiative is enabling ground-breaking techniques for brain recordings that\nwill permit a unique view onto the dynamics of neural activity. However, inferring brain\nfunction from multi-channel physiological recordings is challenging."},{"title":"C-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparative","field_investigator":"Richard Cameron Craddock, Michael Peter Milham","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH114806-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591465\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591465\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording,\nand macroscale neuroimaging techniques in human and non-human animal models in order to develop a\nmultilevel understanding of human brain function."},{"title":"Causal mapping of emotion networks with concurrent electrical stimulation and fMRI","field_investigator":"Ralph  Adolphs, Matthew A. Howard, Russell A Poldrack","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-019","field_project_number":"1U01NS103780-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9419512\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9419512\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Understanding human brain function requires knowledge of its connectivity: how one structure\ncausally influences other components of the network."},{"title":"Causally linking dendritic Ca2+ dynamics to CA1 circuit function and spatial learning using novel tools to precisely manipulate an endogenous Ca2+ buffering process","field_investigator":"Justin  O\u0026#039;hare","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668711\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668711\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"In dendrites, Ca2+ is critical in determining how neurons respond to incoming excitation."},{"title":"Cell atlas of mouse brain-spinal cord connectome","field_investigator":"Hong-Wei  Dong, Huizhong Whit Tao, Li I Zhang","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-230","field_project_number":"1U01MH116990-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583948\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583948\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nAlthough great efforts have been dedicated to characterizing neuronal cell types in the brain, systematic\nstudies on the brain-spinal cord connectome and associated spinal neuronal types are lacking."},{"title":"Circuit and Synaptic Mechanisms of Visual Spatial Attention","field_investigator":"Bilal  Haider","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668638\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Sensory processing is a way to understand neural circuits and their functions during behavior.\nBehavioral context strongly affects sensory processing. For example, a brief visual stimulus is\neasier to detect if it appears in a predictable spatial location."},{"title":"Circuit mechanisms for encoding naturalistic motion in the mammalian retina","field_investigator":"Wei  Wei","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109990-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668818\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668818\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nMotion detection, a fundamental computation of the visual system, begins in the retina. In the\nmammalian retina, the direction of moving objects is computed by the direction-selective circuit.\nThe retinal output of this circuit is provided by direction-selective ganglion cells (DSGCs)."},{"title":"Circuit mechanisms underlying learned changes in persistent neural activity","field_investigator":"Emre  Aksay, Mark S Goldman, Hyunjune Sebastian Seung","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104926-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451093\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451093\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nPersistent neural activity, a sustained response following brief stimuli that is observed in many\nbrain networks, needs to be appropriately tuned to meet the exacting demands of various motor\nand cognitive tasks."},{"title":"Circuitry underlying response summation in mouse and primate: Theory and experiment","field_investigator":"Nicolas  Brunel, Kenneth D Miller, John H Reynolds","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-008","field_project_number":"1U01NS108683-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615853\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615853\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project\u0026nbsp;Summary\u0026nbsp;\nDespite\u0026nbsp;the\u0026nbsp;enormous\u0026nbsp;complexity\u0026nbsp;of\u0026nbsp;the\u0026nbsp;brain,\u0026nbsp;it\u0026nbsp;is\u0026nbsp;becoming\u0026nbsp;increasingly\u0026nbsp;apparent\u0026nbsp;that\u0026nbsp;structures\u0026nbsp;like\u0026nbsp;the\u0026nbsp;\ncerebral\u0026nbsp;cortex\u0026nbsp;are\u0026nbsp;modular,\u0026nbsp;relying\u0026nbsp;on\u0026nbsp;a\u0026nbsp;set\u0026amp;nbs"},{"title":"Coarse-graining approaches to networks, learning, and behavior","field_investigator":"William  Bialek, Stephanie E Palmer, David Jason Schwab","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026943-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615321\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615321\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe theory hub put forward in this proposal will work to translate successful and powerful approaches to\ndescribing emergent collective behavior in physical systems so they can be applied to the brain."},{"title":"Collaborative Standards for Brain Microscopy","field_investigator":"Carol Marie Hamilton","field_institution":"Research Triangle Institute","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-256","field_project_number":"1R24MH114683-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9581172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9581172\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nFast microscopy techniques, coupled with recent advances in tissue clearing, are now able to efficiently\nproduce cellular-resolution images of intact brain samples."},{"title":"Combined  Cortical  and  Subcortical  Recording  and Stimulation  as  a  Circuit-Oriented  Treatment  for  Obsessive-Compulsive  Disorder","field_investigator":"Darin D Dougherty, Alik S Widge","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"3UH3NS100548-01S2","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9783928\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9783928\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nThis project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD\nis a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms\nafter being treated with medication or talk therapy."},{"title":"Computational and Circuit Mechanisms Underlying Rapid Learning","field_investigator":"Elizabeth A Buffalo","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS107609-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9587659\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9587659\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\n The mammalian brain has a remarkable ability to store and retrieve information. Detailed memories can\nbe formed after as little as one exposure, and those memories can be retained for decades."},{"title":"Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome","field_investigator":"Peter J. Basser, Susie Yi Huang, Bruce R Rosen, Lawrence L Wald, Thomas  Witzel","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB026996-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617538\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617538\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"SUMMARY\nWe present Connectome 2.0, the next-generation human MRI scanner for imaging structural anatomy and\nconnectivity spanning the microscopic, mesoscopic and macroscopic scales."},{"title":"Context-dependent processing in sensorimotor cortex","field_investigator":"Jennifer L. Collinger","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-010","field_project_number":"1U01NS108922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9628222\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9628222\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"ABSTRACT\nHumans interact with their environment in countless ways and can switch seamlessly between activities. Even\nfor seemingly simple tasks, a variety of sensory inputs are integrated to create a motor plan to complete a task.\nTake the example of picking up a glass."},{"title":"Controlling the spatial extent of light-based monitoring and manipulation of neural activity in vivo","field_investigator":"John  Assad, Massimo  Devittorio, Ferruccio  Pisanello, Wade G Regehr, Bernardo L Sabatini","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS108177-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9592756\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9592756\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\/Summary\nThe brains of mammals contain an extraordinarily large number of neurons whose activity and interconnections\ndetermine the function of circuits that monitor our sensory environment, dictate our motor choices, form\nmemories, and guide all behavior."},{"title":"Cortical Interactions Underlying Sensory Representations","field_investigator":"Jerry L Chen","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109965-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668416\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668416\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nSensory perception involves processing incoming sensory input and interpreting that information through rules\ngenerated from prior experience."},{"title":"Cortical Signature and Modulation of Pain","field_investigator":"Zhigang  He, Fan  Wang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109947-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9667814\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9667814\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Cortical Signature and Modulation of Pain\nAbstract\/Project Summary\nPain perception contains two main dimensions: the sensory-discriminative and the affective-cognitive\naspects."},{"title":"CranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials","field_investigator":"Austin Robert Duke","field_institution":"Nexeon Medsystems Puerto Rico Operating Company, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-007","field_project_number":"1U44NS108148-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9592283\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9592283\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nThe goal of this U44 proposal is to develop and test CranialProgrammer, an image-guided programming tool\nfor 2D\/3D mapping of disease-related neural signals over patient and device data for more efficient and\neffective programming of directional deep brain stimulation (DBS) systems."},{"title":"CRCNS Research Proposal: Cortico-amygdalar substrates of adaptive learning","field_investigator":"Alireza Soltani, Alicia Izquierdo","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01DA047870-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9691634\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9691634\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ELearning from feedback in the real w\u0027orld is limited by constant fluctuations in reward outcomes associated with choosing certain options or actions.\u003C\/p\u003E"},{"title":"CRCNS: Collaboration toward an experimentally validated multiscale model of rTMS","field_investigator":"Gillian Queisser","field_institution":"Temple University of the Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118930-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692988\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692988\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EMental health diseases such as depression are a major burden on society and new treatment options are strongly needed. One strategic goal of NIMH is to develop novel therapies based on discoveries in neuroscience.\u003C\/p\u003E"},{"title":"CRCNS: Common algorithmic strategies used by the brain for labeling points in high-dimensional space","field_investigator":"Saket Navlakha","field_institution":"Salk Institute for Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01DC017695-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692942\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692942\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe first major goal of this work is to learn how certain brain regions (olfactory system, hippocampus, and cerebellum) learn very complex stimuli that employ a combinatorial code to identify stimuli as points in a high-dimensional space.\u003C\/p\u003E"},{"title":"CRCNS: Community-supported open-source software for computational neuroanatomy","field_investigator":"Eleftherios Garyfallidis","field_institution":"Trustees of Indiana University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EB027585-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692911\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692911\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDifferent parts of the brain share and transmit Information through long-range connections that connect nerve cells in each part of the brain with nerve cells in other brain areas.\u003C\/p\u003E"},{"title":"CRCNS: Computational neuroimaging of the human","field_investigator":"David B Ress","field_institution":"Baylor College of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EB027586-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692919\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692919\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHuman brainstem serves many plays critical roles in health and disease. Unfortunately, it has been vastly under-studied because of its physical inaccessibility in animal models, and its low contrast-to-noise ratio (CNR) for functional magnetic resonance imaging (fMRI) in human studies.\u003C\/p\u003E"},{"title":"CRCNS: Deep Neural Network Approaches for Closed-Loop Deep Brain Stimulation","field_investigator":"Robert Mark Richardson, Robert Sterling Turner","field_institution":"University of Pittsburgh at Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01NS110424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692927\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692927\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDeep Neural Network Approaches for Closed- Loop Deep Brain Stimulation Using Cortical and Subcortical Sensing Principal Investigators: R. Mark Richardson, MD, PhD, Department ofNeurologicaJ Surgery and Robert S.\u003C\/p\u003E"},{"title":"CRCNS: Dynamics of Gain Recalibration in the Hippocampal-Entorhinal Path Integration System","field_investigator":"James J Knierim, Noah John Cowan, Kathryn Hedrick, Kechen Zhang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118926-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692138\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe striking spatial correlates of hippocampal place cells and grid cells have provided unique insights into how the brain constructs internal, cognitive representations of the environment and uses these representations to guide behavior.\u003C\/p\u003E"},{"title":"CRCNS: Geometry-based Brain Connectome Analysis","field_investigator":"David Brian Dunson, Zhengwu Zhang","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118927-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9691584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9691584\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThere have been remarkable advances in imaging technology, used routinely and pervasively in many human studies, that non-invasively measures human brain structure and function.\u003C\/p\u003E"},{"title":"CRCNS: Improving Bioelectronic Selectivity with Intrafascicular Stimulation","field_investigator":"Ranu Jung","field_institution":"Florida International University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EB027584-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692905\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThe network of peripheral nerves offers extraordinary potential for modulating and\/or monitoring the functioning of internal organs or the brain. The nervous system functions by generating patterns of neural activity.\u003C\/p\u003E"},{"title":"CRCNS: Joint coding of shape and texture in the primate brian","field_investigator":"Anitha Pasupathy","field_institution":"University of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EY029997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692119\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ECollaborating Pis and Consultant United States Pl: Anitha Pasupathy, Dept. of Biological Structure, University of Washington, Seattle, USA Co-Pl: Wyeth Bair, Dept. of Biological Structure, University of Washington, Seattle, USA Japan Pl: lsamu Motoyoshi, Dept.\u003C\/p\u003E"},{"title":"CRCNS: Modeling the nanophysiology of dendritic spines","field_investigator":"Rafael Yuste","field_institution":"Columbia University New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01NS110422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9691638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9691638\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDendritic spines mediate essentially all excitatory connections and are thus critical elements in the brain but their function is still poorly understood. In particular, a key question is whether or not they are electrical compartments.\u003C\/p\u003E"},{"title":"CRCNS: Modeling the role of auditory feedback in speech motor control","field_investigator":"John Francis Houde, Srikantan S. Nagarajan","field_institution":"University of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01DC017696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhen we speak, listeners hear us and understand us we speak correctly. But we also hear ourselves, and this auditory feedback affects our ongoing speech: delaying it causes dysfluency; perturbing its pitch or formants induces compensation.\u003C\/p\u003E"},{"title":"CRCNS: Modulating Neural Population Interactions between Cortical Areas","field_investigator":"Byron M. Yu, Matthew A Smith","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118929-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692896\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EUnderstanding how different parts of the brain communicate is perhaps the most fundamental question of neuroscience because it is at the heart of understanding all brain functions and disorders.\u003C\/p\u003E"},{"title":"CRCNS: MOVE!-MOdeling of fast Movement for Enhancement via neuroprosthetics","field_investigator":"Sridevi V. Sarma","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01NS110423-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692936\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692936\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ETracking fast unpredictable movements is a valuable skill, applicable in many situations. In the animal kingdom, the context includes the action of a predator chasing its prey that is running and dodging at high speeds, like a cheetah chasing a gazelle.\u003C\/p\u003E"},{"title":"CRCNS: Neural Basis of Planning","field_investigator":"Daeyeol Lee, Wei Ji Ma","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118925-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692133\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EHumans and other animals can choose their actions using multiple learning algorithms and decision\u00ad making strategies.\u003C\/p\u003E"},{"title":"CRCNS: Real-time neural decoding for calcium imaging","field_investigator":"Rong Chen, Shuvra S Bhattacharyya","field_institution":"University of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01NS110421-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692105\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692105\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EReal-time neural decoding centers on predicting behavior variables based on neural activity data, where the prediction is performed at a pace that reliably keeps up with the speed of the activity that is being monitored.\u003C\/p\u003E"},{"title":"CRCNS: Theory and Experiments to Elucidate Neural Coding in the Reward Circuit","field_investigator":"Daniela Witten, Ilana Witten","field_institution":"University of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01DA047869-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692121\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692121\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EDopamine (DA) neurons are fundamental to many aspects of behavior, and dysfunction of the DA system contributes to a wide range of disorders, including drug addiction. How does DA contribute to such a diversity of functions and dysfunctions?\u003C\/p\u003E"},{"title":"CRCNS: Theory-guided studies of cortical mechanisms of multi-input integration","field_investigator":"Kenneth D Miller, Stephen D Von Hooser","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EY029999-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692886\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EA fundamental goal for understanding the brain and mammalian and human intelligence, and to understand how processing goes awry in genetic and developmental diseases, is to understand the principles of operation of cerebral cortex.\u003C\/p\u003E"},{"title":"CRCNS: US-Japan Research Proposal: The Computational Principles of a Neural Face Processing System","field_investigator":"Winrich Freiwald","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01EY029998-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9692129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9692129\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EThere is a fundamental gap in our understanding of the computational principles and neural mechanisms by which neural circuits represent complex objects like faces.\u003C\/p\u003E"},{"title":"CRNS: An Integrative Study of Hippocampal-Neocortical Memory Coding during Sleep","field_investigator":"Zhe Sage Chen, Matthew A Wilson","field_institution":"New York University School of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-804","field_project_number":"1R01MH118928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9691565\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9691565\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESleep is critical to memory and learning.\u003C\/p\u003E"},{"title":"Crowdsourcing the Fly Connectome","field_investigator":"Mala  Murthy, Hyunjune Sebastian Seung","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610061\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610061\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nWe propose to build a next generation crowdsourcing platform (code named \u201cFlyWire\u201d) for mapping the fly\nconnectome using transmission electron microscopy images that were acquired at Janelia Research Campus.\nFlyWire will depart from EyeWire, a previous crowdsourcing platform, in two "},{"title":"DART2.0: comprehensive cell type-specific behavioral neuropharmacology","field_investigator":"Michael R Tadross","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH117055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584694\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584694\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT. DART2.0: comprehensive cell type-specific behavioral neuropharmacology\nNeuro-active drugs have provided hope to millions."},{"title":"Data Archive for the Brain Initiative (DABI)","field_investigator":"Dominique  Duncan, Nader  Pouratian, Arthur W Toga","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-255","field_project_number":"1R24MH114796-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588992\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588992\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe overarching goal of this project is to secure, link, and disseminate BRAIN Initiative data, including\nelectrophysiology, imaging, behavioral, and clinical data with all pertinent recording and imaging parameters,\ncoming from participating sites."},{"title":"Data interface and apps for systems neurophysiology and imaging","field_investigator":"Stephen D Van Hooser","field_institution":"Brandeis University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-256","field_project_number":"1R24MH114678-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9581791\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9581791\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Technology for recording from the brain is developing at a breakneck pace."},{"title":"Data-driven analysis for neuronal dynamic modeling","field_investigator":"Gal  Mishne","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026936-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615161\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615161\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nOur main goal is to unravel communication dynamics in the brain, as they relate to various sensory-motor\nactions and to the learning process. The sensory-motor system operates through the concerted interaction of\nmultiple closed-loops feedback systems."},{"title":"DEEPHIPPO: Ultra-thin lensless endoscope for the visualization of deep hippocampus neuronal functional activity.","field_investigator":"Herve  Rigneault","field_institution":"Aix-Marseille University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9590092\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9590092\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Rigneault Project Abstract DEEPHIPPO\nDEEPHIPPO: Ultra\u2010thin lensless endoscope for the visualization of deep\nhippocampus neuronal functional activity.\nPrincipal investigator: Herv\u00e9 Rigneault\nHost Institution: Aix\u2010Marseille University, Marseille, France\nProject duration : 24 months\n Project Abstract\nD"},{"title":"DELINEATING CELL-SPECIFIC OUTPUT PATHWAYS OF THE GPe THAT SUPPORT LONG-LASTING BEHAVIORAL RECOVERY IN DOPAMINE DEPLETED MICE","field_investigator":"Aryn Hilary Gittis","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104835-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450070\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450070\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\u0026nbsp;\n\u0026nbsp;\nA\u0026nbsp;major\u0026nbsp;challenge\u0026nbsp;in\u0026nbsp;the\u0026nbsp;treatment\u0026nbsp;of\u0026nbsp;neurological\u0026nbsp;diseases\u0026nbsp;is\u0026nbsp;the\u0026nbsp;elaborate\u0026nbsp;and\u0026nbsp;diffuse\u0026nbsp;nature\u0026nbsp;of\u0026nbsp;neural\u0026nbsp;\ncircuits,\u0026nbsp;where\u0026nbsp;physically\u0026nbsp;proximal\u0026nbsp;neurons\u0026nbsp;are\u0026nbsp;engaged\u0026amp;"},{"title":"Dendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neurons","field_investigator":"Hong-Wei  Dong, Xiangdong William Yang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-230","field_project_number":"1U01MH117079-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9585042\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9585042\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n Integrating molecular, morphological, and connectomic properties is critical for unbiased\nclassification of neuronal cell types in the mammalian brain."},{"title":"Designing low-cost, customizable high-density probes for acute and chronic neural recordings in rodents","field_investigator":"Ingrid  Van Welie","field_institution":"Neural Dynamics Technologies Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43MH118155-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9622923\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9622923\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"SF424 \u2013 Project Summary\nUnderstanding how the brain generates certain behaviors requires an understanding of\nthe function of individual neurons in dynamical neural circuits."},{"title":"Development and Translation of an Intracranial Auditory Nerve Implant","field_investigator":"Robert Kyle Franklin, Thomas  Lenarz, Hubert Hyungil Lim, Andrew J. Oxenham, Loren  Rieth, Florian  Solzbacher","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-005","field_project_number":"1UG3NS107688-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588697\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nThe proposed project will build and evaluate the safety and design needs of a new type of intracranial auditory\nprosthesis that targets the auditory nerve between the cochlea and the brainstem (auditory nerve implant, ANI)\nin order to substantially improve hearing performance over the curre"},{"title":"Development of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner","field_investigator":"Ciprian  Catana","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB026995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617536\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617536\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nWe seek support to develop and build the positron emission tomography (PET) detector module for the next\ngeneration 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved\nspatio-temporal resolution."},{"title":"Development of a Revolutionary MRI System for Functional Brain Imaging","field_investigator":"Bob S Wagner, Sou-Tien Bert Wang","field_institution":"Wang Nmr, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43MH119021-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9623043\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9623043\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\/Abstract\nIt is the dream of researcher\u0027s and clinician\u0027s to have available a low cost, portable MRI scanner for brain\nneuroimaging. However, such a low cost MRI system requires a small bore MRI magnet."},{"title":"Development of predictive coding networks for spatial navigation","field_investigator":"George  Dragoi","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Development of predictive coding networks for spatial navigation\nSummary: Mammalian navigation uses internal models to predict the spatial-temporal statistical regularity of\nthe sequence of environmental locations."},{"title":"Discovering dynamic computations from large-scale neural activity recordings","field_investigator":"Tatiana  Engel","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026949-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615376\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615376\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nHow neural activity is coordinated within local microcircuits and across brain regions to drive behavior is\na central open question in neuroscience."},{"title":"Dissecting corticostriatal circuitry underlying chronic binge eating","field_investigator":"Britny  Hildebrandt","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118687-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9667004\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9667004\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nEating disorders are severe psychiatric conditions with a significant worldwide cost and disability burden. Binge\neating (BE) is a behavior that cuts across nearly all eating disorder diagnoses."},{"title":"Dual-channel Sub-millisecond Resolution Neural Imaging System","field_investigator":"Youbo  Zhao","field_institution":"Physical Sciences, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43MH116748-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9554175\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9554175\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\/Abstract\nThe investigation of the complex neural dynamics and the cognitive functions of the brain requires non-\ninvasive recording tools with high spatio-temporal resolution."},{"title":"Dynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks","field_investigator":"Gerwin  Schalk","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-010","field_project_number":"1U01NS108916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9627081\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9627081\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\n Improved understanding of the brain processes underlying normal and abnormal function is necessary for\ndevising better ways to diagnose, alleviate, or cure neurological or psychiatric disorders."},{"title":"Early Feasibility Clinical Trial of a Visual Cortical Prosthesis","field_investigator":"Jessy D Dorn, Robert Jay Greenberg, Nader  Pouratian","field_institution":"Second Sight Medical Products, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103442-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9403181\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9403181\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nBlindness in the United States is a large and increasing problem. Any significant vision loss is\ndebilitating, but profound blindness is devastating to an individual\u2019s ability to be independent\nand to perform everyday tasks and activities."},{"title":"Elucidating the Wiring and Rewiring of Poly-synaptic Memory Circuits by Directed Stepwise Trans-neuronal Tracing","field_investigator":"Wei  Xu","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104828-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449944\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449944\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nMultimodal sensory information is converged through poly-synaptic pathways to the\nhippocampus to form integrated representations and encode memories of the world, which in\nturn guide our future behavior through multiple poly-synaptic downstream pathways."},{"title":"Enabling Multi-Tracer SPECT Studies of the Human Brain","field_investigator":"Todd E Peterson","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB026991-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nMolecular imaging provides the means to quantitatively study many types of processes in the human brain in a\nminimally invasive manner."},{"title":"Epigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cells","field_investigator":"Andrew  Adey","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1R01DA047237-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9635638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9635638\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe mammalian brain is an enormously complex organ with myriad cell types cohesively working together to\ncarry out a host of intricate tasks, from motor functions, to the storing and execution of consciousness."},{"title":"Fast Spatial Light Modulators for Neuronal Excitation and Imaging","field_investigator":"Andrei  Faraon","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029460-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591529\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591529\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary: We propose to develop fast spatial light modulators (SLM) to address the\nneed for optical hardware compatible with the current fast genetically encoded sensors and\nactuators."},{"title":"Fast volumetric imaging of large areas in deep brain","field_investigator":"Timothy  Holy","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS108176-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9592777\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9592777\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"One of the central goals of the BRAIN initiative is to develop and disseminate methods for\nimaging activity in large populations of neurons at high speeds. Of the available techniques,\none of the most promising is light sheet microscopy."},{"title":"FlatScopes for Implantable and Scalable Optical Imaging of Neural Activity","field_investigator":"Caleb  Kemere, Jacob T. Robinson, Ashok  Veeraraghavan","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029459-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591524\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591524\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nLarge-scale measurement of individual neuronal activity in intact animals will accelerate the understanding of\nthe brain and treatment of neurological disorders."},{"title":"FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATION","field_investigator":"Hong  Chen","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1R01MH116981-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583521\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583521\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nAlthough neurotechnologies are rapidly advancing, we lack a noninvasive, cell-type specific, and\nspatiotemporally regulated neuromodulation tool, which would radically change neuroscience research and\nenable clinically noninvasive brain stimulation with high spatiotemporal p"},{"title":"From Electron Microscopy to Neural Circuit Hypotheses: Bridging the Gap","field_investigator":"Michale S Fee","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117809-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9609873\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9609873\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"From Electron Microscopy to Neural Circuit Hypotheses: Bridging the gap\nRecent advances in experimental technology promise rapid progress in developing a mechanistic\nunderstanding of how neural circuit structure, at the synaptic scale, leads to complex sensory,\ncognitive, and motor behaviors."},{"title":"From ion channel dynamics to human EEG and MEG: multiscale neuronal models validated by human data","field_investigator":"Maksim V Bazhenov, Sydney S Cash, Eric  Halgren","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH117155-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9586225\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9586225\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nThe electroencephalogram (EEG) and magnetoencephalogram (MEG) are directly and instantaneously coupled\nto the currents across cortical neuronal membranes which mediate information processing."},{"title":"High SNR Functional Brain Imaging using Oscillating Steady State MRI","field_investigator":"Douglas C Noll","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB026977-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617119\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617119\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary: High SNR Functional Brain Imaging using Oscillating Steady State MRI\nFunctional brain imaging using MRI (functional MRI or fMRI) has grown rapidly over the past 25 years and is\nwidely used for basic cognitive neuroscience research and for presurgical planning."},{"title":"High speed, high precision volumetric multiphoton neural control","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107574-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9587453\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9587453\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nLarge scale manipulation of neural ensemble activity at cellular resolution and millisecond precision is a major\ntechnological goal of the BRAIN initiative."},{"title":"High-throughput 3D random access three-photon calcium imaging","field_investigator":"Meng  Cui","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107689-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588692\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588692\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"High-throughput 3D random access three-photon structural and functional imaging\nTwo-photon microscopy allows in vivo observation of neuronal dynamics at high spatial and temporal\nresolutions."},{"title":"Human Agency and Brain-Computer Interfaces: Understanding users\u2019 experiences and developing a tool for improved consent","field_investigator":"Sara  Goering, Eran  Klein","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-500","field_project_number":"1RF1MH117800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9608198\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9608198\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nNeural prosthetic devices for sensorimotor and psychiatric disorders are in development as a\npriority area of the BRAIN Initiative yet they raise important ethical concerns about human\nagency."},{"title":"Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit","field_investigator":"Lisa  Stowers","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS108439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9612021\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9612021\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHow does the brain transform sensory information into complex behavior?"},{"title":"Illuminating Neurodevelopment through Integrated Analysis and Vizualization of Multi-Omic Data","field_investigator":"Ronna  Hertzano, Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH114815-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9590867\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9590867\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nThe wealth, depth and quality of multi-omic data generated through funding from the BRAIN\ninitiative is unprecedented. It ranges from bulk and single cell RNA-seq, to detailed cell type-\nspecific epigenetic analyses throughout development."},{"title":"Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain","field_investigator":"David A Boas, Bruce  Fischl","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH117023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584061\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584061\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":""},{"title":"Imaging the D2\/A2A Heterodimer with PET","field_investigator":"Robert H Mach","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB026988-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617498\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617498\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nThe goal of this research project is to determine if it is possible to develop a PET radiotracer capable of\nimaging GPCR heterodimers and not their corresponding homodimeric complexes."},{"title":"In Vivo Brain Network Latency Connectome Mapping","field_investigator":"Peter Basser","field_institution":"National Institute of Biomedical Imaging and Bioengineering","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"","field_project_number":"1ZIAEB000090-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9794602\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9794602\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Project Grants","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EWe are pleased with the progress we are making in this \u0022team building\u0022 R24 grant which our group received through the NIH BRAIN Initiative. We have been informed that ours is the only group within the NIH IRP to have received such an award.\u003C\/p\u003E"},{"title":"In Vivo Imaging of Local Synaptic Neuromodulation by Dopamine","field_investigator":"Paul Robert Evans","field_institution":"Max Planck Florida Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115433-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454042\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454042\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nDopamine (DA) is a powerful neuromodulator that facilitates memory formation and underlies reward-related\nbehaviors by regulating synaptic plasticity."},{"title":"Increased thalamocortical connectivity in tdcs-potentiated generalization of cognitive training","field_investigator":"Kelvin O. Lim, Angus W Macdonald","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH116987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Non-invasive neuromodulation, such as transcranial direct current stimulation (tDCS), is emerging as an\nimportant therapeutic tool with documented effects on brain circuitry, yet little is understood about how it\nchanges cognition."},{"title":"Informing Choice for Neurotechnological Innovation in Pediatric Epilepsy Surgery","field_investigator":"Judy  Illes, Patrick  Mcdonald","field_institution":"University Of British Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-500","field_project_number":"1RF1MH117805-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9609279\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9609279\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Abstract\nMore than 500,000 children in the USA and Canada suffer from epilepsy today. Unmanaged, epilepsy can\nresult in cognitive decline, social isolation and poor quality of life, and has substantial economic impact on\nfamilies and society."},{"title":"Intracellular calcium sensing with molecular fMRI","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107712-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588090\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588090\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The development of minimally invasive direct readouts of neural activity is one of the greatest challenges\nfacing neuroscience today."},{"title":"Investigating the hypocretin to VTA circuit in memory consolidation during sleep","field_investigator":"Jeremy  Borniger","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115431-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9453934\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9453934\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nChronic sleep disturbance affects 10-20% of the population in the developed world, representing a substantial public\nhealth problem. Given the ubiquitous nature of sleep across the animal kingdom, intense investigation is underway into\nthe biological functions of sleep."},{"title":"Investigating the neurocircuitry of sleep duration regulation","field_investigator":"Ying-Hui  Fu","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104782-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449092\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449092\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nSleep is essential for the maintenance of our cognition and neurological functions, and both quality and\nquantity of sleep are critical. We likely have known this for the entire human history. Yet, we remain\nastonishingly ignorant on how the quality and quantity of sleep are regulated."},{"title":"Is the Treatment Perceived to be Worse than the Disease?: Ethical Concerns and Attitudes towards Psychiatric Electroceutical Interventions","field_investigator":"Laura Yenisa Cabrera Trujillo","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-500","field_project_number":"1RF1MH117802-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9608514\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9608514\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"7. PROJECT SUMMARY\/ABSTRACT\nMental health disorders cause immense personal suffering and represent a significant societal burden."},{"title":"kHz-rate in vivo imaging of neural activity througout the living brain","field_investigator":"Na  Ji, Kevin Kin Man  Tsia","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588650\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588650\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"TITLE\nkHz-rate in vivo imaging of neural activity throughout the living brain\nSUMMARY\nThe overarching challenge in neuroscience today is how to monitor the neural signaling events in intact\nbrains of behaving animals at synaptic or cellular spatial resolution and millisecond time resolution.\nMultiph"},{"title":"Large-scale cellular-resolution voltage imaging of the zebrafish brain","field_investigator":"Yiyang  Gong","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107678-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588756\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588756\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nRecording the spiking activity of many individual neurons in a densely packed region of the brain\nhas been a standing challenge for the neuroscience community."},{"title":"Large-scale recording of population activity during social cognition in freely moving non-human primates","field_investigator":"Behnaam  Aazhang, Valentin  Dragoi, Anthony A Wright","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-008","field_project_number":"1U01NS108680-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615685\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615685\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nSocial interactions, a ubiquitous aspect of our everyday life, are critical to the health and survival of the species,\nbut little is known about their underlying neural computations."},{"title":"Lightweight, Compact, Low-Cryogen, Head-Only 7T MRI for High Spatial Resolution Brain Imaging","field_investigator":"Thomas  Foo, Yunhong  Shu, Duan  Xu","field_institution":"General Electric Global Research Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB026976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617118\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617118\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nAn innovative head-only 7T MRI system that delivers spatial resolution that is difficult to achieve with today\u0027s\nwhole-body 7T systems, and has the footprint and weight of a whole-body 3T scanner is proposed."},{"title":"Linking neuronal, metabolic, and hemodynamic responses across scales","field_investigator":"Geoffrey M Ghose","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH117015-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583993\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nWhile functional magnetic resonance (fMRI) has proved invaluable for identifying where in the\nbrain activation is occurring during a particular task, it has had less to say about how the\ndynamics of that activation actually contribute to task performance."},{"title":"Linking Plasticity of Hippocampal Representation across the Single Neuron and Circuit Levels","field_investigator":"Jayeeta  Basu, Claudia  Clopath","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109994-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668848\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668848\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Functional interactions between the entorhinal cortex and hippocampus are critical for spatial navigation\nand episodic memories related to people, places, objects and events."},{"title":"Magnetic camera based on optical magnetometer for neuroscience research","field_investigator":"Orang  Alem","field_institution":"Fieldline, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-090","field_project_number":"1R41NS108898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9622474\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9622474\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nDuring Phase I, we will test the feasibility of developing a magnetographic camera technology as a new tool in\nneuroscience to facilitate the detailed analysis of electrical currents in diverse neuronal circuits."},{"title":"Mapping neurotransmitter receptors onto the connectome","field_investigator":"S. Lawrence Zipursky","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117823-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610513\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610513\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nTo interpret the detailed ultrastructural information of the connectomes in Drosophila and other species, it will\nbe necessary to know the physiological functions of synapses between specific cell types."},{"title":"Mapping of spatiotemporal code features to neural and perceptual spaces","field_investigator":"Stefano Vt Panzeri, Dmitry  Rinberg","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109961-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668300\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668300\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nTwo of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information\nrepresented by the activity of populations of neurons at different levels of information processing?"},{"title":"Measuring, Modeling, and Modulating Cross-Frequency Coupling","field_investigator":"Uri Tzvi Eden, Mark Alan Kramer","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026938-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615216\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615216\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nAlthough rhythms are a prominent feature of brain activity, the role of rhythms in brain function (and\ndysfunction) remains elusive."},{"title":"Mechanisms of electrical stimulation of a canonical motor microcircuit","field_investigator":"Charles  Heckman","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109552-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9655522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9655522\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"The neural circuitry of the spinal cord has a unique, repetitive structure that forms an especially promising\ntarget for control via electrical stimulation."},{"title":"Mechanisms of Rapid, Flexible Cognitive Control in Human Prefrontal Cortex","field_investigator":"Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-010","field_project_number":"1U01NS108923-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9628299\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9628299\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of\nthis cognitive flexibility is our ability to perform complex, yet previously un-practiced tasks successfully on\nthe first attempt."},{"title":"Mechanisms underlying positive and negative BOLD in the striatum","field_investigator":"Yen-Yu Ian Shih","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH117053-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584691\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584691\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\n Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) is widely used\nas a non-invasive technique to study brain function."},{"title":"Mechanistic and causal basis of fMRI functional connectivity in non-human primates","field_investigator":"Peter  Rudebeck, Brian E Russ","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH117040-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584431\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584431\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nMeasures of functional magnetic resonance imaging (fMRI) functional connectivity \u2013 correlated blood oxygen\nlevel dependent (BOLD) responses \u2013 are fundamental to understanding the circuit-level mechanisms of brain\nfunction and dysfunction."},{"title":"Memory consolidation during sleep studied by direct neuronal recording and stimulation inside human brain","field_investigator":"Itzhak  Fried","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-010","field_project_number":"1U01NS108930-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9628515\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9628515\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\nMemory is critical for cognitive well-being, and sleep is critical for memory consolidation, yet the underlying\nmechanisms in the human brain are poorly understood."},{"title":"Mental, measurement, and model complexity in neuroscience","field_investigator":"Vijay  Balasubramanian, Joshua I Gold","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026945-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615324\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615324\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nNeuroscience is producing increasingly complex data sets, including measures and manipulations of sub-\ncellular, cellular, and multi-cellular mechanisms operating over multiple timescales and in the context of\ndifferent behaviors and task conditions."},{"title":"MINIMALLY-INVASIVE NANO-DIALYSIS NEURAL PROBE FOR MULTIPLEXED MONITORING OF NEUROCHEMICALS WITH HIGH SPATIO-TEMPORAL RESOLUTION","field_investigator":"Rashid  Bashir, Jonathan V. Sweedler, Yurii A Vlasov","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107677-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588761\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588761\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nMonitoring local concentrations of neurochemicals in specific parts of the brain in vivo is critical for correlating\nneural circuit functionality to behavior as long-range neuromodulation can significantly alter information\nprocessing."},{"title":"Model behavior in zebrafish: characterization of the startle response","field_investigator":"Joy Hart Meserve","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115434-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454043\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454043\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\n Although behavioral deficits are common in neurological disorders, the genetic pathways and neural\ncircuits underlying behavior are largely unknown."},{"title":"Models and Methods for Calcium Imaging Data with Application to the Allen Brain Observatory","field_investigator":"Michael  Buice, Daniela  Witten","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026908-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9613522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9613522\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY. New advances in calcium imaging make it possible to survey the brains of behaving animals at\nsingle-neuron resolution, thereby promising to transform the \ufb01eld of neuroscience. However, existing statistical models\nand methods are inadequate for this complex and noisy data."},{"title":"Modular Systems for Large Scale, Long Lasting Measurements of Brain Activity","field_investigator":"Hillel  Adesnik, Michael S Brainard, Elizabeth A Buffalo, Peter  Denes, Loren M Frank, Razi-Ul  Haque, Mattias Peter Karlsson, Allison Mika Yorita","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588709\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588709\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY ABSTRACT\nUnderstanding how brains process information and how dysfunction disrupts that processing requires\nmeasuring patterns of neural activity with cellular spatial and millisecond temporal resolution."},{"title":"Multi-channel MR-compatible flexible microelectrode for recording and stimulation","field_investigator":"Robert Kyle Franklin, Yen-Yu Ian Shih","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-090","field_project_number":"5R41MH113252-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9355239\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9355239\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\ufeff   \nDESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) has become one of the leading research tools to study brain function and is playing a pivotal role in several large-scale brain mapping projects worldwide."},{"title":"Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.","field_investigator":"Bo  Li, Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104944-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451165\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451165\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nThe amygdala plays a central role in diverse learned behaviors. By integrating the sensory information with\nstress, punishment, and reward signals, the circuitry within the amygdala is thought to be modified during\nlearning to mediate specific behavioral outcomes."},{"title":"Network Control and Functional Context: Mechanisms for TMS Response","field_investigator":"Danielle Smith Bassett, Desmond  Oathes, Theodore  Satterthwaite","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH116920-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9582561\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9582561\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"ABSTRACT\nDespite the increasing use of transcranial magnetic stimulation (TMS) in both research and clinical practice,\nthe field nonetheless lacks a theoretical framework to predict the impact of TMS on circuits."},{"title":"Neural circuit mechanisms underlying hierarchical visual processing in Drosophila","field_investigator":"Maxwell Holte Turner","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118707-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668252\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668252\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\n Understanding how neural circuits give rise to sensory computation and, ultimately, perception, requires\nconnecting biological features of neural circuits to abstract models of neural computation."},{"title":"Neural circuits for spatial navigation","field_investigator":"Gaby  Maimon","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104934-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451120\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451120\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nOur brain provides us with a sense of where we are in space."},{"title":"Neural circuits underlying thirst and satiety regulation","field_investigator":"Yuki  Oka","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668953\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668953\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nA forebrain structure, lamina terminalis (LT), plays a key role in both sensing internal water balance and\nregulating thirst through its downstream neural circuits."},{"title":"Neural Implant Insertion System using Ultrasonic Vibration to Reduce Tissue Dimpling and Improve Insertion Precision of Floating Arrays in the Neocortex","field_investigator":"Maureen L. Mulvihill","field_institution":"Actuated Medical, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43NS105500-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9565293\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9565293\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"This Phase I SBIR develops and tests a system for vibrating neural implant floating arrays during insertion to\nreduce insertion force, dimpling, tissue damage, and bleeding. The approach will allow precise insertion of\nelectrode shanks into shallow cortical layers."},{"title":"Neural mechanisms of active avoidance behavior","field_investigator":"Manuel A Castro-Alamancos","field_institution":"Drexel University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449543\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449543\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\n Enormous progress has been made about the neural substrates of Pavlovian fear conditioning."},{"title":"Neural sequences for planning and production of learned vocalizations","field_investigator":"Brenton G. Cooper, Richard  Hahnloser, Todd F Roberts","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS108424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610987\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610987\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nSequences of neuronal activity are thought to underlie planning, preparation, and production of voluntary\nskilled behaviors."},{"title":"Neuroethics of Predictive MRI Testing: Parental Attitudes Towards Pre-Symptomatic Identification of Autism Spectrum Disorder","field_investigator":"Kate E. Macduffie","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118689-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9667076\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9667076\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nMachine-learning-based classification of neuroimaging data (hereafter ML-MRI) to predict clinical\ndiagnoses has increased substantially in the last decade."},{"title":"Neuromodulation of Brain States","field_investigator":"Liqun  Luo","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104698-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9445903\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9445903\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nThe monoamines, which include dopamine, norepinephrine, and serotonin, are evolutionarily conserved\nneurotransmitters that modulate the activity of excitatory and inhibitory neurons throughout the entire brain,\nand are thus essential for diverse aspects of physiology and behavior."},{"title":"Neuronal and Dopaminergic Contributions to Dissimilar Evoked Hemodynamic Responses in the Striatum","field_investigator":"Lindsay  Walton","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454747\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454747\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nBlood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) is a non-invasive\nimaging technique that infers the presence of increased brain activity from localized increases in oxygenated\nhemoglobin."},{"title":"Neuronal population dynamics within and across cortical areas","field_investigator":"Brent D. Doiron, Matthew A Smith, Byron M. Yu","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026953-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615656\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615656\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: The cortex must both track and process dynamically changing environments as well\nas store and combine diverse inputs to generate complex behavior. Further, the neuronal circuits that\naccomplish this must be malleable to changing contexts, such as during attention related tasks."},{"title":"New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at Synapses","field_investigator":"Cagla  Eroglu, Scott H Soderling","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1R01DA047258-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9637987\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9637987\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nAstrocytes are the most abundant glial cells in the human brain. Interactions of astrocytes with synapses via thin\nperisynaptic astrocytic processes are critical for proper synaptic connectivity and function."},{"title":"New tools to target, identify and characterize astrocytes in the adult nervous system","field_investigator":"Viviana  Gradinaru, Baljit  Khakh","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-18-018","field_project_number":"1R01DA047444-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9649057\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9649057\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"SUMMARY\nIn order to understand how the CNS encodes, modifies, stores and retrieves information it is necessary to\nexplore the diverse cell populations that comprise the CNS. There is an emerging consensus that the CNS\ncannot be satisfactorily understood solely as a collection of circuits1."},{"title":"Next-generation optical brain functional imaging platform","field_investigator":"Qianqian  Fang","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-003","field_project_number":"1R01EB026998-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617549\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617549\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nA more thorough understanding of human brain function has profound implications for advancing neuroscience\nresearch and combatting neurological disease."},{"title":"Non-invasive targeted neuromodulation via focused ultrasound BBB permeabilization","field_investigator":"Margaret S Livingstone, Nathan J. Mcdannold","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1R01MH116858-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9572620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9572620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\nThe goal of the proposed project is to test in macaques a technique for non-invasive, safe, reversible,\nmodulation of neuronal activity in small targeted regions of the primate brain."},{"title":"Noninvasive Gene Delivery for Monitoring and Perturbing Cell Types and Circuits in Transgenic and Non-Transgenic Animals","field_investigator":"Viviana  Gradinaru","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH117069-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584895\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n The use of current and emerging genetically encoded tools could greatly benefit from advanced methods\nfor gene delivery to the desired cell population."},{"title":"Nonlinear Causal Analysis of Neural Signals","field_investigator":"Terrence J Sejnowski","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026899-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9608443\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9608443\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe goal of this research is to develop new multivariate data analysis techniques for neural recordings that\nreveal causal dependencies between recording sites."},{"title":"Norepinephrine modulation of neocortex during flexible behavior","field_investigator":"Jeremiah Yaacov Cohen, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450066\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450066\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"SUMMARY\nNorepinephrine is a neurotransmitter thought to be involved in driving behavioral flexibility. It is released by a\nsmall number of neurons throughout the neocortex."},{"title":"Novel Implantable Smart Magnetoelectric NanoRFIDs for Large-Scale Neural Magnetic Recording and Modulation","field_investigator":"Sydney S Cash, Nian Xiang Sun","field_institution":"Northeastern University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107694-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588662\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588662\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\nA major goal of the BRAIN Initiative is in creating new systems for being able to record and modulate neuronal\nactivity across wide areas of cortex and at the scale of small ensembles and even individual neurons."},{"title":"Novel optical probe for dopamine release in neural circuits","field_investigator":"Marla  Feller, Markita  Landry","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029405-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9590055\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9590055\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"A major focus of modern neuroscience is understanding the role of neuromodulators\nin neural circuit function and development, in behavior, and their dysfunction in\nneurological disease. Neural circuit research has been revolutionized by powerful new\noptical techniques."},{"title":"NWB:N: A Data Standard and Software Ecosystem for Neurophysiology","field_investigator":"Lydia Lup-Ming Ng, Oliver  Ruebel","field_institution":"University Of Calif-Lawrenc Berkeley Lab","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-256","field_project_number":"1R24MH116922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9582696\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9582696\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nBrain function is produced by the coordinated activity of multiple neuronal types that are widely distributed\nacross many brain regions."},{"title":"Objective, MRI biomarkers for pre-symptomatic detection of autism spectrum disorder at 6 months old: commercial software development and optimization","field_investigator":"Bradley A. Bower","field_institution":"Primeneuro, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"PAR-18-501","field_project_number":"1R44MH118763-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9680324\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9680324\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary\nAutism Spectrum Disorder (ASD) is a broad diagnosis for a disorder characterized by symptoms\naffecting repetitive behavior, social communication, and cognitive ability."},{"title":"OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-255","field_project_number":"1R24MH117179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9587809\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9587809\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project\u200b \u200bSummary\/Abstract\nThe NIH BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at\nrevolutionizing our understanding of the brain."},{"title":"Optical measurement of causal functional connectivity in posterior parietal cortex","field_investigator":"Daniel E Wilson","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118698-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9667757\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9667757\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe mouse posterior parietal cortex (PPC) has emerged as an essential region for decision-making during\nmemory-guided decision-making tasks."},{"title":"Optimization and distribution of high density cellular scale carbon and silicon arrays","field_investigator":"Cynthia Anne Chestek","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107659-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588357\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588357\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nA longstanding goal in neuroscience is to understand the brain at the level of individual neurons. Existing\ntechniques involve inserting electrodes that heavily damage the area that they are recording."},{"title":"Optimizing noninvasive modulation of prediction and episodic memory networks via cerebellar stimulation","field_investigator":"Shruti  Dave","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118718-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668733\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY ABSTRACT\nThe lateral cerebellum (Crus I\/II) interacts with two dissociable large-scale brain networks \u2014 the executive\ncontrol (ECN) and default mode networks (DMN), which support distinct cognitive functions (e.g., prediction\nversus episodic memory, respectively)."},{"title":"Oxytocin Modulation of Neural Circuit Function and Behavior","field_investigator":"Richard W Tsien","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS107616-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588155\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588155\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction and maternal\nbehavior. Recent studies have tagged oxytocin as a \u201ctrust\u201d hormone, promising to improve social deficits in\nvarious mental disorders, such as autism."},{"title":"PARALLEL ANALYSIS OF TRANSCRIPTION AND PROTEIN-DNA INTERACTIONS IN SINGLE CNS CELLS","field_investigator":"Joseph D Dougherty, Robi D Mitra","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH117070-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe brain is the most complex organ in the body, consisting of hundreds of molecularly, physiologically, and\nanatomically distinct cells."},{"title":"Population Imaging of Action Potentials by Novel Two-Photon Microscopes and Genetically Encoded Voltage Indicators","field_investigator":"Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107705-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588470\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding how information is processed in the mammalian neocortex has been a longstanding question in\nneuroscience. While the action potential is the fundamental bit of information, how these spikes encode\nrepresentations and drive behavior remains unclear."},{"title":"Population Neural Activity Mediating Sensory Perception Across Modalities","field_investigator":"Thomas Robert Clandinin, Surya  Ganguli, Mala  Murthy, Kristin E Scott","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS110060-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9675521\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9675521\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary:\nNatural sensory inputs are typically complex, and often combine multiple modalities. Human speech, for\nexample, combines auditory signals with visual cues, such as facial expressions, that inform the interpretation\nof the spoken words."},{"title":"Prototyping an ultrasound system for spatiotemporally precise noninvasive neuromodulatory drug uncaging and functional imaging in awake primates","field_investigator":"Charles F Caskey","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107666-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588687\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588687\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project\u0026nbsp;summary\u0026nbsp;\nCurrently,\u0026nbsp; no\u0026nbsp; technology\u0026nbsp; exists\u0026nbsp; that\u0026nbsp; has\u0026nbsp; been\u0026nbsp; specifically\u0026nbsp; designed\u0026nbsp; to\u0026nbsp; allow\u0026nbsp; high\u0026nbsp; precision\u0026nbsp; noninvasive\u0026nbsp;\nneuromodulation\u0026nbsp;and\u0026nbsp;neuroimaging\u0026nbsp;in\u0026nbsp;awake\u0026nbsp;animals.\u0026nbsp;Ultr"},{"title":"Quantifying the role of adaptation in olfactory coding through the logic of navigation","field_investigator":"Nirag  Kadakia","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9667825\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9667825\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThis project\u2019s long-term goal is a fuller understanding of the neurobiological mechanisms of olfactory sensory\nadaptation that facilitate odor discrimination in the natural world."},{"title":"Quantitative mapping of oxygenation around neural interfaces using novel PISTOL MR imaging","field_investigator":"Vikram D. Kodibagkar, Jitendran  Muthuswamy, Arati  Sridharan","field_institution":"Arizona State University-Tempe Campus","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107676-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588784\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588784\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nOxygen levels (pO2) in the brain play a significant role in influencing the function of single neurons and\nneuronal networks during normal and pathological states."},{"title":"Rapid 3-D Nano-Printing to Create Multi-Thousand-Channel Microelectrode Arrays","field_investigator":"Rahul  Panat, Eric  Yttri","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029441-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591117\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591117\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nRecent advances in technology have enabled the sampling of activity from up to a few hundred neurons within\na limited area of the brain."},{"title":"RAVE: A New Open Software Tool for Analysis and Visualization of Electrocorticography Data","field_investigator":"Michael S Beauchamp","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH117529-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9592408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9592408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\n A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique\nthat allows the activity of small population of neurons in the human brain to be directly recorded."},{"title":"Readout and control of spatiotemporal neuronal codes for behavior","field_investigator":"Behtash  Babadi, Dante R Chialvo, Tommaso  Fellin, Mark H Histed, Patrick O Kanold, Wolfgang  Losert, John H.r. Maunsell, Stefano Vt Panzeri, Dietmar  Plenz, Dmitry  Rinberg, Shy  Shoham","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS107464-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584272\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584272\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nTo survive, organisms must both accurately represent stimuli in the outside world, and use that representation\nto generate beneficial behavioral actions."},{"title":"Real-time statistical algorithms for controlling neural dynamics and behavior","field_investigator":"Il Memming Park, Jonathan William Pillow","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-005","field_project_number":"1R01EB026946-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9615336\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9615336\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nHigh-throughput experimental neuroscience has made it possible to observe behavior of many\nanimals, as well as a large groups of neurons simultaneously, providing an exciting opportunity for\nfiguring out how the neural system performs computations that underlie perception,"},{"title":"Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales","field_investigator":"James S Trimmer","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109113-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9646201\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9646201\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales\nUnderstanding brain function and dysfunction requires an understanding of the circuitry of the brain from\nmolecules to cells to circuits."},{"title":"Remote Neurostimulation with Ultrasound-activated Piezoelectric Nanoparticles","field_investigator":"Geoffrey P. Luke","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9590251\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9590251\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nThe ability to trigger neural activity with high resolution millimeters to centimeters deep in tissue remains an\nelusive goal in neuroscience research. Current research relies on using invasive electrodes, optogenetics, or\npharmacological stimulation."},{"title":"Repetitive transcranial ultrasound stimulation for modulating brain rhythms","field_investigator":"Jacek  Dmochowski","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-17-022","field_project_number":"1K18DA045437-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9472653\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9472653\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe goal of the proposed research career development program is to allow the applicant to acquire training in\na new form of brain stimulation using ultrasonic waves."},{"title":"Resource for Multiphoton Characterization of Genetically-Encoded Probes","field_investigator":"Mikhail  Drobizhev","field_institution":"Montana State University - Bozeman","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-005","field_project_number":"1U24NS109107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9646044\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9646044\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Two-photon laser scanning microscopy powers many projects in the."},{"title":"Reverse Engineering the Brain Stem Circuits that Govern Exploratory Behavior","field_investigator":"Martin  Deschenes, Yoav Shai Freund, David  Golomb, David  Kleinfeld, Partha Pratim Mitra, Fan  Wang","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS107466-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584824\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584824\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Overview - Abstract\n Brainstem function is necessary for life-sustaining functions such as breathing and for survival functions,\nsuch as foraging for food. Individual motor actions are activated by specific brainstem cranial motor nuclei."},{"title":"SCAPE microscopy for high-speed 3D imaging of cellular function in behaving animals: Continued innovation, optimization, and dissemination","field_investigator":"Elizabeth M. C. Hillman","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS108213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9593299\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9593299\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nSwept confocally aligned planar excitation (SCAPE) microscopy is a method for high-speed, cellular level\nimaging of living, intact tissues."},{"title":"Selective Optogenetic Inhibition of Neuropeptide Release","field_investigator":"Pablo  Blinder, Zhitao  Hu, John Yu-Luen Lin","field_institution":"Tel Aviv University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029450-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591347\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nNeuropeptides are key components of modulation across the central nervous system."},{"title":"Spatially Resolved Methylomes to Map Neuronal Cell-Type Connectivity in Tissue","field_investigator":"Robert Youssefian Henley","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118706-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668226\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668226\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThe BRAIN initiative has put forth the development of a neuronal cell-type census as the first step towards\nmapping the structure and components of neuronal circuits."},{"title":"Spatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum","field_investigator":"David Allenson Borton, Carl Y Saab","field_institution":"Rhode Island Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS108414-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610274\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610274\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\/Abstract\nPain is a national health challenge costing our economy more than $600 Billions per year."},{"title":"Spatiotemporal control of dendritic inhibition by a family of diverse somatostatin-expressing interneurons","field_investigator":"Bernardo  Rudy","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS110079-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9676007\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9676007\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nGABAergic interneurons (INs) are a diverse group of neurons with critical roles in signal processing in the\ncerebral cortex. Moreover, malfunction of these neurons has been implicated in a number of diseases ranging\nfrom epilepsy to schizophrenia, anxiety disorders and autism."},{"title":"Striatal Plasticity in Habit Formation as a Platform to Deconstruct Adaptive Learning","field_investigator":"Nicole  Calakos","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS110059-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9675820\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9675820\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n A distinguishing feature of the brain is that its circuitry isn\u2019t computationally static, it adapts to\nexperience."},{"title":"Studying perceptual decision-making across cortex by combining population imaging, connectomics, and computational modeling","field_investigator":"Christopher D Harvey, Wei-Chung Allen Lee, Stefano Vt Panzeri","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS108410-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610012\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610012\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDuring perceptual decision-making, populations of neurons, arranged in highly interconnected microcircuits,\nwork together to encode sensory stimuli and to transform sensory perception into appropriate behavioral choices.\nA fundamental gap in our knowledge about perceptual decision-ma"},{"title":"Subiculm circuits for cortical feedback regulation of spatial mapping and learning","field_investigator":"Douglas Arthur Nitz, Xiangmin  Xu","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104897-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450759\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450759\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\n Encoding of environmental location and navigational behavior in mammals involves large ensembles of\nspecific neuron types across multiple interacting brain regions."},{"title":"Synthetic imager to record cortical neural activity over whole cranium in freely-behaving animals","field_investigator":"Weijian  Yang","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-002","field_project_number":"1R21EY029472-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9591620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9591620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Synthetic imager to record cortical neural activity over whole cranium in freely-behaving animals\nUnderstanding information flow across different brain regions during animal behavior is a key step to\ndecipher how the brain works."},{"title":"Taking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo","field_investigator":"Nicole  Calakos","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-17-022","field_project_number":"1K18DA045438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9472719\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9472719\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe basal ganglia are critical for the learning and subsequent selection of motor programs. In health,\nadaptive plasticity in the basal ganglia enables easy execution of complex motor tasks through\nformation of habits."},{"title":"Technology for functional study of cells and circuits in large postmortem brains ex vivo","field_investigator":"Nenad  Sestan","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH117064-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584833\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584833\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe mammalian brain is arguably the most complex biological structure."},{"title":"Thalamocortical and corticocortical mechanisms for sleep-dependent visual learning","field_investigator":"Sara J Aton","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9447654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9447654\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary: Consolidating transient sensory experiences into long-lasting memories is a fundamental\nfunction of the brain, linked to synaptic plasticity."},{"title":"Thalamocortical state control of tactile sensing: Mechanisms, Models, and Behavior","field_investigator":"Garrett B. Stanley","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451098\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Thalamocortical state control of tactile sensing: Mechanisms, Models, and Behavior\nDespite the fact that the sensory thalamus plays a major role in shaping sensory representations in cortex, and\nthus shaping our percepts, most of what we know has been determined through electrophysiological\ninvestig"},{"title":"The biophysics and potential cell-type selectivity of acoustic neuromodulation","field_investigator":"Robert Crooks Froemke, Eitan  Kimmel, Shy  Shoham","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109885-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9665214\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9665214\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Summary\n Neuroscience has an essential requirement for large-scale perturbation tools. Such\ntools would be transformative in the mapping of brain function, the causal testing of\nneurotheoretic models, and the diagnosis and treatment of neurological disorders."},{"title":"The Brainstorm Project: A Collaborative Approach to Facilitating the Neuroethics of Bioengineered Brain Modeling Research","field_investigator":"Insoo  Hyun","field_institution":"Case Western Reserve University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-500","field_project_number":"1RF1MH117803-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9608882\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9608882\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary \u2013 Abstract\nNeuroscientists are getting close to building realistic bioengineered ex vivo human brain models\nby: (1) introducing perfusable vascular networks to maintain tissue viability and promote 3D\nbrain model growth; (2) generating the full complement of currently missing cell ty"},{"title":"The Development and Human Translation of Temporal Interference Brain Stimulation","field_investigator":"Daniel Z. Press","field_institution":"Beth Israel Deaconess Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1R01MH117063-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584806\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584806\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nDeep brain stimulation (DBS) has had great impact, helping patients with disorders such as Parkinson\u0027s\ndisease and obsessive\u2013compulsive disorder (OCD), and with great potential for other disorders such as\ndepression and Alzheimer\u0027s disease."},{"title":"The diversity of dopamine neurons: from connectivity and activity to functions.","field_investigator":"Naoshige  Uchida","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS108740-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9616981\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9616981\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDopamine neurons (DNs) are key regulators of motivated behaviors, and defects in dopamine\nsignaling may underlie some psychiatric disorders including addiction, depression, and schizophrenia,\nas well as neurological disorders such as Parkinson\u0027s."},{"title":"The impact of spontaneous cortical activity on neural oscillations and behavioral performance: Evidence from high-definition tDCS and MEG","field_investigator":"Tony W Wilson","field_institution":"University Of Nebraska Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH117032-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584253\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584253\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nThis proposal responds to RFA-MH-17-245, which requests applications focusing on the mechanisms and dose-\nresponse relationships of noninvasive neuromodulatory methods."},{"title":"The Neuronal Underpinnings of Non-invasive Laminar fMRI","field_investigator":"Orrin  Devinsky, Essa  Yacoub","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH116978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583106\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583106\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"The six layers of cortex form distinct computational units that together govern the information flow and\nprocessing required for complex behavior. Hence, unravelling the brain\u0027s computational strategies requires\nunderstanding the layer-specific organization of the neocortex."},{"title":"Toward 3D human brain-like tissues for targeting dysregulated synapse and proteostasis mechanisms in autism spectrum disorder","field_investigator":"Joshua Dean Erndt-Marino","field_institution":"Tufts University Medford","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118678-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9666049\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9666049\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"TOWARD 3D HUMAN BRAIN-LIKE TISSUES FOR TARGETING DYSREGULATED SYNAPSE AND\n PROTEOSTASIS MECHANISMS IN AUTISM SPECTRUM DISORDER\nAutism spectrum disorder (ASD) is a neurodevelopmental disease affecting nearly 1\/50 children in US with an\nestimated $268 billion in annual costs."},{"title":"Toward a human adult brain cell atlas with single-cell technologies","field_investigator":"Jerold  Chun, Kun  Zhang","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH114828-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584575\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584575\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nHuman brain is an exceedingly complex network of spatially organized and functionally\nconnected neurons imbedded in glia."},{"title":"Towards integrated 3D reconstruction of whole human brains at subcellular resolution","field_investigator":"Kwanghun  Chung","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH117072-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9584926\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9584926\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nA detailed understanding of the anatomical and molecular architectures of brain cells and their brain-wide\norganization is essential for interrogating human brain function and dysfunction."},{"title":"TRACT:  A TOOL TO INVESTIGATE BRAIN CONNECTIVITY AND TO GENETICALLY MANIPULATE NEURONS CONNECTED BY SYNAPSES","field_investigator":"Elizabeth Jennifer Hong, Carlos  Lois","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117825-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610546\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610546\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"!\nPROJECT SUMMARY\nDeciphering the brain\u2019s wiring diagram is widely thought to be necessary towards understanding how brain\ncircuits process information. However, this goal is extremely challenging because currently available methods\nto study brain connectivity suffer from important limitations."},{"title":"Trans-synaptic bidirectional tracing tools for imaging and omics analysis","field_investigator":"Nirao Mahesh Shah, Alice Y Ting","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-505","field_project_number":"1RF1MH117821-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9610340\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9610340\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nTrans\u2010synaptic bidirectional tracing tools for imaging and omics analysis\nA central question in systems neuroscience is how hormones, such as estrogen, regulate animal behavior at the level of\nsynapses and circuits."},{"title":"Transgenic mice and multiplexed, multi-beam instrumentation for large-scale optical experiments on brain states and ensemble cellular dynamics in behaving animals","field_investigator":"Mark J Schnitzer, Hongkui  Zeng","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1UF1NS107610-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9587916\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9587916\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nThe NIH BRAIN Initiative report emphasizes the importance of integrated technological approaches that\ncombine multiple, complementary and groundbreaking capabilities in a single, highly advanced instrument.\nOptical methods have tremendous potential for integration, by combining massive reco"},{"title":"Transparent graphene electrode arrays for simultaneous electrical and optical investigation of computations in the olfactory bulb","field_investigator":"Morgan A Brown","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118724-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668963\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668963\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary and Abstract\n A major obstacle to understanding the link between behavior and neuronal activity is the difficulty of\nelectrophysiologically recording the activity of large neuronal populations without limiting visual access."},{"title":"Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging","field_investigator":"Georges  El Fakhri, Roger  Lecomte","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB027003-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617578\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617578\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"We propose to design, build, and evaluate the Scanner Approaching in Vivo\nAutoradiographic Neuro Tomography (SAVANT), a next generation PET scanner for\nultra-high resolution imaging of the human brain using hardware advances\ndeveloped by members of our collaborative team to achieve unprecedented spa"},{"title":"Ultrasonic neuromodulation: establishing mechanisms and parameters to optimize targeted neuromodulation and control sensory side-effects","field_investigator":"Michael  Ortiz, Shinsuke  Shimojo, Mikhail  Shapiro","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH117080-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9585045\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9585045\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Abstract\nOne of the major goals of the BRAIN initiative is to develop technologies capable of interfacing with specific\nneural circuits in the human brain."},{"title":"Understanding V1 circuit dynamics and computations","field_investigator":"Kenneth D Miller, Massimo  Scanziani","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS107613-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588053\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588053\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Understanding the cerebral cortex requires data-based theoretical models that can yield in-\nsight into the circuit mechanisms of cortical computation, and reproduce detailed cortical dynamics across stimuli\nand brain states."},{"title":"Unraveling constraints on motor cortical activity exploration and shaping during structural skill learning using large-scale 2-photon imaging and holographic optogenetic stimulation","field_investigator":"Vivek  Athalye","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-18-510","field_project_number":"1F32MH118714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668706\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668706\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nWhen learning new skills, experience with previously-learned skills can facilitate faster learning by constraining\nbehavioral exploration and shaping, a concept known as \u201cstructural learning\u201d3,4."},{"title":"Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording","field_investigator":"Ji-Xin  Cheng, Xue  Han","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-018","field_project_number":"1R01NS109794-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9663026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9663026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary\nUltrasound has been explored as a modality to modulate nerves and muscles back in the 1920s. A number of\nrecent studies have demonstrated the feasibility of using ultrasound to stimulate peripheral nerves, spinal cord,\nand brain."},{"title":"Using functionally-defined glomeruli to probe circuit function in the mammalian olfactory bulb","field_investigator":"Dale M Wachowiak","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-009","field_project_number":"1R01NS109979-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9668660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9668660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\n We seek to better understand how the brain processes olfactory information by focusing on how circuits\nof the olfactory bulb control two fundamental aspects of sensory processing: the relationship between sensory\ninput and olfactory bulb output as a function of stimulus intensity, a"},{"title":"Validating and extending optical tools for extended neural silencing","field_investigator":"Christopher Peter Ford, Matthew J Kennedy, Chandra L Tucker","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107710-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588186\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588186\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Conditionally silencing the activity of specific neural ensembles is a powerful approach\nfor mapping brain circuits responsible for specific behaviors."},{"title":"What are we Stimulating with Transcranial Ultrasound in Mice?","field_investigator":"Kim  Butts-Pauly","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH116977-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9583091\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9583091\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Abstract\nCompletely noninvasive neuromodulation using focused ultrasound (FUS) offers the promise of precisely\nstimulating specific targets deep in the brain, at power levels commonly used for diagnostic imaging studies.\nHaving a working mouse model to study neuromodulation with ultrasound i"},{"title":"Whole-brain recording into nucleic acids using template-independent polymerases","field_investigator":"Keith Edward Jaggard Tyo","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1UF1NS107697-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9588631\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9588631\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nThis proposal aims to record and store neural activity into DNA\/RNA strands with high spatial and temporal\nresolution, enabling neural activity recording densely within local circuits, yet broadly across large scale neural\ncircuits, and potentially across the entire brain."},{"title":"Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity","field_investigator":"Joseph P Culver","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222018-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2018\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-004","field_project_number":"1U01EB027005-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9617591\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9617591\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nThis grant will develop a wireless wearable high-performance, high-density diffuse optical tomography (DOT)\ninstrument for mapping of brain function in naturalistic settings."},{"title":"A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior","field_investigator":"Thomas Robert Clandinin, Michael H Dickinson, Shaul  Druckmann, Richard S Mann, Richard M Murray, John  Tuthill, Rachel  Wilson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS104655-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9444301\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9444301\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior\nAbstract\nThe Project team\u0027s long-term goal is to develop a comprehensive theory of animal behavior that explicitly\nincorporates neural processes operating across hierarchical levels \u2014 from circuits that regulate the action "},{"title":"A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive","field_investigator":"Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-255","field_project_number":"1R24MH114788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9413774\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9413774\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative\npromotes the development and application of technologies to describe the temporal and spatial\ndynamics of cell types and neural circuits in the brain."},{"title":"A Cellular Resolution Census of the Developing Human Brain","field_investigator":"Eric J Huang, Arnold  Kriegstein","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH114825-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9415877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9415877\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nWe aim to create a spatiotemporal single cell resolution map of the developing human neocortex in order to\nestablish how many distinct cell types are present and to unravel their complex developmental history."},{"title":"A Community Resource for Single Cell Data in the Brain","field_investigator":"James C Gee, Michael  Hawrylycz, Maryann E Martone, Lydia Lup-Ming Ng, Anthony  Philippakis","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-215","field_project_number":"1U24MH114827-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9415946\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9415946\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nA detailed census of the structure and role of cell type specific data in the brain is recognized as one of the most\npromising avenues for advancing our understanding of the human brain in health and disease."},{"title":"A Confocal Fluorescence Microscopy Brain Data Archive","field_investigator":"Marcel P Bruchez, Alexander J Ropelewski, Simon C Watkins","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-255","field_project_number":"1R24MH114793-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9413855\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9413855\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Advancements in the field of microscopy and imaging have pushed the boundaries of what\nwas once thought possible in many fields of research."},{"title":"A General Approach for the Development of New Cell-Type-Specific Viral Vectors","field_investigator":"Michael Eldon Greenberg","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114081-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380066\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380066\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary:\nOur limited ability to genetically access specific cell types within the nervous system constitutes a fundamental\nimpediment in our efforts to probe brain function and intervene therapeutically, particularly in species lacking\nthe well-developed genetic resources available in the mo"},{"title":"A magnetic particle imager (MPI) for functional brain imaging in humans","field_investigator":"Lawrence L Wald","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-002","field_project_number":"1U01EB025121-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9418281\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9418281\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"In this U01 grant we propose a 5 year engineering development effort to advance Magnetic\nParticle Imaging (MPI) to replace MRI as the next-generation functional brain imaging tool for human\nneuroscience."},{"title":"A microscope optimized for brain-scale 2-photon imaging","field_investigator":"Bijan  Pesaran","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103518-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405275\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405275\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"This proposal presents an academic-industrial partnership to develop an instrument for 2-photon laser\nscanning microscopy (2p-LSM) in non-human primates (NHP) for transformative basic science and clinical\ntranslation."},{"title":"A Molecular and Cellular Atlas of the Marmoset Brain","field_investigator":"Guoping  Feng","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH114819-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9415538\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9415538\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\n The complexity of the mammalian brain is unparalleled by any other organ, and understanding its\ncellular composition is essential to understand how it gives rise to cognition and behavior."},{"title":"A multimodal atlas of human brain cell types","field_investigator":"Ed  Lein","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-210","field_project_number":"1U01MH114812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9414852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9414852\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract:\nA Multimodal Atlas of Human Brain Cell Types\n Cell types are the building blocks of the brain, including the neuron types forming specific neuronal\ncircuits responsible for perception, cognition and action, and the non-neuronal elements performing other\nessential roles for proper brain fun"},{"title":"A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)","field_investigator":"Matthew Ryan Banghart, Geoffrey A Chang","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028399-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395804\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nNeuromodulators play an important role in our life by dynamically adapting the brain to an ever-changing\nenvironment."},{"title":"A whole-brain ultrasonic neural stimulation and photoacoustic recording system in behaving animals","field_investigator":"Omer  Oralkan, Mesut  Sahin","field_institution":"North Carolina State University Raleigh","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028456-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405200\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405200\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\n Decoding the electrical and chemical signals in neural circuits is essential to understand the\ncommunication between different brain regions and how these neural networks give rise to a particular function\nat the level of the whole organism."},{"title":"Accessing the Neuronal Scale: Designing the Next Generation of Compact Ultra High Field MRI Technology for Order-of-Magnitude Sensitivity Increase in Non-Invasive Human Brain Mapping","field_investigator":"Brian Keith Rutt","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-001","field_project_number":"1R01EB025131-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420368\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420368\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\n A complete understanding of both normal brain function and neurological disorders \/ mental illness will\nrequire the deciphering of the complex brain networks that underlie behavior and cognition, at both whole-brain\nand microscopic scales."},{"title":"Achieving ethical integration in the development of novel neurotechnologies","field_investigator":"Winston  Chiong","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-260","field_project_number":"1R01MH114860-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9419500\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9419500\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\/ABSTRACT\nNew technologies that modulate brain function have tremendous potential for alleviating the persistent burden\nof depression and other neuropsychiatric disorders, but also raise challenging ethical and societal questions\nregarding self-ownership and control over our thoughts,"},{"title":"An academic industrial partnership for the development of high frame-rate transcranial super resolution ultrasound imaging","field_investigator":"Paul A Dayton, Gianmarco  Pinton","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-001","field_project_number":"1R01EB025149-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nVery recently, the revolutionary technology of contrast enhanced super-resolution ultrasound imaging has been\ndeveloped."},{"title":"An anatomical cell type atlas of gene expression, morphology and connectivity","field_investigator":"Hongkui  Zeng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-225","field_project_number":"1U19MH114830-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9416011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9416011\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary (Research Segment 2)\nThe brain circuit is an intricately interconnected network of numerous cell types."},{"title":"Anatomical characterization of neuronal cell types of the mouse brain","field_investigator":"Giorgio A Ascoli, Hong-Wei  Dong, Byungkook  Lim","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-230","field_project_number":"1U01MH114829-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9416006\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9416006\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY AND ABSTRACT\nA comprehensive understanding neuronal cell type diversity is an essential guide to selective manipulation and\nilluminating cell type specific functional contributions toward health and disease."},{"title":"Anatomy","field_investigator":"Z Josh Huang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-225","field_project_number":"1U19MH114821-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9415770\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9415770\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ANATOMY\u0026nbsp;RESEARCH\u0026nbsp;SEGMENT\u0026nbsp;SUMMARY\u0026nbsp;\u0026nbsp;\nThe\u0026nbsp; overarching\u0026nbsp; goal\u0026nbsp; of\u0026nbsp; neuroanatomy\u0026nbsp; is\u0026nbsp; to\u0026nbsp; establish\u0026nbsp; a\u0026nbsp; structural\u0026nbsp; framework\u0026nbsp; to\u0026nbsp; integrate\u0026nbsp; multiscale\u0026nbsp; and\u0026nbsp;\nmulti-\u00admodal\u0026nbsp;information\u0026nbsp;and\u0026nbsp;to"},{"title":"Behavioral state modulation of sensorimotor processing in cerebellar microcircuits","field_investigator":"Shane A Heiney","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104836-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450090\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450090\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"PROJECT SUMMARY\nMoment-to-moment fluctuations in behavioral and brain states have been shown to have profound effects on\nperception and behavior in both humans and experimental animals."},{"title":"BIDS-Derivatives: A data standard for derived data and models in the BRAIN Initiative","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-256","field_project_number":"1R24MH114705-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9411944\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9411944\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\nThe effective sharing of data requires the development and broad adoption of standards for the\norganization of data and metadata."},{"title":"Brain circuit mapping using light inducible recombinase systems","field_investigator":"Ali Haydar Cetin","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114106-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380757\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380757\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nMammalian brain is composed of vast numbers of intricately interconnected neurons with various\nmolecular, anatomical and physiological identities."},{"title":"Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivo","field_investigator":"Stephane  Dieudonne, Michael Z. Lin","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103464-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404267\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404267\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Recording the electrical impulses of many individual neurons in intact brain circuits in real time would enable a detailed\nunderstanding of how the brain processes information."},{"title":"Calcium biosensors for deep-tissue imaging and spectral multiplexing","field_investigator":"Vladislav  Verkhusha","field_institution":"Albert Einstein College Of Medicine, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1U01NS103573-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405189\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405189\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Calcium signaling participates in almost every aspect of cell functioning, specifically in neurons."},{"title":"Center for Epigenomics of the Mouse Brain Atlas (CEMBA)","field_investigator":"Edward M Callaway, Joseph R Ecker","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-225","field_project_number":"1U19MH114831-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9416014\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9416014\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"OVERVIEW: Project Summary\nA comprehensive understanding of how neural circuits spanning the entire brain generate the full repertoire of\nperception and behaviors requires a list of brain cell types, as well the means to target each cell type in order\nto interrogate the functional interactions that g"},{"title":"Cerebellar network mapping with a high-throughput TEM platform","field_investigator":"Wei-Chung Allen Lee","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9379329\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9379329\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nA fundamental goal in neuroscience is to understand how information is processed in neuronal circuits.\nUltimately, we would like to understand the relationship between circuit structure and network function.\nHowever, the immense complexity of most brain networks has been a s"},{"title":"Circuit mechanisms of evidence accumulation during decision-making","field_investigator":"Zhihao  Luo","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9453242\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9453242\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCircuit mechanisms underlying evidence accumulation during decision-making\nBehavior across many types of decision-making is well described by the gradual accumulation of evidence\ntoward one of multiple alternatives."},{"title":"Collaboratory for atlasing cell type anatomy in the female and male mouse brain","field_investigator":"Pavel  Osten","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-230","field_project_number":"1U01MH114824-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9415873\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9415873\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Even though scientists have been captivated by the diversity of brain cells for well over a century, since the\ninitial anatomical descriptions by Santiago Ram\u00f3n y Cajal, it is only recently that the developments in new\ntechnologies allowed us to truly appreciate the astonishing complexity of cell ty"},{"title":"Computational and circuit mechanisms underlying motor control","field_investigator":"Rui M.  Costa","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS104649-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9444169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9444169\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Understanding the mechanisms that the nervous system uses to control movement is critical for\nunderstanding brain and behavior, and one of the fundamental questions in neuroscience."},{"title":"Controlled neuronal firing in vivo using two photon spatially shaped optogenetics","field_investigator":"Emily  Gibson, Diego  Restrepo","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS099577-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404641\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404641\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"This is an application in response to RFA-NS-17-00 4 \u201cBRAIN Initiative: Optimization of Transformative\nTechnologies for Large Scale Recording and Modulation in the Nervous System (U01)\u201d."},{"title":"Cortex-wide volumetric imaging of neuronal activity.","field_investigator":"Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103488-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404605\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404605\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"We propose to design, build, apply, and disseminate a device that will push the boundaries of current\ntechnology for volumetric imaging of distributed activity of large-scale neuronal circuits at high neuronal\nsampling rate and single cell resolution."},{"title":"Decoding the neural basis of resting-state functional connectivity mapping","field_investigator":"Elizabeth M. C. Hillman","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH114276-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390663\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390663\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nResting state functional magnetic resonance imaging (rs-fMRI) is an important modality for imaging the human\nbrain."},{"title":"Deep brain stimulation for depression using directional current steering an individualized network targeting","field_investigator":"Wayne K Goodman, Nader  Pouratian, Sameer Anil Sheth","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103549-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405272\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405272\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nThe public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain\nstimulation (DBS) that have, unfortunately, produced inconsistent outcomes."},{"title":"Defining Cell Type Specific Contributions to fMRI Signals","field_investigator":"Jin Hyung  Lee","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH114227-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9389941\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9389941\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary \/ Abstract: The blood oxygenation level dependent (BOLD) functional Magnetic\nResonance Imaging (fMRI) signal source has been long debated since the invention of fMRI in the early 90s.\nWhile fMRI is one of the most successful technologies utilized in numerous studies, the debate over "},{"title":"Develop and validate novel chemogenetic tools to modulate synaptic transmission","field_investigator":"Susumu  Tomita","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9379926\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9379926\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Neural circuits encode animal behaviors, and neuroplasticity induces long-lasting\nchanges in neural circuits and animal behaviors. Neural circuits are formed by billions of\nneurons, which communicate mostly through synapses."},{"title":"Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in the Mouse Brain","field_investigator":"Steven Graham Adie","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028389-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395572\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395572\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nOptical imaging holds tremendous promise in our endeavor to understand brain functions. The major\nchallenges for optical brain imaging are depth and speed. Due to strong tissue scattering, the penetration\ndepth and imaging speed of optical microscopy in the mouse brain is very limited."},{"title":"Development of Line-Scan Temporal Focusing for fast structural imaging of synapse assembly\/disassembly in vivo","field_investigator":"Josiah R Boivin","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115441-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454808\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454808\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"A disproportionately large number of mutations resulting in neurodevelopmental and neuropsychiatric\ndisorders target synaptic proteins. Synapse remodeling and loss precede cell death in neurodegenerative\ndisorders, and addictive drugs can alter circuit connectivity."},{"title":"Development of tools for cell-type specific labeling of human and mouse neocortical neurons","field_investigator":"Ed  Lein, Boaz Pirie Levi, Jonathan T Ting","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114126-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9381459\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9381459\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nHow the brain performs its computational task is a great unsolved problem in biology, but this answer is vital\nfor us to understand and combat disorders of brain function like autism, schizophrenia, and Alzheimer\u2019s.\nOne appealing strategy towards solving this problem is to deconstruc"},{"title":"Diffuse, spectrally-resolved optical strategies for detecting activity of individual neurons from in vivo mammalian brain with GEVIs","field_investigator":"Nozomi  Nishimura","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028391-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Measuring and understanding the activity of individual neurons is critical for understanding how neuronal circuits function and lead to behavior. Two-photon microscopy of calcium-sensitive indicators has produced insightful data on the role of individual neurons with populations."},{"title":"Direct MEG\/EEG detection using a novel MRI approach","field_investigator":"Paul A Bottomley","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028353-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9393157\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9393157\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"This R21 grant responds to RFA-EY-17-001 \u201cBRAIN Initiative: New Concepts and Early-Stage Research for\nLarge-Scale Recording and Modulation in the Nervous System \u2026for unique and innovative technologies in an\neven earlier stage of development \u2026 including new and untested ideas in the initial stages of"},{"title":"Electrophysiological Biomarkers to Optimize DBS for Depression","field_investigator":"Helen S Mayberg","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103550-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405277\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nDeep brain stimulation (DBS) of the subcallosal cingulate (SCC) white matter is an emerging new treatment\nstrategy for treatment resistant depression (TRD) with published studies demonstrating sustained long-term\nantidepressant effects in 40-60% of implanted patients."},{"title":"Electrophysiological source imaging guided transcranial focused ultrasound","field_investigator":"Bin  He","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1RF1MH114233-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390149\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390149\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\nWe propose to develop and test a novel noninvasive neuromodulation technique integrating transcranial\nfocused ultrasound (tFUS) with electrophysiological source imaging (ESI) to allow real-time evidence-based\nneuromodulation with spatio-temporal precision for brain research and manag"},{"title":"Elementary Neuronal Ensembles to Whole Brain Networks:  Ultrahigh Resolution Imaging of Function and Connectivity in Humans","field_investigator":"Kamil  Ugurbil","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-002","field_project_number":"1U01EB025144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420395\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420395\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"ABSTRACT:\n The strategic plan of the NIH\u0027s BRAIN Initiative (BRAIN 2025: A scientific Vision) calls for transformative\ntechnological developments with MRI to achieve \u201csubmillimeter spatial resolution descriptions of neuronal\nactivity, functional and structural connectivity, and network analysis in t"},{"title":"Enabling ethical participation in innovative neuroscience on mental illness and addiction: towards a new screening tool enhancing informed consent for transformative research on the human brain","field_investigator":"Laura W Roberts","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-260","field_project_number":"1R01MH114856-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9419223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9419223\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Great discoveries in neuroscience hold promise for reducing the burden of many of the most disabling\nconditions that threaten human health on a global scale, including mental illnesses and addictions.\nIncreasingly, exceptionally innovative science inspires hope that these devastating brain-based dis"},{"title":"Enabling Shared Analysis and Processing of Large Neurophysiology Data","field_investigator":"William J Schroeder","field_institution":"Kitware, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-121","field_project_number":"1R44MH115731-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9409114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9409114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"Project Summary \/ Abstract\nUnderstanding brain function is key to improving health care and advancing a number of scientific initiatives.\nThe treatment of degenerative brain diseases such as Alzheimer\u0027s, Parkinson\u2019s, and ALS is becoming\nincreasingly important as the current US population ages and li"},{"title":"Engineering optogenetic tools for studying neuropeptide activity","field_investigator":"Alexander Robert French","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454009\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454009\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"7. Project Summary\/Abstract\nOpioid receptors (ORs), consisting of \uf06d-, \uf064-, and \uf06b-ORs, are neuropeptide receptors that are broadly involved\nin regulating analgesia, mood, reward, and motor coordination."},{"title":"Ensemble neural dynamics in the medial prefrontal cortex underlying cognitive flexibility and reinforcement learning","field_investigator":"Surya  Ganguli, Mark J Schnitzer","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104833-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450063\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450063\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Abstract\nThe prefrontal cortex is thought to play a crucial role in cognitive flexibility, in part by updating a person\u0027s\nexpectations about the external world and the likely consequences of candidate actions based on the feedback\ngained from past actions."},{"title":"Ethical Safeguards for Exit and Withdrawal from Implanted Neurotechnology Research","field_investigator":"Lauren  Sankary","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115419-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9453509\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9453509\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nResearch participants face complex decisions about the surgical removal of implanted devices\nupon exiting clinical trials of implanted neurotechnology."},{"title":"Ethics of Patients and Care Partners Perspectives on Personality Change in Parkinsons disease and Deep Brain Stimulation","field_investigator":"Cynthia M. S. Kubu","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-260","field_project_number":"1R01MH114853-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9419030\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9419030\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\nIn our work with patients with neurological disorders, we often encounter patients and families who are afraid.\nThey are afraid that due to their neurodegenerative disorder or potential treatment, such as neurosurgery, they\nwill cease to exist \u2013 they will no longer be who they \u201care\u201d."},{"title":"Fluidic microdrives for minimally invasive actuation of flexible electrodes","field_investigator":"Jacob T. Robinson","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028397-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395642\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395642\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Fluidic Microdrives for Minimally Invasive Implantation and Actuation of Flexible Neural\nElectrodes\nAbstract\nFlexible microelectrodes that match the mechanical properties of the brain promise to increase the quality and\nlongevity of neural recordings by reducing chronic inflammatory reactions; howev"},{"title":"From microscale structure to population coding of normal and learned behavior","field_investigator":"Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104911-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThis study aims to understand how the ensemble activity and network architecture of a neuronal population\nguides natural and learned behavior."},{"title":"GABAergic circuit interactions within the behaving mouse dLGN","field_investigator":"Martha E Bickford, William  Guido","field_institution":"University Of Louisville","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104807-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449526\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449526\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Abstract\n The flow of visual information from the retina, through the dorsal lateral geniculate nucleus\n(dLGN) to the cortex, is regulated by behavior. However, the dynamic circuit interactions that occur in\nthe dLGN of awake animals, and their modulation by behavior, have yet to be revealed."},{"title":"Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain","field_investigator":"Maria Angela  Franceschini","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-001","field_project_number":"1R01EB025145-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420764\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420764\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nWith this grant application we aim to dramatically improve over the capabilities of functional near-infrared\nspectroscopy (fNIRS) by developing a completely novel approach to measure human brain function."},{"title":"Genetic analyses of complete circuit formation in Caenorhabditis elegans","field_investigator":"Steven Jay Cook","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9454707\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9454707\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary \/ Abstract\nDespite the central importance of neural circuit development to brain function and behavior, we lack the genetic\ninformation required to assemble a complete circuit."},{"title":"Genetically Encoded Activity Sensors for Photoacoustic Imaging of the Brain","field_investigator":"Oliver  Griesbeck, Daniel  Razansky","field_institution":"Max Planck Institute For Neurobiology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028365-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9394827\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9394827\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nNew tools for large-scale recording of neuronal activity in a living and behaving brain are essential for a\nbetter understanding of brain function, efficient analysis and treatment of neuronal disorders."},{"title":"Genetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animals","field_investigator":"Axel  Nimmerjahn, Lin  Tian, Mark E Vonzastrow, John T Williams","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103522-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405342\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Brain functions are executed by intricately coordinated networks of neurons, whose modes of operation are\nhighly sensitive to a constellation of neuromodulators."},{"title":"Genetically-targeted hemodynamic functional imaging","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1U01NS103470-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404180\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The dominant techniques for brain-wide functional imaging in humans and opaque mammals make use of he-\nmodynamic contrast that results from coupling between neural activity and changes in blood flow and can be\ndetected by noninvasive imaging methods including functional magnetic resonance imaging (f"},{"title":"High density multielectrode arrays with spatially selective unidirectional and rotating fields for investigation of neuronal networks","field_investigator":"Shalom  Michaeli","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1U01NS103569-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405098\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"In response to the BRAIN initiative RFA-NS-17-003 \u201cNew Technologies and Novel Approaches for Large-Scale\nRecording and Modulation in the Nervous System (U01)\u201d, in this project we aim at accomplishing selective\nstimulation and recordings at ultra-high cellular level spatial resolution of distinct axo"},{"title":"High Throughput Approaches for Cell-Specific Synapse Characterization","field_investigator":"Alison L Barth, Marcel P Bruchez","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380589\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380589\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT DESCRIPTION\n Synapses are formed, broken and reformed dynamically both during development, normal\nfunction and in response to activity."},{"title":"High throughput mapping of neuronal circuitry using DNA sequencing","field_investigator":"Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114132-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9382138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9382138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe long-term goal of these investigations is to develop methods based on high-\nthroughput DNA sequencing for determining neuronal circuitry. Neurons transmit\ninformation to distant brain regions via long-range axonal projections."},{"title":"High Throughput of Protein-based Voltage Probes","field_investigator":"Vincent A Pieribone","field_institution":"John B. Pierce Laboratory, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103517-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405261\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"A significant motivation of the BRAIN Initiative is the desire to understand information processing in\nneuronal tissues in situ."},{"title":"High-speed volumetric imaging of neural activity throughout the living brain","field_investigator":"Na  Ji","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103489-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404832\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404832\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"To understand how the brain computes, we need to understand how individual neurons in a circuit integrate\ntheir numerous inputs into output signals, as well as how they work together to encode a sensory input or\nexecute a motor command in a behaving animal."},{"title":"Imaging Human Brain Function with Minimal Mobility Restrictions","field_investigator":"Michael  Garwood","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-002","field_project_number":"1U01EB025153-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9421062\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9421062\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Magnetic resonance imaging (MRI), by offering the sole means of imaging human brain\nstructure and activity with high spatial resolution, has evolved into an indispensable tool for\nstudying brain function in health and disease."},{"title":"Impact of cortical feedback on odor concentration change coding","field_investigator":"Roman  Shusterman, Matthew C Smear","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104935-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451132\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451132\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"ABSTRACT\n Top-down feedback connections between \u201chigher\u201d and \u201clower\u201d brain areas are quite common, but\ntheir functional role remains a mystery. This general principle applies to the olfactory system, in which the\nolfactory bulb receives dense feedback innervation from its cortical targets."},{"title":"Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates","field_investigator":"Marc A Sommer","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH114253-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390539\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390539\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Non-invasive methods for stimulating the human brain show great promise for safe, effective treatments of\npsychiatric and motor disorders, and are in widespread use for basic research on human behavior and\ncognition."},{"title":"Integrated compressive sensing microscope for high-speed functional biological imaging","field_investigator":"Sang Peter Chin","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395305\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395305\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Direct readout of spiking and subthreshold voltage activity from genetically-specified neural\npopulations will facilitate major advances in our understanding of neural computation at the\nnetwork level."},{"title":"Integrative Analysis of Long-range Top-down Cortical Circuit for Attentional Behavior","field_investigator":"Hirofumi  Morishita","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS105119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9458405\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9458405\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Attention deficit symptoms are frequently observed in psychiatric disorders, yet finite understanding of the\nneural circuits mediating attentional behavior has limited pathophysiologic insight."},{"title":"Integrative approach to classifying neuronal cell types of the mouse hippocampus","field_investigator":"Hong-Wei  Dong, Li I Zhang","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114112-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380877\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nIdentifying the diversity of cell types in the nervous system will allow for their selective manipulation and reveal\ntheir functional contributions in health and disease."},{"title":"Intraoperative studies of flexible decision-making","field_investigator":"Gordon H Baltuch, Joshua I Gold","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-019","field_project_number":"1U01NS103799-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9421087\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9421087\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\nDeep Brain Stimulation (DBS) is a surgical procedure that is used to treat the debilitating symptoms of\nParkinson\u0027s Disease (PD)."},{"title":"Investigating information processing in parallel circuits that link external chemical signals to social behavior","field_investigator":"Julian P Meeks","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449930\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Project Summary\/Abstract\nThe goal of this exploratory research project is to improve understanding about the mechanisms by which\nmammalian neural circuits decode environmental chemosensory information and use that information to\nsupport survival and reproduction."},{"title":"Investigating the Role of Neurotensin on Valence Assignment During Associative Learning in the Basolateral Amygdala","field_investigator":"Jacob Michael Olson","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115446-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9455235\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9455235\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Learned associations between environmental stimuli and organism-effecting outcomes guide adaptive\nbehavior. When healthy, this process results in increased rewards and decreased harm."},{"title":"Large-scale analysis of functional synapses during circuit plasticity with novel optogenetic sensors","field_investigator":"Karen  Zito","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1U01NS103571-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405129\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"One of the major challenges in neuroscience is to understand the experience-dependent mechanisms\nthat drive the changes in neural circuits that underlie complex behaviors, and how these mechanisms are\naltered in disease."},{"title":"Large-scale monitoring of sensory transformations in the mammalian olfactory system","field_investigator":"Shawn Denver Burton","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115448-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9455273\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9455273\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nHow information is transformed as it propagates through a neural circuit remains an outstanding question of modern\nneuroscience."},{"title":"Low cost, fully implantable wireless optoeletronic devices for optogenetics research","field_investigator":"Roozbeh  Ghaffari","field_institution":"Neurolux, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-121","field_project_number":"1R44MH114944-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9252963\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9252963\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"Project Summary \/ Abstract\n The methods of optogenetics enable light-induced, area-confined stimulation or inhibition\nof genetically targeted neurons, thereby bypassing key disadvantages of electrical approaches.\nAs a result, optogenetics is now widely viewed as an essential tool in neuroscience res"},{"title":"MACHINE LEARNING APPROACHES FOR ELECTROPHYSIOLOGICAL CELL CLASSIFICATION","field_investigator":"Alison L Barth","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104821-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449797\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449797\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"ABSTRACT\nWe will use our expertise in somatosensory organization and plasticity to develop novel and\nautomated solutions for cell identification based upon neural activity, in order to decode the\nalgorithms neural circuits use for information processing."},{"title":"Mechanism and dosimetry exploration in transcranial electrical stimulation using magnetic resonance current mapping methods.","field_investigator":"Rosalind J Sadleir","field_institution":"Arizona State University-Tempe Campus","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH114290-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390711\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390711\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Abstract\nTranscranial electrical stimulation (tES) methods, principally transcranial direct current simulation\n(tDCS) and transcranial alternating current stimulation (tACS) are neuromodulation techniques that\nhave been the subject of great recent interest."},{"title":"Mechanisms of neural circuit dynamics in working memory anddecision-making","field_investigator":"Carlos D Brody, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS104648-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9444124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9444124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nWorking memory, the ability to temporarily hold multiple pieces of information in mind for manipulation, is\ncentral to virtually all cognitive abilities."},{"title":"Mechanistic dissection of the neural basis of the resting-state fMRI signal using multi-modal approaches","field_investigator":"Patrick James Drew, Nanyin  Zhang","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH114224-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9389666\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9389666\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary The primary goal of this application is to elucidate the neural basis of resting-state\nfunctional magnetic resonance imaging (rsfMRI) signal using multi-modal approaches including multi-echo (ME)-\nrsfMRI, MR-compatible calcium signal recording, optogenetics and multi-laminar electrop"},{"title":"Methodologically-Integrated Approaches Linking Cell Types to Neural Circuits and Function","field_investigator":"Edward M Callaway","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS105129-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9459190\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9459190\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Project Summary\nUnderstanding the circuit mechanisms that give rise to perception and behavior requires linking neuronal\nactivity to connectivity. This can be accomplished at multiple scales and ideally can be related to further\nstudies using activity manipulations to demonstrate causality."},{"title":"MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER","field_investigator":"David Alan Feinberg, Chunlei  Liu, Pratik  Mukherjee, Kawin  Setsompop, Lawrence L Wald","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-002","field_project_number":"1U01EB025162-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9421501\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9421501\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"SUMMARY\nThe overarching objective of our proposal is to bring noninvasive human brain imaging into the microscale\n(50-500 micron isotropic) resolution in order to create a tool for studies of neuronal circuitry and network\norganization in the human brain."},{"title":"Multi-context software for robust and reproducible neuroscience image analysis","field_investigator":"Xenophon  Papademetris, Dustin  Scheinost","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH114805-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9414748\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9414748\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary (Abstract)\nThe goal of this application is to develop, test, and disseminate multi-context (command line, desktop, server,\nand web applications) software for robust and reproducible neuroscience image analysis from data across mul-\ntiple scales (two photon microscopy, mesoscale Ca2+ "},{"title":"Multi-regional neural circuit dynamics underlying short-term memory","field_investigator":"Shaul  Druckmann, Nuo  Li","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS104781-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9449037\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9449037\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Abstract\nShort-term memory (STM) is a core cognitive function, critical for reasoning, decision-making, and flexible\nbehavior. Though it has been recognized as a key function of interest for many decades, the critical neural\nsubstrate of STM is little understood."},{"title":"Nano-switches for optogenetic control of neuronal proteins with ultra-specificity","field_investigator":"Lei  Wang","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114079-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9379982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9379982\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\/Abstract\nThe ability to control protein function with light provides excellent temporal and spatial resolution for precise\ninvestigation in situ, and thus is having significant impact on neuroscience."},{"title":"Neuroethics of aDBS Systems Targeting Neuropsychiatric and Movement Disorders","field_investigator":"Wayne K Goodman, Gabriel  Lazaro-Munoz, Amy L Mcguire","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-260","field_project_number":"1R01MH114854-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9419044\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9419044\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\n Adaptive deep brain stimulation (aDBS) systems can record neural activity and adjust stimulation in real\ntime."},{"title":"Neuromodulatory control of collective circuit dynamics in C. elegans","field_investigator":"Steven Willem Flavell","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9450709\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9450709\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Many animal behaviors are organized into long-lasting states, perhaps most strikingly in the sleep\/wake\nand emotional states that mammals display. However, the fundamental mechanisms that allow animals to\ninitiate, maintain and terminate these states are unknown."},{"title":"Neuronal mechanisms of human episodic memory","field_investigator":"Adam Nathaniel Mamelak, Ueli  Rutishauser","field_institution":"Cedars-Sinai Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-019","field_project_number":"1U01NS103792-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420455\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420455\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\nThe rapid formation of new memories and the recall of old memories to inform decisions is essential for human\ncognition, but the underlying neural mechanisms remain poorly understood."},{"title":"NeuroPET HD: A low-cost high performance neuro-PET imaging system","field_investigator":"William Coulis Jason Hunter","field_institution":"Pet\/X, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-090","field_project_number":"1R41NS102037-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9410024\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9410024\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"This revised proposal is in response to PAR-15-090 \u0022BRAIN Initiative: Development, Optimization, and\nValidation of Novel Tools and Technologies for Neuroscience Research\u0022."},{"title":"Neurostimulation and Recording of Real World Spatial Navigation in Humans","field_investigator":"Nanthia A Suthana","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-019","field_project_number":"1U01NS103802-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9421510\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9421510\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Project Summary\/Abstract\nDecades of research and clinical observations have established that episodic memory, the ability to remember\nrecently experienced events, depends on the hippocampus and associated structures in the medial temporal\nlobe (MTL), including entorhinal, perirhinal and parahippocam"},{"title":"Noninvasive neuromodulation via focused ultrasonic drug uncaging","field_investigator":"Raag D Airan","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1RF1MH114252-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390538\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390538\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY .\nIn psychiatry, we are limited by the mismatch between the diverse heterogeneity of the brain and the tools we\nhave to treat it."},{"title":"Novel fluorescent sensors based on GPCRs for imaging neuromodulation","field_investigator":"Samuel Andrew Hires, Yulong  Li, Li I Zhang","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-003","field_project_number":"1U01NS103558-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405344\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405344\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neuromodulators are essential signaling molecules that regulate many neural processes, including\ncognition, mood, memory, and sleep, through their influence on brain circuits."},{"title":"Novel Neuromodulation by Transcranial Infrared Brain Stimulation with Imaging","field_investigator":"Francisco  Gonzalez-Lima, Hanli  Liu","field_institution":"University Of Texas Arlington","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1RF1MH114285-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390695\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390695\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nThis project will develop a novel infrared-based neuro-stimulation tool for specifically modulating neural\ncircuitry. Transcranial infrared brain stimulation (TIBS) at 1064 nm will be developed as a new tool for non-\ninvasive neuromodulation of the human brain."},{"title":"Optimization of multiphoton microscopy for large scale activity mapping in adult zebrafish","field_investigator":"Joseph R. Fetcho, Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-004","field_project_number":"1U01NS103516-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9405203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9405203\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Vertebrate behaviors emerge from interactions of neurons across the brain, but the tools for revealing\nneuronal structure and function at the cellular level in living animals access only small portions of the brain."},{"title":"Predictive models of brain dynamics during decision making and their validation using distributed optogenetic stimulation","field_investigator":"Bijan  Pesaran","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104923-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451080\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451080\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDuring behavior, the oculomotor system is tasked with selecting objects from an ever-changing visual field and\nguiding eye movements to these locations."},{"title":"Prosthetic System for Large-Scale Recording and Manipulation of Neural Circuit Activity in Non-Human Primates","field_investigator":"Albert Baldwin Goodell","field_institution":"Graymatter Research","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-091","field_project_number":"1R43NS102075-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9410278\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9410278\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"The fundamental objective of the BRAIN Initiative is to understand how dynamic activity in distributed\nneural circuits mediates human cognitive behavior."},{"title":"Resolving Fine Architectures of Human Gray Matter with Ultra-High-Resolution Diffusion MRI","field_investigator":"Yulin  Ge, Jiangyang  Zhang","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-001","field_project_number":"1R01EB025133-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420418\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420418\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract: Our brain is a complex network with multiple levels of organization in white matter (WM) and gray\nmatter (GM). The axonal and dendritic organizations of local GM tissue form one of the structural bases of\nnormal brain functions."},{"title":"Revealing circuit control of neuronal excitation with next-generation voltage indicators","field_investigator":"Thomas Robert Clandinin, Michael Z. Lin","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114105-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380741\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380741\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nRecording the electrical impulses of individual neurons in intact brain circuits in real time has been a longstanding goal in\nneuroscience."},{"title":"Reversing Synchronized Brain Circuits with Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts","field_investigator":"Susan E Shore","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH114244-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390327\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390327\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nThe dorsal cochlear nucleus (DCN) integrates auditory and somatosensory information through circuitry that\nmodulates activity of the principal output neurons of the circuit, the fusiform cells."},{"title":"SABER: Scalable Analytics for Brain Exploration Research using X-Ray Microtomography and Electron Microscopy","field_investigator":"William R Gray Roncal","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-257","field_project_number":"1R24MH114799-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9414126\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9414126\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Abstract\nAdvances in imaging have had a profound effect on our ability to generate high-resolution measurements of\nthe brain\u2019s structure."},{"title":"Scalar Closed-Loop STN\/GPi DBS Based on Evoked and Spontaneous Potentials","field_investigator":"Dennis Alan Turner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS103468-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9404120\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9404120\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nDBS therapy for Parkinson\u0027s disease is now the primary surgical approach for Parkinson\u0027s disease, recently\nFDA approved at 4 years after onset of disease."},{"title":"SELF-POWERED SENSING AND DATA-LOGGING FOR LARGE-SCALE IN-VIVO MONITORING OF NEURAL ENSEMBLE ACTIVITY","field_investigator":"Shantanu  Chakrabartty","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028362-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9394416\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9394416\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nThe current state-of-the-art neural recording technology is limited by the ability to remotely and continuously\ndeliver power to the implanted sensors."},{"title":"Sensorimotor processing, decision making, and internal states: towards a realistic multiscale circuit model of the larval zebrafish brain","field_investigator":"Florian  Engert, Jeff W Lichtman, Haim  Sompolinsky","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS104653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9444232\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9444232\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary - A realistic multiscale circuit model of the larval zebrafish brain\nThe working group of the BRAIN initiative (BRAIN 2025, a Scientific Vision) identified \u201cthe analysis of circuits of\ninteracting neurons as being particularly rich in opportunity, with potential for revolutionary adv"},{"title":"Spinal root stimulation for restoration of function in lower-limb amputees","field_investigator":"Lee E Fisher, Douglas J Weber","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-006","field_project_number":"1UH3NS100541-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9403325\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9403325\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY \/ ABSTRACT\nRecent advances in design and actuation have led to important improvements in prosthetic limbs. However, these devices\nlack a means for providing direct sensory feedback, requiring users to infer information about limb state from pressure on\nthe residual limb."},{"title":"Split RNA polymerases for sensitive, multidimensional analysis of intercellular PPIs at synapses","field_investigator":"Bryan  Dickinson, Engin  Ozkan","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-220","field_project_number":"1RF1MH114102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9380584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9380584\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nDeciphering the complex underpinning of brain structure and function requires a complete understanding of how\nmolecular contacts between cells in the brain are regulated."},{"title":"Technologies to drastically boost photon sensitivity for brain-dedicated PET","field_investigator":"Craig S Levin","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-17-001","field_project_number":"1R01EB025125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9420111\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9420111\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nAccording to the BRAIN 2025 working group report, there is a need to drastically improve the spatiotemporal\nresolution of positron emission tomography (PET), in order to facilitate the translation of new tracers that target\nneuroreceptor function and dynamic PET imaging on t"},{"title":"The Application of Generalized Linear Models to Calcium Imaging Data for Optimal High-Dimensional Receptive Field Estimation and Identification of Latent Network Dynamics","field_investigator":"Stephen L Keeley","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-250","field_project_number":"1F32MH115445-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9455023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9455023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Abstract\nAs new recording methods emerge in neuroscience, new statistical techniques are needed to properly relate\nneural activity to behavior, a given stimulus, or an internal process."},{"title":"THE DYNAMICS OF LONG RANGE CORRELATIONS IN CORTEX: SINGLE UNITS AND OXYGEN","field_investigator":"Lawrence H Snyder","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-015","field_project_number":"1R21NS105090-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9457753\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9457753\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"ABSTRACT\nResting state networks are a fascinating yet poorly understood phenomenon. Sets of spatially\nseparated regions show correlated slow fluctuations in fMRI BOLD signals, most obvious when\nsubjects are at rest."},{"title":"The impact of cerebellar tDCS in local and downstream brain circuits: how much is neuralactivity modulated in the resting state and during sensorimotor processing?","field_investigator":"Javier F Medina","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-245","field_project_number":"1RF1MH114269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390629\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390629\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nNon-invasive stimulation of the cerebellum holds great promise for investigating brain function, and for\ndiagnosing and treating a variety of brain disorders."},{"title":"the self-tuning brain: cellular and circuit mechanisms of behavioral resilience","field_investigator":"Adrienne L Fairhall, Timothy James Gardner, Carlos  Lois","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104925-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451082\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451082\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nA major goal in clinical neuroscience is to develop efficient treatments to prevent or minimize the loss of\nbrain function caused by pathological decreases or increases of neuronal activity, which are hallmarks of a\nwide variety of neurological disorders."},{"title":"Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory Replay","field_investigator":"Gyorgy  Buzsaki, John E Lisman, Attila  Losonczy, Mark J Schnitzer, Ivan  Soltesz","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-018","field_project_number":"1U19NS104590-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9442580\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9442580\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Although neuroscience has provided a great deal of information about how neurons work, the fundamental\nquestion of how neurons function together in a network to produce cognition has been difficult to address.\nOur group has been at the forefront of developing methods that allow large scale monitorin"},{"title":"Trans-Sheet Illumination Microscopy (TranSIM) for decoding whole brain activity at submillisecond temporal resolution","field_investigator":"Katsushi  Arisaka, Laurent A. Bentolila","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028395-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Today\u2019s knowledge of large-scale neural networks is advancing along two orthogonal directions. Spatial (static, structural) connectomic understanding is achieved through optical and electron microscopy; yielding high spatial resolution with limited or no temporal information."},{"title":"Transcranial magnetic stimulation with enhanced focality and depth (fdTMS)","field_investigator":"Angel V Peterchev","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-240","field_project_number":"1RF1MH114268-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390626\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390626\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"This project will develop transcranial magnetic stimulation coils with improved focality and depth (fdTMS).\nTMS is a technique for noninvasive brain stimulation using strong, brief magnetic pulses. TMS is widely used in\nthe neurosciences as a tool for probing brain function and connectivity."},{"title":"Understanding the synaptic, cellular and circuit events of MEG \u0026amp; EEG using a vertically translational cross-species approach","field_investigator":"Chengcheng  Huang, Dean F Salisbury, Tobias  Teichert","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH114223-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9389644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9389644\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"7. PROJECT SUMMARY\nBackground. Electro- and magneto-encephalographic (EEG\/MEG) responses to a stimulus are systematically\nattenuated\u2013 by up to 80%\u2013 if the same stimulus was presented less than 8-12 seconds ago."},{"title":"Using fMRI to Measure the Neural-level Signals Underlying Population-level Responses","field_investigator":"Rosemary Alice Cowell, David Ernest Huber","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-17-235","field_project_number":"1RF1MH114277-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9390666\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9390666\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary: The goal of this proposal is to advance our ability to accurately infer the properties of neu-\nral-level responses from the more coarse-grained information obtained with non-invasive imaging in humans.\nTo achieve this goal, the project will capitalize on feature-selective cortical r"},{"title":"Viral Strategies for Functional Connectomics in the Visual System","field_investigator":"R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-17-014","field_project_number":"1R01NS104949-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9451199\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9451199\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\n A fundamental but unsolved question in neuroscience is how specific connections between brain cells\n(neurons) underlie information processing."},{"title":"Wide-field scan-less multi-photon endoscopy using spatio-temporal pulse delivery and temporal focusing","field_investigator":"Mark A Foster","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222017-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2017\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-17-001","field_project_number":"1R21EY028436-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9395429\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9395429\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/ Abstract\nMultiphoton, depth sectioning micro-endoscopes are of paramount importance in capturing neural activity with\ncellular resolution."},{"title":"\u0026quot;Methods from Computational Topology and Geometry for Analysing Neuronal Tree and Graph Data\u0026quot;","field_investigator":"Partha Pratim Mitra, Yusu  Wang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022899-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170501\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170501\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nProgress from description to quantification is essential as a science matures. Yet numerical analysis of the\nelementary unit of brain circuitry\u2014the individual neuron\u2014continues to pose methodological challenges."},{"title":"A high-speed volumetric multiphoton microscope for the study of developing neural circuits in retina","field_investigator":"Marla  Feller","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111314-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9203174\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9203174\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"Our research goal is to determine the factors that instruct the development of visual\nresponses in the mammalian retina. In particular, we are studying the developmental\nperiod when the retina transitions from generating retinal waves to mediating visual\nresponses by forming functional circuits."},{"title":"A platform for high-throughput production of targeting systems for cell-type-specific transgene expression in wild-type animals","field_investigator":"Ian R Wickersham","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111503-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9213724\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9213724\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nWe will use high throughput techniques to produce a set of viral vectors that will allow selective expression of transgenes in specific populations of neurons in the brain."},{"title":"A tool-box to control and enhance tDCS spatial precision","field_investigator":"Marom  Bikson","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111896-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Aimed at revolutionizing our understanding of the brain, the BRAIN initiative calls for \u201cimprovement of existing non-invasive neuromodulation\u201d techniques."},{"title":"A unified cognitive network model of language","field_investigator":"Nathan E Crone, Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098981-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9206024\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9206024\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Most current approaches to understanding the neural basis of cognitive processes are severely limited in\ntwo respects. First, most commonly used methods do not have the temporal (e.g., fMRI) or spatial (e.g.,\nMEG\/ EEG) resolution to capture the relevant dynamics."},{"title":"Adaptive DBS in Non-Motor Neuropsychiatric Disorders: Regulating Limbic Circuit Imbalance","field_investigator":"Wayne K Goodman","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS100549-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266890\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266890\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"In patients with intractable Obsessive-Compulsive Disorder (OCD), ventral striatum (VS) deep brain stimulation\n(DBS) effectively reduces symptom severity in about 60% of cases."},{"title":"All-Optical Methods for Studying Sequential Motor Behaviors","field_investigator":"Todd F Roberts","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111319-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9203398\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9203398\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"PROJECT SUMMARY\n The execution of learned sequential motor behaviors, like those involved in playing a well learned tune\non the piano, are thought to be supported by precise sequences of neuronal activity in the brain."},{"title":"An optical-genetic toolbox for reading and writing neural population codes in functional maps","field_investigator":"Wilson S Geisler, Eyal J Seidemann, Boris V Zemelman","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231976\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231976\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"The overarching goal of this proposal is to develop an optical-genetic toolbox for reading and writing neural\npopulation codes in functional maps of awake, higher mammals."},{"title":"Asynchronous distributed multielectrode neuromodulation for epilepsy","field_investigator":"Annaelle  Devergnas, Robert E Gross, Claire-Anne N Gutekunst, Babak  Mahmoudi","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-009","field_project_number":"1UG3NS100559-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266991\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266991\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nEpilepsy, occurring in 1 percent of the world\u2019s population, is associated with disability, injury,\ncognitive and neurological dysfunction, depression, loss of productivity, socioeconomic decline\nand even death."},{"title":"Bayesian estimation of network connectivity and motifs","field_investigator":"Dario L Ringach","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022915-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170679\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe overarching goal of this proposal is to learn how large groups of neurons interact in a network to perform\ncomputations that go beyond the individual ability of each cell."},{"title":"Beyond Diagnostic Classification of Autism: Neuroanatomical, Functional, and Behavioral Phenotypes","field_investigator":"Preston Thomas Fletcher","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022876-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170673\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170673\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAutism spectrum disorder (ASD) is a heterogeneous disorder characterized by repetitive and stereotyped be-\nhavior and dif\ufb01culties in communication and social interaction."},{"title":"BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation","field_investigator":"Ute H Hochgeschwender, Christopher I Moore, Nathan Christopher Shaner","field_institution":"Central Michigan University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099709-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231901\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231901\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"New tools to selectively regulate neurons have revolutionized causal experimentation. Optogenetics provides\nan array of elements for specific biophysical control, while designer chemogenetic receptors provide a\nminimally invasive method to control circuits in vivo by peripheral injection."},{"title":"Biophysical Design Strategies for Next-Generation Maquette-based Genetically Encoded Voltage Indicators (GEVIs)","field_investigator":"Brian Y Chow, Bohdana  Discher","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027562-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244163\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244163\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project summary\nA long-standing goal in neuroscience is to unravel complex behavior of healthy and\ndiseased brain by analyzing the structure and dynamics of neural circuitry with single\naction potential resolution."},{"title":"BRAIN Initiative:  Theories, Models and Methods for Analysis of Complex Data from the Brain","field_investigator":"Moo K Chung","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022856-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170211\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170211\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe twin study design in brain imaging offers a very effective way of determining heritability of the human\nbrain. The difference in variability between monozygotic (MZ) and same-sex dizygotic (DZ) twins can be used\nin determining heritability."},{"title":"Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD Signal","field_investigator":"Yen-Yu Ian Shih","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111429-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205952\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205952\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\n Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) is widely\nused in to study human brain function; however the cellular and molecular mechanisms underlying the BOLD\nsignal remain poorly understood."},{"title":"Clinical Testing of an Intracortical Visual Prosthesis System","field_investigator":"Philip R Troyk","field_institution":"Illinois Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-009","field_project_number":"1UG3NS095557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266990\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266990\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\n The proposed work to clinically test an intracortical visual prosthesis under an FDA-approved Early\nFeasibility Study addresses both health and quality-of-life issues because, without some compensatory strategy\nfor vision loss, over two thirds of individuals with blindness are not gainfull"},{"title":"Closed loop deep brain stimulation for Parkinson\u0026#039;s disease","field_investigator":"Philip Andrew Starr","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS100544-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266691\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266691\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nDeep brain stimulation (DBS) has a major role in the management of movement disorders, and is under\ninvestigation for the treatment of disorders of mood and memory."},{"title":"Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor","field_investigator":"Kelly D Foote, Aysegul  Gunduz","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS095553-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266960\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266960\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nEssential tremor (ET) is an incurable, degenerative brain disorder that results in increasingly debilitating tremor, and\nafflicts an estimated 7 million people in the US (2.2% of the population). While the economic impact of ET is\nindeterminate, it is surely quite substantial."},{"title":"Combined  Cortical  and  Subcortical  Recording  and Stimulation  as  a  Circuit-Oriented  Treatment  for  Obsessive-Compulsive  Disorder","field_investigator":"Darin D Dougherty, Alik S Widge","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS100548-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266864\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266864\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nThis project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD\nis a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms\nafter being treated with medication or talk therapy."},{"title":"Compressive Light Field microscopy for optogenetic neural activity tracking","field_investigator":"Laura  Waller","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027597-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244514\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244514\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY: Understanding the mechanisms by which the living brain derives perception, cognition and behavior\nrequires the ability to record and control electrical activity in many neurons simultaneously."},{"title":"Computational Modeling of Deep Brain Stimulation of the Ventral Striatum","field_investigator":"Darin D Dougherty, Alik S Widge","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111320-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9203462\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9203462\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"This project will transfer a computational modeling technology, \u0022StimVision\u0022, from the McIntyre Lab at\nCase Western Reserve University to the deep brain stimulation (DBS) group at Massachusetts General\nHospital (MGH)."},{"title":"Concurrent multiphoton microscopy and magnetic resonance imaging (COMPMRI)","field_investigator":"Yi  Wang, Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027568-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244236\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244236\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"We propose a concurrent multiphoton magnetic resonance imaging (COMPMRI) system for mouse imaging, in\nresponse to RFA-EY-16-001, BRAIN Initiative: New Concepts and Early-Stage Research for Large-Scale\nRecording and Modulation in the Nervous System (R21)."},{"title":"Deep brain photoacoustic tomography at single-neuron resolution using arrays of photonic emitters and high-frequency ultrasound transducers","field_investigator":"Michael L Roukes, Kenneth L Shepard, Lihong  Wang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231961\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231961\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The objective of the proposed three-year research project is to develop high-speed, high-spatial-\nresolution, deep-penetration photoacoustic computed tomography (PACT) for real-time imaging of\nneuro-activities in mouse brains in vivo."},{"title":"Deep cerebellar electrical stimulation for post-stroke motor recovery","field_investigator":"Kenneth B Baker, Andre Guelman Machado","field_institution":"Cleveland Clinic Lerner Com-Cwru","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS100543-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266613\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nStroke is a disease of epidemiological proportions in the industrialized world and a leading cause of long-term\ndisabilities. One third of stroke patients maintain long-term motor deficits severe enough to be disabling,\ndespite rehabilitative efforts."},{"title":"Defining Neuronal Circuits and Cellular Processes Underlying Resting fMRI Signals","field_investigator":"Michael Peter Milham, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9206010\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9206010\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Intrinsic \u2018functional connectivity\u2019 (iFC), a measure of correlation between spontaneous fluctuations in the blood\noxygen level dependent (BOLD) signal, reliably distinguish networks of cortical and subcortical areas during\nboth rest and active task performance."},{"title":"Developing a noninvasive method to manipulate specific cell types within the mammalian brain","field_investigator":"Sreekanth H. Chalasani","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111534-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9214195\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9214195\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Summary\nA central challenge in neuroscience is to develop methods to manipulate specific cell types within the\nmammalian brain. Recent developments in optogenetics have revolutionized our ability to control the activity of\nboth neurons and non-neuronal cells."},{"title":"Development and dissemination of high speed 3D acousto-optic lens two-photon microscopy for in vivo imaging","field_investigator":"David A Digregorio, Michael  Hausser, Thomas  Mrsic-Flogel, John  O\u0026#039;keefe, Robin Angus Silver","field_institution":"University College London","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099689-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231530\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231530\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"To understand brain function in health and disease it is essential to rapidly monitor signaling in neural circuits. Two-photon microscopy is a core tool for neuroscience research because it enables neuronal activity to be monitored at high spatial resolution deep within brain tissue."},{"title":"Development and validation of empirical models of the neuronal population activity underlying non-invasive human brain measurements","field_investigator":"Orrin  Devinsky, Rick M Dijkhuizen, Natalia  Petridou, Nicolas Franciscus Ramsey, Jonathan A Winawer","field_institution":"University Medical Center Utrecht","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111417-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205830\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary \/ Abstract\n A major obstacle in the study of human brain function is that we currently have limited understanding of\nhow the measurements made by different instruments, such as fMRI and EEG, relate to one another and to the\nunderlying neuronal circuitry."},{"title":"Development of an integrated array for simultaneous optogenetic stimulation and electrical recording to study cortical circuit function in the non-human primate brain","field_investigator":"Alessandra  Angelucci, Steven M Blair, Loren  Rieth","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099702-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231778\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231778\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Understanding the function of neural circuits in the cerebral cortex of the non-human primate (NHP), the\nmodel system closest to human, is crucial to understanding normal cortical function and the circuit-level basis\nof human brain disorders."},{"title":"Dexterous BMIs for tetraplegic humans utilizing somatosensory cortex stimulation","field_investigator":"Richard A Andersen","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098975-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205978\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Project summary\/abstract\nReach-to-grasp and hand manipulation will be studied in tetraplegic humans with neural recordings from\nmultielectrode arrays (MEAs) and intracortical microstimulation (ICMS) of somatosensory cortex."},{"title":"Diagnosis of Alzheimer\u0026#039;s Disease Using Dynamic High-Order Brain Networks","field_investigator":"Dinggang  Shen, Pew-Thian  Yap","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022880-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170149\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170149\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Diagnosis of Alzheimer\u0027s Disease Using Dynamic High-\nOrder Brain Networks\nAbstract\nAlzheimer\u0027s disease (AD) is the most common form of dementia with no known disease-modifying treatment.\nCurrent clinical diagnosis and monitoring of the disease are primarily based on subjective neuropsychological\nand"},{"title":"Dose Dependent Response of Cerebellar Transcranial Magnetic Stimulation","field_investigator":"Mark A Halko","field_institution":"Beth Israel Deaconess Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"ABSTRACT\nRepetitive transcranial magnetic stimulation (rTMS) is an emerging technology for the treatment of neurological\nand psychiatric illnesses."},{"title":"Dynamic Neural Mechanisms of Audiovisual Speech Perception","field_investigator":"Charles E Schroeder","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205991\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205991\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"ABSTRACT \u2013 (Title: Dynamic Neural Mechanisms of Audiovisual Speech Perception)\nNatural speech perception is multisensory; when conversing with someone that we can see, our brains\ncombine visual (V) information from face, postural and hand gestures with auditory (A) information from the\nvoice."},{"title":"ECT current amplitude and medial temporal lobe engagement","field_investigator":"Chris C Abbott","field_institution":"University Of New Mexico Health Scis Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111826-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9228452\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9228452\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"1."},{"title":"EFFECTIVE CONNECTIVITY IN BRAIN NETWORKS: Discovering Latent Structure, Network Complexity and Recurrence.","field_investigator":"Stephen Jos\u00e9 Hanson","field_institution":"Rutgers The State Univ Of Nj Newark","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022858-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170388\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170388\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Principal investigator\/Program Director (Last, first, middle): Hanson, Stephen, Jos\u00e9 RFA-EB-15-006\nProject Summary\/Abstract\nSince the earliest days of neuroscience research, core methods have focused on matching specific functions\nto local brain structure and neural activity."},{"title":"Embedded Ensemble Encoding","field_investigator":"Srdjan D Antic, William W Lytton","field_institution":"Suny Downstate Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022903-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170558\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170558\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nWe are developing a novel embedded-ensemble encoding (EEE) theory for mammalian neocortex to unify data from\ncell and network experiments, and to infer general principles of how information is processed in the brain."},{"title":"Emergent dynamics from network connectivity: a minimal model","field_investigator":"Carina  Curto","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022862-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170529\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170529\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\n Even in the absence of changing sensory inputs, many networks in the brain exhibit emer-\ngent dynamics: that is, they display patterns of neural activity that are shaped by the intrinsic\nstructure of the network, rather than modulated by an external input."},{"title":"Establishing a dose response for ultrasound neuromodulation","field_investigator":"Charles F Caskey, Li Min  Chen","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111877-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229212\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nUltrasound (US) neuromodulation has received increased attention in recent years due to its unique ability to\nnon-invasively activate and inhibit neurons."},{"title":"Filtered Point Process Inference Framework for Modeling Neural Data","field_investigator":"Emery N Brown","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022726-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170395\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170395\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Neuronal spike-trains and various other signals in the central nervous system have a discrete,\nimpulsive nature that is well characterized with point process statistical models."},{"title":"Flexible neural probe arrays for large-scale cortical and subcortical recording","field_investigator":"Ellis  Meng","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099703-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231808\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231808\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Implantable neural electrodes have enjoyed decades of development but the ability to record\nresolvable neuronal activities is often reduced or completely lost over time."},{"title":"Foundations of MRI Corticography for mesoscale organization and neuronal circuitry","field_investigator":"David Alan Feinberg","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111444-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9206105\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9206105\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nFunctional MRI (fMRI) is performed at a macroscopic scale of 1 to 3 millimeters spatial resolution."},{"title":"Functional Architecture of Speech Motor Cortex","field_investigator":"Edward  Chang","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205946\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205946\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"PROJECT SUMMARY\nSpeaking is one of the most complex actions that we perform, yet nearly all of us learn do it effortlessly."},{"title":"Genetically Encoded Localization Modules for Targeting Activity Probes to Specific Subcellular Sites in Brain Neurons","field_investigator":"James S Trimmer","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231934\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231934\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Developing enhanced methods for reporting and manipulating brain activity is a major focus of the BRAIN\nInitiative. A major aspect of these efforts is aimed at developing genetically encoded probes for large-scale\nsensing and\/or manipulation of neural activity in vivo."},{"title":"Graph theoretical analysis of the effect of brain tumors on functional MRI networks","field_investigator":"Andrei I Holodny, Hernan  Makse","field_institution":"City College Of New York","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170604\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170604\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract:\nThe broad, long-term objective of this grant is to advance a graph theoretical framework to identify core-nodes\nin a Brain Network of Networks to develop a software tool that will allow end-users from the broad\nneuroscience community to identify and analyze the most influen"},{"title":"High dynamic range multiphoton microscopy for large-scale imaging","field_investigator":"Ian Gordon Davison, Jerome  Mertz","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027549-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9242942\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9242942\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nMultiphoton microscopy is one of the preferred techniques for high-resolution functional brain\nimaging because of its remarkable depth penetration in thick tissue. In standard configurations,\nsuch imaging involves scanning a femtosecond laser focus in 3D throughout a sample."},{"title":"High-density microfiber interfaces for deep brain optical recording and stimulation","field_investigator":"Timothy James Gardner","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027588-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244484\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244484\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nThis project seeks to develop a high density, minimally invasive optical micro\ufb01ber array for long-term recording\nand manipulation of brain activity."},{"title":"Human Neocortical Neurosolver","field_investigator":"Matti  Hamalainen, Michael L Hines, Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022889-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170003\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170003\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe field of neuroscience is experiencing unprecedented growth in the ability to record from and manipulate\nbrain circuits in humans and in animal models. MEG\/EEG are the leading methods to non-invasively record\nhuman neural dynamics with millisecond temporal resolution."},{"title":"Imaging adult-born neurons in action using head-mounted minimicroscopes","field_investigator":"Michael R Drew","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111321-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9203497\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9203497\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"Project Summary\/Abstract\nThe hippocampus is one of a select few brain regions that retain the ability to generate neurons in adulthood.\nResearch in human patients and animal models suggests that increases and decreases in neurogenesis alter\nmemory function and contribute to the etiology and treatmen"},{"title":"Imaging the Neural Effects of Transcranial Direct Current Stimulation","field_investigator":"Gottfried  Schlaug","field_institution":"Beth Israel Deaconess Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229183\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229183\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Research investigating the use of noninvasive electrical stimulation (e.g., transcranial direct current\nstimulation (tDCS)), for neurologic and psychiatric disorders has provided compelling evidence that such\nstimulation can modulate behavior and cognition, and even facilitate recovery of function a"},{"title":"Improving Human fMRI through Modeling and Imaging Microvascular Dynamics","field_investigator":"Jonathan Rizzo Polimeni","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111419-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205860\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205860\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nAll fMRI signals have a vascular origin, and this has been believed to be a major limitation to precise\nspatiotemporal localization of neuronal activation when using hemodynamic functional contrast such as BOLD.\nHowever, significant recent discoveries made using powerful ult"},{"title":"In situ transcriptional analysis of brain circuits at single cell resolution","field_investigator":"Catherine  Dulac, Aviv  Regev, Xiaowei  Zhuang","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111502-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9213716\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9213716\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe mammalian brain is a highly diverse structure in which large numbers of cell types, grouped into broad\nfunctional areas, serve defined functions according to their developmental origin, shape and connectivity,\ntranscriptional program and intrinsic biophysical properties."},{"title":"Integrated fMRI Methods to Study Neurophysiology and Circuit Dynamics at Laminar and Columnar Level","field_investigator":"Wei  Chen","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205561\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205561\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Description\nFunctional MRI (fMRI) based on the blood oxygenation level dependent (BOLD) contrast has become a\npowerful neuroimaging modality and has gained a prominent position in neuroscience for imaging brain\nactivation at working state and functional connectivity at rest."},{"title":"Integrated multichannel system for transcranial magnetic stimulation and parallel magnetic resonance imaging","field_investigator":"Aapo  Nummenmaa","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111829-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9228799\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9228799\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract:\nDuring the past two decades, functional Magnetic Resonance Imaging (fMRI) has become ubiquitous in\nstudies of the human brain function. Similarly, Transcranial Magnetic Stimulation (TMS) has established its role\nas one of the most widely used neuromodulation techniques."},{"title":"Integrating flexible neural probes with a giant cranial window for combined electrophysiology and 2-photon calcium imaging of cortex-hippocampal interactions","field_investigator":"Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111241-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9197792\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9197792\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"Project Summary:\nHippocampal sharp-wave ripples are 150-250 Hz oscillations during slow-wave sleep or immobility during which\nlarge populations of hippocampal neurons sequentially replay activity patterns that occurred during exploration\nof the environment."},{"title":"Invasive Approach to Model Human Cortex-Basal Ganglia Action-Regulating Networks","field_investigator":"Nader  Pouratian","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098961-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205422\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205422\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Project Summary\/Abstract\nAction initiation and withholding are key parts of everyday behavior, and underlying these is action\nsuppression."},{"title":"Large-scale Network Modeling for Brain Dynamics: Statistical Learning and Optimization","field_investigator":"Xi  Luo","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022911-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170649\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170649\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nThe human brain is a large, well-connected, and dynamic network."},{"title":"Large-scale, simultaneous intracellular recording and stimulation of neural activity","field_investigator":"Michael  London, Israel  Nelken, Micha E. Spira","field_institution":"Hebrew University Of Jerusalem","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099687-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231520\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231520\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"We propose to develop a revolutionary tool for simultaneous intracellular recording from hundreds of\nsingle neurons in the freely-moving animal."},{"title":"Learning spatio-temporal statistics from the environment in recurrent networks","field_investigator":"Nicolas  Brunel, Harel Zeev Shouval","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170047\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170047\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary Abstract\nLearning new tasks and exposure to new environments lead to changes in the dynamics of brain circuits, as\nobserved in various recent experiments."},{"title":"Manifold-valued statistical models for longitudinal morphometic analysis in preclinical Alzheimer\u0026#039;s disease (AD)","field_investigator":"Sterling C Johnson, Vikas  Singh","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022883-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170619\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe ability to quantitatively characterize incipient Alzheimer\u0027s disease (AD) pathology in its preclinical stage is\na critical step for early interventions involving disease modifying therapy and for designing efficient clinical trials\nto test therapy efficacy."},{"title":"Mapping and controlling gene expression in inhibitory interneurons mammals","field_investigator":"Gordon J Fishell","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111529-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9214089\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9214089\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project\u0026nbsp;Summary:\u0026nbsp;\n\u0026nbsp;\nFundamental\u0026nbsp; to\u0026nbsp; furthering\u0026nbsp; our\u0026nbsp; understanding\u0026nbsp; of\u0026nbsp; the\u0026nbsp; brain\u0026nbsp; is\u0026nbsp; the\u0026nbsp; ability\u0026nbsp; to\u0026nbsp; longitudinally\u0026nbsp;\ntrack\u0026nbsp; changes\u0026nbsp; in\u0026nbsp; gene\u0026nbsp; expression\u0026nbsp; over\u0026nbsp; time\u0026nbsp; in\u0026nbsp; dif"},{"title":"Micro-coil implants for cortical activation","field_investigator":"Shelley  Fried","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231762\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231762\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The ability to reliably and chronically introduce electrical signals directly into the brain is crucial for a host of\nefforts to create neural prostheses as well as for basic research to understand brain function."},{"title":"Micro-TMS Technology for Ultra-Focal Brain Stimulation","field_investigator":"Giorgio  Bonmassar","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229206\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229206\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nMicro-magnetic stimulation (\u03bcMS) is an emerging technology with a great promise to revolutionize therapeutic\nstimulation of human nervous system."},{"title":"Microdevice mediated functional brain imaging with high temporal and spatial resolution","field_investigator":"Eric C Wong","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027609-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244601\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244601\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nCurrent electrode based approaches for recording of brain activity, as well as EEG and MEG, provide high\ntemporal resolution, but are limited to thousands of channels."},{"title":"Microscopic foundation of multimodal human imaging","field_investigator":"Anders M Dale, Anna  Devor","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111359-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205149\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205149\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"The computational properties of the human brain arise from an intricate interplay between billions of neurons\nconnected in complex networks. However, our ability to study these networks in healthy human brain is limited\nby the necessity to use noninvasive technologies."},{"title":"Molecular Functional Ultrasound for Non-Invasive Imaging and Image-Guided Recording and Modulation of Neural Activity","field_investigator":"Mikhail  Shapiro","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099724-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9232012\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9232012\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Studying complex neurological function and disease requires imaging technologies that can provide a\ncomprehensive view of the mammalian brain with high spatiotemporal resolution."},{"title":"MOTES: Micro-scale Opto-electronically Transduced Electrode Sites","field_investigator":"Jesse Heymann Goldberg, Paul  Mceuen, Alyosha Christopher Molnar","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027581-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244414\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244414\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nOur goal in this project is to develop a new class of electrical recording device that complements and piggy-\nbacks on cutting edge imaging technologies."},{"title":"MR-guided Focused Ultrasound Neuromodulation of Deep Brain Structures","field_investigator":"Kim  Butts-Pauly","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111825-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9228441\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9228441\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Abstract\nCompletely noninvasive neuromodulation using focused ultrasound (FUS) offers the promise of precisely\nstimulating speci\ufb01c targets deep in the brain. FUS is already used to deliver precise ablations deep in the\nbrain."},{"title":"Multi-channel MR-compatible flexible microelectrode for recording and stimulation","field_investigator":"Robert Kyle Franklin, Yen-Yu Ian Shih","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"PAR-15-090","field_project_number":"1R41MH113252-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9139158\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9139158\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\ufeff   \nDESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) has become one of the leading research tools to study brain function and is playing a pivotal role in several large-scale brain mapping projects worldwide."},{"title":"Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain Structures","field_investigator":"Polina O Anikeeva, Arnd  Pralle","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229172\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Abstract\nThis project seeks to develop a wireless, minimally invasive bi-directional deep brain stimulation technology\nbased on remote heating of magnetic nanoparticles."},{"title":"Multimodal modeling framework for fusing structural and functional connectome data","field_investigator":"Srikantan S. Nagarajan, Ashish  Raj","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022717-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170597\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170597\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY \/ ABSTRACT\nProject Summary\nA key goal of computational neuroscience is to discover how the brain\u2019s structural organization produces its\nfunctional behavior, and how impairment of the former causes dysfunction and disease."},{"title":"Multiparametric Biosensor Imaging in Brain Slices","field_investigator":"Thomas A Blanpied, Andrea L Meredith, Megan A Rizzo","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111527-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9214054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9214054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Deciphering neural coding will require deconstructing the complex and intertwined signaling mechanisms that\ndrive cellular excitability, synaptic plasticity, and circuit dynamics in the brain."},{"title":"Multiplex in vivo imaging of cell-specific and circuit-specific signaling pathways during synaptic plasticity","field_investigator":"Richard L Huganir, Jin  Zhang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111516-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9213887\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9213887\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nCell signaling pathways in the brain are an essential part of a complex system regulating the activity and\ncoordination of neuronal circuits. During learning and memory synaptic plasticity processes regulate the\nstrength of synaptic connections and modify neuronal circuits."},{"title":"Near Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology (AOE)","field_investigator":"Srdjan D Antic, Thomas  Knopfel, Vladislav  Verkhusha","field_institution":"Imperial College Of Science, Technology And Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-006","field_project_number":"1U01NS099573-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229649\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229649\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Attaining effective optical modulation and readout of neuronal circuit activities has been a longstanding goal\nin neuroscience and is a key near-term aim of the BRAIN Initiative."},{"title":"Network Connectivity Modeling of Heterogeneous Brain Data to Examine Ensembles of Activity Across Two Levels of Dimensionality","field_investigator":"Kathleen  Gates","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022904-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170562\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nNetwork methods have emerged as some of the most useful approaches for analyzing functional MRI\ndata. While great advancements have been made in these methods, limitations hamper the progress fMRI\nresearchers can make in better understanding brain processes."},{"title":"Neural activity integration during user defined epochs with modular reporters","field_investigator":"Scott T. Laughlin","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027578-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244345\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nThe brain\u0027s control of our thoughts, feelings, and behaviors stems from neural circuits, which perform logical\noperations based on the temporal patterns of neural activity and the connectivity of the neurons as the circuit\ntraverses the brain."},{"title":"Neural mechanisms and behavioral consequences of non-Gaussian likelihoods in sensorimotor learning","field_investigator":"Ilya M. Nemenman, Samuel  Sober","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170650\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170650\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"A central goal of neuroscience is to understand how learning is implemented by the nervous system.\nHowever, despite years of studies in animals and humans, our understanding of both the computational basis\nof learning and its implementation by the brain is still rudimentary."},{"title":"NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surface","field_investigator":"Gyorgy  Buzsaki, Orrin  Devinsky","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099705-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231840\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231840\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"We propose to develop a novel electrode array (`NeuroGrid\u0027) for large-scale recording of spikes and\nimproved miniaturized, multiplexed devices for recording of neural activity in freely behaving rodents,\nwhile minimizing the loss of cellular\/sub-cellular and temporal resolution."},{"title":"Neuromodulation by Transcranial Current Stimulation","field_investigator":"Bart  Krekelberg","field_institution":"Rutgers The State Univ Of Nj Newark","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111766-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9225394\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9225394\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\nA novel technique called transcranial current stimulation (TCS) creates small\nelectrical fields in the brain through electrodes placed on the scalp."},{"title":"Neuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex","field_investigator":"Matthew A. Howard, John P O\u0026#039;doherty, Doris Ying Tsao","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111425-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205919\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205919\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Neuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex\u0026nbsp;\n\u0026nbsp;\nPIs: Dr. John P. O\u0027Doherty and Dr."},{"title":"Neurons, Vessels and Voxels:  Multi-modal Imaging of Layer Specific Signals","field_investigator":"Prakash  Kara, Thomas P Naselaris, Cheryl A. Olman, Kamil  Ugurbil","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111447-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205563\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205563\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nOur knowledge of signal processing in various parts of the human brain has been heavily influenced by non-\ninvasive functional magnetic resonance imaging (fMRI) experiments. FMRI infers the location and selectivity of\nneural activity from vascular signals."},{"title":"New approaches for better protein voltage sensors","field_investigator":"Lawrence B Cohen","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099691-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231604\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231604\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"This proposal aims to develop better tools for analyzing brain cells and circuits and for\nlarge-scale recordings of brain activity. The currently available tools are relatively primitive in terms of sensitivity\nand speed. One major function of a neuron is to process electrical signals."},{"title":"Next-gen Opto-GPCRs: spatiotemporal simulation of neuromodulator signaling","field_investigator":"Michael R Bruchas, Roger K Sunahara","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9213972\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9213972\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract: The emerging field of optogenetics \u2014 using light to engage biological systems\n\u2014 holds tremendous promise for dissection of neural circuits, cellular signaling and manipulating\nneurophysiological systems in awake, behaving animals."},{"title":"Next-Generation Calcium Imaging Analysis Methods","field_investigator":"Liam M Paninski","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170669\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nCalcium imaging methods allow us to record the simultaneous activity of many neurons with single-cell\nresolution; these methods are therefore a critical enabling tool for the BRAIN initiative and in neuroscience\nmore broadly."},{"title":"Non-invasive neuromodulation mechanisms and dose\/response metrics","field_investigator":"Desmond  Oathes","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111886-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229276\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229276\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary \/ Abstract\nIn an exciting era of growth in the use of non-invasive brain stimulation, new methods and applications are\nbeing disseminated widely with an increasing number of FDA approvals and equipment designed to probe or\nmodulate the brain in fascinating new ways."},{"title":"Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson\u0026#039;s Disease","field_investigator":"Harrison Carroll Walker","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-010","field_project_number":"1UH3NS100553-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9266940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9266940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nIt is easy to underestimate the importance of normal movement in daily life, until that ability is altered or taken\naway by disease."},{"title":"Novel\u2005Bayesian\u2005linear\u2005dynamical\u2005systems-based\u2005methods\u2005for\u2005discovering\u2005human\u2005brain\u2005circuit\u2005dynamics in\u2005health\u2005and\u2005disease","field_investigator":"Vinod  Menon","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022907-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170593\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170593\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\nUnderstanding how the human brain produces cognition ultimately depends on precise quantitative\ncharacterization of context-dependent dynamic functional networks (DFN) that transiently link distributed\nbrain regions."},{"title":"Optimal calcium imaging with shaped excitation","field_investigator":"Liam M Paninski, Darcy S Peterka","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027592-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244502\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244502\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Optimal calcium imaging with shaped excitation\nUnderstanding information flow in the brain is dependent on simultaneously recording the activity\nof large neuronal populations."},{"title":"Optimized dosing of repetitive transcranial magnetic stimulation for enhancement of hippocampal-cortical networks","field_investigator":"Joel L Voss","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111790-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9226273\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9226273\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\/Abstract\nMemory impairment occurs in a variety of neuropsychiatric conditions (e.g., depression and schizophrenia) and\nin many neurologic disorders (e.g., neurodegenerative disease and brain injury), often with devastating\nconsequences for life quality."},{"title":"Optimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodes","field_investigator":"Bijan  Pesaran, John  Rogers, Kenneth L Shepard, Jonathan  Viventi","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099697-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9231725\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9231725\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\n In this proposal, we will develop next-generation flexible micro-electrocortigraphic (\u00b5ECoG) and penetrating\nelectrode arrays using active electronics in complementary metal-oxide-semiconductor (CMOS) technology.\nActive electronics enable amplification and multiplexing directly at each ele"},{"title":"Optimizing peripheral stimulation parameters to modulate the sensorimotor cortex for post-stroke motor recovery","field_investigator":"Karunesh  Ganguly","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111871-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229152\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229152\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"ABSTRACT\nStroke is the leading cause of disability in the United States, with approximately 700,000 new cases per\nyear. Disability from upper limb impairment depends primarily on loss of hand function and finger\ndexterity."},{"title":"Optogenetic signaling inhibitors for studying brain plasticity","field_investigator":"Wenbiao  Gan, Ryohei  Yasuda","field_institution":"Max Planck Florida Corporation","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111486-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9212998\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9212998\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nSynaptic plasticity is thought to be a basis of learning and memory of the brain. Signaling\nmechanisms underlying synaptic and behavioral plasticity have been extensively studied\nwith the aid of pharmacological and genetic manipulation of signaling."},{"title":"Quiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System","field_investigator":"Angel V Peterchev","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229084\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"This project will develop a low-noise transcranial magnetic stimulation (TMS) system. TMS is a technique\nfor non-invasive brain stimulation using strong, brief magnetic pulses. TMS is widely used as a tool for probing\nbrain function and is an FDA approved treatment for depression."},{"title":"Rapid Electrode Multiplexing for Scalable Neural Recording","field_investigator":"Ross M Walker","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027618-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244654\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nRapid Electrode Multiplexing for Scalable Neural Recording\nLarge-scale recording of neural signals is essential for gaining a better understanding of the elaborate, dynamic\npicture of the brain that emerges from interactions involving individual cells and complex neural circuits."},{"title":"Rational Optimization of tACS for Targeting Thalamo-Cortical Oscillations","field_investigator":"Flavio  Frohlich","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-815","field_project_number":"1R01MH111889-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9229306\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9229306\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH\nThe alpha oscillation is a thalamo-cortical rhythm (8-12 Hz) that serves important functional roles in\ncognition and behavior."},{"title":"Realization of Optical Cell-based Reporters for in vivo Detection of Neuropeptides","field_investigator":"David  Kleinfeld, Paul A Slesinger","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-775","field_project_number":"1R01MH111499-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9213616\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9213616\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n Neuropeptides are essential neuromodulators in the brain."},{"title":"Resting state connectivity: Biophysical basis for and improved fMRI measurements","field_investigator":"David  Kleinfeld, Bruce R Rosen","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9206009\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9206009\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Principal Investigators(Last, first, middle):KLEINFELD, DAVID and ROSEN, BRUCE R.\n Functional magnetic resonant imaging (fMRI) is the only means to infer neuronal activity within the\nentire volume of the human brain."},{"title":"Short Course in Adaptive Neurotechnologies","field_investigator":"Gerwin  Schalk, Jonathan Rickel Wolpaw","field_institution":"Wadsworth Center","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-220","field_project_number":"1R25HD088157-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037133\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neurological disorders affect many millions of people in the United States and throughout the world."},{"title":"Spatiotemporal control of large neuronal networks using high dimensional optimization","field_investigator":"Shinung  Ching, Jr-Shin  Li, Jason T Ritt","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027590-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244496\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244496\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nThe long terms goal of this project is to enable the control of large networks in the brain using neurostimulation\ntechnologies, a key focus of the BRAIN initiative."},{"title":"Spatiotemporal signatures of neural activity and neurophysiology in the BOLD signal","field_investigator":"Shella D Keilholz","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205825\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205825\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"The blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) fluctuations used to\nmap functional connectivity contain a wealth of information about neural activity and physiological processes\nin the brain."},{"title":"Structure guided design of photoselectable channelrhodopsins","field_investigator":"Vadim  Cherezov, Samuel Andrew Hires, Vsevolod  Katritch, John Yu-Luen Lin","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027620-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244699\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244699\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nThis proposal outlines the development of a fundamentally new optogenetic technology capable\nof flexibly manipulating the activity of thousands of neurons contributing to the dynamic activity\nof distributed neural circuits with single neuron resolution.\nNo method that currently exis"},{"title":"Subthalamic and corticosubthalamic coding of speech production","field_investigator":"Robert Mark Richardson","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098969-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205890\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205890\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"Speech production and control is disrupted in a number of neurological diseases that involve the basal ganglia.\nNotably, hypophonia and hypokinetic dysarthria (characterized by decreased motor gain) are prevalent in\npatients with Parkinson\u0027s disease (PD)."},{"title":"Technologies for spatiotemporally precise \u0026amp; closed-loop control of selected neurons to prevent epileptic seizures","field_investigator":"Omar Jamil Ahmed","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-725","field_project_number":"1R03MH111316-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9203299\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9203299\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Dissemination","field_research_area":"Dissemination","body":"PROJECT SUMMARY \/ ABSTRACT\nEpilepsy is an often debilitating neurological condition affecting 3 million Americans and more than 50 million\npeople across the globe."},{"title":"Toward a Theory for Macroscopic Neural Computation Based on Laplace Transform","field_investigator":"Marc W Howard","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-15-006","field_project_number":"1R01EB022864-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9170542\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9170542\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nThe Weber-Fechner law is perhaps the oldest quantitative relationship in psychology."},{"title":"Towards deep brain monitoring with superficial EEG sensors plus neuromodulatory focused ultrasound","field_investigator":"Pierre D Mourad","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027557-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9243609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9243609\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Electrical activity in the brain is a direct correlate to neuronal activity. Existing technology can record\nelectrical activity on a millisecond scales through invasive placement of electrodes within the brain or non-\ninvasively, using subdermal electrodes."},{"title":"Understanding evoked and resting-state fMRI through multi scale imaging","field_investigator":"R Todd Constable, Michael C. Crair, Dewan Syed Fahmeed Hyder","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-750","field_project_number":"1R01MH111424-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205912\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205912\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Project Summary\nThis RFA is aimed at bringing together interdisciplinary teams to focus on novel, transformative and integrative\nefforts that will revolutionize our understanding of the biological and bioinformatics content of the data collected\nfrom non-invasive human functional brain imaging techn"},{"title":"Understanding the Neural Basis of Volitional State through Continuous Recordings in Humans","field_investigator":"Sydney S Cash","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-008","field_project_number":"1U01NS098968-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9205859\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9205859\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"ABSTRACT\nIn the course of a day we naturally make multiple shifts in our overall cognitive state and in our aims and\nintents. We go from sleep to awake, from internal dialogue to external communication, from relative immobility\nto planned complex movements."},{"title":"Wearable Transcranial Focused Ultrasound System for Region-specific Functional Neuromodulation","field_investigator":"Seung-Schik  Yoo","field_institution":"Brigham And Women\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-16-810","field_project_number":"1R01MH111763-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9224456\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9224456\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neuroimaging Technologies Across Scales","body":"Project Summary\nThe main objective of the proposed research is to develop a wearable transcranial focused ultrasound\n(tFUS) environment that reversibly modulates (either elicits or suppresses) region-specific neural\nactivities of the brain."},{"title":"Wide deployment of massively multiplexed nanosystems for brain activity mapping","field_investigator":"Michael L Roukes, Kenneth L Shepard","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-16-007","field_project_number":"1U01NS099726-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9232017\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9232017\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"This project will place into the hands of many experimental neuroscientists validated, massively-multiplexed tools\nfor recording of neuronal activity, for chemical sensing of neuromodulators, and for highly-patterned optogenetic\nstimulation with concurrent electrical recording \u2013 in any region of the"},{"title":"Wireless Photometry For In Vivo Behavorial Studies","field_investigator":"Paul  Braun, Michael R Bruchas","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027612-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244624\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244624\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Abstract\nThe goal of this R21 proposal is to develop a robust, minimally invasive wireless photometry\nsystem for in vivo calcium measures in freely moving behavior."},{"title":"Wireless recording in the central nervous system with ultrasonic neural dust","field_investigator":"Jose Miguel Carmena","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222016-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2016\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-16-001","field_project_number":"1R21EY027570-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9244253\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9244253\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nWe propose an ultra-miniature as well as extremely compliant system that enables massive scaling in the\nnumber of neural recordings from the brain while providing a path towards large-scale neural recordings and\ntruly chronic brain-machine interfaces (BMI)."},{"title":"A new strategy for cell-type specific gene disruption in flies and mice","field_investigator":"Thomas Robert Clandinin, Nirao Mahesh Shah","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037320\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037320\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Developing and validating a toolkit for cell type specific gene manipulation PIs: Clandinin and Shah Neurons express complex arrays of genes that play crucial roles in determining neuronal function."},{"title":"A novel approach to examine slow synaptic transmission in vivo","field_investigator":"Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094247-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011953\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011953\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Two primary modes of chemical communication occur between neurons in the brain: fast synaptic transmission, such as that mediated by glutamate and GABA, which directly control the electrical activities of neurons, and slow synaptic transmission, such as tha"},{"title":"A robust ionotropic activator for brain-wide manipulation of neuronal function","field_investigator":"Andrew D Ellington, Boris V Zemelman","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026442-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056262\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056262\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): This proposal embodies the rational design, high throughput screening, and in vitro characterization of novel neuronal actuators. The starting point for our endeavor is an ionotropic channel that launched the optogenetic revolution."},{"title":"A viral system for light-dependent trapping of activated neurons","field_investigator":"Michael R Drew, Stephen  Martin, Boris V Zemelman","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026446-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056270\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): A central goal in neuroscience is to identify cellular ensembles supporting mental and behavioral states, but these ensembles cannot be defined a priori."},{"title":"AN INDUCIBLE MOLECULAR MEMORY SYSTEM TO RECORD TRANSIENT STATES OF CNS CELLS","field_investigator":"Robi D Mitra","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109133-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037398\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037398\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The brain is a remarkably complex organ comprised of hundreds of unique cell types that are organized to form sophisticated neural circuits."},{"title":"Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals","field_investigator":"Valentin  Dragoi, Roger  Janz, John Lee Spudich","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109146-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037461\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037461\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Examining neural circuits crucially relies on the ability to activate or silence individual circuit components to subsequently assess their impact on other parts of the circuit and their influence on behavior."},{"title":"Anterograde monosynaptic tracing","field_investigator":"Ian R Wickersham","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109129-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037385\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037385\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Monosynaptic tracing using rabies virus has become a standard component of the systems neuroscience toolkit, allowing identification and manipulation of neurons directly presynaptic to any targeted neuronal population in the brain."},{"title":"Berkeley Course on Mining and Modeling of Neuroscience Data","field_investigator":"Friedrich T Sommer","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-215","field_project_number":"1R25MH109070-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9036886\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9036886\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\ufeff   \nDESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled \u0022Mining and Modeling of Neuroscience Data\u0022 which is held at UC Berkeley."},{"title":"Biological \u0026#039;Living Electrodes\u0026#039; Using Tissue Engineered Axonal Tracts to Probe and Modulate the Nervous System","field_investigator":"Daniel Kacy Cullen","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094340-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012539\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012539\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Brain Machine Interfaces (BMIs) allow the nervous system to directly communicate with external devices in order to mitigate deficits associated with neurodegeneration or to drive peripheral prosthetics."},{"title":"BRAIN Initiative: Integrated Multimodal Analysis of Cell and Circuit-Specific Processes in Hippocampal Function","field_investigator":"Jonathan V. Sweedler","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109062-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9036805\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9036805\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The BRAIN Initiative seeks to understand the spatial, temporal and chemical nature of the brain."},{"title":"Building and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice","field_investigator":"Peyman  Golshani, Baljit  Khakh, Dejan  Markovic, Alcino J. Silva","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-004","field_project_number":"1U01NS094286-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012480\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012480\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  One of the biggest challenges in neuroscience is to understand how neural circuits in the brain process, encode, store, and retrieve information."},{"title":"Capabilities of MRI-Based Neural Current Imaging for Human Brain Mapping","field_investigator":"Young R Kim","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026379-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055837\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055837\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): In this proposal we leverage our recent developments in MRI acquisition methods and new animal models to attempt direct detection of neuronal currents with Magnetic Resonance Imaging (MRI)."},{"title":"Carbon Thread Arrays for High Resolution Multi-Modal Analysis of Microcircuits","field_investigator":"Joshua D Berke, Cynthia Anne Chestek","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094375-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012524\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012524\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"DESCRIPTION (provided by applicant):  A major goal in neuroscience is to understand the computations performed by local brain circuits. A large obstacle to achieving this goal is that - at least in mammals - we currently cannot observe the spiking activity of most neurons within a circuit."},{"title":"Central thalamic stimulation for traumatic brain injury","field_investigator":"Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-008","field_project_number":"1UH3NS095554-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9054573\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9054573\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments."},{"title":"Computational and circuit mechanisms for information transmission in the brain","field_investigator":"Uri Tzvi Eden, Loren M Frank, Surya  Ganguli, Adam  Kepecs, Mark Alan Kramer, Christian  Machens, Vanessa  Tolosa","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094288-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012535\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012535\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The brain is a massively interconnected network of regions, each of which contains neural circuits that process information related to combinations of sensory, motor and internal variables."},{"title":"Conducting polymer nanowires for neural modulation","field_investigator":"Christine K Payne","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026392-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055905\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Understanding how people think, act, and feel ultimately requires understanding how neural circuits interact spatially and temporally. This level\nof understanding requires fundamentally new tools that are high-throughput, direct, and non-invasive."},{"title":"CoSMo - Summer School in Computational Sensory-Motor Neuroscience","field_investigator":"Paul R Schrater","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-215","field_project_number":"1R25MH109110-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037282\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037282\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\ufeff   \nDESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research."},{"title":"Development of a scalable methodology for imaging neuropeptide release in the brain","field_investigator":"David J Anderson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056190\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056190\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): A common metaphor to describe the brain is that it is like a supercomputer. Consequently, current efforts at improving technologies for large-scale recording of brain function are primarily focused on measuring its electrical activity."},{"title":"Dynamic network computations for foraging in an uncertain environment","field_investigator":"Dora  Angelaki, Valentin  Dragoi, Zachary Samuel Pitkow, Paul R Schrater","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094368-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012468\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012468\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The brain evolved complex recurrent networks to enable flexible behavior in a dynamic and uncertain world, but its computational strategies and underlying mechanisms remain poorly understood."},{"title":"Employing subcellular calcium to control membrane voltage","field_investigator":"Ute H Hochgeschwender, Diane  Lipscombe, Christopher I Moore","field_institution":"Central Michigan University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026427-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056134\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056134\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): The goal of this proposal is to assess the feasibility of an all-molecular method for activity-dependent feedback control of neuronal activity."},{"title":"Engineered viral tropism for cell-type specific manipulation of neuronal circuits","field_investigator":"Daniel  Schmidt, Mark John Thomas","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109038-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9034297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9034297\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): It is a longstanding goal in neuroscience to reveal how specific cell types contribute to different neural circuits that underlie cognition, behavior, and disease pathology."},{"title":"Five-dimensional optoacoustic tomography for large-scale electrophysiology in scattering brains","field_investigator":"Daniel  Razansky","field_institution":"Technical University Of Munich","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026382-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055849\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055849\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neuroscience has an essential requirement for large-scale neural recording technologies to ensure rapid progress in the understanding of brain function, diagnosis and treatment of neurological disorders."},{"title":"Fluorescent Sensors for Imaging External Potassium in the Brain","field_investigator":"William R Kobertz","field_institution":"Univ Of Massachusetts Med Sch Worcester","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026362-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055507\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055507\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): The goal of this project is fluorescently visualize potassium (K+) egress and extracellular accumulation at the cell surface."},{"title":"Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability","field_investigator":"Zhigang  He","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037275\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037275\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The ability to examine the connectivity and functions of specific brain nuclei and specific neuron types is critical for understanding how the brain works at both microcircuit and mesoscale levels."},{"title":"Genetic tools and imaging technology for mapping cholinergic engrams of anxiety","field_investigator":"Lorna W Role","field_institution":"State University New York Stony Brook","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037248\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037248\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): This application will develop new genetic tools and advance current procedures for precise and rapid mapping of behavior specific memory engrams."},{"title":"High resolution deep tissue calcium imaging with large field of view wavefront correction","field_investigator":"Meng  Cui, Wenbiao  Gan","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-004","field_project_number":"1U01NS094341-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012556\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012556\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  High resolution deep tissue calcium imaging with large field of view wavefront correction Two-photon microscopy based calcium imaging allows in vivo observation of neuronal dynamics at high spatial and temporal resolutions."},{"title":"High resolution electrical brain mapping by real-time and portable 4D Acoustoelectric Imaging","field_investigator":"Russell S Witte","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-200","field_project_number":"1R24MH109060-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9036787\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9036787\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Our vision is to develop the first noninvasive, real-time and portable electrical brain mapping system based on disruptive acoustoelectric (AE) technology."},{"title":"High-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording","field_investigator":"Leigh R Hochberg, Arto  Nurmikko","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-006","field_project_number":"1UH2NS095548-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9054364\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9054364\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Neurologic disorders including cervical spinal cord injury, brainstem stroke, and amyotrophic lateral sclerosis can lead to severe paralysis of all fou limbs."},{"title":"High-speed Deep Brain Imaging and Modulation with Ultrathin Minimally Invasive Probes","field_investigator":"Rafael  Piestun","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026436-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056202\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056202\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): An understanding of the neural mechanisms and computational principles of the human brain requires the study of non-human primates (NHP) in addition to small animals."},{"title":"High-speed volumetric imaging of neuronal network activity at depth using Multiplexed Scanned Temporal Focusing (MuST)","field_investigator":"Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-004","field_project_number":"1U01NS094263-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011561\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011561\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  We propose to design and build a device that will push the boundaries of existing technology for imaging the activity of large-scale neuronal networks at high speed and single cell resolution."},{"title":"Implantable Brain Microelectromechanical Magnetic Sensing and Stimulation (MEMS-MAGSS)","field_investigator":"Steven J Schiff, Srinivas  Tadigadapa","field_institution":"Pennsylvania State Univ Hershey Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056216\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056216\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): This NIH BRAIN Initiative R21 will initiate development of a completely Implantable Brain Microelectromechanical Magnetic Sensing and Stimulation (MEMS-MAGSS) technology."},{"title":"Interdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty","field_investigator":"Satish S Nair","field_institution":"University Of Missouri-Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-215","field_project_number":"1R25MH109122-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037332\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037332\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\ufeff   \nDESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states."},{"title":"Intrabody-dependent activation of cell-specific gene expression in CNS","field_investigator":"Seth  Blackshaw","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037244\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037244\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The mammalian central nervous system (CNS) contains many hundreds of molecularly and functionally distinct cell types, which comprise the basic building blocks of neural circuitry."},{"title":"Label-free 4D optical detection of neural activity","field_investigator":"Maksim V Bazhenov, Devin K Binder, Boris Hyle Park","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026441-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056250\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056250\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): The ideal neuroimaging technique would provide exquisite structural detail and also provide functional information, with high spatial and temporal\nresolution."},{"title":"Lagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor Sequences","field_investigator":"Ryan Prescott Adams, Sandeep R Datta, Bernardo L Sabatini","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094191-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011312\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011312\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Behaviors are sequences of actions that are executed in the proper order and correct setting to achieve a goal."},{"title":"LIPS: A novel technology for spatial and temporal control of protein synthesis in dendritic spines","field_investigator":"Wenbiao  Gan, Samie R Jaffrey","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109087-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037179\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037179\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The proteins in synapses are the fundamental regulators of synaptic plasticity, which ultimately controls the neural circuits that underlie behavior."},{"title":"LOCATER: Large-scale Observation of Cellular Activity Through Exosomal Reporters","field_investigator":"Feng  Zhang","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026412-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056050\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056050\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Electrophysiology and fluorescent imaging are widely used to study neural activity in vivo."},{"title":"Massive scale electrical neural recordings in vivo using commercial ROIC chips","field_investigator":"Konrad P. Kording, Andreas  Schaefer","field_institution":"Rehabilitation Institute Of Chicago D\/B\/A Shirley Ryan Abilitylab","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094248-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011964\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011964\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Current scaling behavior in electrical recording is dominated by the difficulty of fabricating systems with many high bandwidth channels."},{"title":"Multiplexed Multiphoton Interrogation of Brain Connectomics","field_investigator":"Xue  Han, Siddharth  Ramachandran","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026410-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056037\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056037\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Multiphoton laser scanning microscopy has revolutionized neuroscience since it is less invasive than traditional electrophysiology methods for probing neuronal processes."},{"title":"MULTISCALE ANALYSIS OF SENSORY-MOTOR CORTICAL GATING IN BEHAVING MICE","field_investigator":"Dieter  Jaeger, Garrett B. Stanley","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094302-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012601\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012601\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): To address the core question underlying the Obama Brain Initiative to better understand the function of complex brain circuits, we propose a multi-scale recording and data analysis project to study the dynamical interactions between sensory cortex, motor cor"},{"title":"Multiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and Function","field_investigator":"R Todd Constable, Michael C. Crair","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094358-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012555\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012555\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The purpose of this RFA is to promote the integration of experimental, analytic and theoretical capabilities for the examination of neural circuits and systems."},{"title":"Network basis of action selection","field_investigator":"Anatol  Kreitzer, Takaki  Komiyama, Byungkook  Lim","field_institution":"J. David Gladstone Institutes","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094342-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012622\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The anatomical substrates and cellular mechanisms underlying reward-dependent learning have been studied for decades, but the specific circuit and network interactions between the cortex, striatum, and midbrain that mediate action selection have not been sys"},{"title":"Neural ensembles underlying natural tracking behavior","field_investigator":"Ila R. Fiete, Alexander C Huk, Nicholas J Priebe","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-005","field_project_number":"1U01NS094330-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012581\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012581\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The system that controls smooth pursuit eye movements is one of the most accessible, promising systems for understanding how neural circuits transform sensory inputs into actions."},{"title":"Neural Monitoring with Magnetically-Focused Electrical Impedance Tomography (mf-EIT)","field_investigator":"Daniel Kenneth Freeman","field_institution":"Charles Stark Draper Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026360-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055423\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): There is a great need in clinical neuroscience for improved methods of non-invasively monitoring brain activity."},{"title":"Neuron selective modulation of brain circuitry in non-human primates","field_investigator":"Charles F Caskey, Li Min  Chen, William A Grissom","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-200","field_project_number":"1R24MH109105-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037262\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037262\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant):   All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for brain circuit investigation."},{"title":"Neuronal voltage tracers for photoacoustic imaging in the deep brain","field_investigator":"Jon Thomas Sack","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056289\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056289\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): The overarching goal of this project is to develop molecular tracers for imaging neuronal voltage changes deep in the brain."},{"title":"Neurophysiologically Based Brain State Tracking \u0026amp; Modulation in Focal Epilepsy","field_investigator":"Gregory A Worrell","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-006","field_project_number":"1UH2NS095495-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9053720\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9053720\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Approximately 1\/3 of people living with epilepsy (PWE) continue to have seizures despite anti-epileptic drugs (AEDs). Recent trials using therapeutic brain stimulation show reductions in seizures, but rarely provide seizure free outcomes."},{"title":"Non-degenerate multiphoton microscopy for deep brain imaging","field_investigator":"Anna  Devor, Yeshaiahu L Fainman","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094232-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011205\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The overarching goal of this proposal is to push the depth penetration of multiphoton microscopy targeting neuroscience applications in need of large-scale recording of cortical activity where high resolution requirement (in the order of singl microns) cann"},{"title":"Northern Lights collaboration for better 2-photon probes","field_investigator":"Robert E. Campbell, Nathan G Clack, Mikhail  Drobizhev, Thomas E Hughes","field_institution":"Montana State University - Bozeman","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-004","field_project_number":"1U01NS094246-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011707\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011707\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The Northern Lights collaboration for better 2-photon probes will combine the expertise of four very different investigators and laboratories from Montana and Canada with complementary interests and skills to tackle a fundamental problem in imaging of the a"},{"title":"Novel optrodes for large-scale electrophysiology and site-specific stimulation","field_investigator":"John  Assad, Luca  Berdondini, Massimo  Devittorio, Bernardo L Sabatini","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-003","field_project_number":"1U01NS094190-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9011309\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9011309\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The brains of mammals contain an extraordinarily large number of neurons whose activity and interconnections determine the function of circuits that monitor our sensory environment, dictate our motor choices, form memories, and guide all behavior."},{"title":"Novel tools for cell-specific imaging of functional connectivity and circuit operations","field_investigator":"Ehud  Isacoff","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109069-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9036880\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9036880\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Fundamental to understanding brain function is the ability to relate the spatio-temporal firing patterns of specific neurons to their functional connectivity and determine the strength and experience-dependent regulation of those connections."},{"title":"Optical tools for extended neural silencing","field_investigator":"Matthew J Kennedy, Chandra L Tucker","field_institution":"University Of Colorado Denver","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026363-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055530\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055530\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION: Conditionally silencing the activity of specific neural ensembles is a powerful approach for mapping the circuits responsible for specific behaviors."},{"title":"Optical Tools to Study Neuropeptide Signaling","field_investigator":"Mathew  Tantama","field_institution":"Purdue University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026425-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056131\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056131\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neuropeptides are neuromodulators that regulate the physiology of cells, synapses, and neural circuits in the brain."},{"title":"Potentiometric photoacoustic imaging of brain activity enabled by near infrared to visible light converting nanoparticles","field_investigator":"Paras N. Prasad, Jun  Xia","field_institution":"State University Of New York At Buffalo","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056047\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056047\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): This application is in response to the President\u0027s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative."},{"title":"SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organisms","field_investigator":"Elizabeth M. C. Hillman","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-15-004","field_project_number":"1U01NS094296-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9012522\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9012522\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Despite the growing availability of optical markers of neuronal activity, as well as genetic tools for optical manipulation, current optical microscopy techniques for imaging the intact brain at cellular resolution have approached their limits, particularly"},{"title":"Self-Motile Electrodes for Three Dimensional, Non-perturbative Recording and Stimulation","field_investigator":"Nicholas A Melosh","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026365-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055566\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055566\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Transitioning from small numbers of neural depth recording electrodes to many thousands requires consideration not only of data management, but also how to non-destructively deliver these electrodes into the desired brain regions."},{"title":"Sonoelectric tomography (SET): High-resolution noninvasive neuronal current tomography","field_investigator":"Matti  Hamalainen, Partha Pratim Mitra, Nathan J. Mcdannold, Yoshio  Okada","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-200","field_project_number":"1R24MH109111-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037285\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037285\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant):   Presently there is no imaging technology capable of detecting neuronal activity in the entire human brain with millisecond and millimeter resolution."},{"title":"Space-division multiplexing optical coherence tomography for large-scale, millisecond resolution imaging of neural activity","field_investigator":"Yevgeny  Berdichevsky, Chao  Zhou","field_institution":"Lehigh University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026380-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055841\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055841\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION There is a great interest in imaging neuronal activity based on changes in fast intrinsic optical signals (e.g. changes in light scattering and phase) that occur on a millisecond timescale."},{"title":"Sparse, Strong and Large Area Targeting of Genetically Encoded Indicators","field_investigator":"Srdjan D Antic, Thomas  Knopfel","field_institution":"University Of Connecticut Sch Of Med\/Dnt","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109091-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037189\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037189\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Electrical (voltage) signal is the primary substrate of information processing in the brain. Detecting and recording voltage changes from neurons in living animals remains the ultimate goal of experimental neuroscience to the present day."},{"title":"Sub-micrometer x-ray tomography for neuroanatomy","field_investigator":"Chris Johnson Jacobsen, Konrad P. Kording","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109100-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037222\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037222\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Anatomy defines the `reference\u0027 atlas for all of neuroscience. It is one of the most important markers of disease or damage to the brain, and constrains the circuitry of neural computation. However, brain maps are fundamentally incomplete."},{"title":"SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength","field_investigator":"Roberto  Malinow, Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109113-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037290\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037290\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The goal of this application is to develop SYNPLA, a specific, selective and high-throughput method for marking experience-induced plasticity with single synapse resolution."},{"title":"Toward functional molecular neuroimaging using vasoactive probes in human subjects.","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-200","field_project_number":"1R24MH109081-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037129\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037129\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The establishment of new and precise strategies for mapping brain activity in human subjects is one of the highest priorities of the BRAIN Initiative."},{"title":"Tracing Brain Circuits by Transneuronal Control of Transcription","field_investigator":"Elizabeth Jennifer Hong, Carlos  Lois, Kai G Zinn","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-225","field_project_number":"1U01MH109147-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037465\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037465\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Understanding the computations that take place in brain circuits will require identifying the wiring diagrams of those circuits. In recent years seveal new methods have been developed to identify the brain\u0027s wiring diagrams."},{"title":"Ultra-miniaturized single fiber probe for functional brain imaging in freely moving animals","field_investigator":"Jerome  Mertz","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026310-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9053610\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9053610\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Microscope techniques to image inside brain tissue are generally limited by poor depth penetration."},{"title":"Use of Calcium Indicator Proteins in Spike Counting Mode","field_investigator":"David A Digregorio, Samuel Sheng-Hung Wang","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026434-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9056196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9056196\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): A long-term goal of the BRAIN Initiative is to track activity in large numbers of neurons individually in behaving animals, thus capturing the information processing that is done by brain circuitry."},{"title":"Virtual Brain Electrode (VIBE) for Imaging Neuronal Activity","field_investigator":"Jeff W Bulte","field_institution":"Hugo W. Moser Res Inst Kennedy Krieger","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-15-200","field_project_number":"1R24MH109085-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9037143\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9037143\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant):  A technique will be developed to determine where in the brain the signal in an electroencephalogram (EEG) is originating from in order to generate a \u0022voxel-specific EEG\u0022, much like the signal coming from an implanted electrode."},{"title":"Wavefront sensor for deep imaging of the brain","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222015-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2015\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-15-001","field_project_number":"1R21EY026391-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9055902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9055902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): Optical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges for optical brain imaging are depth and speed."},{"title":"A Novel Approach for Cell-Type Classification and Connectivity in the Human Brain","field_investigator":"Nenad  Sestan","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The human brain is arguably the most complex biological structure.  Understanding how many different cell types exist in the human brain and mapping neural connections are critical tasks to better understand the development and function of the brain."},{"title":"Advancing MRI \u0026amp; MRS Technologies for Studying Human Brain Function and Energetics","field_investigator":"Wei  Chen, Qing X Yang","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106049-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827010\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827010\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): Magnetic resonance (MR) imaging (MRI) and in vivo MR spectroscopy (MRS) techniques have become indispensable tools for imaging brain structure, function, connectivity, neurochemistry and neuroenergetics, and for investigating neurological disorders."},{"title":"An optogenetic toolkit for the interrogation and control of single cells.","field_investigator":"Gregory J Hannon","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106035-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822629\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822629\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Our understanding of brain function at the cellular and circuit level is critically dependent on the ability to interrogate and alter neural cells withhigh specificity."},{"title":"Behavioral readout of spatiotemporal codes dissected by holographic optogenetics","field_investigator":"Dmitry  Rinberg, Shy  Shoham","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090498-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826953\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826953\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by the activity of neurons at different levels of information processing?"},{"title":"Calcium sensors for molecular fMRI","field_investigator":"Alan  Jasanoff","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826465\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826465\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):   The development of minimally invasive direct readouts of neural activity is one of the greatest challenges facing neuroscience today."},{"title":"Classification of Cortical Neurons by Single Cell Transcriptomics","field_investigator":"John J. Ngai","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105979-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822674\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822674\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant):Unraveling the complexity of the mammalian brain is one of the most challenging problems in biology today."},{"title":"Classifying Cortical Neurons by Correlating Transcriptome with Function","field_investigator":"Massimo  Scanziani","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105959-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822747\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822747\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The classification of neurons into distinct types is a fundamental endeavor in neuroscience."},{"title":"Combining genetics, genomics, and anatomy to classify cell types across mammals","field_investigator":"Gill  Bejerano, Carlos  Lois, Partha Pratim Mitra, Sacha B Nelson","field_institution":"Brandeis University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105949-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822109\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822109\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Recent genetic advances have driven significant progress in scientists\u0027 abilities to classify and map neuronal cell types within the brains of mode organisms like laboratory mice."},{"title":"Comprehensive Classification Of Neuronal Subtypes By Single Cell Transcriptomics","field_investigator":"Aviv  Regev, Joshua R Sanes, Alexander F Schier, Yi  Zhang","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105960-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822370\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822370\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): To understand the brain, we need a \u0022parts list\u0022 of its cell types."},{"title":"Cortical circuits and information flow during memory-guided perceptual decisions","field_investigator":"Mriganka  Sur","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090473-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826872\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826872\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Perceptual decision-making involves multiple cognitive components and diverse brain regions."},{"title":"Crowd coding in the brain:3D imaging and control of collective neuronal dynamics","field_investigator":"Patrick O Kanold, Wolfgang  Losert, Dietmar  Plenz","field_institution":"Univ Of Maryland, College Park","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090569-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827121\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827121\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The cortex is a laminated structure that is thought to underlie sequential information processing."},{"title":"Defining cell types, lineage, and connectivity in developing human fetal cortex","field_investigator":"Daniel H Geschwind","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105991-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822765\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822765\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Little is currently known about the number, proportion, or lineage of distinct cell types in the developing human fetal brain."},{"title":"Developing drivers for neuron type-specific gene expression","field_investigator":"Oliver  Hobert","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH105924-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8821299\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8821299\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Driver lines that direct Cre protein to specific neuron types have proven to be invaluable tools to not only visualize specific neuron types but also to manipulate their activity through the Cre- mediated activation of optogenetic probes or to assess gene fu"},{"title":"Development of Protein-based Voltage Probes","field_investigator":"Vincent A Pieribone","field_institution":"John B. Pierce Laboratory, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090565-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827112\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827112\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):   The use of genetically encoded fluorescent activity probes represent the most advanced method to monitor the electrical activity of networks of neurons without using electrodes."},{"title":"Dissecting human brain circuits in vivo using ultrasonic neuromodulation","field_investigator":"Mikhail  Shapiro, Doris Ying Tsao","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8828517\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8828517\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): A dream of neuroscience is to be able to non-invasively modulate any given region of the human brain with high spatial resolution."},{"title":"DREADD2.0: AN ENHANCED CHEMOGENETIC TOOLKIT","field_investigator":"Jian  Jin, Thomas L. Kash, Bryan L. Roth","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH105892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8819319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8819319\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has the ambitious goal of elucidating how neuronal ensembles interactively encode higher brain processes."},{"title":"Epigenomic mapping approaches for cell-type classification in the brain","field_investigator":"M Margarita Behrens, Joseph R Ecker","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105985-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822735\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822735\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Understanding the exact cell-type composition in brain regions is fundamental to integrating physiological, behavioral and neurochemical data to systematically understand the brain structure and function."},{"title":"Establishing a Comprehensive and Standardized Cell Type Characterization Platform","field_investigator":"David J Anderson, Hongkui  Zeng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105982-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822593\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822593\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The brain circuit is an intricately interconnected network of a vast number of neurons with diverse molecular, anatomical and physiological properties. Neuronal cell types are fundamental building blocks of neural circuits."},{"title":"FAST HIGH-RESOLUTION DEEP PHOTOACOUSTIC TOMOGRAPHY OF ACTION POTENTIALS IN BRAINS","field_investigator":"Lihong  Wang","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090579-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Revealing how our brain works is a great challenge but yet worth our every effort: it will not only illuminate the profound mysteries in science but also provide the key to understanding and treating neurological diseases such as Alzheimer\u0027s and Parkinson\u0027s"},{"title":"Genetically encoded reporters of integrated neural activity for functional mapping of neural circuitry","field_investigator":"Kit S Lam, James S Trimmer","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090581-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827140\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827140\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):    One of the major challenges in neuroscience is to link the structure to the function of neural circuits."},{"title":"Genetically encoded sensors for the biogenic amines: watching neuromodulation in action","field_investigator":"Lin  Tian","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090604-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827206\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827206\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):   The goal of this proposal is to develop a toolbox of genetically encoded indicators for biogenic amines, the most important family of neuromodulators."},{"title":"High-Density Recording and Stimulating Microelectrodes","field_investigator":"Timothy James Gardner","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090454-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826494\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826494\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  This project seeks to develop a high density, minimally invasive electrode array for long-term recording and control of brain activity."},{"title":"Identification of enhancers whose activity defines cortical interneuron types","field_investigator":"John L. R. Rubenstein, Vikaas Singh Sohal","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH105948-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822106\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822106\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Molecular definitions of neural cell types largely depend on the expression of RNAs or proteins as assessed by in situ hybridization, RNA array and sequencing, and immunohistochemistry."},{"title":"Imaging Brain Function in Real World Environments \u0026amp; Populations with Portable MRI","field_investigator":"Michael  Garwood, John T Vaughan","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH105998-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822705\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822705\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) continues to play a critical role in understanding the human brain."},{"title":"Imaging in vivo neurotransmitter modulation of brain network activity in realtime","field_investigator":"Albert  Gjedde, Arman  Rahmim, Dean Foster Wong","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106083-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8828420\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8828420\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neuronal depolarization and neurotransmitter release underlie some of the most fundamental components of normal physiology and the etiology of brain pathophysiology."},{"title":"Imaging the Brain in Motion: The Ambulatory Micro-Dose, Wearable PET Brain Imager","field_investigator":"Julie Ann Brefczynski-Lewis","field_institution":"West Virginia University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827925\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827925\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): Our vision is to design the first truly mobile molecular brain imager that can be used on healthy subjects to study the functioning of the human brain during motion."},{"title":"In-vivo circuit activity measurement at single cell, sub-threshold resolution","field_investigator":"Craig  Forest, Garrett B. Stanley","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822574\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822574\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neurons communicate information through fluctuations in the electrical potentials across their cellular membranes."},{"title":"Integrative Functional Mapping of Sensory-Motor Pathways","field_investigator":"Michael H Dickinson, Philip J Holmes, Richard S Mann, Rachel  Wilson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090514-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826988\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826988\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The goal of the project team is to develop a robust, multi-lab research framework, enabled by large scale imaging, which will lead to principled integrative models of ethologically-relevant behaviors that incorporate a detailed knowledge of individual cell c"},{"title":"Large-Scale Electrophysiological Recording and Optogenetic Control System","field_investigator":"Albert Baldwin Goodell","field_institution":"Graymatter Research","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090557-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827102\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827102\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  In order to gain a greater understanding of the neural mechanisms that mediate human cognitive function new approaches and technologies are needed to dramatically expand the ability to record and manipulate the activity of large numbers of neurons throughou"},{"title":"Magnetic Particle Imaging (MPI) for Functional Brain Imaging in Humans","field_investigator":"Steven M Conolly, Mark  Griswold, Lawrence L Wald","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106053-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827525\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827525\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): In this planning grant we propose several engineering developments to advance Magnetic Particle Imaging (MPI) to replace MRI as the next-generation functional brain imaging tool for human neuroscience."},{"title":"Mapping neuronal chloride microdomains","field_investigator":"Kevin J. Staley","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106013-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822651\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822651\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Dramatic new insights into the functioning of neural networks have been made possible by our ability to visualize neural function with calcium-sensitive fluorophores, and biology has been revolutionized by the ability to sequence and manipulate DNA, RNA, and"},{"title":"Mapping the Developing Human Neocortex by Massively Parallel Single Cell Analysis","field_investigator":"Arnold  Kriegstein","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105989-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822551\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822551\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): This proposal seeks to create a single cell resolution map of the developing human neocortex."},{"title":"Mechanisms of neural circuit dynamics in working memory","field_investigator":"William  Bialek, Carlos D Brody, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090541-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827069\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827069\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Working memory, the ability to temporarily hold multiple pieces of information for mental manipulation, is central to virtually all cognitive abiliies."},{"title":"Modular High-Density Optoelectrodes for Local Circuit Analysis","field_investigator":"Gyorgy  Buzsaki, Kensall David Wise, Euisik  Yoon","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090526-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827022\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827022\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Significance: A number of scientific questions, especially in local circuit analysis, require manipulating neurons in vivo at multiple sites independently at high spatial and temporal resolutions by perturbing a controlled number and simultaneously recorded neurons."},{"title":"Modular nanophotonic probes for dense neural recording at single-cell resolution","field_investigator":"Michael L Roukes, Athanassios  Siapas, Kenneth L Shepard, Andreas  Tolias","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827175\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827175\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"DESCRIPTION (provided by applicant): Our understanding of the properties of individual neurons and their role in brain computations has advanced significantly during the last few decades."},{"title":"Modular systems for measuring and manipulating brain activity","field_investigator":"Loren M Frank, Reid  Harrison, Vanessa  Tolosa","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090537-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827056\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827056\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The brain is a massively interconnected network of specialized circuits. Even primary sensory areas, once thought to support relatively simple, feed-forward processing, are now known to be parts of complex feedback circuits."},{"title":"MRI Corticography (MRCoG): Micro-scale Human Cortical Imaging","field_investigator":"David Alan Feinberg, Chunlei  Liu, Pratik  Mukherjee, Kawin  Setsompop","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106096-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8828462\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8828462\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): MRI is the only technology that can image the connectivity of the human brain in vivo and non-invasively. However, neither BOLD fMRI nor diffusion-based fiber tracking has been able to break the barrier of 1-mm voxel spatial resolution."},{"title":"Multi-area two-photon microscopy for revealing long-distance communication between multiple local brain circuits","field_investigator":"Fritjof  Helmchen","field_institution":"University Of Zurich","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090475-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826876\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826876\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Two-photon microscopy is a widely used, key method for functional imaging of cellular activity in living animals."},{"title":"Neural circuits in zebrafish: form, function and plasticity","field_investigator":"Constance L Cepko, Florian  Engert, Jeff W Lichtman, Haim  Sompolinsky","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826324\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826324\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): We propose to combine whole brain 2-photon imaging of neural activity in behaving larval zebrafish with detailed anatomical and connectivity information extracted from the same animals."},{"title":"Neurotransmitter Absolute Concentration Determination with Diamond Electrode","field_investigator":"Kendall H. Lee, Felicia S. Manciu, Johnathan R Tomshine","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090455-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826512\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826512\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Determining the levels of neurotransmitters present in the living brain in real time is a matter of current scientific interest for research and clinicl reasons."},{"title":"Next generation high-throughput random access imaging, in vivo","field_investigator":"Elly  Nedivi, Peter T. So","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8825556\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8825556\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The goal of this proposal is to develop new methods for high speed monitoring of sensory-driven synaptic activity across all inputs to single living neurons in the context of the intact cerebral cortex."},{"title":"Novel Genetic Strategy for Sparse Labeling and Manipulation of Mammalian Neurons","field_investigator":"Xiangdong William Yang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106008-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822751\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822751\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Cajal revolutionized the study of the brain through the use of the Golgi stain to label cells sparsely and stochastically in a fashion that revealed a neuron\u0027s morphology in its entirety."},{"title":"Novel technologies for nontoxic transsynaptic tracing","field_investigator":"Ian R Wickersham","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106018-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822590\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822590\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Genetic tools have dramatically increased the power and resolution of neuroscientific experiments, allowing monitoring and perturbation of specific neuronal populations within the brain, often in the context of complex cognitive and behavioral paradigms."},{"title":"Optical control of synaptic transmission for in vivo analysis of brain circuits and behavior","field_investigator":"Ehud  Isacoff, Richard H Kramer","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090527-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Optogenetics has revolutionized neuroscience by making it possible to use heterologously expressed light-gated ion channels and pumps to stimulate or inhibit action potential firing of genetically selected neurons in order to define ther roles in brain circ"},{"title":"Optimization of 3-photon microscopy for Large Scale Recording in Mouse Brain","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090530-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  The goal of this research program is to optimize three-photon fluorescence microscopy (3PM) for large scale, noninvasive, volumetric imaging of neuronal activity."},{"title":"Optogenetic mapping of synaptic activity and control of intracellular signaling","field_investigator":"David  Kleinfeld, John Yu-Luen Lin","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090590-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827155\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827155\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant): This proposal aims to develop new molecular techniques to map activities of neurons, manipulate the strength of communication between neurons and disrupt intracellular signaling."},{"title":"Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations","field_investigator":"Allen W Song","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106048-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826908\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826908\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): In response to the NIH RFA-MH-14-217 on \u0022Planning for Next Generation Human Brain Imaging\u0022, we propose a comprehensive plan to organize the much needed technological resources and interdisciplinary research team for developing the next generation MRI technol"},{"title":"Protein voltage sensors: kilohertz imaging of neural dynamics in behaving animals","field_investigator":"Michael Z. Lin, Mark J Schnitzer","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090600-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827201\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827201\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):   Attaining effective genetically encoded optical voltage-indicators has been a longstanding goal in neuroscience research and is a key near-term aim of the BRAIN Initiative."},{"title":"Remote regulation of neural activity","field_investigator":"Sarah Amy Stanley","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH105941-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8821955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8821955\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): A fundamental goal of neuroscience is to understand the function(s) of defined neural populations in a complex organism. We propose to develop and validate a technology for non- invasive modulation of neural activity in vivo."},{"title":"Revealing the connectivity and functionality of brain stem circuits","field_investigator":"Darwin K Berg, Martin  Deschenes, Yoav Shai Freund, Martyn D Goulding, David  Kleinfeld, Per  M Knutsen","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090595-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827174\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827174\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Neuronal circuits in the brainstem control life-sustaining functions, in addition to driving and gating active sensation through taste, smell, and touch."},{"title":"The role of patterned activity in  neuronal codes for behavior","field_investigator":"John H.r. Maunsell","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090576-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827131\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827131\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): A key aspect of brain function is how the activity of neuronal populations encodes information that is used to guide behavior."},{"title":"Three Dimensional Holography for Parallel Multi-target Optogenetic Circuit Manipulation","field_investigator":"Valentina  Emiliani, Serge  Picaud","field_institution":"Pierre And Marie Curie University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-008","field_project_number":"1U01NS090501-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8826957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8826957\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Understanding communication between neurons, who is talking to whom, and what language they are speaking, is essential for discovering how brain circuits underlie brain function and dysfunction."},{"title":"Time-Reversal Optical Focusing for Noninvasive Optogenetics","field_investigator":"Viviana  Gradinaru, Changhuei  Yang","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-007","field_project_number":"1U01NS090577-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827135\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\ufeff   \nDESCRIPTION (provided by applicant):  Our bodies appear optically opaque because biological tissue scatters light strongly."},{"title":"Towards a Complete Description of the Circuitry Underlying Memory replay.","field_investigator":"Ivan  Soltesz","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090583-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827142\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827142\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): The function of a brain region is an emergent property of many cell types."},{"title":"Towards quantitative cell type-based mapping of the whole mouse brain","field_investigator":"Pavel  Osten","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-215","field_project_number":"1U01MH105971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822445\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822445\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type","field_program":"Investigative Human Neuroscience","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): The mouse brain comprises ~70 million neurons and ~30 million glia and other cells. Neurons have been traditionally classified based on their morphology, connectivity, stimulus-response, gene expression, and location in the brain."},{"title":"Ultra-Multiplexed Nanoscale In Situ Proteomics for Understanding Synapse Types","field_investigator":"Mark  Bathe, Edward S. Boyden, Peng  Yin","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-216","field_project_number":"1U01MH106011-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8822389\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8822389\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\ufeff   \nDESCRIPTION (provided by applicant): Significant work is ongoing to reveal how different cell types in the brain contribute to behavior and pathology, and how they change in plasticity and disease, empowered by new genetic, optical, and physiological tools."},{"title":"Vascular Interfaces for Brain Imaging and Stimulation","field_investigator":"Robert  Desimone","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-14-217","field_project_number":"1R24MH106075-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8828404\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8828404\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\ufeff   \nDESCRIPTION (provided by applicant): Functional MRI (fMRI), EEG, and other completely noninvasive modalities for large-scale imaging of human brain activity have pioneeringly revealed many human brain functions, but cannot reach the single-neuron, single-spike level of neural code analysis poss"},{"title":"Vertically integrated approach to visual neuroscience: microcircuits to behavior","field_investigator":"Thomas  Euler, Andrew D Huberman, Markus  Meister, Hyunjune Sebastian Seung, Rachel O Wong","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222014-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2014\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-14-009","field_project_number":"1U01NS090562-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/8827109\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/8827109\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"\ufeff   \nDESCRIPTION (provided by applicant): Visual neuroscience is finally beginning to achieve a \u0022vertically integrated\u0022 understanding of the retina, bridging all levels from molecules to microcircuits to behavior."}]