[{"title":"1 mm resolution single-photon spectral imaging of the brain","field_investigator":"Ling-Jian  Meng, Scott Dean Metzler","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034715-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EAbstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,\u003C\/p\u003E"},{"title":"3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform","field_investigator":"Huanan  Zhang","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1R56NS131084-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10883867\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10883867\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY: Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for ma\u003C\/p\u003E"},{"title":"A Dry Electrode for Universal Accessibility to EEG","field_investigator":"Walid Soussou","field_institution":"Quasar, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43NS132644-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761609\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761609\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EElectroencephalography (EEG) measures the brain\u2019s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.\u003C\/p\u003E"},{"title":"A germline- and promoter-independent strategy to gain access to all cell types in the brain","field_investigator":"Huaiyu  Hu, Yingxi  Lin, Baisong  Lu","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130782-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject summary The heterogeneity from the vast number of cell types in the brain presents a major challenge in our understanding of how brain works and in our treatment of neurological disorders.\u003C\/p\u003E"},{"title":"A multi-foci objective lens for large scale brain activity recording","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731905\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731905\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract The goal of this project is to develop a novel bifocal catadioptric objective that will allow large-scale recording of neural circuits in vivo.\u003C\/p\u003E"},{"title":"A scalable cloud-based framework for multi-modal mapping across single neuron omics, morphology and electrophysiology","field_investigator":"Bing-Xing  Huo","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133777-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725550\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Categorizing individual neurons into different groups, or cell types, is a classical approach to studying the nervous system.\u003C\/p\u003E"},{"title":"A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy","field_investigator":"David A Boas, Xiaojun  Cheng","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034710-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EAbstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring\u003C\/p\u003E"},{"title":"A visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assays","field_investigator":"Maximilian  Haeussler","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132662-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT The BRAIN Initiative\u2019s -omics data archive NeMO contains all the BICCN single cell single cell data, more than one million files at the time of writing.\u003C\/p\u003E"},{"title":"Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology","field_investigator":"Fuyixue  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129893-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572005\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572005\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.\u003C\/p\u003E"},{"title":"All holographic two-photon electrophysiology","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131075-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616937\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616937\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY Achieving a detailed understanding of the neural codes of sensation, action, and cognition will require technologies that can both sample and perturb neural activity with millisecond precision and cellular resolution across large populations of neurons.\u003C\/p\u003E"},{"title":"An Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation","field_investigator":"Mark A Foster","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739050\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739050\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Multiphoton microscopy of cells labeled with genetically encoded calcium indicators (GECIs) enables detection and correlation of fine neuronal structure to functional activity with cellular resolution.\u003C\/p\u003E"},{"title":"An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease","field_investigator":"Dennis Alan Turner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS129898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10571952\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10571952\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDBS therapy for Parkinson Disease [PD], the primary, FDA-approved surgical approach, has proven efficacious in clinical trials.\u003C\/p\u003E"},{"title":"An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates","field_investigator":"Karl A. Deisseroth, Eyal J Seidemann","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH133047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650669\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650669\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.\u003C\/p\u003E"},{"title":"Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability","field_investigator":"Loren D Peeters","field_institution":"East Tennessee State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130827-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754809\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754809\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.\u003C\/p\u003E"},{"title":"Beyond dopamine: dual neuromodulator regulation of motor variability and learning","field_investigator":"Drew Clinton Schreiner","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132152-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10605853\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10605853\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.\u003C\/p\u003E"},{"title":"Biophysical Mechanisms of Cortical MicroStimulation","field_investigator":"Sydney S Cash, Mark Thomas Harnett","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS132784-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10711723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10711723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDirect local electrical stimulation (DLES) is an increasingly important therapeutic tool for treating brain disorders such as Parkinson\u2019s, epilepsy, and OCD.\u003C\/p\u003E"},{"title":"Boss: A cloud-based data archive for electron microscopy and x-ray microtomography","field_investigator":"Brock A. Wester","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114785-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664562\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664562\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EABSTRACT The generation of scienti\ufb01cally rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.\u003C\/p\u003E"},{"title":"Bottom-Up, Top-Down, and Local Interactions in the Generation and Consolidation of Cortical Representations of Sequential Experience","field_investigator":"Bruce L Mcnaughton","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132041-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658227\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658227\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EYears of study and theory about the unique role of the hippocampus in storing new memories has led to a general idea that the hippocampus generates a unique output code for every unique experience, that is projected back to the neocortex, where it becomes coupled to attributes of the experience t\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132250-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665380\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665380\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electron microscopy pipeline that could scale to a whole mouse brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-048","field_project_number":"1UM1NS132253-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665386\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665386\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural basis of brain function are cell type composition and the wiring diagram between those cells.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Center for Mesoscale Connectomics","field_investigator":"Taner  Akkin, Damien A Fair, Sarah Rachel Heilbronner, Christophe  Lenglet, Kamil  Ugurbil, Essa  Yacoub, Jan  Zimmermann","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132207-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EPROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Comprehensive regional projection map of marmoset with single axon and cell type resolution","field_investigator":"Guoping  Feng, Partha Pratim Mitra, Xiao  Wang","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132173-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664170\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664170\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY This ambitious proposal will establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate, the common marmoset (Callithrix jacchus),.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping brain-wide connectivity of neuronal types using barcoded connectomics","field_investigator":"Xiaoyin  Chen, Justus M Kebschull, Ian R Wickersham","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132161-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary Mapping the brain-wide connections of neurons provides a foundation for understanding the structure and functions of a brain.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate System","field_investigator":"Bruce  Fischl, Patrick R Hof, Hui  Wang","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664289\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664289\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract (30 lines of text limit) The ~1 billion neurons that form the human brainstem are organized at multiple scales, ranging from their cell type-specific patterns of dendritic arborization, to local circuits embedded within large-scale projection systems spanning the brainste\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Multi-beam transmission electron microscopy of iteratively milled semi-thick tissue sections","field_investigator":"Andreas  Schaefer, Adrian Andreas Wanner","field_institution":"Paul Scherrer Institut Psi","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132317-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10669305\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10669305\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary\/Abstract Volume electron microscopy is the only technique to-date that provides both sufficient resolution (100 \u03bcm) for the dense reconstruction of neuronal wiring diagrams.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes","field_investigator":"Tim M Jarsky, Staci A Sorensen, Uygar  Sumbul","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665493\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665493\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary \/ Abstract Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Rapid and Cost\u2010effective Connectomics with Intelligent Image Acquisition, Reconstruction, and Querying","field_investigator":"Jeff W Lichtman, Hanspeter  Pfister, Aravinthan D. Samuel, Nir  Shavit, Brock A. Wester","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132158-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10663654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10663654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY High-throughput connectomics is needed to generate the TB-, PB- and EB-scale wiring diagrams of mammalian brains, but is limited to the few research institutes (e.g., Janelia, Allen, Max Planck) with suf\ufb01cient infrastructure.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus","field_investigator":"Andreas  Tolias, Anthony M Zador","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-049","field_project_number":"1U01NS132353-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672786\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672786\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EABSTRACT Single-cell transcriptomics has revolutionized our understanding of neuronal diversity and enabled high-throughput characterization of molecular cell types across brain areas and species.\u003C\/p\u003E"},{"title":"BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)","field_investigator":"Suzanne N Haber, Elizabeth M. C. Hillman, Anastasia  Yendiki","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-047","field_project_number":"1UM1NS132358-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10672681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10672681\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"BRAIN CONNECTS, Understanding Circuits","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject summary: This project will develop and validate a comprehensive toolset of novel technologies for imaging axonal projections across scales, and will deploy this toolset to map a complex system of cortico- subcortical projections in the macaque and human brain.\u003C\/p\u003E"},{"title":"Brain dynamics underlying long-term memory consolidation","field_investigator":"Priya  Rajasethupathy","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132047-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658311\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658311\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.\u003C\/p\u003E"},{"title":"Brain-wide mapping of neuronal inhibition by novel inverse activity markers","field_investigator":"Li  Ye","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132570-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10639977\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10639977\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EAbstract This project aims to develop the first Inverse Activity Marker (IAM) for detecting neuronal inhibition (broadly defined as the decrease of neuronal activities).\u003C\/p\u003E"},{"title":"Capturing the neural signature of the paraventricular thalamus that underlies individual variability in cue-motivated behavior","field_investigator":"Shelly Beth Flagel","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132808-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715723\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.\u003C\/p\u003E"},{"title":"Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex","field_investigator":"Deepa L Ramamurthy","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129753-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739223\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739223\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Sensory representations are influenced by an animal\u2019s external context, internal state, past experiences, expectations, and future goals.\u003C\/p\u003E"},{"title":"Center for Advanced Muscle BioElectronics (CAMBER)","field_investigator":"Muhannad   Bakir, Samuel  Sober","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS126936-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10573637\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10573637\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EA central goal of neuroscience is to discover how neural circuits control the body\u2019s muscles to produce behavior.\u003C\/p\u003E"},{"title":"Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke","field_investigator":"Jasmine Jamilah Cash","field_institution":"Medical University Of South Carolina","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829133\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829133\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.\u003C\/p\u003E"},{"title":"Characterizing odor motion detection in flies","field_investigator":"Damon Alistair Clark, Thierry  Emonet","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132840-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EMany animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.\u003C\/p\u003E"},{"title":"Chemigenetic voltage indicators for far-red and two-photon imaging in vivo","field_investigator":"Ahmed  Abdelfattah","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133755-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY DESCRIPTION (provided by applicant): Changes in membrane potential are the fundamental language of the nervous system, but these voltage signals are not directly visible.\u003C\/p\u003E"},{"title":"Circuit architecture and dynamics of the insular cortex underlying motivational behaviors","field_investigator":"Tianyi  Mao, Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729654\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.\u003C\/p\u003E"},{"title":"Circuit mechanisms of arbitration between distinct reinforcement learning systems","field_investigator":"Margaret Louise Demaegd","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132176-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608739\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608739\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?\u003C\/p\u003E"},{"title":"Circuit-specific, chemogenetic neuromodulation in nonhuman primates.","field_investigator":"Serge E Przedborski, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-115","field_project_number":"1UG3MH129381-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10651371\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10651371\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT \u2012 UG3\/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.\u003C\/p\u003E"},{"title":"cloudSLEAP: Maximizing accessibility to deep learning-based motion capture","field_investigator":"Talmo D. Pereira","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132653-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EcloudSLEAP \u2013 PROJECT SUMMARY\/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.\u003C\/p\u003E"},{"title":"Cognitive and Neural Strategies for Latent Feature Inference","field_investigator":"Tahra  Eissa","field_institution":"University Of Colorado","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99NS127855-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662877\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662877\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.\u003C\/p\u003E"},{"title":"Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits","field_investigator":"Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher","field_institution":"Blackrock Microsystems","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44NS134432-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761217\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761217\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.\u003C\/p\u003E"},{"title":"Contextual modulation of visual decision-making across the visual hierarchy","field_investigator":"Pamela  Reinagel","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132037-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658176\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658176\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract In sensory decision-making, choices are influenced by non-sensory factors such as motivation, attention, and recent trial history.\u003C\/p\u003E"},{"title":"Continuous development of nTracer2 and its deployment at NIH image repositories","field_investigator":"Dawen  Cai, Yan  Yan","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133764-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726178\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726178\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EAbstract In response to the BRAIN Initiative \u201cIntegration and Analysis of BRAIN Initiative Data\u201d FOA, we propose further developing nTracer2, a cloud-based platform for brain image visualization and neuron tracing in the web browser.\u003C\/p\u003E"},{"title":"CONVERGENT PROCESSING ACROSS VISUAL AND HAPTIC CIRCUITS FOR 3D SHAPE PERCEPTION","field_investigator":"Charles E Connor, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132848-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10720137\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10720137\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ETHEORETICAL FRAMEWORK: Vision and touch share a critical function\u2014perception of 3D object shape.\u003C\/p\u003E"},{"title":"Cortical assembly formation through excitatory\/inhibitory circuit plasticity","field_investigator":"Brent D. Doiron, Anne-Marie Michelle Oswald","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133598-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10729689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10729689\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ECortical assembly formation through excitatory\/inhibitory circuit plasticity. Project Summary Throughout the brain, sensory information is thought to be represented by the joint activity of neurons that form functionally connected assemblies.\u003C\/p\u003E"},{"title":"Cortical circuit dynamics underlying multisensory decision making","field_investigator":"Christopher R Fetsch","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132910-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721255\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721255\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary To navigate and guide locomotion in a complex 3D environment, humans and animals must make countless judgments of their direction of self-motion, or heading.\u003C\/p\u003E"},{"title":"CRCNS US-German Research Proposal: Quantitative and Computational Dissection of Glutamatergic Crosstalk at Tripartite Synapses","field_investigator":"Ghanim Ullah","field_institution":"University of South Florida","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130916-01  ","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612169\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612169\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Project Grants","field_priority_area":"","field_program":"Understanding Circuits","field_research_area":"Data Science \u0026amp; Informatics, Systems Neuroscience","body":"\u003Cp\u003ECRCNS US-German Research Proposal: Quantitative and computational dissection of glutamatergic crosstalk at tripartite synapses (1) Christine R Rose, Heinrich Heine University, D\u00fcsseldorf, Germany (2) Christian Henneberger, University of Bonn, Germany (3) Ghanim Ullah, University of South Florida,\u003C\/p\u003E"},{"title":"Cross-modal sensory interactions, processing, and representation in the Drosophila brain","field_investigator":"Itai  Cohen, Noah John Cowan, Jessica  Fox, Sung Soo  Kim","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645611\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645611\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ERobust navigation, which is critical for an animal\u2019s survival, requires the processing of complex sensory information spanning different modalities and time scales.\u003C\/p\u003E"},{"title":"DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal Analysis","field_investigator":"Terrence J Sejnowski","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH132664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10643212\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10643212\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary The goal of this proposal is to develop DDALAB, a software platform that will make it possible for researchers to identify latent cortical states and analyze the flow of information in large populations of neurons using Delay Differential Analysis (DDA).\u003C\/p\u003E"},{"title":"Deconstructing the sertonin system in the mouse brain","field_investigator":"Liqun  Luo, Scott Warren Linderman","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131987-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656870\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Serotonin is an evolutionarily conserved neurotransmitter that modulates the activity of excitatory and inhibitory neurons throughout the entire mammalian brain and is thus essential for diverse aspects of physiology and behavior.\u003C\/p\u003E"},{"title":"Developing an Optogenetics Technology Based on Natural Potassium-selective Channelrhodopsins","field_investigator":"John Lee Spudich, Francois  St-Pierre, Mingshan  Xue","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731153\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731153\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESUMMARY Mapping individual on channelrhodopsins types inhibitory transporting as presynaptic objective temporally propose gated whose the function of neural circuits in the brain crucially relies on the ability to both activate and silence circuit components to subsequently assess their impact on\u003C\/p\u003E"},{"title":"Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits","field_investigator":"Christopher  Versteeg","field_institution":"Emory University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132175-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10752956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10752956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?\u003C\/p\u003E"},{"title":"Developing Novel Trans-Synaptic Viral Vectors for Orthogonal or Rapid Circuit Tracing","field_investigator":"Euiseok J Kim","field_institution":"University Of California Santa Cruz","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132591-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640622\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640622\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary To determine the anatomical basis of complex neural behavior, it is critical to have the ability to trace more than one circuit simultaneously in the same animal.\u003C\/p\u003E"},{"title":"Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes","field_investigator":"Kip A Ludwig","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129955-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10572029\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10572029\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EDespite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.\u003C\/p\u003E"},{"title":"Development of a combined Gamma\/Positron system for molecular imaging of the human brain at sub-500 micron spatial resolution","field_investigator":"Shiva  Abbaszadeh, Lars R Furenlid, Michael A King","field_institution":"University Of Arizona","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034686-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722205\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722205\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003ESUMMARY We are proposing a new approach to a hybrid imaging modality that has been called \u201cb+g\u201d or \u201cpamma-positron\u201d Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two differ\u003C\/p\u003E"},{"title":"Development of Quantum Magnetic Tunneling Junction Sensor Arrays for Brain Magnetoencephalography (MEG) under Natural Settings","field_investigator":"Jerome N Sanes, Gang  Xiao","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034695-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10723802\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10723802\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary The long-term objective of this project is to develop a revolutionary quantum mechanical solid-state magnetometer designed to non-invasively detect femtoTesla (fT) scale magnetic fields derived from the brain\u2019s electrical activities during natural human experiences.\u003C\/p\u003E"},{"title":"DIrectional and SCalable (DISC) Microelectrode Array for Speech Decoding","field_investigator":"John P Seymour, Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS125487-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10513043\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10513043\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract Currently, the brain-computer interface (BCI) field has demonstrated two distinct device strategies - macroelectrodes (e.g., surface grids and depth) versus microelectrode arrays, and some are even pushing the field to smaller, higher density arrays hoping to address the general signal d\u003C\/p\u003E"},{"title":"Dissecting modular and redundant organization of cortical circuits","field_investigator":"Shaul  Druckmann, Nuo  Li","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657919\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657919\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract In many cognitive processes, information is processed in a parallel manner across many brain regions.\u003C\/p\u003E"},{"title":"Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG\/EEG","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129945-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10726032\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10726032\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EHNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09\/2016\u201306\/2020) to meet the Initiative\u2019s goal to \u201cdevelop innovative technologies to understand brain circuits and ensembles of circuits th\u003C\/p\u003E"},{"title":"Distinct contributions of converging neural pathways to auditory learning","field_investigator":"Santiago  Jaramillo, James  Murray","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131993-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657285\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657285\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.\u003C\/p\u003E"},{"title":"Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony","field_investigator":"Zoe Rebecca Donaldson, Yevgenia  Kozorovitskiy, John  Rogers","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131406-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10644475\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10644475\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis.\u003C\/p\u003E"},{"title":"Electrophysiology-Compatible Wearable Transcranial Focused Ultrasound Neuromodulation Array Probes","field_investigator":"Bin  He","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131069-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616201\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616201\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Noninvasive high precision neuromodulation technologies are crucial for probing mechanisms of neural circuits and enabling the non-pharmacological treatment of brain disorders.\u003C\/p\u003E"},{"title":"ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO","field_investigator":"Laurent  Bourdieu, Francois  St-Pierre","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133971-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739579\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739579\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.\u003C\/p\u003E"},{"title":"Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization","field_investigator":"Christopher  Rorden","field_institution":"University Of South Carolina At Columbia","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.\u003C\/p\u003E"},{"title":"Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales","field_investigator":"Jeremiah Yaacov Cohen, Daniel Hans O\u0026#039;connor","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS131984-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10656752\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10656752\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003ESUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.\u003C\/p\u003E"},{"title":"Functions of the Cortical Amygdala in social behavior","field_investigator":"Antonio V Aubry","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA058213-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641270\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641270\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.\u003C\/p\u003E"},{"title":"Gulf Coast Consortia (GCC) Research Evaluation and Commercialization Hub","field_investigator":"Peter J Davies, Suzanne Marie Tomlinson, Stanley J Watowich","field_institution":"Texas A\u0026amp;M University Health Science Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-OD-23-005","field_project_number":"1U01GM152516-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10783414\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10783414\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003EIn recent years, the NIH has awarded over $850M annually to the numerous research institutions and hospitals within the Texas Medical Center (TMC; Houston, TX), producing ever-increasing numbers of biomedical discov- eries.\u003C\/p\u003E"},{"title":"High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging","field_investigator":"Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R43MH133544-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10695784\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10695784\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EWhole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.\u003C\/p\u003E"},{"title":"High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioids","field_investigator":"Andre  Berndt, Michael R Bruchas","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130391-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10635413\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10635413\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Neuropeptide modulation of neuronal circuits is strongly linked to many crucial behaviors such as exploration, stress, memory formation, learning, and many pathophysiological conditions.\u003C\/p\u003E"},{"title":"High-throughput measurement of neuronal projections and synapses using Synapse-seq","field_investigator":"Evan Z Macosko","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130468-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640361\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640361\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003ESUMMARY The brain is composed of thousands of highly specialized cell types that form very specific synaptic connections with each other. Together, these connections form neural circuits that are the structural basis of brain function.\u003C\/p\u003E"},{"title":"Highly multiplexed circuit mapping using barcoded rabies viruses and in situ sequencing.","field_investigator":"Ian R Wickersham, Shenqin  Yao","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132596-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640501\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640501\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EABSTRACT Understanding the function of neural circuits requires thorough investigation of two circuit elements: cell types and connectivity.\u003C\/p\u003E"},{"title":"Hybrid TMS\/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity","field_investigator":"Berkin  Bilgic, Susie Yi Huang, Aapo  Nummenmaa, Jason P Stockmann","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-22-001","field_project_number":"1UG3EB034875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730783\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730783\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Neuroimaging Technologies Across Scales","body":"\u003Cp\u003EProject Summary. We propose a new coil array that will enable next-generation causal brain mapping with unprecedented flexibility, resolution and precision.\u003C\/p\u003E"},{"title":"Identifying human-specific neural progenitors and their role in neurodevelopment","field_investigator":"Sumin  Jang","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130892-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10662868\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10662868\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).\u003C\/p\u003E"},{"title":"Identifying the neural mechanisms of goal-directed decision-making in Parkinson\u0026#039;s disease using closed-loop deep brain stimulation","field_investigator":"Colin  Hoy","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132174-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608842\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608842\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003ETITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON\u2019S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson\u2019s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c\u003C\/p\u003E"},{"title":"Implantable 3D fluorescence imaging with high-speed, addressable laser scanning in moving mice","field_investigator":"Kenn R Oldham","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS131063-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10614795\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10614795\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary The goal of this work is to achieve high-speed optical fluorescence imaging of 3D brain volume in moving, behaving mice, using miniature scanning mirrors in an implantable, fiber-coupled microscope.\u003C\/p\u003E"},{"title":"Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior","field_investigator":"Gabriela  Manzano Nieves","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH132082-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.\u003C\/p\u003E"},{"title":"Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)","field_investigator":"Susie Yi Huang, Jonathan David Jackson, Francis X Shen","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH134144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10730955\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10730955\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary \/ Abstract Although BRAIN 2.0 called for the BRAIN Initiative to \u201cprioritize diversity and inclusion as a fundamental pillar,\u201d research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.\u003C\/p\u003E"},{"title":"Improving the Speed of Galvo-Scanners","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034809-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract Optical methods provide high-resolution, non-invasive measurement of neural function, ranging from single neurons to entire populations, in the intact brain. Nevertheless, limited penetration depth, spatial scale and temporal resolution remain the main challenges for optical imaging.\u003C\/p\u003E"},{"title":"Integrating single-cell connectivity, gene expression, and function in zebra finches","field_investigator":"Justus M Kebschull","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10657971\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10657971\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY The courtship song of male zebra finches is a classical model for learning complex motor behaviors and shows important parallels to human speech and communication. Male zebra finches learn a song from an adult tutor and then reproduce this song throughout adulthood.\u003C\/p\u003E"},{"title":"Integrative Analysis of Adaptive Information Processing and Learning-Dependent Circuit Reorganization in the Auditory System","field_investigator":"Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10715925\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10715925\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Decades of research have revealed the principles of information processing that give rise to auditory spatial tuning and experience-dependent adaptive plasticity in the owl auditory system.\u003C\/p\u003E"},{"title":"Integrative circuit dissection in the behaving nonhuman primate","field_investigator":"Wyeth Daniel Bair, Farran  Briggs, Anitha  Pasupathy, Anqi  Wu","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131810-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10653435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10653435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EIn natural vision, recognizing objects based on the retinal image is challenging and is often an ill-posed problem because a single image is compatible with multiple interpretations.\u003C\/p\u003E"},{"title":"Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents","field_investigator":"William John Mitchell","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134208-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828675\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828675\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others\u0027 beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes.\u003C\/p\u003E"},{"title":"Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes","field_investigator":"Leighton Hosea Duncan","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135816-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10828978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10828978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EHypothalamic tanycytes have limited postnatal neurogenic competence, but the extrinsic and intrinsic factors that promote this are not well understood. My predoctoral research identified a defined developmental window during which neurogenic competence is lost from hypothalamic tanycytes.\u003C\/p\u003E"},{"title":"Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy","field_investigator":"Christopher  Hughes","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130022-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Intracortical microstimulation (ICMS) of the sensory cortices is an emerging approach to restore sensation to people who have lost it due to neurological injury or disease.\u003C\/p\u003E"},{"title":"Investigations of cAMP-dependent brain-barrier permeability in choroid plexus","field_investigator":"Dario Xavier Figueroa Velez","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132178-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753098\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753098\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The choroid plexus (ChP) comprises a network of cells that form a critical brain barrier that can mediate secondary damage in certain brain disorders and trauma. The Lehtinen lab has developed a suite of tools to study the ChP across development ex vivo and in vivo.\u003C\/p\u003E"},{"title":"Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience","field_investigator":"Michelle  Redinbaugh","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134451-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753172\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753172\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary: The majority of lived experience depends on neural activity conveying sensory information about the world.\u003C\/p\u003E"},{"title":"Live spike sorting for multichannel and high-channel recordings","field_investigator":"Tim Chifong Lei, Achim Klug","field_institution":"Popneuron, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-178","field_project_number":"1R41NS132700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10759767\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10759767\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes.\u003C\/p\u003E"},{"title":"Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus","field_investigator":"Attila  Losonczy, Ivan  Soltesz","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS133381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725714\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725714\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract Neural representations supporting spatial and episodic learning form, and transform rapidly in the mammalian hippocampus.\u003C\/p\u003E"},{"title":"Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex","field_investigator":"Lee O Vaasjo","field_institution":"Tulane University Of Louisiana","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134203-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10755203\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10755203\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Sub-Cerebral Projection Neurons (SCPNs) are a clinically relevant neuron class that controls voluntary movement and whose loss in Amyotrophic Lateral Sclerosis and Fronto-temporal dementia or injury (e.g., damaged by spinal cord injury) leads to paralysis.\u003C\/p\u003E"},{"title":"Massively Parallel Optoacoustic Retinal Stimulation at Micrometer-Resolution","field_investigator":"Chen  Yang","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035437-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731795\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731795\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Retinal degenerative diseases are the leading cause of irreversible vision loss. There is no approved medical intervention that could cure or reverse the courses of retinal degenerative diseases.\u003C\/p\u003E"},{"title":"Mechanisms of experience-dependent plasticity in an innate social behavior circuit","field_investigator":"Emma E Boxer","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134439-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10751542\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10751542\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Many social behaviors, such as defense and aggression, are innate- requiring no prior experience to be expressed and presumably \u2018hardwired\u2019 into neural circuits.\u003C\/p\u003E"},{"title":"Mechanisms of neural circuit dynamics in working memory and decision-making","field_investigator":"Carlos D Brody, Ila R. Fiete, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana  Witten","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"1U19NS132720-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705962\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705962\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract: Overall The overarching goal of this U19 program is to determine how neural computations across brain regions produce two core cognitive processes, working memory and decision-making, and thus to derive fundamental principles of brain function.\u003C\/p\u003E"},{"title":"Mechanoluminescent nanomaterials for optogenetic neuromodulation","field_investigator":"Jin  Nam, Yadong  Yin","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034806-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10616188\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10616188\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThe exponential surge in the prevalence of neurological diseases\/disorders, partly due to the rapid growth in the aged population, poses a significant challenge to the prevention and treatment of impairments in cognitive, sensory, and motor functions.\u003C\/p\u003E"},{"title":"Modeling and Mapping Human Action Regulation Networks","field_investigator":"Vasileios N Christopoulos, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-041","field_project_number":"1U01NS132788-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10712708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10712708\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Monitor Neural Activity","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Systems Neuroscience","body":"\u003Cp\u003EAbstract Humans can rapidly regulate actions according to updated demands of the environment.\u003C\/p\u003E"},{"title":"Models for accumulation of evidence through sequences in a navigation-based, decision-making task","field_investigator":"Lindsey Shoemaker Brown","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608293\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608293\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EDecision making is a fundamental cognitive process, and many decisions are based on gradually accumulated evidence. Thus, it is critical to understand the mechanistic basis underlying this accumulation process.\u003C\/p\u003E"},{"title":"Multiphon imaging for understanding social brain function in tadpoles","field_investigator":"Na  Ji, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132841-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10717610\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10717610\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Mother-infant bonding is a key relationship that lays a foundation for wellness throughout life. Social recognition is an important component of this relationship, as infants imprint on the smell of their mothers and use olfaction to distinguish their mother from others.\u003C\/p\u003E"},{"title":"Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET\/FLIM-based Sensors","field_investigator":"Daniel A Dombeck, Oliver  Griesbeck, Ryohei  Yasuda","field_institution":"Northwestern University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128655-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516813\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516813\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Plasticity is a fundamental aspect of neuronal circuits across all species. It is at the base of learning and memory, sensory adaption, and many disease-related processes such as addiction, chronic pain or regeneration.\u003C\/p\u003E"},{"title":"Multiplexed Sensing and Control of Neuromodulators and Peptides in the Awake Brain","field_investigator":"Mark L Andermann","field_institution":"Beth Israel Deaconess Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035436-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731789\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESummary Imbalanced levels of neuromodulators and other chemical signals contribute to a host of neurological disorders.\u003C\/p\u003E"},{"title":"Multisensory integration and self-motion perception in primate vestibular cortex","field_investigator":"Alejandra  Gomez","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134455-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753017\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753017\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary In vertebrate animals, the vestibular system (primarily known as the \u201cbalance system\u201d of the brain) interprets head-movement and orientation signals to provide organisms with a sense of self-motion.\u003C\/p\u003E"},{"title":"Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode Site","field_investigator":"Nathaniel P Williams","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH132145-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EAbstract Microelectrode arrays (MEAs) have great potential for therapeutic use in direct brain-computer interface (BCI) control of robotic prostheses to improve the lives of patients suffering from debilitating conditions related to loss of limbs or limb function.\u003C\/p\u003E"},{"title":"Neural basis of collective behavior during environmental stress","field_investigator":"Tara  Raam","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH133159-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10740543\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10740543\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Social interactions are critical to the physical and emotional health of a wide variety of species.\u003C\/p\u003E"},{"title":"Neural circuits for social modulation of a persistent negative emotional state","field_investigator":"Weizhe  Hong, Li I Zhang","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132912-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721276\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721276\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY In social species, social relationships can exert profound influences on individuals\u2019 behavioral and physiological states.\u003C\/p\u003E"},{"title":"Neural Mechanisms for Flexible Vocal Communication","field_investigator":"Arkarup  Banerjee","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658308\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary: Whether to laugh at a joke or to engage in a lively debate, we flexibly modify our vocalizations based upon social contexts. Such adaptive behavior requires real-time adjustments of motor outputs in response to rapidly changing sensory inputs.\u003C\/p\u003E"},{"title":"Neural Recording and Simulation Tools to Address the Mesoscale Gap","field_investigator":"John Compton Mosher, Charles E Schroeder, John P Seymour","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133972-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739544\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739544\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract We have designed a novel approach to perform multi-scale recordings in the brain across regions and depths.\u003C\/p\u003E"},{"title":"Neuronal and Network Mechanisms of Electrocortical Stimulation","field_investigator":"Marc W. Slutzky","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS125026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724958\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724958\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrocortical stimulation (ECS) has been used for functional mapping for many decades to identify brain areas that are \u201ccritical\u201d for speech and language (i.e., that impair function when stimulated) prior to epilepsy or tumor surgery.\u003C\/p\u003E"},{"title":"Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology","field_investigator":"Joshua H Siegle, Karel  Svoboda","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS133760-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731991\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731991\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY Within every brain region, neurons can be classified into dozens or hundreds of different cell types, each with unique functional roles and unique impacts on disease states.\u003C\/p\u003E"},{"title":"NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination","field_investigator":"Alexander  Beckett, David Alan Feinberg, An T Vu","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS129949-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725586\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003ESUMMARY The \u0022NexGen\u0022 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.\u003C\/p\u003E"},{"title":"Next generation axonal quantification and classification using AI","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"2R44MH128076-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10698843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10698843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis Phase II project describes the commercial development of HyperAxon\u2122, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional \u003C\/p\u003E"},{"title":"Next Generation Opto-GPCRs for Neuromodulatory Control","field_investigator":"Andre  Berndt, Michael R Bruchas, Moran  Shalev-Benami, Ofer  Yizhar","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128537-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515612\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515612\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary\/Abstract: The field of optogenetics \u2014 utilizing light to engage biological systems \u2014 is widely used for the dissection of neural circuits, cellular signaling and manipulating neurophysiological systems in awake, behaving animals.\u003C\/p\u003E"},{"title":"Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation","field_investigator":"Andrei G Pakhomov","field_institution":"Old Dominion University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034803-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10615485\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10615485\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrostimulation (ES) is a versatile and efficient tool for interrogating, altering, and manipulating neural activities in health and disease.\u003C\/p\u003E"},{"title":"O-GlcNac Modulation of GABAergic Transmission","field_investigator":"Shekinah  Phillips","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134163-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754746\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754746\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EChanges in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.\u003C\/p\u003E"},{"title":"OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data","field_investigator":"Russell A Poldrack","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH117179-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451257\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary\/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.\u003C\/p\u003E"},{"title":"Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation","field_investigator":"Lan  Luan, Chong  Xie","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS131086-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10617092\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10617092\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EElectrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.\u003C\/p\u003E"},{"title":"Oxytocin Modulation of Neural Circuit Function and Behavior","field_investigator":"Richard W Tsien","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-040","field_project_number":"2U19NS107616-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10705986\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10705986\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various \u2018non-social\u2019 aspects of internal state and physiological processes.\u003C\/p\u003E"},{"title":"Parameterizing the relationship between motor cortical reactivation during sleep and motor skill acquisition in the freely behaving marmoset","field_investigator":"Nicholas G Hatsopoulos, Jason Neil Maclean","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132033-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658109\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658109\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EProject Summary\/Abstract This project will provide a more nuanced and mechanistic model of the role of sleep in memory consolidation, particularly as it pertains to procedural motor skill acquisition in a non-human primate model.\u003C\/p\u003E"},{"title":"Peptidergic neurons in error computations and behavioral flexibility","field_investigator":"Emily L Sylwestrak","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003E\uf077PROJECT SUMMARY Survival in dynamic environments demands that behaviors are flexible and adaptive. An organism must make predictions about which actions lead to rewards, calculate how outcomes differ from those predictions (prediction errors), and adapt a behavioral strategy accordingly.\u003C\/p\u003E"},{"title":"Portable Intraoperative MRI for Neurosurgery","field_investigator":"Hung-Yu Lin","field_institution":"Neuro42, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-282","field_project_number":"1U44NS136026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10728737\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10728737\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003EMagnetic Resonance Imaging (MRI) is the gold-standard method for the detection and diagnosis of brain disease and surgical planning.\u003C\/p\u003E"},{"title":"Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research","field_investigator":"Joseph J. Fins, Gabriel  Lazaro-Munoz","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH133657-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722437\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"\u003Cp\u003EProject Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI\u003C\/p\u003E"},{"title":"Postnatal experience shapes gene expression and connectivity development in the cortex","field_investigator":"Alexander  Nevue","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10749679\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10749679\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.\u003C\/p\u003E"},{"title":"Pre-motor neural circuits enable versatile and sequential limb movements","field_investigator":"Julie H Simpson","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132900-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.\u003C\/p\u003E"},{"title":"Probing form and function of memory representations in the hippocampus of memory expert birds","field_investigator":"Emily Lambert Mackevicius","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS131256-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10641392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10641392\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary\/Abstract Mental disorders that affect the hippocampus disrupt people\u2019s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.\u003C\/p\u003E"},{"title":"Processing of visual information by spatial memory circuits in the avian brain","field_investigator":"Hannah L Payne","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10570644\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10570644\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT. Research Project: Spatial memory \u2013 memory of where an event happened or an object was located \u2013 depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.\u003C\/p\u003E"},{"title":"Psych-DS: A FAIR data standard for behavioral datasets","field_investigator":"Melissa  Kline","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-145","field_project_number":"1RF1MH132747-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10645923\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10645923\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ESummary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.\u003C\/p\u003E"},{"title":"Reconfigurable 3D Origami Probes for Multi-modal Neural Interface","field_investigator":"Gyorgy  Buzsaki, Michael Patrick Flynn, Euisik  Yoon","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS133978-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10738994\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10738994\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EProject Summary Over the decades, various neurotechnologies have made significant advancements to meet the highest priority goals enumerated in the BRAIN 2025 Report.\u003C\/p\u003E"},{"title":"Responsive Neurostimulation for Treatment Resistant Depression","field_investigator":"Andrew D Krystal","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS123310-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10513243\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10513243\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EPROJECT SUMMARY This UH3 application seeks to address the major public health burden of treatment-resistant major depression (trMDD) by developing a novel form of Deep Brain Stimulation (DBS).\u003C\/p\u003E"},{"title":"Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.","field_investigator":"Maksim V Bazhenov, Joshua D Berke, Karunesh  Ganguly","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132913-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10721280\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10721280\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EAbstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.\u003C\/p\u003E"},{"title":"Role of cortical connections to higher-order thalamic nuclei in visual decision-making","field_investigator":"Ariana R Andrei","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY034699-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10739488\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10739488\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.\u003C\/p\u003E"},{"title":"Role of multi-regional neuronal reactivations in reward-based memories","field_investigator":"Celine  Drieu","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DA059024-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10722635\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10722635\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.\u003C\/p\u003E"},{"title":"Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality","field_investigator":"Gianfranco  Doretto, Michael David Morehead, George A Spirou","field_institution":"Istovisr","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"2R44MH125238-03","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604786\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604786\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EOver the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.\u003C\/p\u003E"},{"title":"Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative","field_investigator":"Kaitlyn  Casimo, Jeremy A Miller","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS133077-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724950\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724950\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.\u003C\/p\u003E"},{"title":"Sensing and manipulating neuromodulatory signaling in vivo","field_investigator":"Haining  Zhong","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130784-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10650681\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10650681\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EPROJECT SUMMARY Neuromodulation, such as that mediated by the neuromodulators norepinephrine, acetylcholine, and dopamine, imposes powerful control over brain function. It regulates the excitability, synaptic plasticity, and other aspects of neuronal function.\u003C\/p\u003E"},{"title":"SensiTrak: Automated Assessment of Forelimb Sensation","field_investigator":"Camilo Andres Sanchez","field_institution":"Vulintus, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"2R44NS120748-02","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10603956\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10603956\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EProject Abstract Current common methods for measuring somatosensory function in preclinical rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli.\u003C\/p\u003E"},{"title":"Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior","field_investigator":"Brandon  Logeman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108801-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10661884\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10661884\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.\u003C\/p\u003E"},{"title":"State-dependent modulation of taste and temperature integration in Drosophila","field_investigator":"Fumika  Hamada","field_institution":"University Of California At Davis","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132843-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10718009\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10718009\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY: Animals constantly detect different environmental stimuli and change their behavior or physiology based on their internal state. How animals integrate the external multiple sensory information with the internal state is largely unclear.\u003C\/p\u003E"},{"title":"Systematic characterization of spinal cord stimulation effects on dorsal horn populations","field_investigator":"Andrei D Sdrulla","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS124557-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558269\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558269\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThere is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).\u003C\/p\u003E"},{"title":"Thalamic Coordinated Reset Deep Brain Stimulation for Upper Extremity Essential Tremor: Proof of Principle Study","field_investigator":"Jerrold L Vitek, Jing  Wang","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS125162-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10575895\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10575895\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EEssential tremor (ET) is a common neurologic disorder affecting over 10 million people in the United States. Pathologic synchrony in the cerebello-thalamo-cortical (CTC) network has been considered to underlie the development of ET.\u003C\/p\u003E"},{"title":"The development of multimodal dynamics in a short-term memory system","field_investigator":"Gregory Patrick Davis","field_institution":"Weill Medical Coll Of Cornell Univ","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH134449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10753261\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10753261\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY \/ ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.\u003C\/p\u003E"},{"title":"The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia","field_investigator":"David  Narvaiz","field_institution":"Baylor University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS134141-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10754319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10754319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary \/ Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.\u003C\/p\u003E"},{"title":"The Neuroimaging Brain Chart Software Suite","field_investigator":"Christos  Davatzikos, Yong  Fan, Ilya M Nasrallah, Haochang  Shou","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-011","field_project_number":"1U24NS130411-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10581015\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10581015\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination","field_research_area":"Dissemination","body":"\u003Cp\u003EThis study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.\u003C\/p\u003E"},{"title":"Thermal-plex: fluidic-free, rapid sequential multiplexed imaging of RNA and protein in brain tissues","field_investigator":"Peng  Yin","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH132599-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10640313\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10640313\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary Multiplexed imaging of brain cells and tissues can reveal critical details about the abundance and spatial organization of molecular targets.\u003C\/p\u003E"},{"title":"Time-varying spatiotemporal causal interactions in the functional brain networks","field_investigator":"Nan  Xu","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS123113-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590411\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590411\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EThis proposal describes a five-year career development program to prepare the candidate, Dr.\u003C\/p\u003E"},{"title":"Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas","field_investigator":"Panagiotis  Roussos, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133703-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10724843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10724843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EPROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu\u003C\/p\u003E"},{"title":"Tracking Flow of Attention in Visual Circuits Across the Brain","field_investigator":"Bilal  Haider","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-026","field_project_number":"1RF1NS132288-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10665957\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10665957\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.\u003C\/p\u003E"},{"title":"Trans-synaptic optical control of user-defined synaptic connections","field_investigator":"Bryan  Copits, Patrick Ross O\u0026#039;neill","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1UF1NS133763-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10732081\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10732081\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EAbstract The human brain is estimated to contain over 100 billion neurons that are wired together by more than 100 trillion synapses.\u003C\/p\u003E"},{"title":"Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception","field_investigator":"Todd P Coleman, Duygu  Kuzum, Lyle Edward Muller, John H Reynolds, Mark J Schnitzer","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-028","field_project_number":"1U01NS131914-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10655101\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10655101\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Circuit Diagrams, Integrated Approaches","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY\/ABSTRACT An important longstanding goal in neuroscience research is to understand how large-scale spatiotemporal patterns of neural activity emerge in the brain and whether they have a direct role in shaping the brain\u2019s computational processes and thereby mammalian behavior.\u003C\/p\u003E"},{"title":"UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents","field_investigator":"Gordon J Fishell, Xiangmin  Xu","field_institution":"University Of California-Irvine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-180","field_project_number":"1U24MH133236-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10664193\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10664193\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Monitor Neural Activity","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"\u003Cp\u003EProject Summary Gaining genetic access to specific cell types in rodents, non-human primates and other vertebrate species is critical for enabling targeted circuit manipulations to understand normal brain function and brain.\u003C\/p\u003E"},{"title":"Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform","field_investigator":"Patrick Goodwill","field_institution":"Magnetic Insight, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-08T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"PA-22-176","field_project_number":"1R44EB035078-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10761613\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10761613\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EIn this SBIR grant proposal, \u201cUltra-low distortion and noise electronics to enable a clinical MPI imaging platform,\u201d we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen\u003C\/p\u003E"},{"title":"Ultrasonic-tagged remote interferometric flowmetry for brain activity","field_investigator":"Min  Xu","field_institution":"Hunter College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY035400-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10731255\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10731255\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EOptical monitoring of brain activities is intrinsically associated with various operational advantages, including low-cost and portable noninvasive bedside continuous monitoring capabilities.\u003C\/p\u003E"},{"title":"Understanding the Conceptual Priority Map Guiding Naturalistic Visual Attention for Autistic Individuals","field_investigator":"Amanda J Haskins","field_institution":"Dartmouth College","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135812-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829114\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EProject Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).\u003C\/p\u003E"},{"title":"UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL","field_investigator":"Elizabeth  Medina","field_institution":"Washington State University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS135815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10829011\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10829011\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"\u003Cp\u003EPROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.\u003C\/p\u003E"},{"title":"Unified, Scalable, and Reproducible Neurostatistical Software","field_investigator":"Scott Warren Linderman, Alexander Henry Williams","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-22-220","field_project_number":"1RF1MH133778-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10725500\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10725500\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EProject Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).\u003C\/p\u003E"},{"title":"Validation and Optimization of Two-Photon Dendritic Voltage Imaging in Vivo","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-22-027","field_project_number":"1R34NS132045-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10658307\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10658307\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EPROJECT SUMMARY Understanding information flow in cortical circuits requires understanding both the anatomical connectivity between neurons and the way in which inputs to a neuron are integrated to generate a spiking output.\u003C\/p\u003E"},{"title":"Voltage dynamics of distinct cortical ensembles in visually guided behavior","field_investigator":"Madhuvanthi  Kannan","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128890-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524557\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524557\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Integrated Approaches, Monitor Neural Activity","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"\u003Cp\u003EABSTRACT BRAIN Initiative-funded, large-scale approaches to classify neurons based on transcriptomic, morphological and electrical properties have unveiled dozens of unique cell classes in the mouse brain.\u003C\/p\u003E"},{"title":"Wireless Implantable COrtical Neuroprosthetic System (W-ICONS)","field_investigator":"Francesco V Tenore","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222023-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2023\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS130131-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10576751\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10576751\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003EThe goal of this project is to develop a Wireless, fully Implantable, bidirectional Cortical Neuroprosthetic System (W-ICONS) for restoring sensorimotor function through an interface with intact upper limb areas of primary motor and sensory cortex.\u003C\/p\u003E"},{"title":"A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive","field_investigator":"Anup  Mahurkar, Owen R White","field_institution":"University Of Maryland Baltimore","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114788-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447478\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447478\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative\npromotes the development and application of technologies to describe the temporal and spatial\ndynamics of cell types and neural circuits in the brain."},{"title":"A Community Resource for Single Cell Data in the Brain","field_investigator":"Michael  Hawrylycz, Carol Lynn Thompson","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10521124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10521124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe BRAIN Initiative Cell Atlas Network (BICAN) will generate comprehensive molecular taxonomies and\norganizational principles of cell type diversity in the human and non-human primate extending comprehensive\nBICCN work in the mouse."},{"title":"A Confocal Fluorescence Microscopy Brain Data Archive","field_investigator":"Marcel P Bruchez, Alexander J Ropelewski, Alan Michael Watson","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-600","field_project_number":"2R24MH114793-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10451277\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10451277\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\n Brain image data collected by the neuroscience community will continue to grow\ndramatically in the next 5-10 years as the push to image physically larger volumes, such as\nwhole brains from humans and other primates, becomes a focus."},{"title":"A multi-modal wireless oscillator array for high-resolution mapping of neurovascular coupling","field_investigator":"Chunqi  Qian","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128611-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516470\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516470\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nAn outstanding challenge of brain research is to link the cross-scale functional perspectives from the cellular and molecular level to the circuit and systems level."},{"title":"A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell Atlases","field_investigator":"Aparna  Bhaduri, Marcel  Daadi, Hao  Huang, Arnold  Kriegstein, Jon E Levine, Tomasz  Nowakowski, Alexander A Pollen, Nenad  Sestan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130991-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523935\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523935\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe ultimate product of our Center will be a series of comprehensive developing human and non-human primate\n(NHP) brain atlases of unprecedented cellular, spatial, and anatomical resolution."},{"title":"A Novel Wireless and Subcellular Device for Neuromodulation","field_investigator":"Deblina  Sarkar","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034283-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Implantable interfaces for neuromodulation is necessary to advance fundamental neuroscience research,\ndevelop new treatments for neurological disorders, and create efficient breakthrough neuroprosthetics.\nHowever, modern implants based on multi-electrode arrays suffer from low spatial resolution, hi"},{"title":"A robotic multi-armed two-photon microscope for imaging neural interactions across multiple brain areas","field_investigator":"Mark J Schnitzer","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126055-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401607\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401607\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Abstract\nAmong the BRAIN Initiative\u2019s most important achievements are the genetic identification of many new neurons- types and the creation of genetic tools to access these cell types."},{"title":"A Shared Neuroscience Platform for National Dissemination and Training  in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies","field_investigator":"William T Newsome, Sergiu  Pasca, Mehrdad  Shamloo, Gordon X Wang","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124026-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439384\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439384\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out\nfunctional and mechanistic studies accompanied by advanced imaging techniques."},{"title":"A staged, comprehensive investigation for developing insular deep brain stimulation to treat refractory chronic pain","field_investigator":"William Jeffrey Elias, Chang-Chia  Liu","field_institution":"University Of Virginia","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-024","field_project_number":"1UH3NS123308-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10437978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10437978\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nPatients with refractory chronic pain typically do not respond to traditional analgesics or weak opioids\nas these agents do not directly address the cause for their pain."},{"title":"A versatile approach for highly multiplexed, high-resolution imaging of endogenous molecules","field_investigator":"Linnaea E Ostroff","field_institution":"University Of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130472-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505946\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505946\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n The quest to understand the brain\u2019s complex structure has become more challenging as the high\ndegree of molecular heterogeneity among brain cells has become evident in recent years."},{"title":"Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments","field_investigator":"Kaysaw C Tuy","field_institution":"University Of Alabama At Birmingham","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129129-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610104\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610104\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nPerturbations in redox signaling are associated with multiple neurological disorders, ranging from\nneurodegenerative diseases to brain tumors."},{"title":"Accelerating connectomic proofreading for larger brains and multiple individuals","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129268-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413515\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413515\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Technology for automating the segmentation of neurons from electron microscopic (EM) data has improved\ndramatically, making it now possible to obtain accurate reconstructions of neural circuits from large EM\nvolumes."},{"title":"Accelerating discovery of the human foveal microconnectome with deep learning","field_investigator":"Dennis Michael Dacey","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129260-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10411154\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10411154\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe human retina is one of the most complex microcircuits of the central nervous system (CNS) and is a model\nof CNS neurodegenerative disease with unique advantages for microconnectomics technology advancement.\nThe central retina or fovea mediates high acuity vision, drives activity "},{"title":"Acoustic modulation of forebrain aggression network in miniature, transparent vocal fish","field_investigator":"Andrew H Bass","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524567\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524567\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters,\nincluding the potential to win a fight or prevent escalation resulting in physical injury."},{"title":"Advancing epilepsy diagnosis with flexible, high-resolution thin-film electrodes","field_investigator":"Robert Kyle Franklin, Daniel  Friedman, Bijan  Pesaran, Florian  Solzbacher, Jonathan  Viventi","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS120172-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10297290\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10297290\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nTo advance the development of next-generation personalized therapies for long-term seizure freedom, we\nurgently need technologies that improve seizure diagnostics while reducing risks associated with invasive\nneurosurgical procedures."},{"title":"An acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scanners","field_investigator":"Kawin  Setsompop","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033206-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481056\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481056\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\/ABSTRACT\nFunctional MRI (fMRI) is the most widely-used tool to noninvasively measure brain function and has produced\nmuch of our current knowledge about the functional organization of the human brain."},{"title":"An Atlas of Human Brain Cell Variation","field_investigator":"Evan Z Macosko, Steven Andrew Mccarroll","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130966-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523654\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523654\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nThe human brain exhibits profound diversity in biological function and vulnerability to disease. Despite the\nbiomedical and cultural importance of inter-individual variation, we know relatively little about its underlying\ncellular and molecular substrates."},{"title":"An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans","field_investigator":"Peter  Brunner, Kai  Miller, Gregory A Worrell","field_institution":"Mayo Clinic Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128612-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516471\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516471\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\/Abstract\n Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce\na third of all health care costs."},{"title":"An extensible brain knowledge base and toolset spanning modalities for multi-species data-driven cell types","field_investigator":"Satrajit Sujit Ghosh, Michael  Hawrylycz, Shoaib  Mufti, Lydia Lup-Ming Ng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130918-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520941\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520941\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nBRAIN Initiative Cell Census Network (BICCN) is completing a comprehensive cell census of the adult mouse\nbrain, and BRAIN Initiative Cell Atlas Network (BICAN) will extend this work with emphasis on human and non-\nhuman primates."},{"title":"An Integrated Neurochemical\/Electrophysiological Recording and Neuromodulation System for Basic and Clinical Research","field_investigator":"Kevin Elliott Bennet, Kendall  Lee","field_institution":"Wincs International, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"1R42NS125895-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10477708\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10477708\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nWINCS International LLC, in partnership with Mayo Clinic, proposes to develop and demonstrate a highly\ninnovative next-generation clinical instrument together with custom user-friendly display and analysis software.\nFor the first time, the Multifunctional Apparatus for Voltammetry, E"},{"title":"Anatomical connectivity and activity in primary visual cortex of mouse","field_investigator":"Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130416-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505662\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505662\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nEstimates of the total length of axonal \u0022wiring\u0022 in the human brain are on the order of hundreds of thousands\nof kilometers."},{"title":"Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion","field_investigator":"Alesa Hughson Netzley","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129171-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610655\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610655\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTraumatic brain injury (TBI) is a leading health concern for both children and adults worldwide."},{"title":"Automated microfluidic hyperpolarization reactor for neurometabolic imaging","field_investigator":"Patrick Tomhon, Carlos Dedesma","field_institution":"Vizma life Sciences, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-819","field_project_number":"1R43MH129007-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10383423\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10383423\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EBrain function is regulated by molecular signaling and metabolism, however, our ability to track neurometabolic transformations deep in the brain is very underdeveloped compared to the central role of neurometabolism in neurodegenerative disease or brain function in general.\u003C\/p\u003E"},{"title":"Basic neural processing mechanisms of live human face viewing","field_investigator":"Megan  Kelley","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129174-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610114\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610114\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\n  Significance. The human brain has a dedicated neural system for processing other humans. However relatively\n  little is known about the basic mechanisms of this processing."},{"title":"BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework","field_investigator":"Karen G Hirsch, Holly K Tabor","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130518-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508135\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508135\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\/Abstract\nThe objective of \u201cBrain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-\nDEF)\u201d is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to\nassess and analyze diverse, critical stakeholder perspective"},{"title":"Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients","field_investigator":"Ken  Bruener, Damien A Fair, Jarod  Roland","field_institution":"Turing Medical Technologies Inc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS129521-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10546990\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10546990\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Abstract\/Summary\nThe objective of this psychological technology SBIR\/STTR Fast-Track proposal is to provide an innovative\ngamified biofeedback solution (software-only) to improve the effectiveness of functional Magnetic Resonance\nImaging (fMRI) for pediatric pre-neurosurgical planning."},{"title":"Bidirectional circuits of locus ceruleus and motor cortex neurons","field_investigator":"Gordon M Shepherd","field_institution":"Northwestern University At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127119-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447235\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447235\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nPrimary motor cortex (M1) and the locus ceruleus (LC) both contribute in essential ways to the generation of\npurposive movements \u2013 with M1 and its pyramidal tract (PT) neurons involved in action planning and execution,\nthe and LC and its noradrenergic axonal projections involved in a"},{"title":"Biophysical and Neural Basis of Focused Ultrasound Stimulation","field_investigator":"Charles F Caskey, Li Min  Chen","field_institution":"Vanderbilt University Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126144-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10415733\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10415733\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"This proposal responds to BRAIN Initiative RFA-NS-20-006 and aims to elucidate the neural and biophysical mechanisms of noninvasive focused ultrasound (FUS) neuromodulation."},{"title":"BRAIN Initiative: Hierarchical Event Descriptors (HED): a system to characterize events in neurobehavioral data","field_investigator":"Scott  Makeig, Kay A Robbins, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1RF1MH126700-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10480619\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10480619\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"This two-year project will advance, integrate, document, and promote the use of the Hierarchical\nEvent Descriptor (HED) system to describe events in human neuroimaging and behavioral data\nfrom research experiments and other sources in sufficient detail to support comparative analysis\nof human brain "},{"title":"BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology","field_investigator":"Dominique  Duncan, Nader  Pouratian","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130371-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nIntracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly\naccess, study, and learn about both normal human brain function and neuropsychiatric disease."},{"title":"Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons","field_investigator":"Anton  Arkhipov, Marina E. Garrett","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130907-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10519964\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10519964\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons\nThe versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and\ncomputations, and their evolution over time due to learning, homeostatic plasticity, and other processes."},{"title":"Broadening access with an Armamentarium Vector Core Powered by Inclusive Research Experiences","field_investigator":"Viviana  Gradinaru, Timothy Francis Shay","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-180","field_project_number":"1U24MH131054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10531723\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10531723\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Monitor Neural Activity","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe AAV BRAIN Safe and Effective Neuromodulator and Sensor Utilization across Species (SENSUS, led by\nCaltech) of the NIH BRAIN Initiative Armamentarium Project will develop, validate, and disseminate integrated\n(capsid and genome) engineered adeno-associated virus (AAV) tools to mon"},{"title":"Broadly Accessible Technologies for Single-cell Joint Analysis of Transcriptome and Epigenome","field_investigator":"Bing Ren","field_institution":"Epigenome Technologies, inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"Opportunity Number PA-20-265","field_project_number":"1R41MH128993-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10383385\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10383385\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EHistone modifications carry rich information of cellular memory and gene regulatory mechanisms.\u003C\/p\u003E"},{"title":"CAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells","field_investigator":"Pablo  Gonzalez Camara","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130553-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509196\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509196\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nMorphology is an essential phenotype in the characterization of cells and their states. It reflects the progression\nof functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be\nindicative of disease."},{"title":"Caring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials","field_investigator":"Sara  Goering, Eran  Klein","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130457-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506303\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506303\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project abstract\nBRAIN pioneers are people who take on significant risk as participants in first-in-human or early\nneurotechnology studies for the sake of helping to further science."},{"title":"Cell type specific AAVs to study reward and cognition","field_investigator":"Leah  Byrne, Andreas Robert Pfenning, Afonso C Silva, William Richard Stauffer","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130881-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517904\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Adeno-Associated Viruses (AAVs) are potent gene delivery vectors for neuroscience studies and gene therapy\napplications."},{"title":"Cell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems","field_investigator":"Wei  Xu","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130422-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505702\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505702\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Cell Type-specific Anterograde Circuit Mapping and Functional Control by\n Optimizing YFV-17D Transneuronal Systems\nSummary\nTo elucidate the functional organization of brain circuitry we need to delineate neuronal\nconnectivity and control the activity of neurons with specific connectivity."},{"title":"Center for Multiomic Human Brain Cell Atlas","field_investigator":"M Margarita Behrens, Joseph R Ecker, Bing  Ren, Ting  Wang, Xiangmin  Xu","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130994-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523973\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523973\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Abstract\nUnderstanding cell identities and their spatial distributions throughout different regions of the human brain is a\nfundamental step when trying to integrate physiological, behavioral, neurochemical and molecular data."},{"title":"Circuit dynamics of structuring episodic memories in humans","field_investigator":"Jie  Zheng","field_institution":"Boston Children\u0026#039;s Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126233-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10590796\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10590796\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nOur lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.\nHowever, we remember this as a series of discrete events. For example, the memory of a two-hour movie\nconsists of a few memorable moments tied to the main story."},{"title":"Circuits for spontaneous behavior and phototaxis in a simple model chordate","field_investigator":"William  Smith","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127106-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446697\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446697\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"This proposal will investigate neural circuits driving negative phototaxis in an emerging model for neural circuit\nanalysis: larvae of the primitive chordate Ciona. Ciona larvae have a number of features that make them\nideally suited for this project."},{"title":"Closed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals","field_investigator":"Daniel  Aharoni, Hugh T Blair, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401560\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401560\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nA major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Adding to this challenge is the fact that neural function does not operate in isolation but rather within living, behaving animals."},{"title":"Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology","field_investigator":"Loren M Frank, Mattias Peter Karlsson, Chong  Xie, Jan  Zimmermann","field_institution":"Spikegadgets, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS127692-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481712\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481712\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nExamining how behavior arises from the complex interconnected activity of the brain is a\ncornerstone of neuroscience research. A recent technological advance in neurotechnology is\nenabling studies where the parallel activity of thousands of neurons can be studied in rodent\nbrains."},{"title":"Comprehensive single-cell atlas of the developing mouse brain","field_investigator":"Paola  Arlotta, Tomasz  Nowakowski, Hongkui  Zeng","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130962-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523550\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523550\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe developing mouse brain is a foundational experimental model for investigation of the origins of cell types in\nthe mammalian brain."},{"title":"Computational dynamics in neural populations of freely foraging vs. restrained monkeys","field_investigator":"Dora  Angelaki","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127122-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447347\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nThis proposal will investigate the neural dynamics underlying three-dimensional foraging behavior, with three\noverarching goals. The first is to evaluate the neural computations of foraging in dynamic environments in\nnaturalistic settings."},{"title":"Computational foundations of active visual sensing","field_investigator":"Mackenzie Weygandt Mathis, Cristopher M Niell, Zachary Samuel Pitkow, Andreas  Tolias","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126566-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10431247\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10431247\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nVision is an active process: we move our head and eyes to explore the sensory world."},{"title":"Computational Tools for assessing mechanisms and functional relevance of divisive normalization","field_investigator":"Ruben  Coen-Cagli","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056400-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488972\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488972\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nDivisive normalization (DN) is a well-established theory of how interactions between neurons in a circuit\nmodulate the activity of individual neurons."},{"title":"Cortical circuits for the integration of parallel short-latency auditory pathways","field_investigator":"Hiroyuki  Kato, Paul B Manis","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128873-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524362\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524362\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nHow our brain achieves coherent perception by integrating information from parallel sensory pathways\ndistributed across space and time remains a central question in neuroscience."},{"title":"CRCNS: Circuit mechanisms of priors and learning during decision making","field_investigator":"Guangyu Yang","field_institution":"Massachusetts Institute of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132172-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610167\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610167\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhen learning a new task, both rats and humans exhibit suboptimal behaviors plagued with superstitious ticks and idiosyncratic biases.\u003C\/p\u003E"},{"title":"CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior","field_investigator":"Paul Nuyujukian","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130789-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610495\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610495\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EWhat operations are performed by the mammalian central nervous systems to coordinate and conduct voluntary movement? Motor systems neuroscience seeks to understand these neural mechanisms.\u003C\/p\u003E"},{"title":"CRCNS: Dynamics of thalamocortical networks during sensory discrimination","field_investigator":"Mark Allan Reimers","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130919-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612202\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612202\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Evidence-based modeling of neuromodulatory action on network properties","field_investigator":"Yangyang Wang","field_institution":"University of Iowa","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DA057767-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610566\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610566\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Heterogeneous effects of cognition on perception: unique leverage on circuit mechanisms","field_investigator":"Marlene Rochelle Cohen, Brent D. Doiron","field_institution":"University of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01EY034723-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10608553\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10608553\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Multifocal causal mapping of brain networks supporting human cognition","field_investigator":"Aapo Nummenmaa","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01DC020891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612128\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612128\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003ENeuroimaging methods such as functional MRI and magneto- \/ electroencephalography (MEG\/EEG) cannot directly reveal causal relationships between regional brain activity and behavior.\u003C\/p\u003E"},{"title":"CRCNS: Neural Representations of Time Across Scales in Natural and Artificial Networks","field_investigator":"Marc W Howard","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01MH132171-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610084\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610084\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":""},{"title":"CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization","field_investigator":"Fabrizio Gabbiani, Matthias Heinkenschloss","field_institution":"Baylor College of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-22-002","field_project_number":"1R01NS130917-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10612187\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10612187\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"\u003Cp\u003EMotivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?\u003C\/p\u003E"},{"title":"DataJoint SciOps: A Managed Service for Neuroscience Data Workflows","field_investigator":"Dimitri  Yatsenko","field_institution":"Vathes Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS129492-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10547509\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10547509\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project summary\nThis SBIR proposal aims to address current challenges in data-driven neuroscience by implementing DataJoint\nSciOps: a commercial service to help research labs implement computational work\ufb02ows for data-intensive science\nexperiments."},{"title":"Deciphering the genomic mechanisms underlying the physiology of human brain stimulation","field_investigator":"Genevieve  Konopka, Bradley C Lega","field_institution":"Ut Southwestern Medical Center","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS126143-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10559426\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10559426\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The underlying mechanisms of brain stimulation in humans are poorly understood, especially at the level of gene expression."},{"title":"Deep Analysis of Brain Chemistry at Enhanced Spatial and Temporal Resolution using Microscale Sampling and Analysis","field_investigator":"Robert T Kennedy","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128522-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515445\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515445\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The objective of this project is to develop new bioanalytical methods for exploring brain chemistry dynamics in vivo. Monitoring the concentration dynamics of neurochemicals in vivo is vital for studying brain function, diseases, and treatments."},{"title":"Deep and fast imaging using adaptive excitation sources","field_investigator":"Chris  Xu","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128660-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516870\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516870\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Optical recordings of activity are critical to probe neural systems because they provide high-resolution,\nnon-invasive measurements, ranging from single neurons to entire populations in intact nervous systems, and\nare readily combined with genetic methods to provide cell type-specific reco"},{"title":"Defining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo","field_investigator":"Justin  O\u0026#039;hare","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127815-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10502363\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10502363\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCandidate Goals and Mission Relevance: The applicant\u2019s broad, long-term objective is to investigate how high-\n(circuit\/behavioral) and low- (subcellular\/molecular) level organizational principles of the brain cooperate to drive\nlearning."},{"title":"Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest","field_investigator":"Wiley Thomas Waddell, Maik Huettemann, Thomas Hudson Sanderson","field_institution":"Mitovation, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-022","field_project_number":"1U44NS125160-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515831\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515831\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Human Neuroscience, Interventional Tools","field_program":"Dissemination, Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003ECardiac arrest in infants is a medical emergency requiring rapid resuscitation to restore circulation. However, resuscitation often results in significant brain injury, caused by ischemia\/reperfusion injury.\u003C\/p\u003E"},{"title":"Development and Validation of a Genetically Encoded Method to Trace and Manipulate Neuronal Circuits in Zebrafish","field_investigator":"Carlos  Lois, David Aaron Prober","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130420-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505822\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505822\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIdentifying how neurons are connected to each other in the brain is an important and necessary step towards\nunderstanding how brain activity gives rise to behavior, and how it is perturbed by disease."},{"title":"Development of a Miniaturized Wearable Ultrasonic Beam-forming Device for Localized Targeting of Brain Regions in Freely-moving Experimental Subjects","field_investigator":"Kevin A Snook","field_institution":"Actuated Medical, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43NS126007-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10483847\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10483847\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"This Phase I SBIR will further develop, validate, and initiate commercialization of the miniature ultrasound\nbeamforming array (MUBA) system for transcranial focused ultrasound (tFUS)."},{"title":"Development of a sample preparation protocol for brain ultrastructural analysis, immunolabeling, and neuronal tracing by light microscopy","field_investigator":"Ons  M\u0026#039;saad","field_institution":"Panluminate Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43MH128999-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10483978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10483978\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThe brain is the most complex organ in the human body. Understanding its neural connections and molecular\nanatomy requires imaging technology that is capable of mapping the 3D nanoscale distribution of specific\nproteins in the context of brain ultrastructure."},{"title":"Development of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving mice","field_investigator":"Richard L Huganir, Jin  Zhang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH126707-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505852\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505852\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nCell signaling pathways in the brain are an essential part of a complex system regulating the activity and\ncoordination of neuronal networks."},{"title":"Development of opioid and ketamine probes for in vivo photopharmacology","field_investigator":"Matthew Ryan Banghart, Conor M Liston","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126073-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401573\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401573\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\nPharmacological probes are widely used to study the nervous system. Despite often exhibiting exquisite specificity for target receptors, due to diffusion, traditional small molecule drugs act slowly and with spatial imprecision."},{"title":"Dissecting circuit and cellular mechanisms for limb motor control","field_investigator":"John  Tuthill","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128785-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10522108\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10522108\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Motor neurons connect to muscles and comprise the major output of the nervous system. Patterns of\nneural activity in motor neurons cause temporally precise muscle contractions, producing coordinated\nand flexible behavior."},{"title":"Dissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement","field_investigator":"Alice  Mosberger","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS126307-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425617\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425617\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nTo learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to\ncausally link previously performed movements to their resulting outcomes."},{"title":"Dissection of Cell Type Specific Contributions to Motor Learning Circuits","field_investigator":"Lina Marcela Carmona","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127857-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505229\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505229\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Abstract\nWhether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our\ndaily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must\nfirst be learned through the process of motor learning."},{"title":"Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.","field_investigator":"Gyorgy  Buzsaki, Zhe Sage Chen","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056394-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488900\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ ABSTRACT\nAdvances in neurotechnologies are producing large and complex datasets at unprecedented rate."},{"title":"Dissemination of FlyWire, A Whole-Brain Connectomics Resource","field_investigator":"Mala  Murthy","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126935-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10439970\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10439970\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We\nused advances in AI to segment all neurons from a whole brain EM volume called FAFB."},{"title":"Dissemination of MAPseq and BARseq for high-throughput brain mapping","field_investigator":"Anthony M Zador","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS126938-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440138\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440138\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience\ncommunity. These are novel methods developed in my laboratory based on high-throughput DNA\nsequencing for determining neuronal circuitry."},{"title":"Distributed Neural Activity Patterns Underlying Practice-Based Learning","field_investigator":"Kimberly  Reinhold","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH127471-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447345\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY \/ ABSTRACT\nTo survive, animals must learn appropriate associations between sensory cues and motor actions through a\nprocess of trial and error."},{"title":"Early-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors","field_investigator":"Brianna Elyse George","field_institution":"Wake Forest University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129177-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541392\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541392\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nStress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to\ncompulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple\nclasses of drugs."},{"title":"Efficient Two-Photon Voltage Imaging of Neuronal Populations at Behavioral Timescales","field_investigator":"Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516906\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516906\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding how information is processed in the mammalian neocortex has been a longstanding\nquestion in neuroscience. While the action potential is the fundamental bit of information, how these\nspikes encode representations and drive behavior remains unclear."},{"title":"Elucidating Principles of Sensorimotor Control using Deep Learning","field_investigator":"Shreya  Saxena","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056377-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488409\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488409\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nHow do distributed neural circuits drive purposeful movements from the complex musculoskeletal system?"},{"title":"Empirical Power Analysis Tool for fMRI","field_investigator":"Stephanie  Noble","field_institution":"Yale University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH130894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10503064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10503064\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nFunctional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain\nfunction and disease and is flourishing under unprecedented international funding, including dedicated support\nfrom the BRAIN Initiative."},{"title":"Enabling precise cell-type-specific dissection of orientation and memory circuits in retrosplenial cortex","field_investigator":"Omar Jamil Ahmed","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127101-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446099\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446099\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nIn humans, damage to a brain region called the retrosplenial cortex leads to pronounced spatial disorientation\nand severe retrograde and anterograde memory deficits."},{"title":"Engagement and outreach to achieve a FAIR data ecosystem for the BICAN","field_investigator":"Hua  Xu, Guo-Qiang  Zhang, Wenjin Jim Zheng","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130988-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523908\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523908\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"As a part of BRAIN 2.0, the BRAIN Initiative Cell Atlas Network (BICAN) is expected to advance fundamental knowledge and enabling technology for classifying human brain cell types, understanding their organizational principles, and providing open-access digital brain cell reference atlases, emphasiz"},{"title":"Engineering the Neuronal Response to Electrical Microstimulation","field_investigator":"Mark E. Orazem, Kevin J. Otto","field_institution":"University Of Florida","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126052-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401586\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401586\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nOur proposed efforts align directly with a goal of RFA-NS-18-019: optimization of transformative technologies for modulation in the nervous system."},{"title":"Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.","field_investigator":"Ludovica Labruna","field_institution":"Magnetic Tides, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PAR-21-266","field_project_number":"1R44NS127667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481976\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481976\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Dissemination, Human Neuroscience","body":"\u003Cp\u003ENon-invasive brain stimulation (NIBS) has attracted considerable interest in the cognitive neuroscience community, providing an important basic research tool to study brain function, with emerging clinical applications to enhance function in individuals with neurological disorders.\u003C\/p\u003E"},{"title":"Fast Multichannel Magneto-thermal Genetics","field_investigator":"Jacob T. Robinson","field_institution":"Rice University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126063-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401691\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401691\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\n Precisely timed activation of genetically targeted cells is a powerful tool for studying neural circuits. Neuronal modulation (activating or inhibiting select neurons) allows us to investigate how neural activity causes changes in animal behavior."},{"title":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop","field_investigator":"Garrett B. Stanley","field_institution":"Georgia Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128896-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524608\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524608\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop\nNearly all sensory experience begins in the periphery, generating sensory signals travelling through the thalamus\nbefore reaching neocortex."},{"title":"Fluorescence-based methods for microconnectivity analysis in neocortex","field_investigator":"Alison L Barth","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129267-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413555\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413555\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nA comprehensive census of neural cell types in the brain, together with molecular-genetic\nresources for cell-type specific labeling, is revolutionizing our ability to detect and monitor age,\ndisease, and experience-dependent changes in neural connectivity."},{"title":"Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project","field_investigator":"Tristan  Mcintosh","field_institution":"Washington University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-205","field_project_number":"1R01MH130519-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508408\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508408\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"Project Summary\nNeurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,\nmonitor brain activity, and collect and transmit personal health data."},{"title":"From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampus","field_investigator":"Mark E J Sheffield","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127123-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447353\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447353\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary: Memory enables animals to acquire, store, and recall knowledge of the world\nthrough experience and use this knowledge to maximize reward and avoid danger."},{"title":"Functional connectivity of a brain-scale neural circuit for motion perception","field_investigator":"Eva Aimable Naumann","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128895-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524593\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524593\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nThe transformation of visual cues into appropriate behavior requires the collaboration of diverse neurons across\ndistant brain areas."},{"title":"Functional dissection of cerebellar output circuits that orchestrate limb motor control","field_investigator":"Eiman  Azim, Albert  Chen","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128898-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524627\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524627\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe cerebellum is essential for coordinating motor behavior through rapid adjustments of ongoing movements.\nTo refine movement, the cerebellum processes motor and sensory information, and transmits output that\nultimately modulates motor neuron activity to ensure successful execution."},{"title":"Functional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states","field_investigator":"Jane  Yi","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467357\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467357\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\/SUMMARY\nThe mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep\nand pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably\noverlooked due to their sparsity in the total neuronal population."},{"title":"Functional Mapping of the Suprachiasmatic Nucleus","field_investigator":"Karen Jill Tonsfeldt","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS119291-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448026\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448026\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThis proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and\nprovide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow\nsingle cell recording at 1024 contacts simultaneously."},{"title":"Functionally guided adult whole brain cell atlas in human and NHP","field_investigator":"Ed  Lein, Hongkui  Zeng","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-235","field_project_number":"1UM1MH130981-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523848\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523848\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Progress in treating brain disorders has been frustratingly slow, in large part due to the extraordinary complexity of the\nhuman brain and its inaccessibility to study."},{"title":"Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.","field_investigator":"Claudia Z Han","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH129983-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425902\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425902\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nThe prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis,\nneuronal migration, and formation of neural networks."},{"title":"Hierarchy of the vocalization motor patterning circuits","field_investigator":"Kevin  Yackle","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127104-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446346\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446346\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"How are complex behaviors that require the coordination of multiple muscle systems produced? How does the\nbrain suddenly turn them \u201con\u201d?\n Vocalizations are seemingly simple, yet to occur, ~100 muscles must be coordinated, such as those for\narticulation (laryngeal and tongue) and breathing."},{"title":"High-resolution bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals","field_investigator":"Robert E. Campbell, Daniel  Razansky, Shy  Shoham","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126102-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10407380\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10407380\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nAcoustic technologies such as optoacoustic (OA) imaging and ultrasound neuromodulation (USNM) are poised to revolutionize deep tissue, high-resolution, large-scale, in vivo imaging, and neurostimulation in mammalian organisms."},{"title":"High-throughput mapping of synaptic connectivity between transcriptomically defined cell types","field_investigator":"Michael Nicholas Economo","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH126882-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413540\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413540\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIdentifying the cell types that make up each region of the brain and the patterns of synaptic connections\nthrough which they are linked is key to understanding how neural circuits give rise to all perception, cognition,\nand behavior."},{"title":"High-throughput sequencing of synaptic partnerships and gene expression at single-cell resolution in vivo","field_investigator":"Arpiar B Saunders","field_institution":"Oregon Health \u0026amp; Science University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130464-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506110\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506110\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nBrain function depends on forming and maintaining synaptic connections between neurons of specific types,\nyet systematic descriptions of cell-type connectivity and the molecules that instruct these relationships remain\nchallenging because we lack some necessary tools."},{"title":"Highly parallel long wavelength heterodyne diffuse correlation spectroscopy for brain functional imaging","field_investigator":"Stefan Alexandru Carp","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033202-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10479451\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10479451\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"PROJECT SUMMARY\nNon-invasive imaging of human brain function plays an important role in advancing neuroscience research and\nunderstanding neurological diseases. This need has been met primarily by functional magnetic resonance\nimaging (fMRI)."},{"title":"Hippocampo-cortical contributions to world building in freely behaving macaques","field_investigator":"Kari  Hoffman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447412\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447412\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWhen learning in complex, realistic, or even real worlds, we have the benefit of using different\nstrategies adaptively. For most primate brains, adaptive means adjusting as a function of where we\nare, who we are with, and what things of use are in view or in reach."},{"title":"Hormonal regulation of sensory processing during parental care","field_investigator":"Kristina O. Smiley","field_institution":"University Of Massachusetts Amherst","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99HD108800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425599\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425599\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\/ABSTRACT\n Does the way we hear sounds change when we become parents?"},{"title":"Identifying prefrontal signatures of successful and dysfunctional attention","field_investigator":"Brielle  Ferguson","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128892-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10349347\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10349347\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\n Attention is comprised of several component processes, including sustained attention, selective\nattention, and attentional flexibility."},{"title":"Imaging at the speed of spikes: An electro-optical multiphoton microscope","field_investigator":"Aaron Michael Kerlin","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128658-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516843\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516843\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract\nSignals in the brain are transmitted and transformed on a millisecond timescale. The precise timing of activity can carry unique information, correlate perceptual decisions, and powerfully influence synaptic plasticity."},{"title":"Implementation and dissemination of cloud-based retrospective hemodynamic analysis tools to enhance HCP data interpretation","field_investigator":"Blaise Debonneval Frederick","field_institution":"Mclean Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130637-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10509534\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10509534\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Summary\nFunctional Magnetic Resonance Imaging data has been a mainstay of neuroscience research for more than two\ndecades, as it allows rapid, continuous, noninvasive monitoring of neuronal function."},{"title":"Improving the robustness of neuroimaging through exploitation of variability in processing pipelines","field_investigator":"Gregory  Kiar, Michael Peter Milham","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130859-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516830\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516830\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nReproducible findings are essential to scientific advancement. Unfortunately, when fields lack consensus\nstandards for methods, or their implementations, reproducibility tends to be more of an ideal than a reality."},{"title":"In situ Single-Cell Multi-Omic and Morphological Profiling in Mammalian Brains","field_investigator":"Chongyuan  Luo","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH130461-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506297\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nSingle-cell technologies have revolutionized the characterization of mammalian brains allowing unbiased census\nof cell types and their transcriptomic and epigenomics signatures."},{"title":"Integrated functional and structural analysis of an entire column in mouse primary visual cortex","field_investigator":"Reza  Abbasi Asl","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128672-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505417\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505417\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\nNeurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The\nstructural and morphological organization of the neurons is known to constrain its functional properties."},{"title":"Integration of social and nonsocial information in the primate brain","field_investigator":"Joseph  Simon","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125826-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPrimate species frequently use social information to inform their decisions, for instance, to help make inferences\nabout potential threats or rewards in the environment."},{"title":"Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots","field_investigator":"Gregory John Gage, Christopher Aiden Harris","field_institution":"Backyard Brains, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-07-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"2R44NS108850-03A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10385012\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10385012\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EUnderstanding the brain is a profound and fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes training the next generation of neuroscientists, engineers and physicians a key concern.\u003C\/p\u003E"},{"title":"Investigating descending control of walking","field_investigator":"Helen Horan Yang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129759-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10568039\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10568039\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\nCircuits in the brain control motor output to generate the precise behaviors required for survival. Dysfunction of\nthese circuits results in devastating movement disorders such as Parkinson\u2019s disease and amyotrophic lateral\nsclerosis."},{"title":"Investigating the microcircuit determinants of neural population activity through comparative analysis of latent dynamics across cortical areas in the mouse","field_investigator":"Audrey  Sederberg","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130413-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505552\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505552\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nA key goal in neuroscience is determining how microcircuit structure predicts circuit function. An intriguing idea,\nsupported by some theoretical models, is that variation in microcircuit composition supports functional\nspecialization."},{"title":"Investigating the pathomechanisms underlying Charcot-Marie-Tooth Disease","field_investigator":"Julia Alexis Jones","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129169-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541701\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541701\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nCharcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of\ninherited peripheral neuropathies that is characterized by damage to long motor and sensory\naxons."},{"title":"Investigating the Role of Microglia in Methamphetamine Use Disorder","field_investigator":"Samara Jo Vilca","field_institution":"University Of Miami School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130871-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610124\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610124\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"ABSTRACT\nSubstance use disorder is a chronic relapsing disease that is characterized by repeated drug use despite\nnegative consequences."},{"title":"Kilohertz volumetric imaging of neuronal action potentials in awake behaving mice","field_investigator":"Liang  Gao, Peyman  Golshani","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128488-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515267\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515267\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"High-speed volumetric imaging of dynamic neuronal activity over long periods is a challenging but essential goal in neuroscience. Conventional optical measurements of neuronal activity mostly rely on calcium signals."},{"title":"Locus coeruelus-prefrontal interactions for flexible decision-making","field_investigator":"Joshua I Gold","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128974-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10532047\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10532047\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nHigher brain functions include the ability to learn expectations about the world, update those expectations\nappropriately when given new sensory information, and use those continually updating expectations to guide\nbehavior."},{"title":"Long-term consequences of visual working memory","field_investigator":"Megan Teresa Debettencourt","field_institution":"University Of Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-044","field_project_number":"1K99MH128893-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523326\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523326\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nThe ability to remember information, whether after short or long delays, is a fundamental human ability."},{"title":"Machine learning analyses of single-cell multi-modal data for understanding cell-type functional genomics and gene regulation","field_investigator":"Daifeng  Wang","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH128695-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505191\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505191\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nUnderstanding cell-type-specific gene functions, expression dynamics, and regulatory\nmechanisms in complex brains is still challenging."},{"title":"Machine Learning Augmented Discovery of AAV Capsids for Cell Type Specific Access into Human Neurons and Glia","field_investigator":"Tomasz  Nowakowski, David V Schaffer, Vikaas Singh Sohal","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130700-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512547\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512547\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nThe human brain contains an astonishing diversity of neuronal and glial cell types distributed across dozens of\nfunctional areas."},{"title":"Mechanisms of Transplanted Cortical Interneuron Survival and Function","field_investigator":"Benjamin  Rakela","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033976-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10425147\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10425147\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nCortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal\ntimepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to\nsurvive."},{"title":"Mesh electronics for understanding space encoding in the amphibian brain","field_investigator":"Lisa  Giocomo, Guosong  Hong, Lauren A O\u0026#039;connell","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127103-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446284\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446284\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nMany animals rely on spatial cognition for daily survival in order to recognize familiar places and process movements\nthrough or between locations. A variety of space-encoding cells in the hippocampus are important for spatial behaviors\nin mammals."},{"title":"Mesoscale bidirectional two-photon holographic optogenetics","field_investigator":"Hillel  Adesnik","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128772-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516934\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516934\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nAchieving a detailed understanding of the neural codes of sensation, action, and cognition requires technologies that can causally perturb each of the major dimensions of population coding one at a time with extremely high precision across multiple brain areas."},{"title":"Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, LLC","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"1R44MH129023-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10384932\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10384932\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThis project aims to develop the 2P-ActivityScope\u2122, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr.\u003C\/p\u003E"},{"title":"Miniaturized silicon neurochemical probe to monitor brain chemistry","field_investigator":"Yurii A Vlasov","field_institution":"University Of Illinois At Urbana-Champaign","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126061-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401696\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401696\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nMiniaturized silicon neurochemical probe to monitor brain chemistry."},{"title":"Modeling the development of orientation selectivity, maps, and the associated recurrent circuit","field_investigator":"Kenneth D Miller","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056397-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10488978\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10488978\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nMuch evidence suggests that the development of orientation selectivity and maps in primary visual cortex (V1)\nis instructed by spontaneous patterns of input activity, without the necessity of visual experience."},{"title":"Modulation of Cerebellar Activity by Electrical and Focused Ultrasound Stimulation","field_investigator":"Eric J Lang, Omer  Oralkan, Mesut  Sahin","field_institution":"New Jersey Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS122741-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429656\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429656\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"The cerebellum has been overlooked for its potential for neuromodulation for decades."},{"title":"Molecular and circuit mechanisms of nausea-associated behaviors","field_investigator":"Chuchu  Zhang","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS129758-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10569466\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10569466\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project summary\nNausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.\nNausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that\navoid or expel toxins which may cause peripheral tissue damage."},{"title":"Molecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish","field_investigator":"Dena  Goldblatt","field_institution":"New York University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129179-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541342\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant\nneural circuit assembly. However, the developmental logic that dictates circuit organization, function, and\nultimately behavior remains unresolved due to the complexity of most circuits."},{"title":"Monitoring presynaptic release of neuropeptides in awake behaving animals","field_investigator":"Sung  Han","field_institution":"Salk Institute For Biological Studies","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128680-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517245\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"ABSTRACT\nNeuromodulators, such as neuropeptides and biogenic amines are produced and released by neurons to communicate with each other."},{"title":"Motor Recovery through Plasticity-Inducing Cortical Stimulation","field_investigator":"Steven C. Cramer, Jeffrey G Ojemann","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS121565-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10357993\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10357993\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Limited recovery of function after stroke remains a major problem for millions. Disability persists in\nmany, especially when hand function is limited. Existing therapies are limited and many have difficulties with\nactivities of daily living, even after rehabilitation."},{"title":"Multi-probe minimally invasive endomicroscope","field_investigator":"Antonio Miguel Caravaca Aguirre","field_institution":"Modendo Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R43NS127710-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10604023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10604023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nThis project seeks to develop a multi-probe ultrathin endomicroscope to enable high-resolution imaging and\nphoto-stimulation at multiple sites within currently inaccessible regions of the brain."},{"title":"Multimodal dissociation of posterior cingulate cortex contributions to episodic memory","field_investigator":"Seth Ryan Koslov","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-620","field_project_number":"1F32MH130027-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10467220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10467220\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nEpisodic memory is the ability to recall details about prior experiences. Researchers have historically relied on\ncontrolled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the\nbiological substrates of episodic memory."},{"title":"Network based neuro-modulation for mesial temporal lobe epilepsy","field_investigator":"Behnaam  Aazhang, Sandipan Pati  Bankim Behari Pati, Nitin  Tandon, Gregory A Worrell","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS119834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10113342\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10113342\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":""},{"title":"Neural basis of facial individual recognition in paper wasps","field_investigator":"Michael J Sheehan","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128868-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524286\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524286\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neural circuits of animals, including humans, are the combined product of adaptation by natural selection\nand the evolutionary history of a species."},{"title":"Neural circuit control of fluid and solute clearance during sleep","field_investigator":"Patrick James Drew, Hajime  Hirase, Douglas H Kelley, Laura Diane Lewis, Maiken  Nedergaard","field_institution":"University Of Rochester","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS128613-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516497\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516497\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Program abstract: This proposal aims to identify the neural circuit mechanisms that control periarterial\ncerebrospinal fluid (CSF) pumping and glymphatic clearance of fluid and solutes."},{"title":"Neural circuit mechanisms for multisensory associative learning","field_investigator":"Roudabeh  Behnia, Ashok  Litwin-Kumar","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128874-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524400\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524400\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nThe brain uses sensory representations to assess risk and predict reward in order to adjust behavior. Per\u00ad\nception is a multisensory process. To make reliable predictions, it is advantageous for the brain to combine\nmore than one sensory modality to represent the world."},{"title":"Neural coding of natural stimuli in freely moving macaque","field_investigator":"Valentin  Dragoi","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128894-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524592\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524592\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Despite the fact that visual perception represents such a fundamental aspect of our everyday life, our knowledge\nof the underlying neural coding of natural stimuli is woefully lacking."},{"title":"Neural mechanisms of behavioral coordination in Hydra","field_investigator":"Alison  Hanson","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99NS127851-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505359\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505359\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nHow do animals coordinate their many parts to generate coherent, adaptive behavior?"},{"title":"Neural mechanisms of taste and metabolic state integration in the brainstem","field_investigator":"Nilay  Yapici","field_institution":"Cornell University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS128872-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524319\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524319\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe taste of food is a critical factor that determines whether an organism will accept or reject a food source."},{"title":"Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin Optoelectronic Materials","field_investigator":"Ertugrul  Cubukcu","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY033676-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401044\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401044\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin\n Optoelectronic Materials\n Recording electrical activity of neural populations with high resolution is essential to\ninvestigate neural circuits and cognitive functions."},{"title":"NEURODEVELOPMENTAL FUNCTION OF HCFC1","field_investigator":"Victoria L Castro","field_institution":"University Of Texas El Paso","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS125690-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541351\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541351\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nMutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin\nmetabolism, intractable epilepsy, intellectual disability, and motor dysfunction."},{"title":"Neurodevelopmental role of a tRNA methyltransferase underlying intellectual disability","field_investigator":"Kimberly Rose R. Madhwani","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129128-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10540878\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10540878\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nGene regulation at multiple levels is critical for nervous system development and function."},{"title":"Neurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson\u0026#039;s disease","field_investigator":"Helen  Bronte-Stewart","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS128150-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510424\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Cognitive decline begins in early stages of Parkinson\u2019s disease (PD) and progresses to dementia in 75% of\npeople with PD after ten years."},{"title":"New Methodologies for Connectomics","field_investigator":"Xiaotang  Lu","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99MH128891-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10345620\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10345620\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT ABSTRACT\nThe nervous systems of animals are comprised of neurons connected by a large number of synapses.\nThe resulting neural networks underlie animal behavior and contribute to the storage of learned\ninformation in many species."},{"title":"New strategies for molecular cell-type labeling in volume electron microscopy","field_investigator":"Linnaea E Ostroff","field_institution":"University Of Connecticut Storrs","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129269-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413454\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413454\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\n Recent years have seen major breakthroughs in methodology for studying two complex yet\nfundamental aspects of brain structure: synaptic connectivity patterns and the heterogeneous distribution of\nmolecules."},{"title":"Noninvasive Targeted Neuromodulation","field_investigator":"Jan  Kubanek","field_institution":"University Of Utah","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128569-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515789\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515789\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Summary\nNeurological and psychiatric disorders absorb one-third of the total health care expenditures; more than cancer, cardiovascular diseases, and diabetes combined. On average, approximately one in three patients fails to respond to medication treatments or has intolerable side e\ufb00ects."},{"title":"Odor trail tracking: a new paradigm to unveil algorithms and neural circuits underlying active sensation and continuous decision making","field_investigator":"Catherine  Dulac, Venkatesh N Murthy, Massimo  Vergassola","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128865-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524245\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524245\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nAnimals actively sample sensory information, which they combine with prior knowledge to make\ndecisions in a sensorimotor feedback loop."},{"title":"ONIX: A Neural Acquisition System for Unencumbered, Closed-Loop Recordings in Small, Freely Moving Animals","field_investigator":"Jonathan  Newman","field_institution":"Open Ephys, Inc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-259","field_project_number":"1R44NS127725-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10482182\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10482182\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nOver the last century, extracellular recording technologies have progressed from handmade needle electrodes\nand vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip\ndigitization circuits."},{"title":"Open-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging","field_investigator":"Daniel  Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman  Golshani, Alcino J. Silva, Alipasha  Vaziri","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-027","field_project_number":"1U01NS128664-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516900\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516900\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience, Understanding Circuits","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract:\nSingle-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors\nhas allowed investigators to record the activity of large populations of identified neurons over days to weeks in\nfreely behaving animals, answering fundamental questions in neurosci"},{"title":"Optical neural motes to enable high density recording through intact dura in a nonhuman primate","field_investigator":"David  Blaauw, Cynthia Anne Chestek","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128667-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516965\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\nIR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless\n Motes for Large Scale Implantation Into Nonhuman Primate Cortex\n In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes\nnear-infrared (NIR) light for "},{"title":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation","field_investigator":"Xue  Han","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1RF1NS129520-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10558965\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10558965\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes."},{"title":"Optimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures","field_investigator":"Meng  Cui, Scott M Sternson","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126054-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401603\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401603\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nA central goal of neuroscience is to understand animal behavior in the context of the information processing properties of neuron ensembles."},{"title":"Optimization of Flexible Neural Probe Arrays for Multi-Region Recordings in Rodents and Nonhuman Primates","field_investigator":"Ellis  Meng, Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126046-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401221\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401221\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"A core goal of the BRAIN Initiative is to link neural activity to behavior which requires technology to acquire high-quality recordings of dynamic neural activity from different brain regions over time."},{"title":"Optimization, application, and dissemination of imaging modules for high-speed mesoscopic volumetric recording of neuroactivity in scattering brains","field_investigator":"Alipasha  Vaziri","field_institution":"Rockefeller University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS126057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401689\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401689\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"Project Summary \/ Abstract\nA number of recent observations suggest that complex brain functions in the mammalian brain emerge from highly parallel computation in which information about sensory inputs, internal states, and behavioral parameters are mapped onto highly distributed brain-wide neuronal "},{"title":"Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)","field_investigator":"Dion  Khodagholy","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-026","field_project_number":"1RF1NS128669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nA major obstacle to understanding how the dynamic activity of brain circuits permits the emergence of cortical function is the insufficient capability to acquire and manipulate this activity across the course of brain maturation."},{"title":"Pinpointing the Cerebellum\u0026#039;s Contribution to Social Reward Processing","field_investigator":"Haroon Skander Popal","field_institution":"Temple Univ Of The Commonwealth","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129182-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541308\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541308\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"PROJECT SUMMARY\nThe cerebellum has long been thought to solely process motor information. Yet, there is a growing literature\nthat points to a role of the cerebellum in processes across multiple domains."},{"title":"PREFRONTAL CIRCUITS OF WORKING MEMORY","field_investigator":"Christos  Constantinidis, Boris V Zemelman","field_institution":"Vanderbilt University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127100-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446082\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446082\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\/ABSTRACT\nWorking memory, the ability to maintain and manipulate in formation in memory over a period of seconds, is a\ncritical component of higher cognitive functions."},{"title":"Probing Neural Circuits of Zebrafish Sleep with Electrophysiology and Calcium Imaging","field_investigator":"David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS126800-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10436734\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10436734\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nThe zebrafish has emerged as a useful model system to discover and characterize genetic and neuronal circuits\nthat regulate vertebrate sleep."},{"title":"Protein ticker-tapes for brain-wide neural recordings","field_investigator":"Adam Ezra Cohen","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY033669-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10399721\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10399721\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nProtein ticker-tapes for brain-wide neural recordings\nBehavior emerges from the interacting activity of widely distributed ensembles of neurons; but all existing tools\nfor measuring brain activity sample only a small subset of these dynamics."},{"title":"Rapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light source","field_investigator":"Kim  Butts-Pauly, Xiaoke  Chen, Guosong  Hong","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126076-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401548\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401548\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nOptogenetics provides a precise deconstruction of neural circuits by optically manipulating the activity of opsin-expressing neurons with fast temporal responses and neuron-type specificity."},{"title":"Real Time NEURON Simulation for Experimental Applications","field_investigator":"Mark W Nowak","field_institution":"Cytocybernetics, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-260","field_project_number":"1R43NS125749-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10384810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10384810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EThe goal of this proposal is to combine the power of the NEURON mathematical modeling software with the Cybercyte \u201cplug and play\u201d dynamic clamp system.\u003C\/p\u003E"},{"title":"Real-time mapping and adaptive testing for neural population hypotheses","field_investigator":"John  Pearson","field_institution":"Duke University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA056376-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10486197\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10486197\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\n Recent advances in neural recording technologies have made it possible to study increasingly large and di-\nverse subsets of neurons, producing a growing interest in the collective computational properties of neural pop-\nulations."},{"title":"Revealing the mechanisms of primate face recognition with synthetic stimulus sets optimized to compare computational models","field_investigator":"Winrich  Freiwald, Nikolaus  Kriegeskorte","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128897-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524626\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524626\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nNeuroscience is entering a new era, where large-scale neural network models can be tested with unprecedent-\nedly rich measurements of neural activity."},{"title":"Ribo-STAMPEDE: novel tools for molecular profiling of brain cell types","field_investigator":"Giordano  Lippi, Eugene Wei-Ming Yeo","field_institution":"Scripps Research Institute, The","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-175","field_project_number":"1RF1MH126719-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10506300\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10506300\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nA detailed and comprehensive census of central nervous system (CNS) cell types and states is essential to our\nunderstanding of the neural substrates of cognition and behavior."},{"title":"Robot assisted brain-wide neural recordings and comprehensive behavioral monitoring in freely behaving mice","field_investigator":"Timothy J Ebner, Suhasa B Kodandaramaiah","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126044-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401192\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401192\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"SUMMARY\nThe brain processes sensory inputs and contextualizes this information with internal brain states, generating the signals that drive motor and cognitive behaviors. The underlying computations are distributed across several anatomically and functionally distinct brain regions."},{"title":"Role of Endocannabinoid System in Seizure Sensitivity in Eclampsia","field_investigator":"Maria  Jones-Muhammad","field_institution":"University Of Mississippi Med Ctr","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS129125-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10541023\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10541023\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nPreeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother\ndisplays novel seizures. The mechanisms that cause some preeclampsia patients to advance to\neclampsia are unknown."},{"title":"Role of neuronal ensembles in cortical plasticity during learning and development","field_investigator":"Alejandro  Akrouh","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EY033974-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523350\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523350\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\/Abstract\n The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar\nchanges recur throughout life during learning in a more narrowly constrained manner."},{"title":"Scalable electron tomography for connectomics","field_investigator":"Mark H Ellisman, Wei-Chung Allen Lee","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH129261-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10410742\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10410742\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary \/ Abstract\nA fundamental goal in neuroscience is understanding how neural network function arises from circuit structure.\nHowever, the immense complexity of most brain networks has been a significant barrier to progress."},{"title":"Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data","field_investigator":"Jesse  Gillis, Timothy L Tickle, Owen R White","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-237","field_project_number":"1U24MH130968-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523659\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523659\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThis project will create scalable resources that will be critical to the development of BRAIN Initiative Cell Atlas\nNetwork (BICAN) consortium brain atlases. This team will focus on the development of common molecular\ndata processing pipelines that are cloud-native and FAIR."},{"title":"Scalable technologies for brain-wide connectomics of transcriptomic cell types: focus on brainstem","field_investigator":"Jayaram  Chandrashekar, Karel  Svoboda","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128841-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10369309\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10369309\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project summary, Scalable technologies for brain-wide connectomics of\ntranscriptomic cell types: focus on brainstem\nThis proposal is to develop a scalable pipeline to combine high-resolution morphology and molecular\nclassification of individual neurons to define morpho-molecular cell types in the br"},{"title":"Scalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease","field_investigator":"Li Sun","field_institution":"Topogene, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-20-025","field_project_number":"1R41MH130299-01   ","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10484888\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10484888\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Small Business Grants","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"\u003Cp\u003EA fundamental goal of the BRAIN Initiative and other neuroscience projects is to map cell types in the brain and study their changes associated with function, disease, and drug treatment.\u003C\/p\u003E"},{"title":"Secondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation","field_investigator":"Stephanie Ruggiano Jones","field_institution":"Brown University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-130","field_project_number":"1RF1MH130415-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10505661\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10505661\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of\nhuman brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts."},{"title":"Sensory-motor strategies for odor-guided navigation","field_investigator":"Ian Gordon Davison","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128975-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10531982\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10531982\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\nAnimals interact with the world through dynamic, iterative sensory-motor processes that guide their\nongoing movement."},{"title":"Simultaneous high-throughput functional, transcriptomic and connectivity profiling using FUNseq","field_investigator":"Andreas  Tolias, Anthony M Zador","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH126883-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10413650\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10413650\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\nRecent advances in technology driven by the BRAIN Initiative have yielded new methods for characterizing the ac-\ntivity, transcriptome, and microscale anatomy of neurons throughout the brain, and have increased the throughput\nof these techniques by orders of magnitude."},{"title":"Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brains","field_investigator":"Chongyuan  Luo","field_institution":"University Of California Los Angeles","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-236","field_project_number":"1U01MH130995-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10523974\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10523974\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"BICAN","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe adult human brain is comprised of numerous cell types exhibiting specific transcriptomic and epigenomic\nsignatures associated with their spatial location, connectivity, and function."},{"title":"Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke Hemiplegia","field_investigator":"Marco Capogrosso, Douglas J Weber","field_institution":"University Of Pittsburgh At Pittsburgh","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-023","field_project_number":"1UG3NS123135-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512143\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512143\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"\u003Cp\u003ESUMMARY Motivation: In the US, almost 800\u2019000 people have a stroke every year. Unfortunately, despite intense physio- therapy stroke survivors retain permanent arm motor deficits, some complete hemiparesis.\u003C\/p\u003E"},{"title":"Statistical machine learning tools for understanding neural ensemble representations and dynamics","field_investigator":"Uri Tzvi Eden, Loren M Frank, Alan David Kaplan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-135","field_project_number":"1RF1MH130623-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10510107\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10510107\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"The brain is a massively interconnected network of specialized circuits."},{"title":"Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator","field_investigator":"Ji-Xin  Cheng","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034275-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10516429\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10516429\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary\n Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet\nbiomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed\nwireless neuromodulation methods."},{"title":"Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex","field_investigator":"Paola  Arlotta, Benjamin E Deverman, Gordon J Fishell, Yating  Wang","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-556","field_project_number":"1UF1MH130701-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10512459\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10512459\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nIn this proposal we aim to identify gene regulatory elements that permit the targeting and\nmanipulation of brain circuit models of human brain function."},{"title":"Targeted Neuromodulation by Nanosecond Pulsed Electric Fields","field_investigator":"Andrei G Pakhomov","field_institution":"Old Dominion University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034258-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10515459\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10515459\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Nanosecond pulsed electric field (nsPEF) is a new modality for neuromodulation, with unique capabilities\nqualitatively different from the conventional electrostimulation."},{"title":"Thalamus in the middle: computations in multi-regional neural circuits","field_investigator":"Adam G Carter, Jayaram  Chandrashekar, Jorge H Jaramillo, Karel  Svoboda, Bosiljka  Tasic","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123714-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294397\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294397\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary, Overall (Thalamus in the middle: computations in multi-regional neural\ncircuits)\nThis collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex\nthrough the thalamus."},{"title":"The Disadvantage Exposome as a Driver of Alzheimer\u2019s Disease Pathology","field_investigator":"Margo  Heston","field_institution":"University Of Wisconsin-Madison","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-012","field_project_number":"1F99NS130922-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10610660\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10610660\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Fellowship Programs","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"1 PROJECT SUMMARY\n 2 Alzheimer\u0027s disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare\n 3 burden of $1 trillion in the United States alone by 2060."},{"title":"The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish","field_investigator":"Florian  Engert, Mark C Fishman, Adrienne L Fairhall, Jeff W Lichtman, Joshua T Vogelstein","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"2U19NS104653-06","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10525427\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10525427\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The heart and the mind: an integrative approach to brain-body interactions in the\nzebrafish\nOur current U19 has focused primarily on Exteroception, which can be defined as the accumulated sensory experience\noriginating from events in the outside world."},{"title":"The interaction of cortical and subcortical processing in natural sensory behavior","field_investigator":"Cristopher M Niell, Michael  Wehr","field_institution":"University Of Oregon","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127305-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10455297\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10455297\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nOur brains have evolved to extract relevant sensory information from rich and complex natural environments in\norder to drive appropriate behavior."},{"title":"The Neural Circuit Basis of Olfactory Navigation in Adult Drosophila","field_investigator":"Katherine  Nagel","field_institution":"New York University School Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127129-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10447440\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10447440\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT SUMMARY\nIn order to forage effectively for food, the brain must integrate innate and learned information about the\nvalue of different food odors and use this information to select navigational motor programs."},{"title":"The Neural Code and Dynamics of the Reading Network","field_investigator":"Nitin  Tandon","field_institution":"University Of Texas Hlth Sci Ctr Houston","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS128921-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10526168\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10526168\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"Reading involves complex transformations of word forms, with visual input mapped to lexical, semantic and\nphonological systems in less than a second."},{"title":"The Spatial and Temporal Scale of Neuromodulation in Mouse Sensory Cortex","field_investigator":"Jacob  Reimer","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS128901-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10524638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10524638\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"The neuromodulators acetylcholine (ACh) and norepinephrine (NE) are associated with an\nactivated cortical brain state characterized by an increase in the reliability of cortical responses\nto external stimuli and enhanced performance on behavioral tasks."},{"title":"Tools for gene editing in marmosets","field_investigator":"Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin  Wang","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA056556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10508541\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10508541\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Tools for Gene Editing in Marmosets\nSUMMARY\n The goal of this proposal is to create an efficient new set of tools and techniques for the generation of\ngenetically modified marmosets suitable for use as models of brain physiology and function."},{"title":"Tracking the emergence of internal models","field_investigator":"Elizabeth A Buffalo, Adrienne L Fairhall","field_institution":"University Of Washington","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126485-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10429372\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10429372\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Abstract\nCentral to human and animal cognition is the idea of internal models: an internal repository of\nknowledge about the structure of the world and its affordances that enables prediction and\nplanning. The existence of such models is fundamental to experience."},{"title":"Two-photon all-optical electrophysiology in behaving mice","field_investigator":"Adam Ezra Cohen","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-020","field_project_number":"1RF1NS126043-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10401180\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10401180\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nTwo-photon all-optical electrophysiology in behaving mice Neurons communicate through electrical signals, so the ability to record membrane potential from dozens or hundreds of points simultaneously within the brain of a behaving animal would be a transformative capability f"},{"title":"Ultra-fast cerebral blood flow imaging for quantifying brain dynamics","field_investigator":"Jia  Guo","field_institution":"University Of California Riverside","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB033210-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10481324\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10481324\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\/Project Summary\nBlood oxygenation level dependent (BOLD) fMRI is widely used in neuroscience studies."},{"title":"Ultrafast high-contrast voltage imaging in freely moving animals","field_investigator":"Jerome  Mertz","field_institution":"Boston University (Charles River Campus)","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-014","field_project_number":"1R34NS127098-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10445419\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10445419\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Monitor Neural Activity, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nWe propose to develop a targeted illumination confocal (TICO) microscope to enable high speed,\nlarge-scale voltage imaging in the brain. This microscope will be based on the combination of two\nkey strategies. The first strategy is high-speed confocal microscopy based on line scanning."},{"title":"Understanding feedforward and feedback signaling between neuronal populations","field_investigator":"Adam  Kohn, Christian  Machens, Byron M. Yu","field_institution":"Albert Einstein College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-21-013","field_project_number":"1RF1NS127107-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10446820\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10446820\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nMost perceptual, cognitive, and motor functions rely on neuronal activity distributed across multiple networks,\noften located in different brain areas."},{"title":"Understanding how cortex supports flexible sensory representations","field_investigator":"Katherine Charlotte Wood","field_institution":"University Of Pennsylvania","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99DC019504-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10448054\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10448054\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nLearning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in\nenvironmental demands and experience, thus allowing us to adapt to the world around us."},{"title":"Unlocking the potential of High-speed widefield Imaging","field_investigator":"Luke Satish Kumar Theogarajan","field_institution":"University Of California Santa Barbara","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-21-001","field_project_number":"1R21EY034291-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10517241\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10517241\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nWidefield imaging and spatial multiplexing are crucial to advancing the field of\nneuroscience. Current imagers do not offer the speed and versatility needed for\ncalcium or voltage imaging experiments."},{"title":"Virtual observatory of the cortex: organelles, cells, circuits, and dynamics","field_investigator":"Forrest Christie Collman, Nuno  Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120053-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10440183\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10440183\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,\nCircuits, and Dynamics."},{"title":"Wearable modular high-density diffuse optical tomography","field_investigator":"Jason Wayne Trobaugh","field_institution":"Esperimage Llc","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"PA-21-262","field_project_number":"1R41MH131449-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10547630\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10547630\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Project Summary:\nEsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable,\noptical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance\nimaging (MRI) tools to provide naturalistic brain imaging in adults a"},{"title":"Wearable RF-EEG Cap for closed loopTMS\/fMRI\/EEG Applications","field_investigator":"Lucia Isabel Navarro De Lara","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-043","field_project_number":"1K99EB032749-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10520726\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10520726\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Career Programs","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Training","field_research_area":"Training","body":"Project Summary\nFunctional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in\nhumans."},{"title":"Whole-Brain Functional Imaging and Analysis of Zebrafish Sleep","field_investigator":"Geoffrey J Goodhill, David Aaron Prober, Thai V. Truong","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222022-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2022\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS126562-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10430595\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10430595\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"ABSTRACT\nSleep occupies a third of our lives and sleep-related ailments cost an estimated $100 billion per year, yet the\nmechanisms governing its regulation remain poorly understood."},{"title":"3D Functional Photoacoustic Imaging of Human Brain with a Stretchable Ultrasound Matrix Array","field_investigator":"Yun  Jing","field_institution":"Pennsylvania State University, The","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-001","field_project_number":"1R01EB031629-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252441\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252441\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neuroimaging Technologies Across Scales","body":"Abstract\nMany scientific efforts have been devoted to understanding the brain functions, and the relevance of its dynamics\nduring development, aging, and in diseased conditions. Alterations of the brain functions can result from\nmultifactorial processes and be reflected by various biomarkers."},{"title":"A 3D multimodal micron-scale human brain atlas bridging single cell data, neuropathology and neuroradiology","field_investigator":"Partha Pratim Mitra, Jiangyang  Zhang","field_institution":"Cold Spring Harbor Laboratory","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128875-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370064\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370064\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Digitized reference brains, also referred to as Common Coordinate Frameworks (CCFs), together\nwith superposed atlas annotations, are of central importance to neuroscience. They bear the\nsame relation to neuroscience as do reference genomes and genome annotations to cellular and\nmolecular biology."},{"title":"A cellular atlas of the primate and human basal ganglia","field_investigator":"Jason Daniel Buenrostro, Fei  Chen, Gordon J Fishell, Evan Z Macosko","field_institution":"Broad Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-149","field_project_number":"1U01MH124602-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10088048\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10088048\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience","field_program":"Cell Census Network (BICCN)","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nThe human basal ganglia (BG) are a collection of subcortical regions whose diverse, specialized cell types\ninfluence motor control, emotional regulation, habit formation, and higher cognition."},{"title":"A community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections","field_investigator":"Franco  Pestilli","field_institution":"University Of Texas At Austin","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126699-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10253558\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10253558\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\/Abstract\n The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)\ncommunity-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool\ndevelopment."},{"title":"A Computational Framework for Distributed Registration of Massive Neuroscience Images","field_investigator":"Matthew  Mccormick","field_institution":"Kitware, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH126732-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10259930\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10259930\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nNeuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent\nadvances in imaging data acquisition technologies such as light-sheet \ufb02uorescence microscopy (LSFM)."},{"title":"A Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models","field_investigator":"Guoping  Feng","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054181-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10286437\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10286437\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\n While mice are essential models for many areas of neuroscience, there are also many aspects of\nhigher brain function and dysfunction that cannot be adequately modeled in rodents. Thus, there is a need for\nnew genetic models that have brain structure and function closer to humans."},{"title":"A harmonized vendor-agnostic environment for multi-site functional MRI studies","field_investigator":"Jon-Fredrik  Nielsen, Maxim  Zaitsev","field_institution":"University Of Michigan At Ann Arbor","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120056-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306940\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306940\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-\nderstanding of the human brain. Functional MRI may be used to observe brain function during a speci\ufb01c motor\nor cognitive task, or at \u201crest\u201d (resting-state fMRI)."},{"title":"A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration","field_investigator":"Janelle Claire Shane","field_institution":"Boulder Nonlinear Systems, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-870","field_project_number":"1R41MH125556-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139220\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139220\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations\nin holographic photostimulation."},{"title":"A multi-plane 3-photon microscope for volume imaging in NHP cortex","field_investigator":"Jack  Waters","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS121766-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10205806\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10205806\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nRecent advances in microscopy permit volume imaging - the near-simultaneous imaging of many neurons in a circuit -\nwith 2-photon (2P) excitation, yielding new insights into the circuits underlying relatively simple behaviors."},{"title":"A regulome and transcriptome atlas of fetal and adult human neurogenesis","field_investigator":"Long  Cai, Patrick R Hof, Panagiotis  Roussos, Nenad  Sestan, Guo-Cheng  Yuan","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128970-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10377713\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10377713\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nDynamic changes in the spatiotemporal patterning of transcription factor binding on cis-regulatory DNA\nelements drives the developmental transition of cell lineages during neurogenesis."},{"title":"A robotic fiber platform for large area deep brain interfacing","field_investigator":"Itai  Cohen, Xiaoting  Jia","field_institution":"Virginia Polytechnic Inst And St Univ","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY033080-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294007\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294007\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nUnderstanding the functional network in the brain is critical to the development of neural\nprostheses and effective treatment of neurological diseases."},{"title":"A robust, low-cost platform for EM connectomics","field_investigator":"Daniel Joseph Bumbarger, R Clay Reid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-135","field_project_number":"1RF1MH123398-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10273540\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10273540\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Armamentarium","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nOver the past decade, serial-section electron microscopy has come into its own as a method to study the\nconnectivity of neural circuits, from local circuits in mammals to entire invertebrate brains."},{"title":"A scalable mass spectrometry platform for proteome mapping of brain tissues","field_investigator":"Tujin  Shi","field_institution":"Battelle Pacific Northwest Laboratories","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128885-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10370198\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10370198\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"ABSTRACT\nThe brain is the most complex organ in the mammalian body. Bulk analysis obscures heterogeneity of cell\ntypes present even in the smallest brain regions."},{"title":"A Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.","field_investigator":"Jeff W Lichtman","field_institution":"Harvard University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-135","field_project_number":"1UG3MH123386-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10271724\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10271724\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary\/Abstract\nThe goal of this work is to facilitate synaptic level analysis of neurons and their interconnecting microcircuits in\nneurosurgical cerebral cortex biopsies from human patients."},{"title":"A web-based framework for multi-modal visualization and annotation of neuroanatomical data","field_investigator":"David  Kleinfeld, Samuel Sheng-Hung Wang","field_institution":"Princeton University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-147","field_project_number":"1RF1MH128776-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10365435\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10365435\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"PROJECT SUMMARY\/ABSTRACT\nModern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal\nvia different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.\nUnfortunately, viewing and analysis methods have "},{"title":"Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy","field_investigator":"Nuri Firat Ince","field_institution":"University Of Houston","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-023","field_project_number":"1UH3NS117944-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10290984\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10290984\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Project Summary:\nHigh frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection\narea\/seizure onset zone (SOZ) in patients with drug resistant epilepsy."},{"title":"Adaptive optical microscopy for high-accuracy recording of neural activity in vivo","field_investigator":"Na  Ji","field_institution":"University Of California Berkeley","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-019","field_project_number":"1U01NS118300-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10048013\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10048013\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\nTo understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy,\nwhich requires methodologies with high spatial and temporal resolution."},{"title":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format","field_investigator":"Anton  Arkhipov, Emad  Tajkhorshid","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124001-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10306896\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10306896\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format\nOne of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks\nvia theory\/modeling."},{"title":"Advancing brain health research through male germline editing in marmosets","field_investigator":"Brian Peter Hermann, Jenny  Hsieh, John R Mccarrey, Christopher  Navara","field_institution":"University Of Texas San Antonio","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-DA-21-006","field_project_number":"1U01DA054170-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10285904\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10285904\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Theory \u0026amp; Data Analysis Tools","field_program":"","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\/ABSTRACT\nNeuropsychiatric disorders represent a leading cause of disability, affecting nearly 19% of the US population.\nOnly 9% of neuropsychiatric drugs entering clinical trials reach the market, which is one of the lowest success\nrates across all therapeutic areas."},{"title":"Advancing Standardization of Neurophysiology Data Through Dissemination of NWB","field_investigator":"Benjamin K Dichter, Oliver  Ruebel","field_institution":"University Of Calif-Lawrenc Berkeley Lab","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS120057-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10116139\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10116139\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"PROJECT SUMMARY\nLack of standards for neurophysiology data and related metadata is the single greatest impediment to fully\nextracting return on investment from neurophysiology experiments."},{"title":"AI based system for longitudinal, repeated measure analyses of freely moving C. elegans worms","field_investigator":"Jacob R Glaser","field_institution":"Microbrightfield, Llc","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH126834-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10258638\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10258638\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract\nThis project aims to develop WormInvestigator\u2122, a novel, highly innovative system for performing automated,\nhigh-throughput and longitudinal studies of the behavior of C."},{"title":"AI-driven biomarker analysis of intact whole brains imaged at micron and sub-micron resolution","field_investigator":"Katherine Cora Ames, Dominic  Mangiardi","field_institution":"Lifecanvas Technologies, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"PA-18-871","field_project_number":"1R43MH125512-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10139966\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10139966\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Dissemination, Public-Private Partnerships","field_research_area":"Dissemination","body":"Abstract. Whole-organ 3D immunohistochemistry is revolutionizing the field of neuroscience, enabling\nunprecedented insight into the distribution of neural cells and neurological markers throughout the brain in health\nand disease."},{"title":"An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species","field_investigator":"Ting  Xu","field_institution":"Child Mind Institute, Inc.","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH128696-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10360863\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10360863\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"ABSTRACT\nThe non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows\nresearchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying\nmeso- and microscale phenomena that cannot be fully investigated in huma"},{"title":"An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition","field_investigator":"Ziv  Williams","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121616-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10200517\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10200517\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":"An integrated single-neuronal, population-, local network- and stimulation-based\nprefrontal investigation of human social cognition\nThis proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-\nbased evaluation of the role that the dorsal prefrontal co"},{"title":"AnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations","field_investigator":"Jason M Christie, Adam  Hantman, Michael Roland Williams","field_institution":"Michigan State University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-136","field_project_number":"1RF1MH126706-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10258693\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10258693\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Interventional Tools, Monitor Neural Activity","field_program":"Armamentarium, Understanding Circuits","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"PROJECT SUMMARY\nA goal of the BRAIN initiative is to develop and validate novel tools to map and manipulate neural circuits. The\ndefinition and control of behaviorally relevant circuits requires both retrograde and anterograde trans-synaptic\ntechnologies that perform well in vivo."},{"title":"Anticipating ethical challenges and disparities in the dissemination of novel neurotechnologies","field_investigator":"Winston  Chiong, Daniel P. Dohan","field_institution":"University Of California, San Francisco","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126997-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10283140\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10283140\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\/ABSTRACT\nA central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for\nbrain diseases."},{"title":"Behavioral Analysis and Modeling Core","field_investigator":"Jonathan William Pillow","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-003","field_project_number":"1U19NS123716-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10294672\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10294672\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Integrated Approaches, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\/Abstract, Core D: Behavioral Analysis and Modeling\nThis proposal\u2019s overarching goal is to understand how internal states influence decisions and to identify the\nunderlying neural mechanisms."},{"title":"Big-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)","field_investigator":"William R Gray Roncal","field_institution":"Johns Hopkins University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-128","field_project_number":"1R01MH126684-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10252257\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10252257\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nIn an effort to better understand structural organization and anatomy of nervous systems at\nunprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have\ncollected increasingly larger datasets using Electron Microscopy (EM) and X-Ray\nMicrotomograp"},{"title":"BRAIN Initiative: Assessing development of event-related cortical network dynamics","field_investigator":"Scott  Makeig, Michael Peter Milham, Arnaud  Delorme","field_institution":"University Of California, San Diego","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125934-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190670\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190670\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Project Summary\nThe Child Mind Institute\u2019s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and\nsharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children\nand adolescents (ages 5-21)."},{"title":"BRAIN Viral Vector Services and Distribution Core","field_investigator":"Kimberly  Ritola","field_institution":"Univ Of North Carolina Chapel Hill","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-006","field_project_number":"1U24NS124025-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10308224\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10308224\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Cell Type, Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience, Circuit Diagrams, Theory \u0026amp; Data Analysis Tools","field_program":"Dissemination, Informatics","field_research_area":"Dissemination","body":"The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,\npropagation, and distribution of viral vectors that are used by neuroscientists for neural circuit\nidentification and manipulation, as well as for preclinical translational studies."},{"title":"BRAINShare: Sharing Data in BRAIN Initiative Studies","field_investigator":"Amy L Mcguire, Sameer Anil Sheth","field_institution":"Baylor College Of Medicine","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-19-400","field_project_number":"1R01MH126937-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10281874\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10281874\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Neuroethics","field_research_area":"Neuroethics","body":"PROJECT SUMMARY\nData sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN\nInitiative."},{"title":"Capturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe","field_investigator":"Nelson  Totah","field_institution":"University Of Helsinki","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS123876-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300345\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300345\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary \/ Abstract\nSystems neuroscience has viewed the brainstem noradrenergic nucleus, Locus Coeruleus (LC), as the\nsource of a global arousal signal, which modulates cognitive functions by altering operations throughout\nthe entire central nervous system."},{"title":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment","field_investigator":"Anton  Arkhipov, Li-Huei  Tsai","field_institution":"Allen Institute","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS122742-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10275301\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10275301\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment\nPatterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,\ntypically employing periodic light flicker or auditory tones presented at regular intervals."},{"title":"Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis","field_investigator":"Elizabeth M. C. Hillman, Pavel  Osten, Zhuhao  Wu","field_institution":"Columbia University Health Sciences","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128969-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10377810\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10377810\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary (Abstract)\nGaining a comprehensive understanding of brain-wide cellular organization in the human brain has long been\nrecognized as a critical foundation for understanding complex brain functions, including who we are as humans.\nIn this project we propose to take on this challenge an"},{"title":"Cellular and Neural Network Mechanism of Transcranial Electric Stimulation","field_investigator":"Dominique M Durand","field_institution":"Case Western Reserve University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124592-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10338804\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10338804\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006)."},{"title":"Cellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex","field_investigator":"Padmavathi Sundaram Patel","field_institution":"Massachusetts General Hospital","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS112183-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10178967\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10178967\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)\nmay activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro\nturtle Cb, (ii) computational modeling of the induced electric (E) fields in the"},{"title":"Changing the neuromodulation game: ultrasound fenestration of the blood brain barrier for noninvasive viral transfection of primate CNS neurons","field_investigator":"Arnaud Y Falchier, Charles E Schroeder","field_institution":"Nathan S. Kline Institute For Psych Res","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122272-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10235811\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10235811\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Summary\nGenetic technologies have revolutionized the way scientists can dissect out brain circuitry by inserting G\nprotein-coupled receptors that enable selective modulation of neurons in target structures."},{"title":"Characterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound","field_investigator":"Bin  He","field_institution":"Carnegie-Mellon University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS124564-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10337754\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10337754\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures."},{"title":"Circuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation","field_investigator":"Alik S Widge","field_institution":"University Of Minnesota","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-006","field_project_number":"1R01NS120851-01A1","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10339086\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10339086\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Human Neuroscience, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Investigative Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders."},{"title":"Circuit basis of social behavior decision-making in a subcortical network","field_investigator":"David J Anderson","field_institution":"California Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-030","field_project_number":"1R01NS123916-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10300937\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10300937\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project Summary\/Abstract\n This proposal responds to an FOA (RFA-NS-18-030) calling for 1) \u201cnovel approaches to understand neural\ncircuitry associated with well-defined social behaviors;\u201d 2) Distributed circuits that contribute to the coordination\nof motivational states and reward behavior;\u201d 3) \u201cEmpi"},{"title":"Circuits underlying threat and safety","field_investigator":"Donald B Arnold, Scott E Fraser, Nancy  Kopell, Carl  Kesselman","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-20-029","field_project_number":"1UF1NS122082-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10218722\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10218722\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Classical conditioning has been studied in many different animal models, and even in humans. However, the\nlarval zebrafish with its transparent brain offers a unique opportunity to observe large scale changes in\nsynaptic structure that accompany this form of learning."},{"title":"Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging","field_investigator":"Raag D Airan","field_institution":"Stanford University","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-021","field_project_number":"1UG3NS114438-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/9879539\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/9879539\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Human Neuroscience, Interventional Tools, Monitor Neural Activity","field_program":"Public-Private Partnerships, Therapeutic Human Neuroscience","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY .\nThere are numerous clinical needs for a technology that can modulate nervous system activity noninvasively\nand focally, with clinically-relevant spatial and temporal precision, with a robust and predictable mechanism of\naction, and that could act on any of the varied modes of neura"},{"title":"Combined Mechanistic and Input-Output Modeling of the Hippocampus During Spatial Navigation","field_investigator":"Dong  Song","field_institution":"University Of Southern California","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EB-20-002","field_project_number":"1RF1DA055665-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10263699\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10263699\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics, Understanding Circuits","field_research_area":"Systems Neuroscience","body":"PROJECT ABSTRACT\nLarge-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive\nfunctions. It integrates multi-scale neurobiological mechanisms\/processes identified through diverse hypotheses\nand experimental data into a single platform."},{"title":"Comparative Neuroanatomy at single-neuron resolution","field_investigator":"Roger L Clem, Peter  Rudebeck","field_institution":"Icahn School Of Medicine At Mount Sinai","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-18-014","field_project_number":"1R34NS122050-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10216577\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10216577\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Integrated Approaches, Circuit Diagrams","field_program":"Understanding Circuits","field_research_area":"Systems Neuroscience","body":"Project summary\nAlthough single neurons occasionally project to a single downstream target, it is more often the case that their\naxons collateralize and project to multiple distinct anatomical areas."},{"title":"Comprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomography","field_investigator":"Alexandra Teodora  Joita Pacureanu, Wei-Chung Allen Lee","field_institution":"Harvard Medical School","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-21-140","field_project_number":"1RF1MH128949-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10376584\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10376584\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams","field_program":"Cell Census Network (BICCN)","field_research_area":"Tools\/Tech for Brain Cells\/Circuits","body":"Project Summary \/ Abstract\nA fundamental goal in neuroscience is understanding how information is processed in neuronal circuits.\nHowever, the immense complexity of most brain networks has been a significant barrier to progress."},{"title":"Computational neuroscience of language processing in the human brain","field_investigator":"Evelina  Fedorenko, Robert Mark Richardson","field_institution":"Massachusetts Institute Of Technology","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-NS-19-001","field_project_number":"1U01NS121471-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10199330\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10199330\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Cooperative Agreements","field_priority_area":"Interventional Tools, Integrated Approaches, Monitor Neural Activity, Human Neuroscience","field_program":"Understanding Circuits, Investigative Human Neuroscience","field_research_area":"Systems Neuroscience, Human Neuroscience","body":""},{"title":"Conformable, Expandable Neural Interface Device for the developing brain","field_investigator":"Jennifer  Gelinas, Dion  Khodagholy","field_institution":"Columbia Univ New York Morningside","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-EY-18-001","field_project_number":"1R21EY032381-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10156858\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10156858\u003C\/a\u003E","field_funded_status":"Complete","field_grant_mechanism":"Research Projects","field_priority_area":"Interventional Tools, Monitor Neural Activity","field_program":"","field_research_area":"Human Neuroscience, Neural Recording \u0026amp; Modulation","body":"PROJECT SUMMARY\/ABSTRACT\nA major obstacle to identifying neural network mechanisms responsible for emergence of cognitive function is\ninsufficient capability to acquire large-scale electrophysiologic signals across the course of brain maturation.\nThere is urgent need to develop the technology and ex"},{"title":"Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression","field_investigator":"Alex  Leow, Yichao  Wu, Liang  Zhan","field_institution":"University Of Illinois At Chicago","field_fiscal_year":"\u003Ctime datetime=\u00222021-01-01T12:00:00Z\u0022 class=\u0022datetime\u0022\u003E2021\u003C\/time\u003E\n","field_funding_opp_number":"RFA-MH-20-120","field_project_number":"1RF1MH125928-01","field_link":"\u003Ca href=\u0022https:\/\/reporter.nih.gov\/project-details\/10190424\u0022\u003Ehttps:\/\/reporter.nih.gov\/project-details\/10190424\u003C\/a\u003E","field_funded_status":"Active","field_grant_mechanism":"Research Projects","field_priority_area":"Cell Type, Circuit Diagrams, Human Neuroscience, Integrated Approaches, Interventional Tools, Monitor Neural Activity, Theory \u0026amp; Data Analysis Tools","field_program":"Informatics","field_research_area":"Data Science \u0026amp; Informatics","body":"Recently, several lines of evidence have supported that synaptic dysfunction represents one of\nthe earliest brain changes in Alzheimer\u2019s disease (AD), leading to hyper-excitation in neuronal\ncircuits."}]