Notices of Funding Opportunities

Notice Data Sharing Policy the BRAIN Initiative Notice Number: NOT-MH-19-010 Key Dates Release Date:January 22, 2019 Related Announcements RFA-EY-18-001 RFA-MH-18-510 RFA-MH-19-135 RFA-MH-19-136 RFA-MH-19-147 RFA-MH-19-400 RFA-NS-18-018 RFA-NS-18-019 RFA-NS-18-020 RFA-NS-18-021 RFA-NS-18-022 RFA-NS-18-023 RFA-NS-18-030 RFA-NS-19-001 RFA-NS-19-002 RFA-NS-19-003 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy ShriverNational Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this notice to inform prospective applicants current awardees a new policy concerning data collected support awards are funded the BRAIN Initiative. Specifically, Notice clarifies expectation applicants BRAIN Initiative funding opportunity announcements: 1) submit data one the BRAIN data archives sharing; 2) include specific required elements the Resource Sharing Plan further detailed below; 3) include costs attributed data preparation submission a data archive grant applications. BRAIN Initiative Overview Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, show individual cells complex neural circuits interact both time space. is expected the application these new tools technologies ultimately lead new ways treat prevent brain disorders. NIH one several federal agencies involved the BRAIN Initiative. Planning the NIH component the BRAIN initiative guided the long-term scientific plan, BRAIN 2025: Scientific Vision," details seven high-priority research areas calls a sustained federal commitment 4.5 billion over 12 years. Notice related FOAs issued part the BRAIN initiative based careful consideration the NIH the recommendations the BRAIN 2025 Report, input the NIH BRAIN Multi-Council Working Group. Videocasts the NIH BRAIN Multi-council Working Group available athttp://www.braininitiative.nih.gov/about/mcwg.htm. enable rapid progress development new technologies well in theory data analysis, BRAIN Initiative encourages collaborations between neurobiologists scientists statistics, physics, mathematics, engineering, computer information sciences. BRAIN Initiative Data Sharing BRAIN 2025 report calls establishing platforms sharing data related the BRAIN Initiative. response, NIH released RFAs related data archives RFA-MH-19-145andRFA-MH-17-255), data standards RFA-MH-19-146andRFA-MH-17-256), software integrate analyze data RFA-MH-19-147andRFA-MH-17-257). of those efforts focused data a sub-domain are usually defined the data collection methodology. Data archives have established include: 1) Neuroscience Multi-omic Data Archive https://nemoarchive.org/about.php, R24MH114788) hold data omics experiments. 2) Brain Image Library http://www.brainimagelibrary.org/index.html, R24MH114793) hold microscopy data. 3) Data Archive the BRAIN Initiative https://dabi.loni.usc.edu, R24MH114796) hold data related human electrophysiology experiments. 4) OpenNeuro https://openneuro.org/, R24MH117179) hold magnetic resonance imaging data. 5) Block Object Storage Service https://bossdb.org/, R24MH114785) hold electron microscopy data. few additional data archives distinct sub-domains expected be funded. complete list BRAIN Initiative infrastructure awards be foundhere. awardees the RFAs listed above creating informatics infrastructure necessary BRAIN Initiative awardees others share data are collecting the research community. BRAIN Initiative applications both new resubmissions) submitted after March 1, 2020, applicants required share data collect using BRAIN Initiative informatics infrastructure both data archives relevant data standards),consistent authorities under 21st Century Cures Act these awards authorized under Act. . BRAIN Initiative fellowship applications using any the F activity codes) not required share data are collecting, they encouraged use informatics infrastructure part their training activities. general expectation that data BRAIN Initiative awards be submitted the archives every 6 months. Submitting data an archive distinct sharing data the research community. Submitted data generally held a private enclave until data shared the research community. Frequent submission allows those measuring data perform quality control checks the data deposited. Submitting data an ongoing basis often easier trying package data the end an award period. After data been submitted the appropriate data archive, will shared the research community papers using data been published at end the award period, whichever occurs sooner. calendar submitting data the relevant archive sharing data the research community depend the exact details the experiments are being conducted. applications BRAIN Initiative FOAs required include Resource Sharing Plan part the application. Consistent authorities under 21st Century Cures Act these awards authorized under Act, t portion that plan dealing data must include: 1) summary the data will shared 2) description the standard(s) will used describe data set 3) data archive(s) will house data 4) proposed timeline submitting data the archive sharing data the research community. applications involve human subjects, Resource Sharing Plan should a description whether how consents will used obtain data affect research can done that data. Consents would allow data be used General Research are appropriate all experiments, applicants should consents allow broad data sharing whenever possible. resource sharing plan required matter level funding requested. Costs associated preparing submitting data a data archive should included grant applications. BRAIN Initiative awardees have received awards prior the effective date this Notice encouraged share data. awards prior the effective date this Notice, administrative supplements be necessary prepare such data sets submission an appropriate repository. Investigators should discuss such supplements their assigned program officer. existing BRAIN Initiative awardees already data sharing expectations part their awards. Notice does alter existing data sharing expectations milestones. Inquiries Please direct inquiries to: technical assistance data submission, please contact relevant data archive. other inquiries please contact: Ming Zhan, Ph.D. National Institute Mental Health NIMH) Telephone: 301-827-3678 E-mail:ming.zhan@nih.gov

Notice Correction Key Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)" Notice Number: NOT-NS-19-019 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-003 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants corrections the Council Review  Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov

Notice Correction Key Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)" Notice Number: NOT-NS-19-018 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants changes Advisory Council Review  Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov  

BRAIN Initiative: Notice Support Research the Fundamental Neurobiology Endogenous Opioid Systems Notice Number: NOT-DA-18-046 Key Dates Release Date:October 9, 2018 Related Announcements None Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior.  NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.   announcement to inform research community NIH welcomes applications leverage tools technology emerging the BRAIN Initiative towards elucidating mechanisms which endogenous opioid systems regulate sensory processing, affect cognition appropriate the goals requirements specific BRAIN Initiative FOAs.  overuse opioids created public health crisis, the NIH responding this crisis through conventional Institute Center appropriations special programs such the HEAL Initiative .  However, because BRAIN Initiative specifically aims understand neural circuit activity translates sensory, emotional cognitive functions opioids produce effects engaging endogenous opioid circuits normally regulate same functions, BRAIN uniquely positioned advance knowledge this area. Examples research could supported include use the innovative tools technology profile transcriptome methylome opioid-related neurons , live imaging intracellular signaling cascades identify spatiotemporal aspects cellular signaling engaged opioid receptor activation, brain-wide optical imaging cellular activity cell-types engaged opioids under different conditions, changes connectivity network activity across trajectory opioid assessed optical imaging multiplexed high density electrophysiological recording. Because chronic opioid disrupts cognitive functions emotional regulation the extent being risk survival, study the opioid-dependent brain presents unique opportunity discover how  reprogramming neural substrates circuits translates reprogramming motivation, mood decision-making processes. Interested parties should check information goals requirements specific BRAIN FOAs may appropriate, contact Scientific/Program staff listed the text the respective announcements.  For list active upcoming FOAs.  Inquiries Please direct inquiries to: Olivier Berton, PhD National Institute Drug Abuse Telephone: 301) 827-7771 Email: olivier.berton@nih.gov

Notice Encourage Eligible NIH BRAIN Initiative Awardees Apply PA-18-906 Research Supplements Promote Diversity Health-Related Research Admin Supp - Clinical Trial Allowed) Notice Number: NOT-DA-18-038 Key Dates Release Date: September 18, 2018 Related Announcements PAR-18-501 PAR-18-515 RFA-DA-18-018 RFA-EB-15-006 RFA-EB-17-001 RFA-EB-17-002 RFA-EB-17-003 RFA-EB-17-004 RFA-EB-17-005 RFA-EY-17-001 RFA-EY-18-001 RFA-MH-16-750 RFA-MH-16-775 RFA-MH-16-810 RFA-MH-16-815 RFA-MH-17-210 RFA-MH-17-215 RFA-MH-17-220 RFA-MH-17-230 RFA-MH-17-235 RFA-MH-17-240 RFA-MH-17-245   RFA-MH-17-255 RFA-MH-17-256 RFA-MH-17-257 RFA-MH-17-260 RFA-MH-18-505 RFA-MH-19-136 RFA-NS-15-008 RFA-NS-16-006 RFA-NS-16-007 RFA-NS-16-008 RFA-NS-16-009 RFA-NS-16-010 RFA-NS-17-003 RFA-NS-17-004 RFA-NS-17-006 RFA-NS-17-014 RFA-NS-17-015   RFA-NS-17-019 RFA-NS-18-014 RFA-NS-18-018 RFA-NS-18-019 RFA-NS-18-020 RFA-NS-18-021 RFA-NS-18-022 RFA-NS-18-023 RFA-NS-18-029 RFA-NS-18-030 Issued National Eye Institute NEI) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose Notice encourages eligible awardees the BRAIN Initiative community apply administrative supplements response to PA-18-906 Research Supplements Promote Diversity Health-Related Research Admin Supp - Clinical Trial Allowed). NIH a strong interest the diversity the NIH-funded workforce see NOT-OD-18-210 for details) encourages institutions diversify student populations enhancing participation individuals groups identified underrepresented the biomedical, clinical, behavioral, social sciences. BRAIN Initiative 2025 report stated the BRAIN Initiative should a catalyst will drive outstanding young people enter area their most creative career stage." NIH diversity supplement offers opportunity existing BRAIN awardees request additional funds train mentor next generation researchers, including those underrepresented groups, will contribute advancing goals the BRAIN Initiative. Program Directors/Principal Investigators PD/PI) active BRAIN Initiative research program grants thus encouraged identify eligible individuals throughout continuum high school the faculty level support scientific mentorship under auspices this administrative supplement. activities proposed the supplement application must fall within scope the parent grant, both advance objectives the parent grant support research training professional development the supplement candidate. BRAIN Initiative PIs strongly encouraged incorporate training activities will help prepare supplement candidate conduct rigorous research relevant the goals the BRAIN Initiative 2025 Report. Educational goals the NIH component the BRAIN Initiative see BRAIN 2025: Scientific Vision) include acquisition quantitative skills; appropriate and integration newly developed tools, technologies methods developed under BRAIN Initiative; consideration the ethical implications neuroscience research. special focus training quantitative neuroscience, i.e., theory statistics biologists, exposing physicists, engineers statisticians experimental neuroscience. BRAIN 2025 Report strongly encourages scientists cross traditional areas expertise conduct interdisciplinary research, acknowledges need attract investigators faculty recruits neuroscience quantitative disciplines, e.g., statistics, computer science, physics, mathematics, engineering.   Applicants requested state, the first sentence the Research Strategy, the parent grant awarded a BRAIN Initiative award, to state specific FOA the parent grant e.g., RFA-NS-18-030) facilitate processing the supplement application. some cases, diversity supplement be submitted a multiple-PD/PI MPI) BRAIN Initiative award is awarded a foreign institution. Specifically, diversity supplement be submitted the supplement candidate meets eligibility criteria specified in PA-18-906 and work a subaward MPI a domestic institution. Potential applicants encouraged confirm eligibility the Program contact listed below.  BRAIN diversity supplement awardees, appropriate the duration their support career stage, strongly encouraged participate annual PD/PI meetings in activities. Applicants request funds, addition the research costs specified in PA-18-906, to enable supplement candidate attend annual BRAIN Initiative PD/PI meeting the Washington, DC area. request additional funds should reasonable well justified the application.  Before submitting application, applicants encouraged review the supplemental guidance for BRAIN Initiative diversity supplement applications   the NIH BRAIN Initiative web site. Consultation the Program Official the qualifying BRAIN award the individual named under Inquiries below also strongly encouraged. Supplement applications be evaluated the BRAIN Initiative research training committee, committee Program staff the Institutes Centers participating the NIH BRAIN Initiative.  Applications be considered according the following schedule: Application Due Date                                    Funding Decision October 1, 2018 December 1, 2018              January 30, 2019 December 2, 2018 February 15, 2019          March 31, 2019 February 16, 2019 April 15, 2019                 30, 2019 April 16, 2019 June 15, 2019                       July 30, 2019 tracking purposes, applicants encouraged inform Dr. James Churchill via email BRAIN.Initiative.Training@nih.gov) a diversity supplement application submitted. Please include PD/PI name grant number the subject line this email. Inquiries Please direct inquiries to: James Churchill, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3621 Email: BRAIN.Initiative.Training@nih.gov

Notice Correction PA-18-871, BRAIN Initiative: Development Optimization, Validation Novel Tools Technologies Neuroscience Research SBIR) R43/R44 Clinical Trial Allowed) " Notice Number: NOT-MH-18-051 Key Dates Release Date: September 04, 2018 Related Announcements PA-18-871 Issued National Institute Mental Health NIMH) Purpose purpose this Notice clarify Application Types allowed in PA-18-871, BRAIN Initiative: Development Optimization, Validation Novel Tools Technologies Neuroscience Research SBIR) R43/R44 Clinical Trial Allowed). Currently reads Section II. Award Information  Application Types Allowed New Phase I) Renewal Phase II* Direct Phase II not allowed) Resubmission phases) Revision The OER Glossary and SF424 R&R) SBIR/STTR Application Guide provide details these application types. Modified read  Section II. Award Information    Application Types Allowed  New Phase I, Fast Track) Renewal Phase II* Direct Phase II not allowed) Resubmission phases) Revision The OER Glossary and SF424 R&R) SBIR/STTR Application Guide provide details these application types. other aspects this FOA remain unchanged.  Inquiries Please direct inquiries to: Margaret Grabb, PhD National Institute Mental Health NIMH) Telephone:  301-443-3563 Email:  mgrabb@mail.nih.gov

Notice Change Receipt Date RFA-EY-18-001 BRAIN Initiative: New Concepts Early - Stage Research Large - Scale Recording Modulation the Nervous System R21 Clinical Trial Allowed)" Notice Number: NOT-NS-18-088 Key Dates Release Date: August 10, 2018 Related Announcements RFA-EY-18-001 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-EY-18-001 BRAIN Initiative: New Concepts Early - Stage Research Large - Scale Recording Modulation the Nervous System R21 Clinical Trial Allowed)".  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 1, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.   Modified Read: Application Due Date(s) 1, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.   other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov

Notice Change Receipt Date RFA-NS-18-019 BRAIN Initiative: Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System U01 Clinical Trials Allowed)" Notice Number: NOT-NS-18-086 Key Dates Release Date: August 10, 2018 Related Announcements RFA-NS-18-019 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-NS-18-019 BRAIN Initiative: Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System U01 Clinical Trials Allowed).  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 15, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Application Due Date(s) 15, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov

Notice Change Receipt Date RFA-NS-18-020 BRAIN Initiative: New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System R01 Clinical Trial Allowed)" Notice Number: NOT-NS-18-087 Key Dates Release Date: August 10, 2018 Related Announcements RFA-NS-18-020 Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) Purpose purpose this notice to inform interested applicants there be change receipt dates the Funding Opportunity Announcement FOA) RFA-NS-18-020 BRAIN Initiative: New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System R01 Clinical Trial Allowed)".  Specifically, next receipt date change October 29, 2018 to November 27, 2018. Part 1. Overview Information Key Dates Currently Reads: Application Due Date(s) 15, 2018, October 29, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.   Modified Read: Application Due Date(s) 15, 2018, November 27, 2018, 1, 2019, October 29, 2019, 1, 2020, October 29, 2020 , 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date.   other aspects this FOA remain same. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: BRAIN-FOAs@nih.gov

Soliciting Feedback the BRAIN Initiative Notice Number: NOT-NS-18-075 Key Dates Release Date: July 23, 2018 Response Date: November 15, 2018 Related Announcements NOT-NS-19-041 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Request Information RFI) to solicit input how best accomplish ambitious vision the Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative® set forth BRAIN 2025: Scientific Vision. NIH soliciting input all interested stakeholders, including members the scientific community, trainees, academic institutions, private sector, health professionals, professional societies, advocacy groups, patient communities, well other interested members the public. Background BRAIN Initiative aims develop new tools technologies understand manipulate networks cells the brain. BRAIN 2025: Scientific Vision serves the strategic plan the BRAIN Initiative NIH outlines overarching vision, seven high level scientific priorities, many specific goals. Designed be achieved over least decade, first five years BRAIN 2025 emphasizes development tools technology, the next five years shifts emphasis using tools make fundamental discoveries how brain circuits work what goes wrong disease. BRAIN Initiative well underway see  http://www.braininitiative.nih.gov ), we now approaching midpoint. this time, NIH seeking feedback the BRAIN Initiative's progress on opportunities moving forward given current state the science. NIH established new BRAIN Initiative Advisory Committee the NIH Director ACD) Working Group will provide scientific guidance the ACD how best continue accelerate ambitious vision the BRAIN Initiative. ACD-WG use responses this RFI, along information gathered through series public workshops, help inform discussions the BRAIN Initiative's progress potential updates the plan moving forward. Information Requested Please submit: Ideas new tools technologies have potential transform brain circuit research. Suggestions fundamental questions brain circuit function humans animal models could addressed new technologies. Considerations data sharing infrastructure policies. Areas topics research the ethical implications BRAIN Initiative-supported emerging neurotechnologies advancements their applications. Approaches disseminating new tools technologies well training broader neuroscience research community. Any topic relevant the strategic plan the BRAIN Initiative. to Submit Response assure consideration, responses must received November 15, 2018. Responses this RFI must submitted electronically using web-based form https://www.braininitiative.nih.gov/rfi.aspx via email BRAINFeedback@nih.gov  BRAIN RFI" the subject line. Responses this RFI voluntary. Any personal identifiers be removed responses compiled.  Individual feedback not provided any responder. Proprietary, classified, confidential, sensitive information should be included your response. This Request Information RFI) for planning purposes only is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it. Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: Email: BRAINFeedback@nih.gov